用作血管紧张素Ⅱ激动剂的三环化合物

... 提供了式I化合物，其中X#-[1]、X#-[2]、X#-[3]、X#-[4]、Y#-[1]、Y#-[2]、Y#-[3]、Y#-[4]、Z#-[1]、Z#-[2]、R#+[4]和R#+[5]具有如说明书中给定的含义，及其可药用盐，这些化合物可用作AT2受体的选择性激动剂，并因此尤其用于治疗胃肠道疾病，如消化不良、IBS和MOF，以及心血管疾病。 ...

IMPROVED UNIVERSAL JOINT CROSS

Croix de cardan (1) comprenant un corps comprenant quatre équerres (10), chaque équerre (10) possédant deux bras (10a, 10b) perpendiculaires l'un à l'autre, le bras (10a) d'une équerre (10) étant assemblé au bras (10a) d'une équerre (10) adjacente de manière à former une croix comportant quatre branches (la, lb, 1c, 1d).

INCOMPRESSIBLE VEHICLE WITH A FIXED ELEMENT ON A COMPRESSIBLE MEMBER IN THE EVENT OF A CRASH

ADHESIVE COMPOSITION INCLUDING/UNDERSTANDING OF CHITOSANE DESACETYLE

La présente invention concerne une composition adhésive comprenant au moins un chitosane désacétylé, un acide et un composé additionnel.

METHOD AND DEVICE FOR MONITORING A BABY AND INTERACTION

Procédé d'évaluation par vidéo du rythme cardiaque et/ou du rythme respiratoire d'un bébé (B), notamment en conditions de pénombre ou nocturne, dans un dispositif comprenant une caméra vidéo (2) et une source d'illumination infrarouge (3), le procédé comprenant les étapes : A1- illuminer le bébé avec la source infrarouge, A2- capturer des images vidéo du bébé, B1- déterminer la position de la tête (T) du bébé par une recherche d'ellipse formant un contour de la tête, B2- identifier une zone d'intérêt (7) centrée sur une ellipse élue (6), C- évaluer, par une analyse pléthysmographique sur la zone d'intérêt, le rythme cardiaque (FC) et/ou le rythme respiratoire (RR) du bébé, et système associé.

HUB INTERMEDIATE HOUSING FOR AN AIRCRAFT JET ENGINE COMPRISING A DUCT FOR CLEANING SEWERS

L'objet principal de l'invention est un moyeu de carter intermédiaire pour turboréacteur d'aéronef, comportant : une virole externe (14) destinée à délimiter extérieurement un espace d'écoulement secondaire d'un flux de gaz secondaire et intérieurement une zone inter veines, la virole externe (14) étant pourvue d'un orifice secondaire (29), et une vanne de décharge comprenant un conduit de décharge (30) en matériau composite, situé dans la zone inter veines, caractérisé en ce que le conduit de décharge (30) est fixé à la virole externe (14) au niveau de l'orifice secondaire (29), au moins un joint d'étanchéité (33) à l'air et au feu étant disposé entre le conduit de décharge (30) et la virole externe (14), et en ce que le conduit de décharge (30) en matériau composite comporte une paroi composite (30a, 30b) drapée, constituée d'une pluralité de plis imprégnés de résine. The main object of the invention is an intermediate case hub for an aircraft turbojet, comprising: an outer shell (14) intended to externally delimit a secondary flow space of a secondary gas flow and internally an inter zone veins, the outer ferrule (14) being provided with a secondary orifice (29), and a discharge valve comprising a discharge duct (30) of composite material, located in the inter-vein zone, characterized in that the discharge (30) is attached to the outer shroud (14) at the secondary orifice (29), at least one air and fire seal (33) being disposed between the discharge conduit (30). ) and the outer shell (14), and in that the discharge pipe (30) of composite material comprises a composite wall (30a, 30b) draped, consisting of a plurality of folds impregnated with resin.

ASSEMBLING TWO PARTS COMPRISING A CENTERING CUP REMOVABLE FOR AN AIRCRAFT TURBINE ENGINE

CONNECTION UNIT BRAZES

Est proposé un ensemble raccord contenant un raccord, une première plaque et une seconde plaque. La première plaque a une paroi de première plaque et une ouverture de première plaque, la paroi de première plaque étant positionnée le long d'un bord de la première plaque qui définit l'ouverture de première plaque. La seconde plaque a une paroi de seconde plaque et une ouverture de seconde plaque, la paroi de seconde plaque étant positionnée le long d'un bord de la seconde plaque qui définit l'ouverture de seconde plaque. L'ensemble raccord a le raccord pris en sandwich entre la paroi de première plaque et la paroi de seconde plaque. Sont également divulgués un échangeur de chaleur ayant l'ensemble raccord tel que décrit ici, et un procédé pour former l'ensemble raccord.

CARRY FRONT LUGGAGE FOR MOTOR BIKE

METHOD OF DISPLAYING A GRID ENTER A PASSWORD ON A USER TERMINAL

L'invention concerne un procédé d'affichage d'une grille de saisie d'un mot de passe sur un terminal utilisateur, ladite grille comprenant une pluralité d'images affichables, une image affichable comprenant au moins un signe, l'image affichable étant destinée à être sélectionnée par l'utilisateur en tant que composante du mot de passe, le procédé comprend les étapes suivantes : - génération (EO) de la grille de saisie, les images affichables étant positionnées de manière aléatoire dans la grille, - pour un signe composant l'image, génération (E1) d'un aléa propre au signe de l'image, - affichage (E2) du signe à une position obtenue pour l'image à partir de la grille de saisie, lorsque l'aléa propre au signe est inférieur à une probabilité d'affichage, les étapes de génération de l'aléa et d'affichage du signe étant réitérées à intervalles réguliers.

VEHICLE WITH A FASTENING ELEMENT FIXED ON A SQUEEZER UNCOMPRESSIBLE COLLISION

METHOD FOR SECURING A REQUEST TO PERFORM A FIRST APPLICATION WITH A SECOND APPLICATION

L'invention concerne un procédé de sécurisation d'une demande d'exécution d'une première application (P1) dans un premier dispositif (11) d'un environnement sécurisé, par une deuxième application (P2) située dans un deuxième dispositif (10), ledit procédé comprenant les étapes suivantes : -réception d'une première demande d'exécution de la première application, en provenance de la deuxième application, - génération d'un aléa et d'une clé de session dépendant de l'aléa, - envoi dudit aléa à une entité de confiance (12), ledit aléa étant destiné à permettre à l'entité de confiance de générer la clé de session, -réception d'une deuxième demande d'exécution de la première application, en provenance d'une troisième application (P3) générée par l'entité de confiance et transmise au deuxième dispositif, ladite troisième application comprenant la clé de session, - authentification de la troisième application au moyen de la clé de session, ladite authentification conditionnant l'exécution de la ...

METHOD AND DEVICE FOR MONITORING A BABY AND INTERACTION

ADHESIVE COMPOSITION INCLUDING/UNDERSTANDING OF CHITOSANE DESACETYLE

BRAZED CONNECTOR ASSEMBLY

METHOD FOR AUTHENTICATING A USER HAVING A FIRST DEVICE IN RELATION TO A SECOND DEVICE

L'invention concerne un procédé d'authentification d'un utilisateur (10) équipé d'un premier dispositif (11) par un deuxième dispositif (12), une association dudit utilisateur avec une liste d'éléments d'authentification étant connue au niveau du deuxième dispositif et au niveau de l'utilisateur, comprenant les étapes suivantes : - envoi (E1) au premier dispositif d'un contenu multimédia, -réception (E4) du premier dispositif d'informations de localisation relatives à des zones du contenu multimédia sélectionnées par l'utilisateur sur le premier dispositif, lesdites zones représentant les éléments d'authentification, - détermination (E5), à partir du contenu multimédia et des informations de localisation reçues, de listes d'éléments descriptifs courants associées respectivement à une zone sélectionnée, -comparaison (E6) de la liste des éléments d'authentification associée à l'utilisateur avec les listes des éléments descriptifs courants, l'authentification étant réussie lorsque chaque élément ...

SYSTEM HAVING A MOVABLE PLATEN

ASSEMBLY OF TWO PARTS COMPRISING A CUP REMOVABLE CENTERING FOR AIRCRAFT TURBOMACHINE

Une turbomachine pour aéronef comporte en général au moins un assemblage formé d'une première pièce (70) sur laquelle une deuxième pièce (72) est fixée à l'aide de moyens de fixation (18) comprenant une tête (26) appliquée sur la première pièce et un corps (19) coopérant avec la deuxième pièce pour opérer un serrage des pièces. Le logement de la tête (26) d'un tel moyen de fixation requiert un bossage au niveau de la première pièce, complexe et coûteux à réaliser avec des techniques conventionnelles. Un tel bossage peut être remplacé par une coupelle (80) amovible comprenant un orifice (82) au travers duquel passe le corps (19) et formant un logement pour la tête (26), une surface d'appui pour la tête (26), et des moyens de butée (92) appliqués sur la première pièce pour empêcher un déplacement de la coupelle (80) en direction de la deuxième pièce. An aircraft turbomachine generally comprises at least one assembly formed of a first piece (70) on which a second piece (72) is fixed by means of fastening means (18) comprising a head (26) applied on the first piece and a body (19) cooperating with the second piece to operate a clamping parts. The housing of the head (26) of such a fastening means requires a boss at the first piece, complex and expensive to achieve with conventional techniques. Such a boss may be replaced by a removable cup (80) comprising an orifice (82) through which the body (19) passes and forming a housing for the head (26), a bearing surface for the head (26). and abutment means (92) applied to the first piece to prevent displacement of the cup (80) towards the second piece.

