24-06-2015 дата публикации
Номер: CN104725302A
Принадлежит:
The invention discloses a preparation method of liranaftate and belongs to the technical field of synthesis of an antifungal drug liranaftate. According to the key points of the technical scheme, the preparation method of liranaftate comprises the following four steps: synthesizing 6-methoxy-2-chloropyridine, synthesizing 6-methoxy-2-methylaminopyridine, synthesizing 5,6,7,8-tetrahydro-2-naphthoxy sulfuryl chloride, and synthesizing liranaftate. The preparation method of liranaftate has the advantages that reaction conditions are mild, operation is simple, a product is easy to separate and purify, yield is high, purity is high, residual quantity of related substances and organic solvent is low, medicinal standards can be met, environment friendliness is realized, ionic liquid can be taken as a reaction medium and can also realize catalytic action, and after reaction is finished, the ionic liquid can be recycled and can be effectively recycled for multiple times.
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