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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
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Применить Всего найдено 14. Отображено 14.
02-05-2023 дата публикации

Application of compound EGTA in preparation of medicine for preventing or treating porcine epidemic diarrhea

Номер: CN116036065A
Автор: XIAO SHUQI, GUO XUYANG, JEONG HAE-HAK, ZHAO XIAOJING, MA ZHIQIAN, LI ZHIWEI, LI YANG, ZHENG ZIFANG, FENG YINGTONG
Принадлежит:

The invention belongs to the technical field of animal epidemic disease prevention and control, and particularly relates to application of a compound EGTA in preparation of a medicine for preventing or treating porcine epidemic diarrhea. It is accidentally found that the compound EGTA can inhibit proliferation of PEDV in eukaryotic cells, has a certain inhibition effect on PEDV, can inhibit infection amplification of PEDV in cells, can be used for preparing drugs for preventing or treating porcine epidemic diarrhea, lays a certain technical foundation for prevention and control of PED, and has a wide application prospect.

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Номер записи: 1
27-01-2016 дата публикации

Massager with topical application of drug water function

Номер: CN0204995775U
Автор: WANG DAIJUN, ZHENG ZIFANG, HAN SILIANG
Принадлежит:

The utility model belongs to the technical field of the massager technique and specifically relates to a massager with topical application of drug water function is related to. The utility model provides a massager with topical application of drug water function, walk the pearl bottle including massager and at least one, it all sets up to walk the pearl bottle the massage of massager is overhead. The utility model provides a massager with topical application of drug water function walks the pearl bottle and sets up overheadly in the massage of massager, during the use, opens away the pearl bottle, opens the massager simultaneously, makes the skin of pearl partial contact people of pearl bottle, when cleaning liquid medicine, carries out massage therapy, promotes the medicine water uptake, has improved treatment greatly.

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Номер записи: 2
23-06-2023 дата публикации

Construction of PPAR gamma knockout cell line and application of PPAR gamma knockout cell line as PRRSV (porcine reproductive and respiratory syndrome virus) production cell line

Номер: CN116286816A
Автор: XIAO SHUQI, ZHENG ZIFANG, JEONG HAE-HAK, LI YANG, MA ZHIQIAN, LI ZHIWEI, FENG YINGTONG, LIU XIAO
Принадлежит:

The invention belongs to the technical field of antiviral research, and particularly relates to construction of a PPAR gamma knockout cell line and application of the PPAR gamma knockout cell line as a PRRSV (porcine reproductive and respiratory syndrome virus) production cell line. Firstly, the invention accidentally finds that the replication of the PRRSV can be obviously promoted by knocking out the PPAR gamma gene in the host cell, so that the cell line constructed by inhibiting/interfering/silencing/knocking out the PPAR gamma gene in the host cell can be used as a PRRSV or PRRSV vaccine production cell line to promote the production of the PRRSV or PRRSV vaccine; secondly, the PPAR gamma gene can be used as a target spot for screening drugs for preventing or treating PRRS, is used for developing drugs for preventing and treating PRRSV and researching anti-PRRSV transgenic pigs, and has a wide application prospect.

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Номер записи: 3
30-09-2015 дата публикации

Novel anti -drop solar energy tile of building abat -vent

Номер: CN0204676789U
Автор: WANG LEI, XU YA, ZHENG ZIFANG, WANG LIMIN, DU JUAN, WANG LING
Принадлежит:

The utility model discloses a novel anti -drop solar energy tile of building abat -vent, the on -line screen storage device comprises a base, the inner chamber upper portion of base is equipped with the recess, and movable mounting has solar cell panel on the recess, and the both sides fixed surface of base installs circuit concatenation tang, buckle card hole is installed to the upper surface of base bottom, and the upper surface top of base and tile spine be the integrated into one piece structure, the lower surface of tile spine be equipped with with buckle card hole matched with buckle riser, this novel anti -drop solar energy tile of building abat -vent installs circuit concatenation tang through both sides, can be convenient splice the solar energy tile, the installation is succinct, save material, the upper surface through the base is equipped with the recess, can install solar cell panel inside the recess, is convenient for change or the installation in the future.

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Номер записи: 4
08-08-2023 дата публикации

Construction of YY1 gene knockout cell line and application of YY1 gene knockout cell line as PRRSV production cell line

Номер: CN116555255A
Автор: XIAO SHUQI, ZHENG ZIFANG, JEONG HAE-HAK, LING XUE, LI YANG, MA ZHIQIAN, LI ZHIWEI, FENG YINGTONG
Принадлежит:

The invention belongs to the technical field of antiviral research, and particularly relates to construction of a YY1 gene knockout cell line and application of the YY1 gene knockout cell line as a PRRSV (porcine reproductive and respiratory syndrome virus) production cell line. Firstly, the invention accidentally finds that the knockout of the YY1 gene in the host cell can obviously promote the replication of the PRRSV, so that the cell line constructed by inhibiting/interfering/silencing/knocking out the YY1 gene in the host cell can be used as a PRRSV or PRRSV vaccine production cell line to promote the production of the PRRSV or PRRSV vaccine; secondly, the YY1 gene can be used as a target spot for screening drugs for preventing or treating PRRS, is used for developing drugs for preventing and treating PRRSV and researching anti-PRRSV transgenic pigs, and has a wide application prospect.