Handling device for handling suspension triangles of car in industrial production line, has orientation mechanism driven by movement of plate along guide, which changes orientation of supports of suspension triangles

Dispositif de manutention de pièces, comportant un plateau mobile (6) disposant de moyens de positionnement (12) des pièces (22) suivant une certaine orientation, ce dispositif comprenant un guidage (4) permettant un déplacement manuel du plateau le long de ce guidage, caractérisé en ce qu'il comporte un mécanisme d'orientation (14) entraîné par le déplacement du plateau (6) le long de son guidage, qui modifie par cet entraînement l'orientation des moyens de positionnement (12) des pièces (22).

PROCESS AND DEVICE HAVE TWO CAMERAS Of OBSERVATION FOR THREE-DIMENSIONAL MEASUREMENTS Of a COMPLEX STRUCTURE

JOINT HAS COMPOSITE MATERIAL BRUSHES

Method and device for quantifying situ morphology and thickness in a localized area of a surface layer being processed on a thin film structure.

Metodo para elaborar una bebida instantanea en polvo que posee un tamaño de particulas mayor a 1 mm, que comprende las etapas de: proporcionar una base de polvo particulado porosa, sinterizar dicho polvo para formar una torta aglomerada y texturizar la torta aglomerada para obtener una bebida instantanea en polvo.

Bebida instantánea en polvo que tiene una porosidad de espuma de al menos 35%, un volumen de poro abierto de menos de 3ml/g y un diámetro promedio de poro cerrado d50 de menos de80 micrómetros; y método para la elaboración de dicha bebida.

Method and Device for Preparing Broken Glass

The invention relates to a method and a device for processing broken glass, to which residues of stickers adhere. 116-. (canceled)17. A method for processing broken glass subject to moisture , to which residues of stickers adhere , having the following method steps:the broken glass is delivered continuously onto one end of a drum at a delivery point;the broken glass travels as a stream of broken glass particles in the drum to a discharge point, where it is removed;the drum executes movements which result in circulation and mutual friction of the broken glass particles;a gas stream is applied to the stream of broken glass particles and guided over it to remove detached stickers;hot air is used as the gas for drying the broken glass and for removing the moisture.18. The method according to claim 17 , characterized in that the stream of glass particles and the gas stream are oriented in the same direction or in opposite directions to one another.19. The method according to claim 17 , characterized in that the traveling movement of the broken glass stream is decelerated immediately after the delivery point.20. The method according to claim 18 , characterized in that the traveling movement of the broken glass stream is decelerated immediately after the delivery point.21. The method according to claim 17 , characterized in that the broken glass conducts liquid medium with it upon placement claim 17 , or such a medium is supplied at the delivery point or immediately thereafter.22. The method according to claim 18 , characterized in that the broken glass conducts liquid medium with it upon placement claim 18 , or such a medium is supplied at the delivery point or immediately thereafter.23. The method according to claim 19 , characterized in that the broken glass conducts liquid medium with it upon placement claim 19 , or such a medium is supplied at the delivery point or immediately thereafter.24. The method according to claim 20 , characterized in that the broken glass ...

Use of protein satb2 as a marker for colorectal cancer

The invention provides new methods, means and uses in connection with detection, characterization and prognosis of colo-rectal cancer, via the identification of the SATB2 protein as a marker for this cancer type.

LASER IGNITION DEVICE FOR AN INTERNAL COMBUSTION ENGINE

A laser ignition device for an internal combustion engine, in particular of a motor vehicle, having a laser device for generating laser pulses, and having a pumped light source for optically pumping the laser device. A photodiode system is situated in the area of an optical connection between the pumped light source and the laser device in such a way that pumped radiation generated by the pumped light source and the laser radiation generated by the laser device may each be irradiated at least partially onto a photodiode of the photodiode system. 115-. (canceled)16. A laser ignition device for an internal combustion engine of a motor vehicle , comprising:a laser device to generate laser pulses;a pumped light source to optically pump the laser device; anda photodiode system situated in an area of an optical connection between the pumped light source and the laser device in such a way that pumped radiation generated by the pumped light source and the laser radiation generated by the laser device may each be irradiated at least partially onto a photodiode of the photodiode system.17. The laser ignition device as recited in claim 16 , wherein the photodiode is situated in an area of an optical terminal of one of the pumped light source or the laser device.18. The laser ignition device as recited in claim 16 , wherein the optical connection between the pumped light source and the laser device has an optical cross-section converter claim 16 , and the photodiode is situated in an area of the cross-section converter.19. The laser ignition device as recited in claim 18 , wherein the photodiode is situated directly on the cross-section converter.20. The laser ignition device as recited in claim 16 , wherein the photodiode system has at least one of a high-pass filter claim 16 , and a bandpass filter claim 16 , to filter an output signal of the photodiode.21. The laser ignition device as recited in claim 20 , wherein an inductive element is switched in parallel to the ...

Bifunctional compounds comprising insulin peptides and egf(a) peptides

The present invention relates to novel covalently linked bi-functional fusion proteins comprising insulin and EGF(A) analogues or derivatives thereof, and their pharmaceutical use. Furthermore, the invention relates to pharmaceutical compositions comprising such bi-functional compounds, and to the use of such compounds for the treatment or prevention of medical conditions relating to diabetes and dyslipidaemia associated with diabetes.

Method and Apparatus for Sample Separation and Collection

A centrifuge device and method for use are presented. The centrifuge device includes a housing, a chamber, a channel, and a cover. The housing includes a first port and a vent opening and is designed to rotate about an axis passing through a center of the housing. The chamber is defined within the housing and is coupled to the first port. A first portion of the chamber has a width that tapers between a first width at a first position and a second width at a second position within the chamber, the first width being greater than the second width. The channel is coupled to the second position of the chamber and arranged such that a path exists for gas to travel from the channel to the vent opening. The cover provides a wall that seals the chamber.

System and Method for the Gravimetric Sorting of a Mixture of Substances

The invention relates to a system for the gravimetric sorting of a mixture of substances during the processing and/or the recycling of residual building materials and/or demolition materials, comprising a fractioning unit () adapted to divide the mixture of substances into at least m fractions (A, B, C); at least n·m gravimetric densimetric tables (A., A., A.), arranged in m cascades each with at least n densimetric tables distributed to n stages, wherein the fractioning unit is coupled to them densimetric tables (A.) of the first stage such that a different one of the at least m fractions can be supplied to each of the densimetric tables of the first stage; wherein, within each cascade, each densimetric table of a considered stage (A., A.) is coupled to a densimetric table (A., A.) of the preceding stage such that either the first partial fraction or the second partial fraction () of the densimetric table (A., A.) of the preceding stage can be supplied to the densimetric table (A., A.) of the considered stage. An appropriate method is also part of the invention. 1. A system for the gravimetric sorting of a mixture of substances during the processing and/or the recycling of residual building materials and/or demolition materials , comprising:{'b': '2', '#text': 'a fractioning unit () adapted to divide the mixture of substances into at least m, m≥1, fractions (A, B, C), wherein each fraction comprises particles of a predetermined size distribution;'}{'b': ['5', '501', '502', '503', '1', '2', '1', '2', '2', '3', '1', '3', '2', '5', '501', '502', '503', '5', '501', '502', '503', '1', '2', '1', '2', '2', '3', '1', '3', '2'], '#text': 'at least n·m gravimetric densimetric tables (, , , , A., A.., A.., A.., A..) arranged in m cascades each with at least n, n≥1, gravimetric densimetric tables (, , , ) distributed to n stages such that each stage comprises per cascade at least one gravimetric densimetric table (, , , , A., A.., A.., A.., A..),'}{'b': ['2', '5', '501', '502 ...

SYSTEM AND METHOD FOR MONITORING A SCREENING MACHINE

There is provided a system for monitoring a screening machine, comprising a vibration sensor configured to record a vibration response of a screen fabric of the screening machine; and a signal processing device for digitally processing and evaluating the vibration response. In this connection, the signal processing device comprises an adaptive algorithm which is based on the methods of artificial intelligence, is related to vibration responses of one or several comparative screen fabrics and is adapted to characterize the vibration response recorded by the vibration sensor. Furthermore, a method for monitoring a screening machine is presented. 2100. The system () according to claim 1 ,{'b': ['250', '250', '200', '200'], '#text': 'wherein the characterization of the recorded vibration response () is performed with the aid of error signatures which are characteristic for deviations of the recorded vibration responses () between a normal state of the screen fabric () and an error state of the screen fabric (),'}{'b': ['200', '200'], '#text': 'wherein the normal state characterizes the screen fabric () having no defect, and the error state characterizes the screen fabric () having a defect.'}3100200280. The system () according to claim 1 , wherein the comparative screen fabrics comprise screen fabrics which are different from the screen fabric () of the screening machine () to be monitored.4100250200220240. The system () according to claim 1 , wherein the adaptive algorithm is related to previous vibration responses () of the screen fabric () recorded by the vibration sensor ( claim 1 , ).5100210225200280. The system () according to which further comprises an excitation device () which is configured to impress a vibration () to the screen fabric () of the screening machine ().6100210200280. The system () according to claim 5 , wherein the excitation device () is configured to impress a broadband vibration spectrum to the screen fabric () of the screening machine (). ...

Hydrogel-Linked IL-1ra Prodrug

The present invention relates to a hydrogel-linked IL-Ira prodrug or pharmaceutically acceptable salt thereof. It further relates to a pharmaceutical composition comprising said hydrogel-linked IL-Ira prodrug, its use as medicament for the treatment of a IL-1 mediated disease, ways of application of such hydrogel-linked IL-Ira prodrugs or pharmaceutical compositions, and containers comprising the hydrogel-linked IL-Ira prodrugs or pharmaceutically acceptable salt thereof or a pharmaceutical composition comprising said hydrogel-linked IL-Ira prodrug or pharmaceutically acceptable salt thereof.

