Biothermal power source for implantable devices

An implantable, rechargeable assembly comprised of an implantable device disposed within a living organism, an electrical storage device connected to the implantable device, and a thermoelectric charging assembly operatively connected to the electrical storage device. The thermoelectric charging assembly has devices for transferring thermal energy between the living organism and a thermoelectric module, for generating an electrical current from the thermal energy, for charging the electrical storage device with the electrical current, for determining the extent to which the electrical storage device is being charged with the electrical current, and for generating a signal whenever the extent to which the electrical storage device is being charged with the electrical current falls below a specified value.

Multi-component substances and processes for preparation thereof

The present invention is a method and apparatus for the synthesis of multi-component substances, comprising entities of at least two elements, molecules, grains, crystals, structural units, or phases of matter, in which the scale of the distribution of the elements, molecules, or phases of matter may range from on the order of nanometers or less, to about one millimeter, depending upon the specific materials and process conditions that are chosen. The method and apparatus of the present invention further provides processes for preparing these compositions of matter as thin films or particles.

Biothermal power source for implantable devices

An implantable, rechargeable assembly comprised of an implantable device disposed within a living organism, an electrical storage device connected to the implantable device, and a thermoelectric charging assembly operatively connected to the electrical storage device. The thermoelectric charging assembly has devices for transferring thermal energy between the living organism and a thermoelectric module, for generating an electrical current from the thermal energy, for charging the electrical storage device with the electrical current, for determining the extent to which the electrical storage device is being charged with the electrical current, and for generating a signal whenever the extent to which the electrical storage device is being charged with the electrical current falls below a specified value.

Electromagnetic interference immune tissue invasive system

An electromagnetic immune tissue invasive system includes a primary device housing. The primary device housing having a control circuit therein. A shielding is formed around the primary device housing to shield the primary device housing and any circuits therein from electromagnetic interference. A lead system transmits and receives signals between the primary device housing. The lead system is either a fiber optic system or an electrically shielded electrical lead system.

TISSUE CUTTING SYSTEMS AND METHODS

The disclosure provides various embodiments of systems to facilitate the cutting of tissue structures and other tissue structures percutaneously.

ANNULOPLASTY PROCEDURES, RELATED DEVICES AND METHODS

Devices and methods are disclosed for the treatment or repair of regurgitant cardiac valves, such as a mitral valve. An illustrative annuloplasty device can be placed in the coronary sinus to reshape the mitral valve and reduce mitral valve regurgitation. The disclosure also provides improved techniques for cardiac pacing.

ELECTROMAGNETIC RESONANT CIRCUIT SLEEVE FOR IMPLANTABLE MEDICAL DEVICE

A medical device enables effective magnetic resonance imaging inside a lumen of a medical device. The medical device includes a plurality of conductive traces formed on a substrate. The conductive traces form an inductive-capacitance circuit or a resistive-inductive-capacitance circuit. The inductive-capacitance circuit or resistive-inductive-capacitance circuit is tuned to a frequency associated with magnetic resonance imaging, an operating frequency associated with a magnetic resonance imaging scanner, a harmonic of an operating frequency associated with a magnetic resonance imaging scanner, or a sub-harmonic of an operating frequency associated with a magnetic resonance imaging scanner.

Electromagnetic interference immune tissue invasive system

An electromagnetic immune tissue invasive system includes a primary device housing. The primary device housing having a control circuit therein. A shielding is formed around the primary device housing to shield the primary device housing and any circuits therein from electromagnetic interference. A lead system transmits and receives signals between the primary device housing. The lead system is either a fiber optic system or an electrically shielded electrical lead system.

ANNULOPLASTY PROCEDURES, RELATED DEVICES AND METHODS

Devices and methods are disclosed for the treatment or repair of regurgitant cardiac valves, such as a mitral valve. An illustrative annuloplasty device can be placed in the coronary sinus to reshape the mitral valve and reduce mitral valve regurgitation. An improved protective device can be placed between the annuloplasty device and an underlying coronary artery to inhibit compression of the underlying coronary artery by the annuloplasty device in the coronary sinus. In addition, the protective device can inhibit compression of the coronary artery from inside the heart, such as from a prosthetic mitral valve that exerts radially outward pressure toward the coronary artery. The annuloplasty device can also create an artificial inner ridge or retaining feature projecting into the native mitral valve region to help secure a prosthetic mitral valve. 1. An implant , comprising:a) a bridge having a proximal end, a distal end, and an arched portion defined between the proximal end and the distal end of the bridge;b) an elongate inner tether coupled to the bridge;d) an outer sheath material surrounding and encasing the bridge and elongate inner tether.2. The implant of claim 1 , wherein at least one of the elongate inner tether and the outer sheath material includes radiopaque material along its length.3. The implant of claim 2 , wherein the radiopaque material within the elongate inner tether includes a radiopaque wire disposed within a length of heat shrunk polymeric tube that resides within a hollow core of the elongate inner tether.4. The implant of claim 1 , further comprising an outer polymeric tube within the outer sheath material that is shrunk around the bridge and the inner elongate tether claim 1 , the polymeric tube extending axially beyond the proximal end and the distal end of the bridge.5. The implant of claim 4 , wherein the elongate inner tether passes over a top face of the arched portion of the bridge within the shrunk outer polymeric tube and outer ...

Electromagnetic radiation transparent device and method of making thereof

A medical device includes a pattern of electrically conductive material. The pattern of electrically conductive material has an anti-antenna geometrical shape such that the anti-antenna geometrical shape substantially prevents the medical device from creating an imaging artifact and/or substantially allows imaging of a volume within the medical device. The pattern may be formed by multiple “figure-8” shaped electrical conductors, multiple “figure-8” emulating electrical conductors, multiple sine-wave-like shaped electrical conductors, multiple zig-zag patterned electrical conductors, by multiple electrical conductors, each having sequential conductive loops, and/or a single conductor weaved into a loop mesh. The electrically conductive material may be titanium, tantalum, nitinol, stainless steel, and/or NbZr.

ELECTROMAGNETIC RESONANT CIRCUIT SLEEVE FOR IMPLANTABLE MEDICAL DEVICE

A medical device enables effective magnetic resonance imaging inside a lumen of a medical device. The medical device includes a plurality of conductive traces formed on a substrate. The conductive traces form an inductive-capacitance circuit or a resistive-inductive-capacitance circuit. The inductive-capacitance circuit or resistive-inductive-capacitance circuit is tuned to a frequency associated with magnetic resonance imaging, an operating frequency associated with a magnetic resonance imaging scanner, a harmonic of an operating frequency associated with a magnetic resonance imaging scanner, or a sub-harmonic of an operating frequency associated with a magnetic resonance imaging scanner.

Flow cytometer shunt

A flow cytometer containg a device for sampling cellular material within a body. The flow cytometer is adapted to mark cells within bodily fluid with a marker to produce marked cells, to analyze the marked cells, to sort the cells within the bodily fluid to produce sorted cells, to maintain the sorted cells cells in a viable state, and to remove the marker from the marked cells. Two marker removal devices are used in the flow cytomter.

Electromagnetic interference immune tissue invasive system

An electromagnetic immune tissue invasive system includes a primary device housing. The primary device housing having a control circuit therein. A shielding is formed around the primary device housing to shield the primary device housing and any circuits therein from electromagnetic interference. A lead system transmits and receives signals between the primary device housing. The lead system is either a fiber optic system or an electrically shielded electrical lead system.

Prosthetic implants having enhanced utility

A prosthetic implant system connected to the tissue of a living organism. The system contains a first device for measuring the mechanical strain in the implant in an area thereof which is not exposed to tissue regrowth, a second device for measuring the mechanical strain in the implant in an area thereof which is exposed to tissue regrowth, a device for continuously determining the stress/strain relationship of said implant, and a device for treating said tissue.

ELECTROMAGNETIC RESONANT CIRCUIT SLEEVE FOR IMPLANTABLE MEDICAL DEVICE

A medical device enables effective magnetic resonance imaging inside a lumen of a medical device. The medical device includes a plurality of conductive traces formed on a substrate. The conductive traces form an inductive-capacitance circuit or a resistive-inductive-capacitance circuit. The inductive-capacitance circuit or resistive-inductive-capacitance circuit is tuned to a frequency associated with magnetic resonance imaging, an operating frequency associated with a magnetic resonance imaging scanner, a harmonic of an operating frequency associated with a magnetic resonance imaging scanner, or a sub-harmonic of an operating frequency associated with a magnetic resonance imaging scanner.

Electromagnetic interference immune pacing/defibrillation lead

An electromagnetic interference immune defibrillator lead has a first electromagnetic insulating layer. A first layer is formed on the first electromagnetic insulating layer, the first layer having a plurality of first conductive rings composed of first conductive material, each first conductive ring being separated by first insulating material. A second electromagnetic insulating layer is formed on the first layer. A second layer is, formed on the second electromagnetic insulating layer, the second layer having a plurality of second conductive rings composed of second conductive material, each second conductive ring being separated by second insulating material. A third electromagnetic insulating layer is formed on the second layer. The second conductive rings of second conductive material are positioned such that a second conductive ring overlaps a portion of a first conductive ring and overlaps a portion of a second conductive ring, the second conductive ring being adjacent to the first ...