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Номер записи: 5
11-04-2023 дата публикации

Application of oleic acid in preparation of medicine for preventing or treating porcine reproductive and respiratory syndrome

Номер: CN115944615A
Автор: XIAO SHUQI, ZHENG ZIFANG, JEONG HAE-HAK, LI YANG, MA ZHIQIAN, FENG YINGTONG, LI ZHIWEI, LIU XIAO
Принадлежит:

The invention belongs to the technical field of biological medicines, and particularly relates to application of oleic acid in preparation of a medicine for preventing or treating porcine reproductive and respiratory syndrome. Oleic acid is used for incubation treatment of PRRSV infected MARC-145 cells, the influence of oleic acid on PRRSV infected host cells is detected through Western blot and TCID50, it is found that replication and proliferation of PRRSV can be significantly inhibited after oleic acid treatment, the method is expected to be applied to development of drugs for prevention or treatment of PRRSV, and a new method is provided for effective prevention and control of PRRSV.

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Номер записи: 6
30-09-2015 дата публикации

Comprehensive utilization method of asparagus

Номер: CN104939242A
Автор: WANG DAIJUN, ZHENG ZIFANG, HAN SILIANG
Принадлежит:

The invention provides a comprehensive utilization method of asparagus. The method includes the following steps that the asparagus is preprocessed; the preprocessed asparagus is crushed and pulped, and slurry is obtained; cellulose and pectinase are added into the slurry, enzymolysis reaction is conducted at 45 DEG C to 55 DEG C under the acidic condition, and a decomposition product is obtained; flavones in the decomposition product is adsorbed, and asparagus flavones and residual liquor are obtained; lactobacillus bulgaricus and streptococcus thermophilus are added to the residual liquor, fermentation is conducted at 35 DEG C to 45 DEG C, and fermentation liquor is obtained; the fermentation liquor is filtered, and trapped fluid and permeate liquid are obtained. According to the comprehensive utilization method of the asparagus, the asparagus is deeply developed, at least two target products of asparagus liquid beverage and asparagus flavones can be obtained, and the method has the advantages ...

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Номер записи: 7
14-04-2023 дата публикации

Application of IL-8 as target spot in inhibition of porcine epidemic diarrhea virus infection and vaccine production

Номер: CN115961104A
Автор: XIAO SHUQI, GUO XUYANG, JEONG HAE-HAK, ZHAO XIAOJING, MA ZHIQIAN, LI ZHIWEI, LI YANG, ZHENG ZIFANG, FENG YINGTONG
Принадлежит:

The invention belongs to the field of gene engineering, and particularly relates to application of IL-8 as a target spot in inhibition of porcine epidemic diarrhea virus infection and vaccine production. The invention firstly finds that knockout of IL-8 can significantly inhibit the duplication of PEDV, based on this, IL-8 as a target can be used for screening anti-PEDV infection drugs, that is, a reagent capable of inhibiting or silencing IL-8 expression can be used as an anti-PEDV infection drug for preventing or treating PED, and a new thought is provided for treatment of PED; secondly, overexpression of the IL-8 can significantly promote duplication of the PEDV, so that the reagent for promoting expression of the IL-8 can be used as a production synergist of the PEDV or a PEDV vaccine; in addition, the cells over-expressing IL-8 can be used as PEDV or PEDV vaccine production cell lines for production of PEDV or PEDV vaccines.

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Номер записи: 8
12-05-2023 дата публикации

Application of NEP as target spot in inhibition of porcine epidemic diarrhea virus infection and vaccine production

Номер: CN116103446A
Автор: XIAO SHUQI, GUO XUYANG, JEONG HAE-HAK, ZHAO XIAOJING, MA ZHIQIAN, LI ZHIWEI, LI YANG, ZHENG ZIFANG, FENG YINGTONG
Принадлежит:

The invention belongs to the field of gene engineering, and particularly relates to application of NEP as a target spot in inhibition of porcine epidemic diarrhea virus infection and vaccine production. The invention firstly finds that the knockout of the NEP protein/MME gene can inhibit the duplication of PEDV, that is, the NEP protein/MME gene can be used as a target spot for screening drugs for resisting PEDV infection, which indicates that a reagent for inhibiting/silencing the NEP protein/MME gene can be used as a drug for resisting PEDV infection and is used for preventing or treating PED, and a new thought is provided for the treatment of PED; secondly, overexpression of the NEP protein/MME gene can promote duplication of the PEDV, that is, a reagent for promoting expression of the NEP protein/MME gene can be used as a production synergist of the PEDV or a PEDV vaccine; and the cells over-expressing the NEP protein/MME gene can be used as a PEDV (porcine epidemic diarrhea virus) ...