Methods and apparatuses for a cooking device

A cooking device, in particular a baking oven, includes a cooking chamber having cooking chamber walls and also a fan opening into the cooking chamber. This fan opening is provided on a fan plate fitted in front of a cooking chamber wall, an antenna being provided for wireless signal transmission with a measuring arrangement which is located in the cooking chamber and has a transceiving antenna. The antenna is arranged between the fan plate and cooking chamber wall and is thus covered or inwardly protected.

Method for transferring cargo from a cargo receiving portion of a vehicle, and vehicle for carrying out said method

According to a method for transferring a cargo from a cargo receiving portion of a vehicle onto a cargo take-up station, the vehicle is controlled by a vehicle control unit such that the vector of the velocity of the vehicle is modified immediately before, or upon its arrival at the cargo take-up station and the vehicle is oriented by the vehicle control unit and/or by at least one guide system positioned in the region of the cargo take-up station before the arrival of the vehicle at the cargo take-up station, such that the trajectory of the cargo that is moving away from the cargo receiving portion as a result of the modification in the velocity vector, ends at a receiving region of the cargo take-up station.

Method for predicting the response to chemotherapy in a patient suffering from or at risk of developing recurrent breast cancer

A method for predicting a response to and/or benefit of chemotherapy, including neoadjuvant chemotherapy, in a patient suffering from or at risk of developing recurrent neoplastic disease, in particular breast cancer, said method comprising the steps of: (a) determining in a tumor sample from said patient the RNA expression levels of the following 8 genes: UBE2C, RACGAP1, DHCR7, STC2, AZGP1, RBBP8, IL6ST, and MGP, indicative of a response to chemotherapy for a tumor, or (b) determining in a tumor sample from said patient the RNA expression levels of the following 8 genes: UBE2C, BIRC5, DHCR7, STC2, AZGP1, RBBP8, IL6ST, and MGP; indicative of a response to chemotherapy for a tumor (c) mathematically combining expression level values for the genes of the said set which values were determined in the tumor sample to yield a combined score, wherein said combined score is predicting said response and/or benefit of chemotherapy.

Device and Method for Drying or Heating and Cooling Bulk Material

The device for drying or heating and cooling bulk material in accordance with the invention consists of a rotatable drum comprising means for receiving the bulk material in a first region and means for discharging the bulk material from a second region, wherein a central region is arranged between the first and second regions, said central region consisting of an annular structure with a first and a second diaphragm with central diaphragm apertures each, which form substantially two diaphragm planes parallel to each other, and comprise a plurality of transport channels closed toward the central region for transporting the bulk material from the first region to the second region of the rotatable drum through the central region, wherein the transport channels extend from the first to the second diaphragms at a non-90° angle relative to the two diaphragm planes. 1. A device for drying and/or heating and cooling bulk material , comprising:a rotatable drum with means receiving the bulk material in a first region and means for discharging the bulk material from a second region,wherein a central region is arranged between the first region and the second region, said central region consisting of an annular structure with a first diaphragm and a second diaphragm with central diaphragm apertures each, which form substantially two diaphragm planes parallel to each other, and comprise a plurality of transport channels closed toward the central region for transporting the bulk material from the first region to the second region of the rotatable drum, the transport channels extend from the first diaphragm to the second diaphragm at a non-90° angle α relative to the two diaphragm planes, and the central region is divided by a separating wall parallel to the diaphragm planes for the separate guiding of the drying air and the cooling air and merely the transport channels are exempt from the separating wall.2. The device according to claim 1 , wherein the transport channels are ...

System for and method of rapid peripheral nerve stimulation assessment of gradient coils

A method for assessing peripheral nerve stimulation (PNS) for a coil geometry includes retrieving a PNS Huygens' P-matrix for a body model. The PNS Huygens' P-matrix is defined on a Huygens' surface enclosing the body model. The method further includes generating a coil specific PNS P-matrix for the coil geometry based on at least the PNS Huygens' P-matrix for the body model, determining at least one PNS threshold for the coil geometry based on the coil specific PNS P-matrix, and storing the at least one PNS threshold in a storage device.

Method for predicting the response to chemotherapy in a patient suffering from or at risk of developing recurrent breast cancer

A method for predicting a response to and/or benefit of chemotherapy, including neoadjuvant chemotherapy, in a patient suffering from or at risk of developing recurrent neoplastic disease, in particular breast cancer, said method comprising the steps of:(a) determining in a tumor sample from said patient the RNA expression levels of the following 8 genes: UBE2C, RACGAP1, DHCR7, STC2, AZGP1, RBBP8, IL6ST, and MGP, indicative of a response to chemotherapy for a tumor, or(b) determining in a tumor sample from said patient the RNA expression levels of the following 8 genes: UBE2C, BIRC5, DHCR7, STC2, AZGP1, RBBP8, IL6ST, and MGP; indicative of a response to chemotherapy for a tumor(c) mathematically combining expression level values for the genes of the said set which values were determined in the tumor sample to yield a combined score, wherein said combined score is predicting said response and/or benefit of chemotherapy.

Rotary Cooler and Method for Operating a Rotary Cooler

A rotary cooler is provided, consisting of a plurality of transport tubes for transporting material to be cooled, wherein the plurality of transport tubes are arranged about an axis of rotation and are adapted to be filled jointly via a filling region with material to be cooled, characterized in that each transport tube is arranged substantially concentrically in a cooling tube in which a cooling medium flows and cools the material to be cooled via the wall of the transport tube. Furthermore, a method for operating said rotary cooler is provided.

Solid phase labeling method

The invention provides for the labeling of antibodies with a fluorescent label, using a solid support comprising an affinity for an Fc portion of an antibody. Thus, the invention provides a method for labeling an antibody or fragment thereof with a fluorescent label, comprising the steps of immobilizing an antibody on the solid support and covalently coupling a fluorescent label to the immobilized antibody, as well as a kit for performing such method.

DEVICE AND METHOD FOR CAPTURING MOVEMENT PATTERNS OF TUMBLER SCREENING MACHINES

A method for recording motion patterns () of tumbler screening machines () is disclosed, wherein the method comprises applying of an active or passive optical marking () at a tumbler screening machine (), recording an image of the optical marking () during operation of the tumbler screening machine (), establishing image data for a motion curve (), and internally or externally evaluating the recorded image data and determining machine parameters and diagnosis data. Furthermore, a device for recording motion patterns () of tumbler screening machines () is introduced. 1210410. A method for recording motion patterns () of a tumbler screening machine () , characterized in that the method comprises the following method steps:{'b': 500', '510', '410, 'a. applying an optical marking (, ) at the tumbler screening machine ();'}{'b': 500', '510', '410', '200, 'b. recording the optical marking (, ) during operation of the tumbler screening machine () and establishing image data for a motion curve ();'}c. evaluating the recorded image data.2500510410. The method according to claim 1 , characterized in that the optical marking ( claim 1 , ) is applied in a region in which the motion of the tumbler screening machine () is to be determined.3500400410. The method according to claim 1 , characterized in that the optical marking is a passive reading point () which is applied to the housing () of the tumbler screening machine ().4510400410. The method according to claim 1 , characterized in that the optical marking is an active light source () which is arranged on the housing () of the tumbler screening machine () claim 1 , in particular a light emitting diode claim 1 , which is provided with a button cell for power supply claim 1 , a pressure switch or toggle switch for switching on and off claim 1 , and a miniature housing.5500510410300310. The method according to claim 1 , characterized in that the recording of the optical marking ( claim 1 , ) during operation of the tumbler ...

RBM3 Protein in Colorectal Cancer Prognostics

The present invention provides means, such as a method, for determining whether a mammalian subject having a colorectal cancer belongs to a first or a second group, wherein the prognosis of subjects of the first group is better than the prognosis of subjects of the second group. The method comprises the steps of: evaluating an amount of RBM3 protein or RBM3 mRNA molecule in at least part of a sample earlier obtained from the subject and determining a sample value corresponding to the evaluated amount; comparing said sample value with a predetermined reference value; and if said sample value is higher than said reference value, concluding that the subject belongs to the first group; and if said sample value is lower than or equal to said reference value, concluding that the subject belongs to the second group.

Safety system and method for localizing a person or object in a monitored zone using a safety system

A method of localizing a person or object in a monitored zone using a safety system, having a movable machine, having a control and evaluation unit, having at least one radio location system, and having at least one spatially resolving sensor for the position determination of the person or object, wherein the radio location system has arranged radio stations, wherein at least one radio transponder is arranged at the person or object, wherein position data of the person or object can be determined by means of the radio location system, and wherein the position data are transmitted from the radio stations of the radio location system to the control and evaluation unit and position data of the person or object are determined by means of the spatially resolving sensor, wherein the control and evaluation unit compares the position data of the radio location system and the position data of the spatially resolving sensor and forms tested position data on an agreement.

ADJUSTABLE STAND FOR AN OPTICAL OBSERVATION INSTRUMENT

The invention relates to an adjustable stand for an optical observation instrument, in particular for a surgical microscope, with a tilt spindle and with a swivel spindle for the optical observation instrument and with a flange for connection to the optical observation instrument or a further member of the adjustable stand, wherein, on at least one of the two spindles a first torque compensation device is arranged, which has a first brake for securing the spindle and which has a first spring which is connected to a first motor for adjusting the spring tension of the first spring and the first motor is connected to a first motor controller, and which has a first torque transmission device which is formed between the first spring and the spindle and which has a first position sensor for determining the position of the spindle and which has first force sensor for determining the spring tension of the first spring wherein the position sensor and the force sensor are connected to a control unit. 1. Adjustable stand for an optical observation instrument , in particular for a surgical microscope ,{'b': 1', '2, 'with a tilt spindle () and with a swivel spindle () for the optical observation instrument'}{'b': '4', 'and with a flange () for connection to the optical observation instrument or a further member of the adjustable stand,'}{'b': 1', '2, 'wherein, on at least one of the two spindles (, ), a first torque compensation device is arranged,'}{'b': 13', '1', '2, 'which has a first brake () for securing the spindle (, ),'}{'b': 11', '12', '11, 'and which has a first spring () which is connected to a first motor () for adjusting the spring tension of the first spring (),'}{'b': '12', 'and the first motor () is connected to a first motor controller,'}{'b': 14', '11', '1', '2, 'and which has a first torque transmission device () which is formed between the first spring () and the spindle (, ),'}{'b': 16', '1', '2, 'and which has a first position sensor () for determining the ...

