03-09-2015 дата публикации
Номер: US20150247869A1
Disclosed is a novel NASH marker for use in a method for detecting NASH or evaluating the severity of NASH, which utilizes at least one factor selected from the group consisting of an IL-1 receptor antagonist, sCD40, HMGB1, sPLA2 group IIA and an sPLA2 activity as the marker. Also disclosed is a method for detecting NASH or evaluating the severity of NASH in a subject, which utilizes the marker. 1. A method for evaluating therapeutic effects on non-alcoholic steatohepatitis (NASH) in a subject , said method comprising:measuring at least one member selected from the group consisting of IL-2, apolipoprotein A-IV, apolipoprotein C-II, CCL2, thrombospondin 1, trehalase, MMP12, MMP13, TIMP1, complement factor D, lipoprotein lipase, alpha chain of IL-3 receptor, locus D of lymphocyte antigen 6 complex, COL1aI, member 19 of TNFR superfamily (TAJ), TNFAIP6, VLDLR, Members 1, 2, 3, and 12 of EarA family, INSL5, TGFβ2, HAMP, lipase H, and CYP7BI in the biological specimen from the subject as a marker.2. A method for evaluating therapeutic effects on non-alcoholic steatohepatitis (NASH) in a subject , said method comprising:measuring at least a first factor selected from the group consisting of IL-I receptor antagonist, sCD40, HMGB1, sPLA2 group IIA, sPLA2 activity, or a second factor selected from the group consisting of IL-2, apolipoprotein apolipoprotein C-II, CCL2, thrombospondin 1, trehalase, MMP12, MMP13, TIMP1, complement factor D, lipoprotein lipase, alpha chain of IL-3 receptor, locus D of lymphocyte antigen 6 complex, COLlaI, member 19 of TNFR superfamily (TAJ), TNFAIP6, VLDLR, Members 1, 2, 3, and 12 of EarA family, INSL5, TGF β2, HAMP, lipase H, and CYP7BI, in a biological specimen from the subject as a marker at least twice at a certain interval, andcomparing the measured values.3. The method according to claim 2 , wherein a pharmaceutical composition containing at least one member selected from the group consisting of icosapentaenoic acid and pharmaceutically ...
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