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Номер записи: 9
11-04-2023 дата публикации

Application of rosiglitazone in preparation of medicine for preventing or treating porcine reproductive and respiratory syndrome

Номер: CN115944634A
Автор: XIAO SHUQI, ZHENG ZIFANG, JEONG HAE-HAK, LING XUE, LI YANG, FENG YINGTONG, MA ZHIQIAN, LI ZHIWEI
Принадлежит:

The invention belongs to the technical field of biological medicine, and particularly relates to application of rosiglitazone in preparation of medicine for preventing or treating porcine reproductive and respiratory syndrome. According to the present invention, the PRRSV infected MARC-145 cells are subjected to incubation treatment by using the rosiglitazone, the influence of the rosiglitazone on the PRRSV infected host cells is detected through Western blot and TCID50, the results show that the replication and the proliferation of the PRRSV can be significantly inhibited after the rosiglitazone is treated, the rosiglitazone is expected to be used for developing the drugs for preventing or treating the PRRSV, and the new method is provided for the effective prevention and control of the PRRSV.

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Номер записи: 10
09-06-2023 дата публикации

Application of compound BAPTA-AM in preparation of medicine for preventing or treating porcine epidemic diarrhea

Номер: CN116236472A
Автор: XIAO SHUQI, GUO XUYANG, JEONG HAE-HAK, ZHAO XIAOJING, MA ZHIQIAN, LI ZHIWEI, LI YANG, ZHENG ZIFANG, FENG YINGTONG
Принадлежит:

The invention belongs to the technical field of animal epidemic disease prevention and control, and particularly relates to application of a compound BAPTA-AM in preparation of a medicine for preventing or treating porcine epidemic diarrhea. The invention accidentally finds that the compound BAPTA-AM can inhibit proliferation of PEDV in eukaryotic cells, has a certain inhibition effect on PEDV, can inhibit infection amplification of PEDV in cells, can be used for preparing drugs for preventing or treating porcine epidemic diarrhea, lays a certain technical foundation for prevention and control of PED, and has a wide application prospect.

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Номер записи: 11
09-06-2023 дата публикации

Application of sanggenone C or composition containing sanggenone C in preparation of antiviral drugs

Номер: CN116236474A
Автор: XIAO SHUQI, LIU XIAO, JEONG HAE-HAK, ZHU YANAN, ZHENG ZIFANG, LI YANG, FENG YINGTONG, MA ZHIQIAN
Принадлежит:

The invention belongs to the field of medicines, and particularly relates to application of sanggenone C or a composition containing sanggenone C in preparation of antiviral drugs. According to the application disclosed by the invention, firstly, the sanggenone C is found to have the effects of down-regulating expression of capsid protein of porcine reproductive and respiratory syndrome virus, inhibiting virus titer of PRRSV and inhibiting replication and proliferation of PRRSV, and an in-vitro cell pharmacological experiment shows that the sanggenone C has an exact and good antiviral effect; secondly, the sanggenone C and arctigenin composition can significantly down-regulate the expression of porcine reproductive and respiratory syndrome virus capsid protein, inhibit the virus titer of PRRSV, and inhibit the replication and proliferation of PRRSV, and in-vitro cell pharmacological experiments show that the drug combination has a more exact antiviral effect. The invention provides a new ...

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Номер записи: 12
12-05-2023 дата публикации

Application of compound Thapsigargin in preparation of medicine for preventing or treating porcine epidemic diarrhea

Номер: CN116098893A
Автор: XIAO SHUQI, GUO XUYANG, JEONG HAE-HAK, ZHAO XIAOJING, MA ZHIQIAN, LI ZHIWEI, LI YANG, ZHENG ZIFANG, FENG YINGTONG
Принадлежит:

The invention belongs to the technical field of animal epidemic disease prevention and control, and particularly relates to application of a compound Thapsigargin in preparation of a medicine for preventing or treating porcine epidemic diarrhea. The invention accidentally finds that the compound Thapsigargin can inhibit PEDV proliferation, has a certain inhibition effect on PEDV, can inhibit infection amplification of PEDV in cells, can be used for preparing medicines for preventing or treating porcine epidemic diarrhea, lays a certain technical foundation for prevention and control of PED, and has a wide application prospect.

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Номер записи: 13
21-07-2023 дата публикации

Recombinant nano antibody targeting BVDV non-structural protein and application

Номер: CN116462752A
Автор: XIAO SHUQI, MA ZHIQIAN, JEONG HAE-HAK, LI ZHIWEI, LI YANG, GUO XUYANG, ZHENG ZIFANG, FENG YINGTONG, LIU XIAO
Принадлежит:

The invention belongs to the technical field of biology, and particularly relates to a recombinant nano antibody targeting a BVDV non-structural protein and application of the recombinant nano antibody. The amino acid sequence of the recombinant nano antibody disclosed by the invention is as shown in SQE ID NO. 1. The recombinant nano antibody is obtained through expression of an escherichia coli expression system, and the preparation method is simple; and compared with the existing nano antibody targeting the BVDV non-structural protein, the recombinant nano antibody disclosed by the invention can autonomously penetrate through a cell membrane, and can inhibit the replication of the BVDV in cells, thereby providing a new technical means for prevention and control of the BVDV.

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Номер записи: 14