Vehicle for lifting, transporting, and lowering load carriers

A vehicle has at least two axles, each having at least one wheel for lifting, transporting, and lowering load carriers. A first axle is mounted in a chassis. Lifting elements are provided for lifting and lowering the load carriers. The distance of the second axle relative to the first axle can be changed in the horizontal longitudinal vehicle direction, and the lifting elements are lifted or lowered by a change in the distance of the second axle from the first axle. The at least one wheel of the first axle can be driven by a drive motor that is arranged on the chassis, and at least one lifting element is displaced horizontally inward or outward by the change in the distance of the second axle from the first axle in the transverse vehicle direction.

Hydrogel-Linked IL-1ra Prodrug

The present invention relates to a hydrogel-linked IL-1ra prodrug or pharmaceutically acceptable salt thereof. It further relates to a pharmaceutical composition comprising said hydrogel-linked IL-1ra prodrug, its use as medicament for the treatment of a IL-1 mediated disease, methods of application of such hydrogel-linked IL-1ra prodrugs or pharmaceutical compositions, methods of treatment, and containers comprising the hydrogel-linked IL-1ra prodrugs or pharmaceutically acceptable salt thereof or a pharmaceutical composition comprising said hydrogel-linked IL-1ra prodrug or pharmaceutically acceptable salt thereof.

Method for Creating a Recipe for a Process-Related Process Plant

Method for creating a recipe for a process-related process plant based on at least one service, wherein the at least one service is a representation, in terms of automation technology, of concrete physical embodiments of process-related operations of the process-related process plant, where in order to create the recipe, a substitute object assigned to the service is used for each individual service, the substitute object has a parameterization, via which, when merging the created recipe and a topology of the process-related process plant, the concrete physical embodiments of the process-related operations of the process-related process plant can be incorporated into the recipe, and where the substitute object(s) is/are realized in a programmable logic controller of a control system of the process-related process plant or in a batch system of the control system of the process-related process plant.

Fluidic system for performing assays

A fluidic testing system and method for use are presented. The fluidic testing system includes a microfluidic channel, a first chamber and second chamber. The microfluidic channel has only one port for the introduction and/or extraction of fluid through the microfluidic channel. The first chamber is disposed at a terminal end of the microfluidic channel. The second chamber is coupled to the fluidic channel and is aligned such that each opening to the second chamber is configured to be aligned substantially parallel to a gravity vector during operation.

Method of sequencing dna

The present invention provides a method of identifying a base at a target position in a single-stranded sample DNA sequence wherein an extension primer, which hybridises to the sample DNA immediately adjacent to the target position is provided and the sample DNA and extension primer are subjected to a polymerase reaction in the presence of a deoxynucleotide or dideoxynucleotide whereby the deoxynucleotide or dideoxynucleotide will only become incorporated and release pyrophosphate (PPi) if it is complementary to the base in the target position, any release of PPi being detected enzymically, different deoxynucleotides or dideoxynucleotides being added either to separate aliquots of sample-primer mixture or successively to the same sample-primer mixture and subjected to the polymerase reaction to indicate which deoxynucleotide or dideoxynucleotide is incorporated, characterised in that, the PPi-detection enzyme(s) are included in the polymerase reaction step and in that in place of deoxy- or dideoxy adenosine triphosphate (ATP) a dATP or ddATP analogue is used which is capable of acting as a substrate for a polymerase but incapable of acting as a substrate for a said PPi-detection enzyme. The method of the invention advantageously permits large-scale non-electrophoretic solid phase DNA sequencing, which allows for continuous determination of the progress of the polymerisation reaction with time.

Biodegradable polyethylene glycol based water-insoluble hydrogels

The present invention relates to biodegradable polyethylene glycol based water-insoluble hydrogels comprising backbone moieties which are interconnected by hydrolytically degradable bonds, the backbone moieties further comprising reactive functional groups, wherein the water-insoluble hydrogel is further characterized in that the ratio between the time period for the complete degradation of the hydrogel by hydrolysis of the degradable bonds into water-soluble degradation products comprising one or more backbone moieties and the time period for the release of the first 10 mol-% of water-soluble degradation products comprising one or more backbone moieties based on the total amount of backbone moieties in the hydrogel is greater than 1 and equal to or less than 2. The invention further relates to conjugates of such hydrogels with ligands or ligating groups, prodrugs and pharmaceutical compositions as well as their use in a medicament.

Methods and kits for isolating primer extension products using modular oligonucleotides

The invention provides a method of improving the binding of a series of consecutive nucleotide bases to a complementary target nucleic acid molecule in a sample, wherein said method comprises at least the step or steps of binding a complementary modular oligonucleotide of at least two parts (modules) including said nucleotide bases to adjacent stretches of said target nucleic acid molecule in said sample, especially methods of detection/isolation, particularly in the isolation of primer extension products and methods in which the modular oligonucleotide is a primer, modular oligonucleotides themselves and their use in methods of the invention.

Bacterial receptor structures

Bacterial receptor structures

Novel proteins obtainable by mutagenesis of surface-exposed amino acids of domains of natural bacterial receptors, said proteins being obtained without substantial loss of basic structure and stability of said natural bacterial receptors; proteins which have been selected from a protein library embodying a repertoire of said novel proteins; and methods for the manufacture of artificial bacterial receptor structures.

Stabilized protein or peptide conjugates

A process for extending the half-life in vivo by a biologically active protein or peptide, characterized by covalently coupling said protein or peptide to a polypeptide fragment capable of binding to a serum protein, whereby when administering the resulting protein or peptide congugate its binding to the serum protein results in extended biological activity; the use of the protein or peptide conjugate above for manufacturing a medicament which, when administered to a mammal including man, shows extended half-life in vivo; and a method of therapeutic or prophylactic treatment.

Dryer for treating garden waste

The invention relates to a dryer for drying garden waste, in particular shredded green waste and other free-flowing goods, comprising an elongated, horizontal container having a bottom that has an at least partially round cross-section; the container has an inlet at one end thereof and an outlet at the other end thereof for the goods; the container wall is perforated at least on a part of the length thereof; the perforations are connected to compressed air; conveying devices are provided for gripping the goods in an ascending quadrant at the container wall and for conveying the goods along the container wall upwards for a certain distance.

Coating of food products with a particulate coating material

Catalytic treatment of combustible carbonaceous materials

Apparatus and process for drying wet solid particles in fluidized beds

In a fluidised bed process and assembly to dry moist solid particles, one zone (A) within the fluidised bed (30) incorporates a heat exchanger (3). The fluidised bed zone (30) containing the heat exchanger (3) is separated from the particle inlet zone (B) by an under-flow weir screen (2). A a proportion of the particles which have been part-dried in zone (A) of the heat exchanger (3) is returned via the under-flow weir (2) to the particle inlet zone (B).

Method for diagnosing a loaded combustion engine in terms of a leakage in a section of the fresh gas section

Es ist ein Verfahren zur Diagnose einer Brennkraftmaschine vorgesehen, wobei die Brennkraftmaschine zumindest einen Verbrennungsmotor 1 und einen Frischgasstrang 5, über den dem Verbrennungsmotor 1 Frischgas zuführbar ist, umfasst. In den Frischgasstrang 5 sind weiterhin zumindest ein Frischgasverdichter 8 und, stromauf des Frischgasverdichters 8, eine Steuerklappe 15 integriert. In einem Betriebszustand der Brennkraftmaschine wird die Steuerklappe so weit geschlossen, dass mittels des laufenden Verbrennungsmotors 1 in dem zwischen der Steuerklappe 15 und dem Verbrennungsmotor 1 liegenden Abschnitt des Frischgasstrangs 5 ein Unterdruck im Vergleich zu dem Umgebungsdruck erzeugt wird, wobei ein diesem Unterdruck zugeordneter Istwert mit einem Sollwert verglichen wird und das Vorliegen oder das Nicht-Vorliegen einer Leckage in diesem Abschnitt des Frischgasstrangs 5 aus einer gegebenenfalls vorhandenen Differenz zwischen dem Istwert und dem Sollwert abgeleitet wird. A method for diagnosing an internal combustion engine is provided, the internal combustion engine comprising at least one internal combustion engine 1 and one fresh gas line 5, via which fresh gas can be supplied to the internal combustion engine 1. At least one fresh gas compressor 8 and, upstream of the fresh gas compressor 8, a control flap 15 are also integrated in the fresh gas line 5. In an operating state of the internal combustion engine, the control flap is closed to such an extent that, by means of the running internal combustion engine 1, a vacuum is generated in the section of the fresh gas line 5 lying between the control flap 15 and the internal combustion engine 1, with an actual value associated with this vacuum being included a target value is compared and the presence or absence of a leak in this section of the fresh gas line 5 is derived from a possibly existing difference between the actual value and the target value.