ANNULOPLASTY PROCEDURES, RELATED DEVICES AND METHODS

Devices and methods are disclosed for the treatment or repair of regurgitant cardiac valves, such as a mitral valve. An illustrative annuloplasty device can be placed in the coronary sinus to reshape the mitral valve and reduce mitral valve regurgitation. The disclosure also provides improved techniques for cardiac pacing. 1. A lock delivery catheter , comprising:a) an elongate inner tubular member having a proximal end and a distal end;b) an elongate outer tubular member having a proximal end, a distal end and defining an elongate lumen therethrough for slidably receiving the elongate inner tubular member therein;c) a deployable lock attached to the lock delivery catheter including a lock body and a wedge, the wedge being configured to wedge against the lock body when the lock body and wedge are pressed together.2. The lock delivery catheter of claim 1 , wherein the lock body is detachably attached to the distal end of the elongate outer tubular member claim 1 , and further wherein the wedge is detachably attached to the distal end of the elongate inner tubular member.3. The lock delivery catheter of claim 2 , further comprising at least one guiding suture routed between the lock body and the wedge and extending proximally through the elongate inner tubular member.4. The lock delivery catheter of claim 3 , wherein the at least one guiding suture is a snare suture including a loop formed at a distal end thereof for attaching to a second suture to facilitate drawing the second suture through the lock delivery catheter.5. The lock delivery catheter of claim 1 , wherein the lock body includes a pin that spans the lock body claim 1 , wherein the pin passes through a portion of the wedge to couple the lock body to the wedge.6. The lock delivery catheter of claim 5 , wherein the pin passes through a longitudinal groove formed into the wedge claim 5 , such that the lock body and wedge can slide with respect to each other along the longitudinal groove.7. The lock delivery ...

ELECTROMAGNETIC RESONANT CIRCUIT SLEEVE FOR IMPLANTABLE MEDICAL DEVICE

A medical device enables effective magnetic resonance imaging inside a lumen of a medical device. The medical device includes a plurality of conductive traces formed on a substrate. The conductive traces form an inductive-capacitance circuit or a resistive-inductive-capacitance circuit. The inductive-capacitance circuit or resistive-inductive-capacitance circuit is tuned to a frequency associated with magnetic resonance imaging, an operating frequency associated with a magnetic resonance imaging scanner, a harmonic of an operating frequency associated with a magnetic resonance imaging scanner, or a sub-harmonic of an operating frequency associated with a magnetic resonance imaging scanner.

ELECTROMAGNETIC RESONANT CIRCUIT SLEEVE FOR IMPLANTABLE MEDICAL DEVICE

A medical device enables effective magnetic resonance imaging inside a lumen of a medical device. The medical device includes a plurality of conductive traces formed on a substrate. The conductive traces form an inductive-capacitance circuit or a resistive-inductive-capacitance circuit. The inductive-capacitance circuit or resistive-inductive-capacitance circuit is tuned to a frequency associated with magnetic resonance imaging, an operating frequency associated with a magnetic resonance imaging scanner, a harmonic of an operating frequency associated with a magnetic resonance imaging scanner, or a sub-harmonic of an operating frequency associated with a magnetic resonance imaging scanner.

Indicating lubricant additive

An indicating lubricant additive comprising a color-changable polymer having an outer layer of a first color, and an intermediate layer of a second color; and a lubricant sensing dipstick comprising a circuit housing, an elongated body having a proximal end and a distal end, and lubricant sensing means disposed at said distal end, wherein in one embodiment, the sensing means detects a change in the indicating lubricant additive that is. present in a lubricant.

DEVICES AND METHODS FOR CLOSURE OF TRANSVASCULAR OR TRANSCAMERAL ACCESS PORTS

The present disclosure provides a variety of prostheses, delivery systems and techniques to facilitate closure of transvascular or transcameral access ports. Various embodiments of prostheses are provided including a plurality of radially expandable mesh discs filled with material to facilitate coagulation and to reduce or stop leakage from punctures in vessel walls. 1. A prosthesis comprising:a) a radially expandable mesh body that is configured to self-expand into at least one disc after becoming radially unconstrained, the radially expandable mesh body defining a volume therein when expanded, the at least one disc including a deployable paddle attached to a proximal or distal face the at least one disc, the paddle being configured to assume a radial orientation as the at least one disc expands outwardly radially, the deployable paddle being configured to extend radially outwardly beyond the at least one disc; andb) a resilient member disposed within the mesh that is attached to a proximal end and distal end of the prosthesis along an axis that defines a central region of the prosthesis, the resilient member being configured to cause the prosthesis to shorten along the axis and expand radially when the resilient member is relaxed.2. The prosthesis of claim 1 , wherein the prosthesis includes a material disposed within the mesh that is configured to encourage hemostasis when exposed to blood.3. The prosthesis of claim 2 , wherein the material disposed within the mesh includes first and second fabric discs that are disposed within the at least one disc of the radially expandable mesh body to line the radially expandable mesh body with fabric.4. The prosthesis of claim 3 , further comprising a tubular fabric portion attached to at least one of the fabric discs claim 3 , the tubular fabric portion extending proximally into a neck region of the prosthesis.5. The prosthesis of claim 1 , wherein the resilient member is a coil spring that causes the prosthesis to collapse ...

ELECTROMAGNETIC RESONANT CIRCUIT SLEEVE FOR IMPLANTABLE MEDICAL DEVICE

A medical device enables effective magnetic resonance imaging inside a lumen of a medical device. The medical device includes a plurality of conductive traces formed on a substrate. The conductive traces form an inductive-capacitance circuit or a resistive-inductive-capacitance circuit. The inductive-capacitance circuit or resistive-inductive-capacitance circuit is tuned to a frequency associated with magnetic resonance imaging, an operating frequency associated with a magnetic resonance imaging scanner, a harmonic of an operating frequency associated with a magnetic resonance imaging scanner, or a sub-harmonic of an operating frequency associated with a magnetic resonance imaging scanner.

ELECTROMAGNETIC RESONANT CIRCUIT SLEEVE FOR IMPLANTABLE MEDICAL DEVICE

A medical device enables effective magnetic resonance imaging inside a lumen of a medical device. The medical device includes a plurality of conductive traces formed on a substrate. The conductive traces form an inductive-capacitance circuit or a resistive-inductive-capacitance circuit. The inductive-capacitance circuit or resistive-inductive-capacitance circuit is tuned to a frequency associated with magnetic resonance imaging, an operating frequency associated with a magnetic resonance imaging scanner, a harmonic of an operating frequency associated with a magnetic resonance imaging scanner, or a sub-harmonic of an operating frequency associated with a magnetic resonance imaging scanner.

Electromagnetic interference immune tissue invasive system

An electromagnetic immune tissue invasive system includes a primary device housing. The primary device housing having a control circuit therein. A shielding is formed around the primary device housing to shield the primary device housing and any circuits therein from electromagnetic interference. A lead system transmits and receives signals between the primary device housing. The lead system is either a fiber optic system or an electrically shielded electrical lead system.

DEVICES AND METHODS FOR EFFECTUATING PERCUTANEOUS SHUNT PROCEDURES

In some implementations, a radially self-expanding endograft prosthesis is provided that includes (i) distal flange that is self-expanding and configured to flip generally perpendicularly with respect to a body of the prosthesis to help seat the prosthesis against a tissue wall, (ii) a distal segment extending proximally from the distal flange that has sufficient stiffness to maintain a puncture open that is formed through a vessel wall (iii) a compliant middle segment extending proximally from the distal segment, the middle segment being more compliant than the distal segment, and having independently movable undulating strut rings attached to a tubular fabric, the combined structure providing flexibility and compliance to allow for full patency while flexed, the segment being configured to accommodate up to a 90 degree bend, (iv) a proximal segment having a plurality of adjacent undulating strut rings that are connected to each other.

Delivery system for insulin and other therapeutic agents

An automated, non-implanted, closed-loop system for measurement of a biological material in an individual, determination of appropriate steady-state and bolus drug delivery response to the measured level of the biological material, and storage and delivery of a hormone, drug, or other chemical or biochemical therapeutic agent that serves to regulate or otherwise therapeutically react to the biological material.

MAGNETIC RESONANCE IMAGING INTERFERENCE IMMUNE DEVICE

A voltage compensation unit reduces the effects of induced voltages upon a device having a single wire line. The single wire line has balanced characteristic impedance. The voltage compensation unit includes a tunable compensation circuit connected to the wire line. The tunable compensation circuit applies supplemental impedance to the wire line. The supplemental impedance causes the characteristic impedance of the wire line to become unbalanced, thereby reducing the effects of induced voltages caused by changing magnetic fields.

