20-04-2017 дата публикации
Номер: US20170105965A1
The present invention provides A PPARγ activator comprising a butenolide compound represented by the formula (1) or a pharmaceutically acceptable salt thereof: 14-. (canceled)6. The method according to claim 5 , wherein the pathological condition claim 5 , the symptom claim 5 , or the disease involving PPARγ is one or more pathological conditions claim 5 , symptoms claim 5 , or diseases selected from the group consisting of diabetes mellitus claim 5 , insulin resistance claim 5 , obesity claim 5 , body weight gain claim 5 , visceral fat accumulation claim 5 , subcutaneous fat accumulation claim 5 , leptin resistance claim 5 , abnormal lipid metabolism claim 5 , hyperlipidemia claim 5 , arteriosclerosis claim 5 , and metabolic syndrome. The present invention relates to a PPARγ activator that can be used for a lipid metabolism activator, an antidiabetic agent, or the prevention or amelioration, etc., of obesity, lifestyle-related diseases, or the like.Fragrance vinegars (aromatic vinegars) are fermented foods that are typically produced by the fermentation of glutinous rice followed by aging for a long period, and have been used as vinegar seasonings in China from a long time ago. The fragrance vinegars have also become increasingly popular in Japan in recent years as health foods that help maintain or promote health, because of their higher contents of organic compounds such as amino acids than those of rice vinegars, which are vinegars generally used in Japan.For example, the present inventors disclose, in Patent Literature 1, a peroxisome proliferator-activated receptor α activator and a peroxisome proliferator-activated receptor γ activator each containing a lower alkanol extract of fragrance vinegar as an active ingredient. This literature states that the lower alkanol extract of a fragrance vinegar exhibits the peroxisome proliferator-activated receptor (PPAR) α-activating effect of improving sugar metabolism by participating in the stimulation of fatty acid, ...
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