Method for diagnosing a supercharged internal combustion engine with regard to a leak in a section of the fresh gas line

Es ist ein Verfahren zur Diagnose einer Brennkraftmaschine vorgesehen, wobei die Brennkraftmaschine zumindest einen Verbrennungsmotor 1 und einen Frischgasstrang 5, über den dem Verbrennungsmotor 1 Frischgas zuführbar ist, umfasst. In den Frischgasstrang 5 sind weiterhin zumindest ein Frischgasverdichter 8 und, stromauf des Frischgasverdichters 8, eine Steuerklappe 15 integriert. In einem Betriebszustand der Brennkraftmaschine wird die Steuerklappe so weit geschlossen, dass mittels des laufenden Verbrennungsmotors 1 in dem zwischen der Steuerklappe 15 und dem Verbrennungsmotor 1 liegenden Abschnitt des Frischgasstrangs 5 ein Unterdruck im Vergleich zu dem Umgebungsdruck erzeugt wird, wobei ein diesem Unterdruck zugeordneter Istwert mit einem Sollwert verglichen wird und das Vorliegen oder das Nicht-Vorliegen einer Leckage in diesem Abschnitt des Frischgasstrangs 5 aus einer gegebenenfalls vorhandenen Differenz zwischen dem Istwert und dem Sollwert abgeleitet wird. A method for diagnosing an internal combustion engine is provided, the internal combustion engine comprising at least one internal combustion engine 1 and one fresh gas line 5, via which fresh gas can be supplied to the internal combustion engine 1. At least one fresh gas compressor 8 and, upstream of the fresh gas compressor 8, a control flap 15 are also integrated in the fresh gas line 5. In an operating state of the internal combustion engine, the control flap is closed to such an extent that, by means of the running internal combustion engine 1, a vacuum is generated in the section of the fresh gas line 5 lying between the control flap 15 and the internal combustion engine 1, with an actual value associated with this vacuum being included a target value is compared and the presence or absence of a leak in this section of the fresh gas line 5 is derived from a possibly existing difference between the actual value and the target value.

Method for diagnosing a supercharged internal combustion engine for leakage in a portion of the intake air line

A method for diagnosing a combustion machine, wherein the combustion machine comprises at least one internal combustion engine and one intake air line via which fresh air can be fed to the internal combustion engine. In addition, at least one intake air compressor and, upstream from the intake air compressor, a control flap are integrated into the intake air line. In one operating state of the combustion machine, the control flap is closed so far that a negative pressure relative to the ambient pressure is produced by means of the running internal combustion engine in the portion of the intake air line that lies between the control flap and the internal combustion engine, with an actual value that is associated with this negative pressure being compared with a target value and the presence or absence of leakage in this portion of the intake air line being deduced from any difference that might exist between the actual value and the target value.

Diagnostic methods, control, motor vehicle

Diagnoseverfahren für eine Niederdruck-Abgasrückführung einer Brennkraftmaschine, umfassend:Ausführen (41; 51) einer Abgasrückführung;Erfassen (42; 52) eines aktuellen Diagnosesensorwertes für ein Niederdruck-Abgasrückführsystem (12) mittels eines Diagnosesensors (10, 16, 17, 19, 20), wobei der Diagnosesensorwert indikativ ist für eine Abweichung eines Ist-Abgasflusses der Niederdruck-Abgasrückführung von einem Soll-Abgasfluss; undErmitteln (43; 54), ob die Abweichung vorliegt basierend auf dem Diagnosesensorwert. Diagnostic method for low-pressure exhaust gas recirculation of an internal combustion engine, comprising:performing (41; 51) exhaust gas recirculation;detecting (42; 52) a current diagnostic sensor value for a low-pressure exhaust gas recirculation system (12) by means of a diagnostic sensor (10, 16, 17, 19, 20 ), wherein the diagnostic sensor value is indicative of a deviation of an actual exhaust flow of the low-pressure exhaust gas recirculation from a target exhaust flow; anddetermining (43; 54) whether the abnormality is present based on the diagnostic sensor value.

DIAGNOSIS OF LIVER FIBROSIS WITH THE HELP OF SERUM MARKER ALGORITHMS

Cryo hexapod positioning system.

Conversion of carbonaceous materials into useful hydrocarbon products

Elimination of contrast agent concentration dependency in mri

The present invention relates to a method for MRI imaging to obtain information about a local physiochemical parameter after administration to a patient of a contrast agent comprising at least one non-responsive contrast enhancing entity that does not occur naturally in a human body and at least one responsive contrast enhancing entity attached to or mixed with the non-responsive contrast enhancing entity. By using such non-responsive contrast enhancing entities, a value for the physicochemical parameter can be obtained by acquiring only three images through which the method according to the present invention will be easier to apply in clinical routine since it will be faster and less sensitive to motion or flow artefacts.

Elimination of contrast agent concentration dependency in MRI

A method for MRI imaging to obtain information about a local physiochemical parameter after administration to a patient of a contrast agent including at least one non-responsive contrast enhancing entity that does not occur naturally in a human body and at least one responsive contrast enhancing entity attached to or mixed with the non-responsive contrast enhancing entity. By using such non-responsive contrast enhancing entities, a value for the physicochemical parameter can be obtained by acquiring only three images, providing a method which will be easier to apply in a clinical routine, since it will be faster and less sensitive to motion or flow artifacts.

Inhibitors of il-11 or il-11ra for use in the treatment of abnormal uterine bleeding

The present invention is related to agents capable of binding to and inhibiting or antagonizing the action of IL-11 and/or IL-11RA for the treatment and/or prevention of abnormal uterine bleeding, which comprises heavy menstrual bleeding, prolonged bleeding, altered bleeding pattern, dysmenorrhea, as well as of the underlying diseases leiomyoma and endometriosis and the use of the agent to inhibit menstruation. Furthermore, the invention provides novel IL-11 antibodies.

Moulding food products from a pumpable foodstuff mass

A method for predicting the response of a tumor in a patient suffering from or at risk of developing recurrent gynecologic cancer towards a chemotherapeutic agent

The present invention relates to a method for predicting a response of a tumor in a patient suffering from or at risk of developing recurrent gynecologic cancer towards a chemotherapeutic agent, said method comprising the steps of: a) obtaining a biological sample from said patient; b) determining the pattern of expression level of at least one gene of the group comprising AKR1C1, MLPH, ESR1, PGR, COMP, DCN, IGKC, CCL5, FBN1 and/or UBE2C, or of genes coregulated therewith, in said sample; c) comparing the pattern of expression levels determined in (b) with one or several reference pattern(s) of expression levels; d) identifying at least one marker gene; e) determining a molecular subtype for said sample on the basis of (d); and f) predicting from said molecular subtype response of a tumor for a chemotherapeutic agent, wherein the molecular subtype is selected from the group comprising the subtypes basal, stromal-high, stromal-low, luminal A, immune system-high, immune system-low, proliferation-high and/or proliferation-low.

Method of sequencing DNA

The present invention provides a method of identifying a base at a target position in a single-stranded sample DNA sequence wherein an extension primer, which hybridizes to the sample DNA immediately adjacent to the target position, is provided and the sample DNA and extension primer are subjected to a polymerization reaction in the presence of a deoxynucleotide or dideoxynucleotide, whereby the deoxynucleotide or dideoxynucleotide will only become incorporated and release pyrophosphate if it is complementary to the base in the target position. Release of pyrophosphate is detected enzymatically and pyrophosphate detection enzyme(s) are included in the polymerization step.

Stabilized protein or peptide conjugates able to bond albumin having extended biological half-lives

A process for extending the half-life in vivo by a biologically active protein or peptide, characterized by covalently coupling said protein or peptide to a polypeptide fragment capable of binding to a serum protein, whereby when administering the resulting protein or peptide conjugate its binding to the serum protein results in extended biological activity, the use of the protein or peptide conjugate above for manufacturing a medicament which, when administered to a mammal including man, shows extended half-life in vivo; and a method of therapeutic or prophylactic treatment.

Use of stabilized protein or peptide conjugates for the preparation of a drug

A process for extending the half-life in vivo by a biologically active protein or peptide, characterized by covalently coupling said protein or peptide to a polypeptide fragment capable of binding to a serum protein, whereby when administering the resulting protein or peptide congugate its binding to the serum protein results in extended biological activity; the use of the protein or peptide conjugate above for manufacturing a medicament which, when administered to a mammal including man, shows extended half-life in vivo; and a method of therapeutic or prophylactic treatment.

Exhaust train assembly

Eine Abgasstranganordnung für ein landwirtschaftliches Fahrzeug mit einem von Abgasen eines Verbrennungsmotors des Fahrzeuges durchströmten Abgasstrang, welcher mindestens eine erste Abgasstrangkomponente und eine zweite Abgasstrangkomponente umfasst, wobei die erste Abgasstrangkomponente und die zweite Abgasstrangkomponente, insbesondere außerhalb eines Motorraums des Fahrzeuges, vertikal beabstandet zueinander angeordnet sind, und einem Abgasstutzen zur Leitung der Abgase von dem Verbrennungsmotor zu der ersten Abgasstrang-komponente. Erfindungsgemäß ist eine Tragstruktur zur Aufnahme mindestens der zweiten Abgasstrangkomponente vorgesehen, wobei die Tragstruktur derart ausgebildet und angeordnet ist, dass die Tragstruktur im Wesentlichen das gesamte Gewicht der zweiten Abgasstrangkomponente aufnimmt und die Tragstruktur die erste Abgasstrangkomponente außenseitig und im Wesentlichen frei von vertikalen Lasten umfasst

Biodegradable polyethylene glycol based water-insoluble hydrogels

The invention relates to a process for the preparation of a hydrogel prodrug, comprising the steps of (a) providing a reactive biodegradable hydrogel, wherein said hydrogel comprises backbone moieties which are linked together through crosslinker moieties, each crosslinker moiety being terminated by at least two hydrolytically degradable bonds, and wherein from a branching core 3 to 16 linear PEG-based polymeric chains extend and wherein one terminus of said polymeric chains is connected to the branching core and the other to a hyperbranched dendritic moiety; wherein each said hyperbranched dendritic moiety has at least 3 branchings and at least 4 reactive functional groups; (b) conjugating a prodrug linker to a biologically active moiety, resulting in a biologically active moiety-prodrug linker conjugate; and (c) reacting the biologically active moiety-prodrug linker conjugate from step (b) with the reactive functional groups of the hydrogel of step (a). The invention further relates to a hydrogel prodrug obtainable from the process.

