31-03-2022 дата публикации
Номер: US20220098180A1
Автор:
ARIKAWA Yasuyoshi,
ASANO Yasutomi,
Homma Misaki,
Imaeda Yasuhiro,
Ito Masahiro,
KAKEGAWA Keiko,
KAMITANI Hirotaka,
KIKUCHI Fumiaki,
KOJIMA Takuto,
Kokubo Hironori,
KUBO Osamu,
MAEZAKI Hironobu,
MIYAZAKI Tohru,
Okawa Tomohiro,
SASAKI Minoru,
SASAKI Shiinobu,
Sato Ayumu,
Sugiyama Hideyuki,
TOITA Akinori,
YAMAMOTO Takeshi,
YONEMORI Jinichi,
Yoshikawa Masato
The present invention provides a heterocyclic compound having a HDAC inhibitory action, which is useful for the treatment of central nervous system diseases including neurodegenerative diseases, and the like, and a medicament comprising the compound. 4. The compound or salt of which is 5-[(2-{4-[5-(Difluoromethyl)-1 claim 2 ,3 claim 2 ,4-oxadiazol-2-yl]pyridin-2-yl}-1H-imidazol-1-yl)methyl]-2-fluorobenzonitrile or a salt thereof claim 2 , 2-{4-[5-(difluoromethyl)-1 claim 2 ,3 claim 2 ,4-oxadiazol-2-yl]pyridin-2-yl}-1-[(3-fluorophenyl)methyl]-1H-imidazole-5-carbonitrile or a salt thereof claim 2 , or 4-[5-(difluoromethyl)-1 claim 2 ,3 claim 2 ,4-oxadiazol-2-yl]-2-{1-[(3-fluorophenyl)methyl]-1H-1 claim 2 ,2 claim 2 ,4-triazol-5-yl}pyridine or a salt thereof.6. The compound or salt according to claim 5 , wherein{'sup': 'b', 'Xis CH or N;'}{'sup': 'b', 'Ring Ais (i) a benzene ring, or (ii) a pyridine ring;'}{'sup': 'b', 'Yis an oxygen atom or methylene;'}{'sup': 'b', 'Zis'}{'sup': 3b′', '4b′, 'claim-text': [{'sup': '3b′', 'R is'}, '(a) a hydrogen atom, or', {'sub': 1-6', '1-6, '(b) a Calkyl group optionally substituted by 1 to 3 Calkoxy groups; and'}, {'sup': '4b′', 'R is'}, '(a) a hydrogen atom,', {'sub': '3-6', '(b) a Ccycloalkyl group,'}, {'sub': '6-10', 'claim-text': (i) a halogen atom,', '(ii) a cyano group,', {'sub': '1-6', '(iii) an optionally halogenated Calkyl group, and'}, {'sub': '1-6', '(iv) an optionally halogenated Calkoxy group, or'}], '(c) a Caryl group optionally substituted by 1 to 3 substituents selected from'}], '(1) a group represented by CRR wherein'}(d) a 5- or 6-membered aromatic heterocyclic group, or{'sup': '5b′', 'claim-text': [{'sup': '5b′', 'R is'}, {'sub': '1-6', '(a) an optionally halogenated Calkyl group,'}, {'sub': '3-6', '(b) a Ccycloalkyl group optionally substituted by 1 to 3 halogen atoms,'}, {'sub': '6-10', '(c) a Caryl group optionally substituted by 1 to 3 halogen atoms, or'}, '(d) a 5- or 6-membered non-aromatic heterocyclic ...
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