ANNULOPLASTY PROCEDURES, RELATED DEVICES AND METHODS

Devices and methods are disclosed for the treatment or repair of regurgitant cardiac valves, such as a mitral valve. An illustrative annuloplasty device can be placed in the coronary sinus to reshape the mitral valve and reduce mitral valve regurgitation. The disclosure also provides improved techniques for cardiac pacing. 1. A snare catheter , comprising:a) an elongate core member having a proximal end and a distal end;b) an elongate intermediate tubular member having a proximal end, a distal end and defining an elongate lumen therethrough for slidably receiving the elongate core member therein;c) a collapsible tubular perforated body formed from a plurality of elongate filaments attached at a proximal end thereof to the distal end of the elongate intermediate tubular member, and at a distal end thereof to the distal end of the elongate core member, wherein relative axial displacement of the distal end of the elongate intermediate tubular member toward the distal end of the elongate core member causes the collapsible tubular perforated body to expand radially outwardly and for the elongate filaments to mutually separate, and relative axial displacement of the distal end of the elongate intermediate tubular member away from the distal end of the elongate core member causes the collapsible tubular perforated body to collapse radially inwardly and for the elongate filaments members to collapse together;d) a target wire disposed within the collapsible tubular perforated body that extends along the elongate core member and has a proximal end attached to the elongate intermediate tubular member and a distal end attached to the elongate core member, wherein the target wire is configured to assume a first generally straight configuration when the collapsible tubular perforated body is collapsed radially inwardly, and a second substantially nonlinear configuration when the collapsible tubular perforated body is expanded radially outwardly; ande) an elongate tubular ...

Electromagnetic interference immune pacing/defibrillation lead

An electromagnetic interference immune defibrillator lead has a first electromagnetic insulating layer. A first layer is formed on the first electromagnetic insulating layer, the first layer having a plurality of first conductive rings composed of first conductive material, each first conductive ring being separated by first insulating material. A second electromagnetic insulating layer is formed on the first layer. A second layer is, formed on the second electromagnetic insulating layer, the second layer having a plurality of second conductive rings composed of second conductive material, each second conductive ring being separated by second insulating material. A third electromagnetic insulating layer is formed on the second layer. The second conductive rings of second conductive material are positioned such that a second conductive ring overlaps a portion of a first conductive ring and overlaps a portion of a second conductive ring, the second conductive ring being adjacent to the first ...

Electromagnetic interference immune pacing/defibrillation lead

An electromagnetic interference immune defibrillator lead has a first electromagnetic insulating layer. A first layer is formed on the first electromagnetic insulating layer, the first layer having a plurality of first conductive rings composed of first conductive material, each first conductive ring being separated by first insulating material. A second electromagnetic insulating layer is formed on the first layer. A second layer is, formed on the second electromagnetic insulating layer, the second layer having a plurality of second conductive rings composed of second conductive material, each second conductive ring being separated by second insulating material. A third electromagnetic insulating layer is formed on the second layer. The second conductive rings of second conductive material are positioned such that a second conductive ring overlaps a portion of a first conductive ring and overlaps a portion of a second conductive ring, the second conductive ring being adjacent to the first conductive ring. The second electromagnetically insulating layer is composed of a self-healing dielectric material.

Pulsed arc molecular beam process

A process for preparing a material in which a gas mixture is subjected to a a temperature of at least 1,000 degrees Celsius while its pressure increased to at least 1,000 Torr. The pressurized hot gas mixture, which contains inert gas and fullerene ions, is then quenched by decreasing its temperature to a temperature of less than 500 degrees Celsius in a period of less than about 1 millisecond, and by decreasing its pressure of to a pressure of less than about 1 Torr in a period of less than about 10 milliseconds.

Electromagnetic interference immune tissue invasive system

An electromagnetic immune tissue invasive system includes a primary device housing. The primary device housing having a control circuit therein. A shielding is formed around the primary device housing to shield the primary device housing and any circuits therein from electromagnetic interference. A lead system transmits and receives signals between the primary device housing. The lead system is either a fiber optic system or an electrically shielded electrical lead system.

FILMS CONTAINING NUTRIENTS OR COMPONENTS FOR USE BY SOIL OR PLANTS

Polymer films containing nutrients and/or components for use by soil, plants and/or animals are biodegradable and compostable. Film compositions may include bio-based and fossil-based polymers along with nutrients and other components that can be utilized by soil, plants, animals, as well as pigments and additives. The films may be configured as three-layer coextruded films with two outside layers and an inside layer therebetween. The films of the present disclosure may be produced using blown film processes. The films are used in agricultural or other growing settings and provide a biodegradable, compostable film that delivers nutrients and/or components to soil, plants and/or animals over the course of and following film degradation. 1. A film for use in agriculture or horticulture comprising a cross-linked biodegradable polymer film and one or more nutrients or components within the cross-linked film for use by one or more of soil or plants , the film adapted to be flexible and to release the one or more nutrients or components after deployment.2. The film of claim 1 , wherein the one or more nutrients or components comprises at least one of: nitrogen claim 1 , phosphorous claim 1 , fertilizers claim 1 , metals claim 1 , micronutrients claim 1 , herbicides claim 1 , silicon dioxide claim 1 , alumina claim 1 , calcium oxide claim 1 , ferric oxide or potassium oxide.3. The film of claim 1 , wherein the biodegradable polymer comprises a composition of bio-based and fossil-based polymers.4. The film of claim 3 , wherein the biodegradable polymer comprises polylactic acid (PLA) and polybutyrate (PBAT).5. The film of claim 1 , wherein a thickness of the film is about 0.5 mils to about 1.0 mil.6. The film of claim 1 , wherein the film is a three-layer coextruded film comprising two outside layers and an inside layer therebetween.7. The film of claim 6 , wherein each of the outside layers account for about 15 to 20 percent of the total thickness of the film claim 6 , and ...

Devices and methods for closure of transvascular or transcameral access ports

The present disclosure provides a variety of prostheses, delivery systems and techniques to facilitate closure of transvascular or transcameral access ports. Various embodiments of prostheses are provided including a plurality of radially expandable mesh discs filled with material to facilitate coagulation and to reduce or stop leakage from punctures in vessel walls.

Electromagnetic interference immune pacing/defibrillation lead

An electromagnetic interference immune defibrillator lead has a first electromagnetic insulating layer. A first layer is formed on the first electromagnetic insulating layer, the first layer having a plurality of first conductive rings composed of first conductive material, each first conductive ring being separated by first insulating material. A second electromagnetic insulating layer is formed on the first layer. A second layer is, formed on the second electromagnetic insulating layer, the second layer having a plurality of second conductive rings composed of second conductive material, each second conductive ring being separated by second insulating material. A third electromagnetic insulating layer is formed on the second layer. The second conductive rings of second conductive material are positioned such that a second conductive ring overlaps a portion of a first conductive ring and overlaps a portion of a second conductive ring, the second conductive ring being adjacent to the first ...

Electromagnetic interference immune pacing/defibrillation lead

An electromagnetic interference immune defibrillator lead has a first electromagnetic insulating layer. A first layer is formed on the first electromagnetic insulating layer, the first layer having a plurality of first conductive rings composed of first conductive material, each first conductive ring being separated by first insulating material. A second electromagnetic insulating layer is formed on the first layer. A second layer is, formed on the second electromagnetic insulating layer, the second layer having a plurality of second conductive rings composed of second conductive material, each second conductive ring being separated by second insulating material. A third electromagnetic insulating layer is formed on the second layer. The second conductive rings of second conductive material are positioned such that a second conductive ring overlaps a portion of a first conductive ring and overlaps a portion of a second conductive ring, the second conductive ring being adjacent to the first ...

ELECTROMAGNETIC RESONANT CIRCUIT SLEEVE FOR IMPLANTABLE MEDICAL DEVICE

A medical device enables effective magnetic resonance imaging inside a lumen of a medical device. The medical device includes a plurality of conductive traces formed on a substrate. The conductive traces form an inductive-capacitance circuit or a resistive-inductive-capacitance circuit. The inductive-capacitance circuit or resistive-inductive-capacitance circuit is tuned to a frequency associated with magnetic resonance imaging, an operating frequency associated with a magnetic resonance imaging scanner, a harmonic of an operating frequency associated with a magnetic resonance imaging scanner, or a sub-harmonic of an operating frequency associated with a magnetic resonance imaging scanner.

BIOTHERMAL POWER SOURCE FOR IMPLANTABLE DEVICES

An implantable, rechargeable assembly that contains an implantable device within a living organism; an electrical storage device is connected to the implantable device, and a thermoelectric charging assembly is connected to said electrical storage device. A thermoelectric charging assembly contains devices for transferring thermal energy between the living organism and a thermoelectric module, for creating an electrical current of a first polarity from thermal energy, for creating an electrical current with a second polarity from thermal energy, for charging the electrical storage device with the electrical current of said first polarity, and for charging the electrical storage device with the electrical current of the second polarity.

ELECTROMAGNETIC RESONANT CIRCUIT SLEEVE FOR IMPLANTABLE MEDICAL DEVICE

A medical device enables effective magnetic resonance imaging inside a lumen of a medical device. The medical device includes a plurality of conductive traces formed on a substrate. The conductive traces form an inductive-capacitance circuit or a resistive-inductive-capacitance circuit. The inductive-capacitance circuit or resistive-inductive-capacitance circuit is tuned to a frequency associated with magnetic resonance imaging, an operating frequency associated with a magnetic resonance imaging scanner, a harmonic of an operating frequency associated with a magnetic resonance imaging scanner, or a sub-harmonic of an operating frequency associated with a magnetic resonance imaging scanner.

