GASTRORETENTIVE PHARMACEUTICAL DOSAGE FORM

A pharmaceutical dosage form, comprising: a pharmaceutical unit which includes a drug, at least one unfolding member, and a retaining member, wherein the unfolding member is connected to the pharmaceutical unit, and is constructed to have a contracted shape, which makes the unfolding member become closer the pharmaceutical unit, and an unfolding shape, which makes the unfolding member become farther away from the pharmaceutical unit; the retaining member is connected to the at least one unfolding member, and applies a constraint force to the at least one unfolding member, so as to make the unfolding member be in the contracted shape; and the retaining member contains a water-soluble material, and is constructed to remove the constraint force from the unfolding member when the water-soluble material is dissolved, such that the at least one unfolding member can change from the contracted shape to the unfolding shape.

Oral drug dosage forms for stomach retention

Provided herein are drug dosage forms designed to provide a desired retention in an individual based on geometric differences between a pre-administration and post-administration state of the dosage form. In certain aspects, provided are oral drug dosage forms comprising a swellable and expandable material configured, upon swelling or expanding, to drive expansion of the overall size of the oral drug dosage forms such that the oral drug dosage forms are retained in the stomach for a desired period of time. In certain other aspects, provided is directed to components useful for the oral drug dosage forms taught herein. In certain other aspects, provided is directed to methods of designing, methods of making, such as involving three-dimensional (3D) printing, injection molding, ultrasonic welding, or any combination thereof, commercial batches, and methods of delivering a drug to an individual comprising administering an oral drug dosage form taught herein.

Gastroretentive pharmaceutical dosage form

Oral drug dosage forms for colon delivery and methods of use and making thereof

Provided, in some aspects, is directed to oral drug dosage forms configured to release a drug at a desired location in the colon of an individual. As provided in certain aspects, the oral drug dosage forms comprise a drug component comprising an erodible material admixed with the drug, and a delay component not admixed with the drug, wherein the delay component is configured to prevent release of the drug from the drug component until the oral drug dosage form reaches the colon of the individual following administration. In other aspects, the provided is directed to methods of designing, methods of making, such as using three-dimensional printing, and methods of treatment associated with the oral drug dosage forms described herein.