Method of sequencing DNA

The invention relates to a method of sequencing target DNA in which said DNA is provided in double stranded form immobilized on a solid support via one terminus of one of the two strands thereof and is then subjected to strand separation whereby the unattached strand is removed prior to sequencing the immobilized strand. The target DNA, e.g genomic DNA, may initially be amplified by the PCR method using at least one oligonucleotide primer which is either attached to a solid support or carries means for attachment to a solid support.

Inhibitors of il-11 or il-11ra for use in the treatment of abnormal uterine bleeding

The present invention is related to agents capable of binding to and inhibiting or antagonizing the action of IL-11 and/or IL-11RA for the treatment and/or prevention of abnormal uterine bleeding, which comprises heavy menstrual bleeding, prolonged bleeding, altered bleeding pattern, dysmenorrhea, as well as of the underlying diseases leiomyoma and endometriosis and the use of the agent to inhibit menstruation. Furthermore, the invention provides novel IL-11 antibodies.

Insulin containing pharmaceutical compositions

The present invention is in the field of pharmaceutical compositions for the treatment of medical conditions relating to diabetes. More specifically the invention provides pharmaceutical compositions comprising a long-acting acylated derivative of a human insulin analog, and to the medical use of such compositions for basal insulin administration therapy.

Insulin containing pharmaceutical compositions

The present invention is in the field of pharmaceutical compositions for the treatment of medical conditions relating to diabetes. More specifically the invention provides pharmaceutical compositions comprising a long-acting acylated derivative of a human insulin analogue, and to the medical use of such compositions for basal insulin administration therapy.

Vane pump

Die Erfindung betrifft eine Flügelzellenpumpe (1), – mit einem Gehäuse, welches einen Gehäusetopf und einen an diesem befestigbaren oder befestigten Gehäusedeckel (4) aufweist, – mit einem im Gehäuse vorgesehenen Förderraum, in welchem eine Fördereinheit zum Fördern eines Fluids vorgesehen ist, – wobei der Gehäusedeckel (4) auf einer ersten und/oder zweiten Deckelseite (4a, 4b) wenigstens bereichsweise eine Mehrzahl von Ausnehmungen (10) zur Reduzierung mechanischer Spannungen im Gehäusedeckel (4) aufweist, welche auf der jeweiligen Deckelseite (4a, 4b) bezüglich einer Draufsicht auf diese Deckelseite (4a, 4b) musterartig angeordnet sind.

Torque sensor with radial elastic torque transmission

Die Erfindung betrifft einen Drehmomentsensor (100) mit einem Grundkörper (101), der sich in einer radialen Richtung (Y) des Grundkörpers von einem ringförmigen Innenflansch (103) mit ersten Krafteinleitungsstellen (105) über einen mit Ausgangssignale generierenden Messwertaufnehmern (10, 20) ausgestatteten, mechanisch geschwächten Sensorabschnitt (107) zu einem ringförmigen Außenflansch (109) mit zweiten Krafteinleitungsstellen (111) erstreckt, wobei die zweiten Krafteinleitungsstellen (111) durch einen radialelastischen Materialabschnitt (113) mit dem Sensorabschnitt (107) verbunden sind. The invention relates to a torque sensor (100) having a base body (101) which extends in a radial direction (Y) of the base body from an annular inner flange (103) with first force introduction points (105) via a transducer (10, 20) generating output signals. equipped, mechanically weakened sensor portion (107) to an annular outer flange (109) having second force introduction points (111), wherein the second force introduction points (111) by a radially elastic material portion (113) to the sensor portion (107) are connected.

Torque sensor with sealing membrane

Die Erfindung betrifft einen Drehmomentsensor (1000; 1100) mit einem Grundkörper (1001; 1101), der sich in einer radialen Richtung (Y) des Grundkörpers von einem ringförmigen Innenflansch (1003; 1103) mit ersten Krafteinleitungsstellen (1005; 1105) über einen mit Ausgangssignale generierenden Messwertaufnehmern (10, 20) ausgestatteten, mechanisch geschwächten Sensorabschnitt (1007; 1107) zu einem ringförmigen Außenflansch (1009; 1109) mit zweiten Krafteinleitungsstellen (1011; 1111) erstreckt, wobei eine axial zwischen dem Außenflansch (1009; 1109) und dem Innenflansch (1003; 1103) angeordnete gummielastische Dichtungsmembran (1031; 1131) den mechanisch geschwächten Sensorabschnitt (1007; 1107) fluiddicht überdeckt. The invention relates to a torque sensor (1000, 1100) having a base body (1001, 1101) extending in a radial direction (Y) of the base body from an annular inner flange (1003, 1103) with first force introduction points (1005, 1105) via a Output-generating transducer (100, 1107) to a ring-shaped outer flange (1009; 1109) having second force introduction points (1011; 1111) extending axially between the outer flange (1009; 1109) and the Rubber-elastic sealing membrane (1031, 1131) which covers the mechanically weakened sensor section (1007, 1107) in a fluid-tight manner covers the inner flange (1003, 1103).

Torque sensor with shunt spokes

Die Erfindung betrifft einen Drehmomentsensor (500; 600) mit einem Grundkörper (501; 601), der sich in einer radialen Richtung (Y) des Grundkörpers von einem ringförmigen Innenflansch (503; 603) mit ersten Krafteinleitungsstellen (505; 605) über einen mit Ausgangssignale generierenden Messwertaufnehmern (10, 20) ausgestatteten, mechanisch geschwächten Sensorabschnitt (507; 607) zu einem ringförmigen Außenflansch (509; 609) mit zweiten Krafteinleitungsstellen (511; 611) erstreckt, wobei der mechanisch geschwächte Sensorabschnitt (507; 607) radial verlaufende erste Verbindungsstege (519; 619a) und zweite Verbindungsstege (519; 619b) umfasst, welche gleiche oder unterschiedliche mechanische Eigenschaften haben und in Umfangsrichtung alternierend angeordnet sind. The invention relates to a torque sensor (500; 600) having a base body (501; 601) extending in a radial direction (Y) of the base body from an annular inner flange (503; 603) with first force introduction points (505; 607) extending to an annular outer flange (509; 609) with second force introduction points (511; 611), wherein the mechanically weakened sensor section (507; 607) has radially extending first Comprises connecting webs (519; 619a) and second connecting webs (519; 619b) which have the same or different mechanical properties and are arranged alternately in the circumferential direction.

Torque sensor with a radially elastic torque transfer

Torque sensor with radially elastic material section

Die Erfindung betrifft einen Drehmomentsensor (10) mit einem sich axial und in Umfangsrichtung erstreckenden Grundkörper (12), der sich in einer radialen Richtung des Grundkörpers von einem ringförmigen Innenflansch (18) mit ersten Krafteinleitungsstellen (16) über einen mechanisch geschwächten Sensorabschnitt (20), der mit Messwertaufnehmern zur Erzeugung von Ausgangssignalen versehen ist, zu einem ringförmigen Außenflansch (32) mit zweiten Krafteinleitungsstellen (34) erstreckt, wobei die zweiten Krafteinleitungsstellen (34) über einen radialelastischen Materialabschnitt (28) mit dem Sensorabschnitt (20) verbunden sind. Der radialelastische Materialabschnitt (28) ist durch mehrere radialelastische Biegebalken (31) gebildet, die über einen Umfang des Grundkörpers (12) verteilt angeordnet sind, und ist über einen ringförmigen, radial steifen Entkopplungsbereich (27) mit dem mechanisch geschwächten Sensorabschnitt (20) verbunden. The invention relates to a torque sensor (10) with an axially and circumferentially extending base body (12) which extends in a radial direction of the base body from an annular inner flange (18) with first force introduction points (16) via a mechanically weakened sensor section (20) , which is provided with transducers for generating output signals, extends to an annular outer flange (32) with second force introduction points (34), the second force introduction points (34) being connected to the sensor section (20) via a radially elastic material section (28). The radially elastic material section (28) is formed by several radially elastic bending bars (31) which are arranged distributed over a circumference of the base body (12) and is connected to the mechanically weakened sensor section (20) via an annular, radially rigid decoupling area (27) .

Antibody-enzyme conjugates for prodrug activation

HANDLE KIT FOR WINDOW OR DOOR OPENINGS

L'invention concerne un ensemble de poignée (100), comprenant au moins : une première poignée (110) comprenant au moins un logement (111), un carré d'ouvrant (120) configuré pour être logé au moins partiellement dans le logement (111) de la première poignée (110), dans une configuration initiale, la première poignée (110) est configurée pour coulisser librement le long de l'axe longitudinal du carré d'ouvrant (120) sur une distance déterminée, ledit ensemble de poignée (100) étant caractérisé en ce que la première poignée (110) est configurée pour passer de la configuration initiale à une configuration de solidarisation dans laquelle la première poignée (110) est bloquée en translation et dans au moins un sens de rotation par rapport au carré d'ouvrant (120), par au moins un déplacement en rotation de la première poignée (110) autour de l'axe longitudinal du carré d'ouvrant (120) selon un angle strictement inférieur à 360°. The invention relates to a handle assembly (100), comprising at least: a first handle (110) comprising at least one housing (111), a sash square (120) configured to be housed at least partially in the housing ( 111) of the first handle (110), in an initial configuration, the first handle (110) is configured to slide freely along the longitudinal axis of the sash square (120) for a determined distance, said handle assembly (100) being characterized in that the first handle (110) is configured to pass from the initial configuration to a connection configuration in which the first handle (110) is blocked in translation and in at least one direction of rotation with respect to the square opening (120), by at least one rotational displacement of the first handle (110) around the longitudinal axis of the square opening (120) at an angle strictly less than 360 °.