Devices and methods for effectuating percutaneous Glenn and Fontan procedures

In some implementations, a radially self-expanding endograft prosthesis is provided that includes (i) distal flange that is self-expanding and configured to flip generally perpendicularly with respect to a body of the prosthesis to help seat the prosthesis against a tissue wall, (ii) a distal segment extending proximally from the distal flange that has sufficient stiffness to maintain a puncture open that is formed through a vessel wall (iii) a compliant middle segment extending proximally from the distal segment, the middle segment being more compliant than the distal segment, and having independently movable undulating strut rings attached to a tubular fabric, the combined structure providing flexibility and compliance to allow for full patency while flexed, the segment being configured to accommodate up to a 90 degree bend, (iv) a proximal segment having a plurality of adjacent undulating strut rings that are connected to each other.

ELECTROMAGNETIC RESONANT CIRCUIT SLEEVE FOR IMPLANTABLE MEDICAL DEVICE

A medical device enables effective magnetic resonance imaging inside a lumen of a medical device. The medical device includes a plurality of conductive traces formed on a substrate. The conductive traces form an inductive-capacitance circuit or a resistive-inductive-capacitance circuit. The inductive-capacitance circuit or resistive-inductive-capacitance circuit is tuned to a frequency associated with magnetic resonance imaging, an operating frequency associated with a magnetic resonance imaging scanner, a harmonic of an operating frequency associated with a magnetic resonance imaging scanner, or a sub-harmonic of an operating frequency associated with a magnetic resonance imaging scanner.

ELECTROMAGNETIC RESONANT CIRCUIT SLEEVE FOR IMPLANTABLE MEDICAL DEVICE

A medical device enables effective magnetic resonance imaging inside a lumen of a medical device. The medical device includes a plurality of conductive traces formed on a substrate. The conductive traces form an inductive-capacitance circuit or a resistive-inductive-capacitance circuit. The inductive-capacitance circuit or resistive-inductive-capacitance circuit is tuned to a frequency associated with magnetic resonance imaging, an operating frequency associated with a magnetic resonance imaging scanner, a harmonic of an operating frequency associated with a magnetic resonance imaging scanner, or a sub-harmonic of an operating frequency associated with a magnetic resonance imaging scanner.

Electromagnetic interference immune tissue invasive system

An electromagnetic immune tissue invasive system includes a primary device housing. The primary device housing having a control circuit therein. A shielding is formed around the primary device housing to shield the primary device housing and any circuits therein from electromagnetic interference. A lead system transmits and receives signals between the primary device housing. The lead system is either a fiber optic system or an electrically shielded electrical lead system.

Electromagnetic interference immune pacing/defibrillation lead

An electromagnetic interference immune defibrillator lead has a first electromagnetic insulating layer. A first layer is formed on the first electromagnetic insulating layer, the first layer having a plurality of first conductive rings composed of first conductive material, each first conductive ring being separated by first insulating material. A second electromagnetic insulating layer is formed on the first layer. A second layer is, formed on the second electromagnetic insulating layer, the second layer having a plurality of second conductive rings composed of second conductive material, each second conductive ring being separated by second insulating material. A third electromagnetic insulating layer is formed on the second layer. The second conductive rings of second conductive material are positioned such that a second conductive ring overlaps a portion of a first conductive ring and overlaps a portion of a second conductive ring, the second conductive ring being adjacent to the first ...

Annuloplasty procedures, related devices and methods

Devices and methods are disclosed for the treatment or repair of regurgitant cardiac valves, such as a mitral valve. An illustrative annuloplasty device can be placed in the coronary sinus to reshape the mitral valve and reduce mitral valve regurgitation. An improved protective device can be placed between the annuloplasty device and an underlying coronary artery to inhibit compression of the underlying coronary artery by the annuloplasty device in the coronary sinus. In addition, the protective device can inhibit compression of the coronary artery from inside the heart, such as from a prosthetic mitral valve that exerts radially outward pressure toward the coronary artery. The annuloplasty device can also create an artificial inner ridge or retaining feature projecting into the native mitral valve region to help secure a prosthetic mitral valve.

Electromagnetic interference immune tissue invasive system

An electromagnetic immune tissue invasive system includes a primary device housing. The primary device housing having a control circuit therein. A shielding is formed around the primary device housing to shield the primary device housing and any circuits therein from electromagnetic interference. A lead system transmits and receives signals between the primary device housing. The lead system is either a fiber optic system or an electrically shielded electrical lead system.

Electromagnetic interference immune pacing/defibrillation lead

An electromagnetic interference immune defibrillator lead has a first electromagnetic insulating layer. A first layer is formed on the first electromagnetic insulating layer, the first layer having a plurality of first conductive rings composed of first conductive material, each first conductive ring being separated by first insulating material. A second electromagnetic insulating layer is formed on the first layer. A second layer is, formed on the second electromagnetic insulating layer, the second layer having a plurality of second conductive rings composed of second conductive material, each second conductive ring being separated by second insulating material. A third electromagnetic insulating layer is formed on the second layer. The second conductive rings of second conductive material are positioned such that a second conductive ring overlaps a portion of a first conductive ring and overlaps a portion of a second conductive ring, the second conductive ring being adjacent to the first ...

Devices and methods for effectuating percutaneous glenn and fontan procedures

In some implementations, a radially self-expanding endograft prosthesis is provided that includes (i) distal flange that is self-expanding and configured to flip generally perpendicularly with respect to a body of the prosthesis to help seat the prosthesis against a tissue wall, (ii) a distal segment extending proximally from the distal flange that has sufficient stiffness to maintain a puncture open that is formed through a vessel wall (iii) a compliant middle segment extending proximally from the distal segment, the middle segment being more compliant than the distal segment, and having independently movable undulating strut rings attached to a tubular fabric, the combined structure providing flexibility and compliance to allow for full patency while flexed, the segment being configured to accommodate up to a 90 degree bend, (iv) a proximal segment having a plurality of adjacent undulating strut rings that are connected to each other.

RESONANCE TUNING MODULE FOR IMPLANTABLE DEVICES AND LEADS

An implantable medical assist device includes a medical device. The medical device has a housing and electronics contained therein. A lead provides an electrical path to or from the electronics within the medical device. A resonance tuning module is located in the housing and is connected to the lead. The resonance tuning module includes a control circuit for determining a resonant frequency of the implantable medical assist device and an adjustable impedance circuit to change the combined resonant frequency of the medical device and lead.

Infundibular reducer devices

Described is a prosthetic valve assembly comprising: a radially self-expandable stent configured to expand to bear against a wall of a native body lumen; and an implantable prosthetic valve, having a diameter, the valve being mounted inside the stent; wherein the diameter of the stent is greater than the diameter of the prosthetic valve.

PERCUTANEOUS SHUNT DEVICES AND RELATED METHODS

The disclosure provides various embodiments of prostheses and delivery systems to permit an interventional cardiologist to create shunts between various blood vessels. Moreover, the disclosed shunts can be used to shunt between various hollow organs, as set forth in the present disclosure. 1. A tubular prosthesis , comprising:an elongate compliant tubular body having a proximal end and a distal end;a distal sealing flange coupled to the distal end of the elongate compliant tubular body, the distal sealing flange being configured and arranged to facilitate seating the tubular prosthesis against a first concave vessel wall of a first vessel, wherein the tubular prosthesis is configured to extend outwardly through an ostium formed in the first concave vessel wall when deployed, wherein the distal sealing flange remains inside the ostium after deployment; andat least one laterally extending projection structurally distinct from the distal sealing flange, the at least one laterally extending projection being located proximate the distal sealing flange and extending laterally beyond the distal sealing flange, the at least one laterally extending projection being configured and arranged to resist being pulled through said ostium.2. The tubular prosthesis of claim 1 , wherein the at least one laterally extending projection includes two laterally extending projections oriented about 180 degrees with respect to each other about a longitudinal axis of the tubular prosthesis claim 1 , and further wherein the two laterally extending projections are configured and arranged to rest near a bottom of the first concave vessel wall next to the ostium claim 1 , and further wherein both laterally extending projections are configured and arranged to prevent the distal end of prosthesis from being pulled proximally through the ostium.3. The tubular prosthesis of claim 1 , wherein the two laterally extending projections are connected to a framework of the tubular prosthesis disposed ...

DEVICES AND METHODS FOR DELIVERY OF EXPANDABLE PROSTHESES

The present disclosure provides a variety of prostheses, delivery systems and techniques to facilitate closure of transvascular or transcameral access ports. Various embodiments of prostheses are provided including a plurality of radially expandable discs that can be filled with material to facilitate coagulation and to reduce or stop leakage from punctures in vessel walls.

Electromagnetic interference immune pacing/defibrillation lead

An electromagnetic interference immune defibrillator lead has a first electromagnetic insulating layer. A first layer is formed on the first electromagnetic insulating layer, the first layer having a plurality of first conductive rings composed of first conductive material, each first conductive ring being separated by first insulating material. A second electromagnetic insulating layer is formed on the first layer. A second layer is, formed on the second electromagnetic insulating layer, the second layer having a plurality of second conductive rings composed of second conductive material, each second conductive ring being separated by second insulating material. A third electromagnetic insulating layer is formed on the second layer. The second conductive rings of second conductive material are positioned such that a second conductive ring overlaps a portion of a first conductive ring and overlaps a portion of a second conductive ring, the second conductive ring being adjacent to the first ...

