17-02-2022 дата публикации
Номер: US20220047717A1
Автор:
Cho Jongun,
Ha Jihyeon,
Jung Doohwan,
Kim Sena,
KIM Sunyoung,
Ko Yunjung,
Lee Eunjin,
Lee Hyang Sook,
LEE Hyun Ju,
Lee Hyun Mi,
Lee Jaeho,
Lee Minju,
Lee Sangkwang,
Park Jae Eun,
Park Okku,
PARK Suho,
Park Taekyo,
Park Young Woo,
REW Yosup,
Seo Beomseok,
Seo Donghoon,
Seol Minah,
Shim Eun-Young,
Song Jina,
Song Youngja,
Woo Sung Ho,
Yun Sanghyeon
Принадлежит:
The present disclosure relates to antibody-drug conjugates (ADCs) wherein one or more active agents are conjugated to an anti-B7-H3 antibody through a linker. The linker may comprise a unit that covalently links active agents to the antibody. The disclosure further relates to monoclonal antibodies and antigen binding fragments, variants, multimeric versions, or bispecifics thereof that specifically bind B7-H3, as well as methods of making and using these anti-B7-H3 antibodies and antigen-binding fragments thereof in a variety of therapeutic, diagnostic and prophylactic indications. 1. A antibody conjugate represented by Formula I or pharmaceutically acceptable salt or solvate thereof:{'br': None, 'sub': 'n', 'Ab-(G)\u2003\u2003Formula I'}wherein:Ab is an anti-B7-H3 antibody or antigen-binding fragment thereof comprising a variable heavy chain complementarity determining region 1 (CDRH1), a variable heavy chain complementarity determining region 2 (CDRH2), a variable heavy chain complementarity determining region 3 (CDRH3), a variable light chain complementarity determining region 1 (CDRL1), a variable light chain complementarity determining region 2 (CDRL2), and a variable light chain complementarity determining region 3 (CDRL3); wherein,CDRH1 comprises an amino acid sequence of SEQ ID NO: 1, 7, 13, 19, 25, 31, 37, or 43;CDRH2 comprises an amino acid sequence of SEQ ID NO: 2, 8, 14, 20, 26, 32, 38, or 44;CDRH3 comprises an amino acid sequence of SEQ ID NO: 3, 9, 15, 21, 27, 33, 39, or 45;CDRL1 comprises an amino acid sequence of SEQ ID NO: 4, 10, 16, 22, 28, 34, 40, or 46,CDRL2 comprises an amino acid sequence of SEQ ID NO: 5, 11, 17, 23, 29, 35, 41, or 47;CDRL3 comprises an amino acid sequence of SEQ ID NO: 6, 12, 18, 24, 30, 36, 42, or 48;each G is, independently, a chemical moiety comprising one or more active agents and a linker, wherein the linker links Ab to the active agent(s); andn is an integer between 1 to 20.2. The antibody conjugate of claim 1 , wherein ...
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