A method for predicting the response of a tumor in a patient suffering from or at risk of developing recurrent gynecologic cancer towards a chemotherapeutic agent

The present invention relates to a method for predicting a response of a tumor in a patient suffering from or at risk of developing recurrent gynecologic cancer towards a chemotherapeutic agent, said method comprising the steps of: a) obtaining a biological sample from said patient; b) determining the pattern of expression level of at least one gene of the group comprising AKR1C1, MLPH, ESR1, PGR, COMP, DCN, IGKC, CCL5, FBN1 and/or UBE2C, or of genes coregulated therewith, in said sample; c) comparing the pattern of expression levels determined in (b) with one or several reference pattern(s) of expression levels; d) identifying at least one marker gene; e) determining a molecular subtype for said sample on the basis of (d); and f) predicting from said molecular subtype response of a tumor for a chemotherapeutic agent, wherein the molecular subtype is selected from the group comprising the subtypes basal, stromal-high, stromal-low, luminal A, immune system-high, immune system-low, proliferation-high and/or proliferation-low.

Method for activating a reversibly inactivated immobilized enzyme by release from an immobilising moiety and its use in nucleic acid amplification reactions

The invention provides a method of activating a reversibly inactivated enzyme or catalytic fragment or mutant thereof, wherein the enzyme is inactivated by attachment to an immobilizing moiety and is activated by release from said moiety, particularly heat-activated release and activation of enzymes, particularly for use in nucleic acid amplification techniques, the immobilized enzymes and kits for performing methods of the invention.

METHOD FOR SEQUENCE ANALYSIS OF DNA.

Carbonic Acid Derivatives, Method for the Manufacture Thereof and the Use Thereof

The invention relates to carboxylic acid derivatives which are obtained by reacting an unsaturated dicarboxylic acid anhydride (A) with a hydrophobic reactive component (B) that contains at least one group reacting to carboxylic acid anhydrides and has an average molecular weight of 200 to 50,000 Dalton. The inventive carboxylic acid derivatives are excellent as a substance for preventing efflorescences on surfaces of hardened cementitious construction materials and/or hydrophobizing the corresponding cementitious systems. Furthermore, said cementitious products absorb considerably smaller amounts of water as a result of the inventive additives such that frost damage and premature rusting of the reinforcing steel can be significantly reduced.

Siren

DEVICE FOR ATTACHING THE SKIN TO A CATHETER EXCEEDING A SKIN EMERGENCE SITE.

TRIBOSYSTEM AND METHOD FOR ITS MANUFACTURE

Turbomachine comprising improved harness support means

L'invention concerne une turbomachine (10) d'aéronef d'axe principal A comportant : - un bras radial (18) par rapport à l'axe principal A s'étendant au travers d'une veine (14) d'écoulement d'air ; - une paroi de support (22) appartenant au bras radial (18) et qui comporte deux ouvertures (24) ; - une pluralité de harnais (16) électriques s'étendant en partie au travers du bras radial (18) et dont un tronçon (26) de chaque harnais (16) est fixé à ladite paroi de support (22) du bras (18) ; caractérisée en ce qu'elle comporte deux blocs de montage (20) dont chaque bloc de montage (20) est associé à un groupe de tronçons (26) de harnais (16). Figure pour l’abrégé : figure 3 The invention relates to an aircraft turbomachine (10) of main axis A comprising: - a radial arm (18) with respect to the main axis A extending through a flow path (14) of 'air ; - a support wall (22) belonging to the radial arm (18) and which has two openings (24); - a plurality of electrical harnesses (16) extending partly through the radial arm (18) and of which a section (26) of each harness (16) is fixed to said support wall (22) of the arm (18) ; characterized in that it comprises two mounting blocks (20), each mounting block (20) of which is associated with a group of sections (26) of harness (16). Figure for abstract: Figure 3

MECHANICAL FRICTION PART COATED WITH A TRIBOACTIVE COATING BASED ON METAL OXIDE BRONZES

Valve and pump for liquid or viscous product

Selon un aspect, la présente description concerne une valve de sortie (200) comprenant une membrane (203) déformable élastiquement sous l'effet d'une surpression d’un produit liquide ou visqueux par rapport à l'extérieur, une surface extérieure (204) de la membrane (203) étant destinée à être mise en contact avec un milieu extérieur, au niveau d’au moins une première fente (205) apte à permettre l’écoulement d’un débit dudit produit induit par ladite suppression ; au moins une première paroi (210) configurée pour se trouver, en l’absence d’une surpression du produit, en contact avec une surface intérieure (206) de la membrane selon au moins une première ligne de contact (211) agencée à la périphérie de la fente (205), et configurée pour permettre un écartement de ladite surface intérieure de la membrane avec une partie au moins de ladite au moins une première paroi en cas de surpression du produit. FIG. 2A According to one aspect, the present description relates to an outlet valve (200) comprising a membrane (203) elastically deformable under the effect of an overpressure of a liquid or viscous product relative to the outside, an outer surface (204 ) of the membrane (203) being intended to be brought into contact with an external medium, at the level of at least a first slot (205) capable of allowing the flow of a flow rate of said product induced by said suppression; at least one first wall (210) configured to be, in the absence of an overpressure of the product, in contact with an inner surface (206) of the membrane along at least one first line of contact (211) arranged at the periphery of the slot (205), and configured to allow separation of said inner surface of the membrane with at least part of said at least one first wall in the event of overpressure of the product. FIG. 2A

IMPROVEMENTS ON HIGH POWER MOTORS.

Mechanical friction piece for panic stop equipment of e.g. tram car has surface equipped with set of projecting units subjected to friction, where units are made of metallic material of specific Vickers hardness

The piece has a surface (3) equipped with a set of projecting units (2) subjected to the friction. The projecting units are made of a metallic material of Vickers hardness > 4,000 MPa. The projecting units comprise of multiple grousers, studs and/or points. The shape of each projecting unit is selected from a cone, a pyramid with triangular, square or polygonal base, a sphere and/or a torus. An independent claim is also included for a panic stop system comprising a friction piece.

MECHANICAL FRICTION PART COVERED WITH TRIBOACTIVE OXIDES HAVING A DEFECT OF METAL CATIONS

INJECTION HEAD OF A FLUID SUBSTANCE FOR INJECTION SITE MONITORING INJECTION OF THE FLUID SUBSTANCE AND SYRINGE COMPRISING SUCH A HEAD

L'invention concerne une tête d'injection (10) d'une substance fluide et une seringue comprenant une telle tête, ladite tête étant caractérisée en ce qu'elle présente un corps de liaison (11) prolongé par un tube creux (15), destiné à communiquer avec le débouché du réservoir, présentant une extrémité distale et une aiguille (16) présentant une extrémité distale pointue, la tête comprenant en outre des moyens pour commander le déplacement relatif de ladite aiguille (16) par rapport audit tube creux (15) entre une position de piquage dans laquelle l'extrémité pointue de l'aiguille (16), laquelle est gigogne dans le tube creux (15), dépasse l'extrémité distale du tube creux (15) et une position de contrôle et de caractérisation du liquide en provenance du site d'injection, l'extrémité distale pointue de l'aiguille (16) étant en retrait de l'extrémité distale du tube creux (15) dans ladite position.

PROCESS FOR IMPROVING THE IMMUNOGENICITY OF AN IMMUNOGENIC COMPOUND OR A HAPTENA AND APPLICATION TO THE PREPARATION OF VACCINES

FUNCTIONAL FLUID FOR MOTOR VEHICLES COMPRISING UREA

Recombinant DNA Coding for Signal Peptide, Selective Interacting Polypeptide and Membrane Anchoring Sequence

Recombinant DNA sequence comprising a first DNA fragment coding for a first amino acid sequence operating as a signal peptide operable in a Gram positive host, operatively linked to a second DNA fragment coding for a second amino acid sequence not naturally found on the surface of Gram positive bacteria and capable of selective interaction, said second DNA fragment being operatively linked to a third DNA fragment coding for a third amino acid sequence operable in a Gram positive host as a cell wall spanning and membrane anchoring sequence; an expression vector or plasmid containing such recombinant DNA sequence; Gram positive bacterial cell containing such vector or plasmid; and a process for selective isolation or identification of Gram positive bacterial cells.

Process for the extraction of organic compounds

PRODUCTION OF HYDROPHOBIC PEPTIDE-LIKE PEPTIDES, RECOMBINANT PEPTIDE, CORRESPONDING DNA SEQUENCE

A method for secreting a biologically active recombinant peptide as an analogue of a natural peptide having at least one hydrophobic region, by culturing cells transformed by a nucleic acid construct comprising elements for the expression and secretion of said peptide by the cell, and a sequence coding for a peptide with an amino acid sequence that differs from the natural peptide sequence in that it has at least one modification in a non-transmembrane hydrophobic region of the peptide; and by recovering the peptide and/or cells carrying said recombinant peptide. The resulting recombinant peptide, a corresponding DNA sequence, and a bacterium containing same, are also disclosed.