CARDIAC ANNULOPLASTY AND PACING PROCEDURES, RELATED DEVICES AND METHODS

Devices and methods are disclosed for the treatment or repair of regurgitant cardiac valves, such as a mitral valve. An illustrative annuloplasty device can be placed in the coronary sinus to reshape the mitral valve and reduce mitral valve regurgitation. The disclosure also provides improved techniques for cardiac pacing. 1. An implantable pacing system configured and arranged to circumnavigate a loop in a heart , comprising:a) an elongate inner tether having a proximal end and a distal end;b) an outer sheath material surrounding the elongate inner tether having a proximal end and a distal end;c) at least one electrical conductor disposed along or within at least one of the elongate inner tether and the outer sheath;d) a cardiac pacing controller including a power source, a pulse generator, and control circuitry operably coupled to the at least one electrical conductor; ande) at least one cardiac pacing electrode configured and arranged to be implanted in cardiac tissue, the at least one cardiac pacing electrode being electrically coupled to the cardiac pacing controller by way of the at least one electrical conductor; andf) a lock securing the proximal end and distal end of the outer sheath material.2. The pacing system of claim 1 , wherein the lock is coupled to the cardiac pacing controller.3. The pacing system of claim 1 , wherein the at least one electrical conductor is disposed at least partially within the elongate inner tether.4. The pacing system of claim 1 , wherein the lock includes cardiac pacing lead routed therethrough.5. The pacing system of claim 4 , wherein electrical communication is established with the cardiac pacing lead by engaging a portion of the lock.6. The pacing system of claim 1 , further comprising at least one lumen along a length of the outer sheath for receiving a pacing lead claim 1 , wherein the pacing system can be slid along the pacing lead into the coronary sinus.7. The pacing system of claim 6 , wherein the at least one lumen ...

Electromagnetic interference immune pacing/defibrillation lead

An electromagnetic interference immune defibrillator lead has a first electromagnetic insulating layer. A first layer is formed on the first electromagnetic insulating layer, the first layer having a plurality of first conductive rings composed of first conductive material, each first conductive ring being separated by first insulating material. A second electromagnetic insulating layer is formed on the first layer. A second layer is, formed on the second electromagnetic insulating layer, the second layer having a plurality of second conductive rings composed of second conductive material, each second conductive ring being separated by second insulating material. A third electromagnetic insulating layer is formed on the second layer. The second conductive rings of second conductive material are positioned such that a second conductive ring overlaps a portion of a first conductive ring and overlaps a portion of a second conductive ring, the second conductive ring being adjacent to the first conductive ring. The second electromagnetically insulating layer is composed of a self-healing dielectric material.

Infundibular Reducer Devices

Described is a prosthetic valve assembly comprising: a radially self-expandable stent configured to expand to bear against a wall of a native body lumen; and an implantable prosthetic valve, having a diameter, the valve being mounted inside the stent; wherein the diameter of the stent is greater than the diameter of the prosthetic valve.

ANNULOPLASTY PROCEDURES, RELATED DEVICES AND METHODS

Devices and methods are disclosed for the treatment or repair of regurgitant cardiac valves, such as a mitral valve. An illustrative annuloplasty device can be placed in the coronary sinus to reshape the mitral valve and reduce mitral valve regurgitation. An improved protective device can be placed between the annuloplasty device and an underlying coronary artery to inhibit compression of the underlying coronary artery by the annuloplasty device in the coronary sinus. In addition, the protective device can inhibit compression of the coronary artery from inside the heart, such as from a prosthetic mitral valve that exerts radially outward pressure toward the coronary artery. The annuloplasty device can also create an artificial inner ridge or retaining feature projecting into the native mitral valve region to help secure a prosthetic mitral valve.

DEVICES AND METHODS FOR CLOSING OPENINGS IN TISSUE STRUCTURES

In accordance with the disclosure, devices are provided for closing an opening in tissue. The devices include a proximal portion configured and arranged to occlude the tissue opening, and a distal anchor portion configured and arranged to anchor the device in the tissue opening. If desired, the distal anchor portion can be moved proximally or distally with respect to the proximal portion during implantation. The proximal portion can be configured and arranged to fit into a left atrial appendage of a patient, and further wherein the distal anchor portion is configured and arranged to extend into the left atrial appendage. 1. A cardiac implant comprising:a distal anchor having a first expanded portion configured to be situated in the pericardial cavity and a second expanded portion configured to be situated within an apex of a left or right ventricle, wherein a neck portion of the distal anchor is configured to traverse an opening formed in the wall of the heart proximate the apex of the left or right ventricle, from inside the heart into the pericardial cavity; andan artificial valve configured to be coupled to the distal anchor by at least one tether, the artificial valve being configured to be received in an annulus of a cardiac valve, wherein the artificial valve is configured to be removably coupled to the distal anchor by a mechanical coupling that can be engaged and disengaged.2. A method of implanting an artificial cardiac valve , comprising:providing a cardiac implant that includes (i) a distal anchor having a first expanded portion configured to be situated in the pericardial cavity and a second expanded portion configured to be situated within an apex of a left or right ventricle, wherein a neck portion of the distal anchor is configured to traverse an opening formed in the wall of the heart proximate the apex of the left or right ventricle, from inside the heart into the pericardial cavity;anchoring the distal anchor across the wall of a heart proximate ...

Multi-component substances and apparatus for preparation thereof

An apparatus for the synthesis of multi-component substances, comprising entities of at least two elements, molecules, grains, crystals, structural units, or phases of matter, in which the scale of the distribution of the elements, molecules, or phases of matter may range from on the order of nanometers or less, to about one millimeter, depending upon the specific materials and process conditions that are chosen. The apparatus of the present invention comprises a vacuum chamber, a target assembly, an energy source for generating a plasma containing materials ablated from the target assembly, and a reagent gas supply for directing gas into the vacuum chamber toward the plasma.

Electromagnetic interference immune tissue invasive system

An electromagnetic immune tissue invasive system includes a primary device housing. The primary device housing having a control circuit therein. A shielding is formed around the primary device housing to shield the primary device housing and any circuits therein from electromagnetic interference. A lead system transmits and receives signals between the primary device housing. The lead system is either a fiber optic system or an electrically shielded electrical lead system.

Optical MRI catheter system

An assembly for delivering optical signals that has a nuclear magnetic resonance system, an optical interface assembly, and a catheter assembly with a fiber optic cable assembly and an optical interface and an antenna. The catheter assembly converts electromagnetic signals received by the antenna into optical signals. The optical interface assembly converts optical signals into electrical signals and electrical signals into optical signals.

ELECTROMAGNETIC RESONANT CIRCUIT SLEEVE FOR IMPLANTABLE MEDICAL DEVICE

A medical device enables effective magnetic resonance imaging inside a lumen of a medical device. The medical device includes a plurality of conductive traces formed on a substrate. The conductive traces form an inductive-capacitance circuit or a resistive-inductive-capacitance circuit. The inductive-capacitance circuit or resistive-inductive-capacitance circuit is tuned to a frequency associated with magnetic resonance imaging, an operating frequency associated with a magnetic resonance imaging scanner, a harmonic of an operating frequency associated with a magnetic resonance imaging scanner, or a sub-harmonic of an operating frequency associated with a magnetic resonance imaging scanner.

ELECTROMAGNETIC RESONANT CIRCUIT SLEEVE FOR IMPLANTABLE MEDICAL DEVICE

A medical device enables effective magnetic resonance imaging inside a lumen of a medical device. The medical device includes a plurality of conductive traces formed on a substrate. The conductive traces form an inductive-capacitance circuit or a resistive-inductive-capacitance circuit. The inductive-capacitance circuit or resistive-inductive-capacitance circuit is tuned to a frequency associated with magnetic resonance imaging, an operating frequency associated with a magnetic resonance imaging scanner, a harmonic of an operating frequency associated with a magnetic resonance imaging scanner, or a sub-harmonic of an operating frequency associated with a magnetic resonance imaging scanner.

Pulse width cardiac pacing apparatus

A cardiac assist system containing a device for delivering a first pacing pulse from said system to a heart, for ceasing the delivery of said first pacing pulse to said heart, for sensing whether the heart is beating, and for delivering a second pacing pulse from said system to the heart. Each of the first pacing pulse and the second pacing pulse are delivered to the heart within a period of less than about 100 milliseconds, and has a voltage of from about 2 to about 5 volts direct current. The time between the delivery of the first pacing pulse and the second pacing pulse is at least about 1 microsecond. The first pacing pulse and the second pacing pulse are delivered to the heart at a frequency of from about 2 kiloherz to about 5 megahertz; and they each have a duration of from about 0.1 microseconds to about 500 milliseconds. The cardiac assist system also contains a device for varying the voltage and/or the frequency of each of the pacing pulses.

Electromagnetic interference immune tissue invasive system

An electromagnetic immune tissue invasive system includes a primary device housing. The primary device housing having a control circuit therein. A shielding is formed around the primary device housing to shield the primary device housing and any circuits therein from electromagnetic interference. A lead system transmits and receives signals between the primary device housing. The lead system is either a fiber optic system or an electrically shielded electrical lead system.

DEVICES AND METHODS FOR CLOSURE OF TRANSVASCULAR OR TRANSCAMERAL ACCESS PORTS

The present disclosure provides a variety of prostheses, delivery systems and techniques to facilitate closure of transvascular or transcameral access ports. Various embodiments of prostheses are provided including a plurality of radially expandable discs that can be filled with material to facilitate coagulation and to reduce or stop leakage from punctures in vessel walls.

Electromagnetic interference immune tissue invasive system

An electromagnetic immune tissue invasive system includes a primary device housing. The primary device housing having a control circuit therein. A shielding is formed around the primary device housing to shield the primary device housing and any circuits therein from electromagnetic interference. A lead system transmits and receives signals between the primary device housing. The lead system is either a fiber optic system or an electrically shielded electrical lead system.

Annuloplasty procedures, related devices and methods

Devices and methods are disclosed for the treatment or repair of regurgitant cardiac valves, such as a mitral valve. An illustrative annuloplasty device can be placed in the coronary sinus to reshape the mitral valve and reduce mitral valve regurgitation. The disclosure also provides improved techniques for cardiac pacing.

Optical MRI catheter system

An assembly for delivering optical signals comprising a nuclear magnetic resonance system; an optical interface assembly electrically connected to the nuclear magnetic resonance system, the optical interface assembly comprising a first laser for producing laser optical signals, an interface optical to electrical signal convertor, and an interface optical connector assembly; and a catheter assembly comprising a proximal end, a distal end, and a catheter optical connector assembly disposed at the proximal end and connected to the interface optical connector assembly of the optical interface assembly, a fiber optic cable assembly, an electronics assembly disposed at the distal end comprised of a catheter electrical to optical signal convertor and a catheter optical to electrical signal convertor, and a first receiving coil disposed at the distal end.

MEDICAL DEVICE WITH A MRI-INDUCED SIGNAL ATTENUATING MEMBER

A lead includes a conductor having a distal end and a proximal end. The lead also includes a filter circuit in the conductor. The filter circuit filters out magnetic resonance imaging induced signals.

Optical MRI catheter system

An assembly for delivering optical signals comprising a nuclear magnetic resonance system comprised of magnets, an NMR programmable logic unit, a signal input channel, and a command output channel; an optical interface assembly electrically connected to the nuclear magnetic resonance system, the optical interface assembly comprising a first laser modulated so as to produce laser optical signals, an interface optical to electrical signal convertor; and a catheter assembly connected to said optical interface assembly, the catheter assembly comprising a proximal end, a distal end, a fiber optic cable assembly, an electronics assembly disposed at the distal end comprised of a catheter electrical to optical signal convertor and a catheter optical to electrical signal convertor, and a first receiving coil disposed at the distal end.

DEVICES AND METHODS FOR CLOSURE OF TRANSVASCULAR OR TRANSCAMERAL ACCESS PORTS

The present disclosure provides a variety of prostheses, delivery systems and techniques to facilitate closure of transvascular or transcameral access ports. Various embodiments of prostheses are provided including a plurality of radially expandable mesh discs filled with material to facilitate coagulation and to reduce or stop leakage from punctures in vessel walls. 1. A prosthesis comprising:a) a radially expandable mesh body that is configured to self-expand into at least one disc after becoming radially unconstrained, the radially expandable mesh body defining a volume therein when expanded, the at least one disc including a deployable paddle attached to a proximal or distal face the at least one disc, the paddle being configured to assume a radial orientation as the at least one disc expands outwardly radially, the deployable paddle being configured to extend radially outwardly beyond the at least one disc; andb) at least one tether attached to the radially expandable mesh body that is configured to cause the radially expandable mesh body to collapse radially when tension is applied to the at least one tether.2. A prosthesis according to claim 1 , further comprising at least one tether attached to the radially expandable mesh body that is configured to cause the radially expandable mesh body to collapse radially when tension is applied to the at least one tether.3. The prosthesis of claim 1 , wherein the radially expandable mesh body is configured to self-expand into at least two discs connected by a neck region after becoming radially unconstrained claim 1 , a first disc of the two discs being configured to mitigate high pressure leaks in an artery claim 1 , and a second disc of the two discs being configured to mitigate low pressure leaks originating from a vein claim 1 , and further wherein the neck region is configured to cooperate with the first and second discs to prevent leakage from the artery and the vein.4. The prosthesis of claim 1 , wherein the ...

Electromagnetic interference immune tissue invasive system

An electromagnetic immune tissue invasive system includes a primary device housing. The primary device housing having a control circuit therein. A shielding is formed around the primary device housing to shield the primary device housing and any circuits therein from electromagnetic interference. A lead system transmits and receives signals between the primary device housing. The lead system is either a fiber optic system or an electrically shielded electrical lead system.

Magnetically shielded assembly

A shielded assembly containing a substrate and a shield. The shield contains both nanomagnetic material and a material with an electrical resistivity of from about 1 microohm-centimeter to about 1×10 25 microohm centimeters. The nanomagnetic material has a mass density of at least about 0.01 grams per cubic centimeter, a saturation magnetization of from about 1 to about 36,000 Gauss, a coercive force of from about 0.01 to about 5000 Oersteds, a relative magnetic permeability of from about 1 to about 500,000, and an average particle size of less than about 100 nanometers.

Electromagnetic interference immune tissue invasive system

An electromagnetic immune tissue invasive system includes a primary device housing. The primary device housing having a control circuit therein. A shielding is formed around the primary device housing to shield the primary device housing and any circuits therein from electromagnetic interference. A lead system transmits and receives signals between the primary device housing. The lead system is either a fiber optic system or an electrically shielded electrical lead system.

ELECTROMAGNETIC RADIATION IMMUNE MEDICAL ASSIST DEVICE ADAPTER

An electromagnetic radiation immune medical assist system includes a medical assist device; a photonic lead having a proximal end and a distal end; and an adapter to operatively connect the medical assist device with the photonic catheter. The adapter includes a housing, an interface to provide an operative communication connection between the adapter and the medical assist device, a transducer to convert information from the medical assist device into optical energy, and an optical interface to provide an operative connection between the adapter and the photonic catheter.

Process for regulating gene expression

A process for stimulating the expression of a gene in which two different DNA constructs are disposed within a biological system and contacted with electromagnetic radiation, thereby causing each of the DNA constructs to express a gene product.

Therapeutic agent delivery apparatus with direct mechanical ventricular assistance capability

A therapeutic apparatus for delivering at least one therapeutic agent directly and preferentially to a desired tissue to be treated, comprising at least one membrane adapted to deliver the therapeutic agent to the desired tissue, wherein the membrane is in contact with at least a part of the desired tissue to be treated; and at least one shell surrounding the membrane, wherein the shell isolates the membrane from tissues other than the desired tissue to be treated. In one embodiment, the apparatus is a direct mechanical ventricular assistance apparatus comprising a liner in which the membrane is formed.

DEVICES AND METHODS FOR CLOSING OPENINGS IN TISSUE STRUCTURES

In accordance with the disclosure, devices are provided for closing an opening in tissue. The devices include a proximal portion configured and arranged to occlude the tissue opening, and a distal anchor portion configured and arranged to anchor the device in the tissue opening. If desired, the distal anchor portion can be moved proximally or distally with respect to the proximal portion during implantation. The proximal portion can be configured and arranged to fit into a left atrial appendage of a patient, and further wherein the distal anchor portion is configured and arranged to extend into the left atrial appendage. 1. An implant to occlude a left atrial appendage (LAA) in the heart , comprising:a distal anchor having a first expanded portion situated in the pericardial cavity and a second expanded portion situated inside the LAA, wherein a neck portion of the distal anchor traverses an opening formed in the wall of the LAA from inside the heart into the pericardial cavity; anda LAA occluder expanded into the LAA to occlude a substantial volume of the LAA, the LAA occluder being removably coupled to the distal anchor.2. The implant of claim 1 , wherein the LAA occluder is removably coupled to the distal anchor by a threaded connection.3. The implant of claim 1 , wherein the LAA occluder is removably coupled to the distal anchor by a keyed connection.4. The implant of claim 1 , wherein the LAA occluder is removably coupled to the distal anchor by a lock.5. The implant of claim 1 , wherein the LAA occluder is coupled to at least one length limiting tether that connects to a first coupling claim 1 , wherein the first coupling of the LAA occluder is configured to couple to the distal anchor.6. The implant of claim 1 , wherein the distal anchor is displaceable proximally or distally with respect to the proximal portion during implantation.7. The implant of claim 1 , wherein the distal anchor is formed from at least one expandable braided disc.8. The implant of claim ...

Electromagnetic interference immune tissue invasive system

An electromagnetic immune tissue invasive system includes a primary device housing. The primary device housing having a control circuit therein. A shielding is formed around the primary device housing to shield the primary device housing and any circuits therein from electromagnetic interference. A lead system transmits and receives signals between the primary device housing. The lead system is either a fiber optic system or an electrically shielded electrical lead system.

Annuloplasty procedures, related devices and methods

Devices and methods are disclosed for the treatment or repair of regurgitant cardiac valves, such as a mitral valve. An illustrative annuloplasty device can be placed in the coronary sinus to reshape the mitral valve and reduce mitral valve regurgitation. The disclosure also provides improved techniques for cardiac pacing.