MECHANICAL FRICTION PIECE FOR EMERGENCY BRAKING SYSTEM AND EMERGENCY BRAKE SYSTEM PROVIDED WITH SUCH A PART

PROCESS FOR OBTAINING A PEPTIDE DERIVED FROM THE SYNCITIAL RESPIRATORY VIRUS, POLYPEPTIDE AND BACTERIA EXPRESSING THE SAME, AND THEIR APPLICATIONS AS MEDICAMENTS

A method for preparing a peptide or protein, wherein (a) a DNA sequence coding for a heterologous polypeptide on a peptide sequence between amino acid residues 130 and 230 of respiratory syncytial virus protein G, sub-groups A and B, or a peptide sequence at least 80 % homologous thereto, and (b) means enabling the expression of the polypeptide on the bacterial membrane surface, are inserted into a bacterium which is not pathogenic for mammals. The resulting conjugate polypeptide and a live bacterium expressing same, pharmaceutical compositions containing them and their use for preparing a vaccine, as well as a DNA sequence coding for said polypeptide, are also disclosed.

DEVICE FOR ATTACHING THE SKIN TO A CATHETER LEAVING A SKIN EMERGENCE SITE

IMPROVEMENT TO CYLINDER MATERIALS OF ACTIVE PISTON ACTUATORS

FUNCTIONAL FLUID FOR MOTOR VEHICLES COMPRISING UREA

L'invention concerne un nouveau fluide fonctionnel pour véhicules automobiles comprenant outre les additifs usuels, un agent réducteur capable de réduire les oxydes d'azote émis lors de la combustion, l'acide nitrique et l'acide nitreux, et capable de protéger les PAG contre l'oxydation par ces acides. Cet agent réducteur est de préférence l'urée. The invention relates to a new functional fluid for motor vehicles comprising, in addition to the usual additives, a reducing agent capable of reducing the nitrogen oxides emitted during combustion, nitric acid and nitrous acid, and capable of protecting PAGs. against oxidation by these acids. This reducing agent is preferably urea.

Arrangement of a loading platform at the rear of a motor vehicle.

Agencement, sur un faux-plancher (20) d’une zone de chargement arrière (10) d’un véhicule automobile présentant une barre de seuil arrière (18), d’un plateau de chargement mobile (24), comportant un bord transversal avant (34) et un bord transversal arrière (36), et une face inférieure (26) et une face supérieure (30), caractérisé en ce que le plateau de chargement (24) est monté mobile entre une configuration de repos dans laquelle il se trouve à l’intérieur d’un logement (22) ménagé dans le faux plancher (20) et une première configuration relevée de chargement dans laquelle le plateau de chargement (24) est décalé vers l’arrière du véhicule, une partie inférieure de son bord arrière (36) étant en contact avec la barre de seuil arrière (18) de la zone de chargement (10). Figure pour abrégé : Figure 3 Arrangement, on a false floor (20) of a rear loading area (10) of a motor vehicle having a rear sill bar (18), of a movable loading platform (24), comprising a transverse edge front (34) and a rear transverse edge (36), and a lower face (26) and an upper face (30), characterized in that the loading platform (24) is movably mounted between a rest configuration in which it is inside a housing (22) provided in the false floor (20) and a first raised loading configuration in which the loading platform (24) is offset towards the rear of the vehicle, a lower part of its rear edge (36) being in contact with the rear sill bar (18) of the loading area (10). Figure for abstract: Figure 3

DEVICE FOR THE INTRODUCTION OF A CANNULA WITH A ROUNDED TIP UNDER THE SKIN OF A PATIENT

Ester oils

According to a first aspect, an ester oil, in particular for producing a hydraulic fluid and/or a lubricant, containing an esterification product from the esterification of at least one monoalcohol with at least one polycarboxylic acid, is characterized in that the monoalcohol and/or the polycarboxylic acid originates from renewable raw materials. According to a second aspect, an ester oil, in particular for producing a hydraulic fluid and/or a lubricant, containing an esterification product from the esterification of at least one monocarboxylic acid with at least one dialcohol, is characterized in that the dialcohol and/or the monocarboxylic acid originates from renewable raw materials.

New endolysin plyp40

The present invention relates to a polypeptide with an amino acid sequence according to SEQ ID NO: 1. The present invention further relates to the nucleic acid molecules comprising a nucleotide sequence coding for the polypeptide, vectors comprising the nucleic acid molecules, and host cells for the expression of the polypeptides. In addition, the present invention relates to the use of the polypeptide as a human medical, veterinary medical or diagnostic substance, as an antimicrobial substance in food, in cosmetics, as disinfecting agent or in the environmental field.

Mri systems and methods for indicating brain tissue damage of a subject

The invention provides concepts for indicating brain tissue damage or neuro-inflammation using MR thermometry. In particular, it is proposed that MR thermometry may be employed to determine a variation in the water PRF across a plurality of differently-timed MRI images (captured during an imaging time window) and such a variation may be used to determine an indication of brain tissue damage or neuro-inflammation.

Production of fusion proteins or polypeptides

PROCESS FOR OBTAINING A PEPTIDE DERIVED FROM THE SYNCITIAL RESPIRATORY VIRUS, POLYPEPTIDE AND BACTERIA EXPRESSING THE SAME, AND THEIR APPLICATIONS AS MEDICAMENTS

Pharmaceutical compositions containing insulin

Una composición farmacéutica que comprende un derivado de insulina seleccionado del grupo que consiste en insulina humana A14E, B16H, B25H, B29K((Nε-Eicosanodioil-γGlu-[2-(2-{2-[2-(2-aminoetoxi)etoxi]acetil- amino}etoxi)etoxi]acetil)), desB30 (Compuesto 1); insulina humana A14E, B16H, B25H, B29K(Nε-Hexadecandioil-γGlu), desB30 (Compuesto 2); insulina humana A14E, B16H, B25H, B29K(Nε-Eicosanodioil-γGlu), desB30 (Compuesto 3); y insulina humana A14E, B25H, desB27, B29K(Nε-Octadecandioil-γGlu), desB30 (Compuesto 4); y, además, comprende de 1 a 2 % (peso/peso) de glicerol; de 45 a 75 mM de fenol; de 0 a 19 mM de m-cresol; de 1,5 a 2,5 moles de iones zinc por seis moles de dicho derivado de insulina; de 5 a 50 mM de cloruro de sodio; y que tiene un valor de pH en el intervalo de 7,2 a 8,0. A pharmaceutical composition comprising an insulin derivative selected from the group consisting of human insulin A14E, B16H, B25H, B29K((Nε-Eicosanedioyl-γGlu-[2-(2-{2-[2-(2-aminoethoxy)ethoxy ]acetyl-amino}ethoxy)ethoxy]acetyl)), desB30 (Compound 1); human insulin A14E, B16H, B25H, B29K(Nε-Hexadecandioyl-γGlu), desB30 (Compound 2); human insulin A14E, B16H, B25H, B29K(Nε-Eicosanedioyl-γGlu), desB30 (Compound 3); and human insulin A14E, B25H, desB27, B29K(Nε-Octadecandioyl-γGlu), desB30 (Compound 4); and, in addition, it comprises 1 to 2% (w/w) of glycerol; 45 to 75 mM phenol; 0 to 19 mM m-cresol; from 1.5 to 2.5 moles of zinc ions per six moles of said insulin derivative; 5 to 50 mM sodium chloride; and having a pH value in the range of 7.2 to 8.0.

Torque transmission device

Die Erfindung betrifft eine Drehmomentübertragungseinrichtung (1) mit einem motorseitig an einer Kurbelwelle (10) eines Verbrennungsmotors aufgenommenen, einen Drehschwingungsdämpfer (5) aufweisenden ersten Übertragungsteil (2) und einem getriebeseitig angeordneten, mittels einer Steckverzahnung (4) mit dem ersten Übertragungsteil (2) drehschlüssig verbundenen zweiten Übertragungsteil (3), wobei ein Eingangsteil (6) des Drehschwingungsdämpfers (5) mittels auf einem Teilkreis (Tk) angeordneten Befestigungsschrauben (9) mit der Kurbelwelle (10) verbunden ist und ein entgegen der Wirkung einer Federeinrichtung (8) gegenüber dem Eingangsteil (6) um die Drehachse (d) der Kurbelwelle (10) begrenzt verdrehbares Ausgangsteil (7) mit einer Ausgangsnabe (18) angeordnet ist, wobei die Ausgangsnabe (18) ein erstes Verzahnungsteil (19) und ein Wellenabschnitt (40) des zweiten Übertragungsteils (3) ein zweites Verzahnungsteil (20) aufweist, wobei die Verzahnungsteile (19) die Steckverzahnung (4) bilden. Um während einer Montage des ersten Übertragungsteils an der Kurbelwelle auf Durchgriffsöffnungen an der Ausgangsnabe oder dem mit diesem verbundenen Flanschteil verzichten zu können und die Ausgangsnabe dennoch bei einem kleinen Durchmesser anordnen zu können, sind die Verzahnungsteile (19, 20) der Ausgangsnabe (18) und des Wellenabschnitts (40) auf einen Durchmesser (D) größer als der Durchmesser des Teilkreises (Tk) erweitert. The invention relates to a torque transmission device (1) with a first transmission part (2) which is received on the engine side on a crankshaft (10) of an internal combustion engine, has a torsional vibration damper (5) and a transmission part (2) arranged on the transmission side and connected to the first transmission part (2) by means of a spline (4) second transmission part (3) connected in a rotationally locking manner, an input part (6) of the torsional vibration damper (5) being connected to the crankshaft (10) by means of fastening screws (9) ...

Bacterial receptor structures

Novel proteins obtainable by mutagenesis of surface-exposed amino acids of domains of natural bacterial receptors, said proteins being obtained without substantial loss of basic structure and stability of said natural bacterial receptors; proteins which have been selected from a protein library embodying a repertoire of said novel proteins; and methods for the manufacture of artificial bacterial receptor structures.

Production of lower boiling hydrocarbons from heavy hydrocarbons