DEVICES AND METHODS FOR EFFECTUATING PERCUTANEOUS GLENN AND FONTAN PROCEDURES

In some implementations, a radially self-expanding endograft prosthesis is provided that includes (i) distal flange that is self-expanding and configured to flip generally perpendicularly with respect to a body of the prosthesis to help seat the prosthesis against a tissue wall, (ii) a distal segment extending proximally from the distal flange that has sufficient stiffness to maintain a puncture open that is formed through a vessel wall (iii) a compliant middle segment extending proximally from the distal segment, the middle segment being more compliant than the distal segment, and having independently movable undulating strut rings attached to a tubular fabric, the combined structure providing flexibility and compliance to allow for full patency while flexed, the segment being configured to accommodate up to a 90 degree bend, (iv) a proximal segment having a plurality of adjacent undulating strut rings that are connected to each other. 1. A method of installing a tubular prosthesis through a sidewall of a native lumenal vessel , comprising: a distal annular flange configured to help seat the prosthesis when it is pulled proximally;', 'a distal tubular segment extending proximally from the distal flange that has sufficient stiffness to maintain a puncture in an open condition that is formed through a first vessel wall through which the distal segment passes;', 'a proximal tubular segment that is sufficiently stiff to seat within and urge against a second vessel wall; and, 'providing a prosthesis havingcollapsing the prosthesis onto a delivery system;delivering a distal end of the delivery system to an opening defined through a native lumenal vessel wall; anddeploying the distal annular flange inside of the native lumenal vessel wall.2. The method of claim 1 , further comprising pulling proximally on the delivery system to seat the distal annular flange.3. The method of claim 2 , further comprising deploying the distal tubular segment from the delivery system.4. The ...

Devices and methods for closing openings in tissue structures

In accordance with the disclosure, devices are provided for closing an opening in tissue. The devices include a proximal portion configured and arranged to occlude the tissue opening, and a distal anchor portion configured and arranged to anchor the device in the tissue opening. If desired, the distal anchor portion can be moved proximally or distally with respect to the proximal portion during implantation. The proximal portion can be configured and arranged to fit into a left atrial appendage of a patient, and further wherein the distal anchor portion is configured and arranged to extend into the left atrial appendage.

Biothermal power source for implantable devices

An implantable, rechargeable assembly comprised of an implantable device disposed within a living organism, an electrical storage device connected to the implantable device, and a thermoelectric charging assembly operatively connected to the electrical storage device. The thermoelectric charging assembly has devices for transferring thermal energy between the living organism and a thermoelectric module, for generating an electrical current from the thermal energy, for charging the electrical storage device with the electrical current, for determining the extent to which the electrical storage device is being charged with the electrical current, and for generating a signal whenever the extent to which the electrical storage device is being charged with the electrical current falls below a specified value.

Method and apparatus for direct mechanical ventricular actuation with favorable conditioning and minimal heart stress

A process for assisting the function of a heart disposed within a body, comprising the steps of supporting the heart in providing circulation of blood for perfusion of an organ in the body, remodeling the heart to render the heart in an improved state, and stabilizing the heart in the improved state. The process is preferably performed with an apparatus comprising a cup-shaped shell having an exterior surface and an interior surface; a liner having an outer surface, an upper edge joined to said interior surface of said cup-shaped shell, and a lower edge joined of said interior surface of said cup-shaped shell, thereby forming a cavity between said outer surface thereof and said interior surface of said shell; a drive fluid cyclically interposed within said cavity; and at least one sensor measuring at least one macroscopic parameter indicative of said function of said heart. Further embodiments of the process and apparatus include means and use thereof for delivering a therapeutic agent ...

Flow cytometer

A flow cytometer containg a device for sampling cellular material within a body, comprising. The flow cytometer is adapted to mark cells within bodily fluid with a marker to produce marked cells, to analyze the marked cells, to sort the cells within the bodily fluid to produce sorted cells, and to maintain the sorted cells cells in a viable state.

Electromagnetic interference immune tissue invasive system

An electromagnetic immune tissue invasive system includes a primary device housing. The primary device housing having a control circuit therein. A shielding is formed around the primary device housing to shield the primary device housing and any circuits therein from electromagnetic interference. A lead system transmits and receives signals between the primary device housing. The lead system is either a fiber optic system or an electrically shielded electrical lead system.

Method and apparatus for direct mechanical ventricular actuation with favorable conditioning and minimal heart stress

A process for assisting the function of a heart disposed within a body, comprising the steps of supporting the heart in providing circulation of blood for perfusion of an organ in the body, remodeling the heart to render the heart in an improved state, and stabilizing the heart in the improved state. The process is preferably performed with an apparatus comprising a cup-shaped shell having an exterior surface and an interior surface; a liner having an outer surface, an upper edge joined to said interior surface of said cup-shaped shell, and a lower edge joined of said interior surface of said cup-shaped shell, thereby forming a cavity between said outer surface thereof and said interior surface of said shell; a drive fluid cyclically interposed within said cavity; and at least one sensor measuring at least one macroscopic parameter indicative of said function of said heart. Further embodiments of the process and apparatus include means and use thereof for delivering a therapeutic agent ...

Temporary percutaneous cardioverter-defibrillator

An assembly that contains a device for the insertion of a temporary percutaneous cardioverter-defibrillator in contact with biological tissue of a biological organism. The assembly contains a conductor located on the periphery of the distal section of the assembly. The assembly is located in the vascular system of the biological organism, near the heart; it also contains a device for flowing electrical current through the conductor; and it also contains a cutaneous or subcutaneous electrode.

Medical device with an electrically conductive anti-antenna geometrical shaped member

A medical device having electrically conductive properties includes an electrically conductive member. The electrically conductive member has an anti-antenna geometrical shape. The anti-antenna geometrical shaped electrically conductive member is shaped such that currents induced in the anti-antenna geometrical shaped electrically conductive member, by radio frequency fields, offset currents induced in the medical device by the radio frequency fields.

Electromagnetic interference immune tissue invasive system

An electromagnetic immune tissue invasive system includes a primary device housing. The primary device housing having a control circuit therein. A shielding is formed around the primary device housing to shield the primary device housing and any circuits therein from electromagnetic interference. A lead system transmits and receives signals between the primary device housing. The lead system is either a fiber optic system or an electrically shielded electrical lead system.

Pulsewidth electrical stimulation

A process for stimulating tissue such as cardiac tissue, nerve tissue, and brain tissue. In one step of the process, there is delivered an electrical stimulating signal to the tissue that contains from about 10 to about 1,000 individual pulses. Each individual pulse has a duration of from about one microsecond to about 100 microseconds and is discontinuous, with a spacing between adjacent pulses of at least from about 1 microsecond to about 100 microseconds. The individual pulses have a voltage of from about 10 millivolts to about 100 volts.

Cardiac annuloplasty and pacing procedures, related devices and methods

Devices and methods are disclosed for the treatment or repair of regurgitant cardiac valves, such as a mitral valve. An illustrative annuloplasty device can be placed in the coronary sinus to reshape the mitral valve and reduce mitral valve regurgitation. The disclosure also provides improved techniques for cardiac pacing.

Annuloplasty procedures, related devices and methods

Devices and methods are disclosed for the treatment or repair of regurgitant cardiac valves, such as a mitral valve. An illustrative annuloplasty device can be placed in the coronary sinus to reshape the mitral valve and reduce mitral valve regurgitation. The disclosure also provides improved techniques for cardiac pacing.

HELICAL GUIDEWIRES AND RELATED SYSTEMS

In accordance with some implementations, various embodiments of a guidewire or catheter having an elongate core with a helical section are provided. In accordance with one implementation, a guidewire is provided. The guidewire includes a core wire having a proximal end, a distal end and is defined by an outer surface between the proximal end and the distal end of the core wire. The core wire has a centerline that traverses the length of the core wire from the proximal end to the distal end of the core wire. The centerline is located approximately at the center of mass along the core wire within the outer surface of the core wire. Preferably, the core wire has a substantially straight proximal portion and a helically curved segment located distally with respect to the proximal portion. The centerline of the core wire is substantially straight along the straight proximal portion, and, the centerline is helically curved along the helically curved segment. The disclosure similarly provides a catheter having the aforementioned attributes. 1. A guidewire , comprising a core wire having a proximal end , and a distal end and being defined by an outer surface between the proximal end and the distal end of the core wire , said core wire having a centerline that traverses the length of the core wire from the proximal end to the distal end of the core wire , said centerline being located approximately at the center of mass along said core wire within said outer surface of said core wire , said core wire having a substantially straight proximal portion and a helically curved segment located distally with respect to said proximal portion , wherein:the centerline of the core wire is substantially straight along said straight proximal portion;said centerline is helically curved along said helically curved segment;a distal end region of the guidewire is helically shaped; andthe distal end region has a lower durometer than a proximal portion of the guidewire to permit the helically ...

Devices and methods for closure of transvascular or transcameral access ports

The present disclosure provides a variety of prostheses, delivery systems and techniques to facilitate closure of transvascular or transcameral access ports. Various embodiments of prostheses are provided including a plurality of radially expandable discs that can be filled with material to facilitate coagulation and to reduce or stop leakage from punctures in vessel walls.

ELECTROMAGNETIC RESONANT CIRCUIT SLEEVE FOR IMPLANTABLE MEDICAL DEVICE

A medical device enables effective magnetic resonance imaging inside a lumen of a medical device. The medical device includes a plurality of conductive traces formed on a substrate. The conductive traces form an inductive-capacitance circuit or a resistive-inductive-capacitance circuit. The inductive-capacitance circuit or resistive-inductive-capacitance circuit is tuned to a frequency associated with magnetic resonance imaging, an operating frequency associated with a magnetic resonance imaging scanner, a harmonic of an operating frequency associated with a magnetic resonance imaging scanner, or a sub-harmonic of an operating frequency associated with a magnetic resonance imaging scanner.

Process and apparatus for treating biological organisms

An apparatus for treating a biological organism comprising a device for emitting and delivering energy to the biological organism, a programmable controller for varying the type and amount of energy emitted, and apparatus for sensing a condition of the biological organism.

Magnetic resonance imaging interference immune device

A voltage compensation unit reduces the effects of induced voltages upon a device having a single wire line. The single wire line has balanced characteristic impedance. The voltage compensation unit includes a tunable compensation circuit connected to the wire line. The tunable compensation circuit applies supplemental impedance to the wire line. The supplemental impedance causes the characteristic impedance of the wire line to become unbalanced, thereby reducing the effects of induced voltages caused by changing magnetic fields.

CATHETER AND ACTUATOR SYSTEMS AND METHODS

The disclosure provides various embodiments of systems to facilitate the cutting of tissue structures and other tissue structures percutaneously.

PROCESS AND APPARATUS FOR TREATING BIOLOGICAL ORGANISMS

Disclosed in this specification is an apparatus and method for treating a biological organism comprising a device for emitting and delivering energy to the biological organism, a programmable controller for varying the type and amount of energy emitted, and apparatus for sensing a condition of the biological organism. 1. A process for treating a biological organism , said process comprising the steps of:measuring a first electromagnetic energy signal characteristic of a biological sample while experiencing the effect of a therapeutic agent;measuring a second electromagnetic energy signal characteristic of the biological sample while not experiencing the effect of the therapeutic agent, wherein the first and second electromagnetic energy signals are different;comparing the first and second electromagnetic energy signals and, based on this comparison, determining a third electromagnetic energy signal that, when superimposed on the second electromagnetic energy signal, results in a fourth electromagnetic energy signal that is substantially identical to the first electromagnetic energy signal; anddelivering the third electromagnetic energy signal to a biological organism which corresponds to the biological sample while the biological organism is not experiencing the effect of the therapeutic agent.2. The method as recited in claim 1 , wherein the step of measuring the first electromagnetic energy signal includes the step of subjecting the biological sample to an electromagnetic excitation field claim 1 , wherein the first electromagnetic energy signal is produced in response to the electromagnetic excitation field.3. The method as recited in claim 2 , wherein the step of measuring the second electromagnetic energy signal includes the step of subjecting the biological sample to the electromagnetic excitation field claim 2 , wherein the second electromagnetic energy signal is produced in response to the electromagnetic excitation field.4. The method as recited in claim 1 ...

Run-To-Completion Thread Model for Software Bypass Fail Open for an Inline Intrusion Protection System

A processing-based bypass “fail open” mode is provided for an intrusion prevention system by a primary process running on a first logical core (lcore) is used as a control plane, which invokes bypass-open run-to-completion threads in other lcores comprising a bypass data plane, and which spawns a secondary process to fully configure intrusion prevention threads on other lcores to create an Intrusion Prevention System data plane. Upon a ready signal from the secondary process, the primary process quiesces such that the secondary process IPS data plane exclusively owns and executes on the other lcores. 1. A method of providing a bypass fail open mode for an inline intrusion prevention system comprising the steps of: configuring one or more logical core pools, two or more network ports, and a bypass option;', 'starting one or more bypass threads on at least one logical core separate from the first single logical core, wherein the bypass threads provide a fail-open communications processing between the network ports; and', 'spawning a secondary process;, 'executing by one or more processors a primary process utilizing a first single logical core as a control plane, the primary process;'} opening an interprocess communication channel by a secondary process control plane with the primary control plane;', 'initializing and invoking by the secondary process one or more intrusion prevention threads comprising an intrusion prevention system data plane, wherein the one or more intrusion prevention threads are executed by one or more logical cores separate from the first logical core to process frames between the network ports; and', 'notifying the primary process by the secondary process via the interprocess communication channel of readiness of the intrusion detection threads; and, 'while the primary process owns and performs frame processing using one or more bypass data plane threadsresponsive to receiving the notification, the primary process relinquishing ownership of the ...

TISSUE EXCISION, CUTTING, AND REMOVAL SYSTEMS AND METHODS

The disclosure provides various embodiments of catheters having articulable ends that can be used for various procedures. Embodiments of methods are also provided that can be performed with catheters in accordance with the present disclosure. 1. A catheter including a distal end , the distal end including:a collapsible basket mounted thereon; anda deployable snare, wherein a user can use the basket to at least partially surround an object attached to a tissue mass, collapse the basket around the object, and then sever the tissue mass by cutting through the tissue mass with the snare.2. A method of using the catheter of to remove a mitral clip device from a native mitral leaflet.3. The catheter of claim 1 , wherein the cutting step is accomplished at least in part by withdrawing the snare back into the catheter.4. A catheter including an outer tubular member with at least one sharpened distal protrusion claim 1 , and an inner rod including a tissue grasper claim 1 , wherein the tissue grasper can be advanced distally out of a distal end of the tubular member to grasp tissue claim 1 , and further wherein the at least one sharpened distal tip can be used to cut through tissue by rotating the outer tubular member about a central axis of the outer tubular member.5. A method of using any device herein to remove a mitral clip claim 1 , a cyst claim 1 , or other tissue structure.6. The catheter of claim 1 , wherein the collapsible basket can be moved distally with respect to a second portion of the catheter to permit the collapsible basket to be maneuvered around the object.7. The catheter of claim 4 , wherein the outer tubular member includes a laser cut hypotube. The present patent application is a continuation of and claims the benefit of priority to U.S. patent application Ser. No. 17/086,431, filed Nov. 1, 2020, which in turn is a continuation of and claims the benefit of priority to International Application No. PCT/US2020/55160, filed Oct. 9, 2020, which in turn ...

TISSUE EXCISION, CUTTING, AND REMOVAL SYSTEMS AND METHODS

The disclosure provides various embodiments of catheters having articulable ends that can be used for various procedures. Embodiments of methods are also provided that can be performed with catheters in accordance with the present disclosure. 1. A catheter including a distal end , the distal end including:a collapsible basket mounted thereon; anda deployable snare, wherein a user can use the basket to at least partially surround an object attached to a tissue mass, collapse the basket around the object, and then sever the tissue mass by cutting through the tissue mass with the snare.2. A method of using the catheter of to remove a mitral clip device from a native mitral leaflet.3. The catheter of claim 1 , wherein the cutting step is accomplished at least in part by withdrawing the snare back into the catheter.4. A catheter including an outer tubular member with at least one sharpened distal protrusion claim 1 , and an inner rod including a tissue grasper claim 1 , wherein the tissue grasper can be advanced distally out of a distal end of the tubular member to grasp tissue claim 1 , and further wherein the at least one sharpened distal tip can be used to cut through tissue by rotating the outer tubular member about a central axis of the outer tubular member.5. A method of using any device herein to remove a mitral clip claim 1 , a cyst claim 1 , or other tissue structure.6. The catheter of claim 1 , wherein the collapsible basket can be moved distally with respect to a second portion of the catheter to permit the collapsible basket to be maneuvered around the object.7. The catheter of claim 4 , wherein the outer tubular member includes a laser cut hypotube. The present patent application is a continuation of and claims the benefit of priority to U.S. patent application Ser. No. 17/086,431, filed Nov. 1, 2020, which in turn is a continuation of and claims the benefit of priority to International Application No. PCT/US2020/55160, filed Oct. 9, 2020, which in turn ...

CARDIAC ANNULOPLASTY PROCEDURES, RELATED DEVICES AND METHODS

Devices and methods are disclosed for the treatment or repair of regurgitant cardiac valves, such as a mitral valve and/or tricuspid valve. An illustrative annuloplasty device can be placed in the coronary sinus to reshape the mitral valve and reduce mitral valve regurgitation as well as tricuspid regurgitation. The disclosure also provides improved techniques for cardiac pacing. 1. An implant , comprising:a) a tether formed into a loop shape;b) a lock slid over the tether and engaged with the tether to maintain tension in the tether; andc) a spacer coupled to the lock and extending from the implant, the spacer being configured to be disposed between leaflets of a cardiac valve to permit leaflets of the cardiac valve to coapt against the spacer.2. The implant of claim 1 , wherein the tether includes an elongate inner tether and an outer sheath material claim 1 , wherein the tether includes radiopaque material along its length.3. The implant of claim 2 , wherein the radiopaque material within the elongate inner tether includes a radiopaque wire disposed within a length of heat shrunk polymeric tube that resides within a hollow core of the elongate inner tether.4. The implant of claim 1 , wherein the spacer includes an inflatable member or self-expanding volume that expands to a predetermined size to occupy a portion of a patient's native tricuspid valve annulus.5. The implant of claim 1 , wherein the spacer includes a plurality of self-expanding filaments having first and second ends at proximal and distal hubs that expand radially outwardly from a compressed configuration to occupy a volume in the right ventricular outflow tract.6. The implant of claim 1 , wherein the spacer includes an elongate inflatable member configured to occupy a portion of a patient's RVOT in the region of the patient's tricuspid valve.7. The implant of claim 6 , wherein the inflatable member includes a core member coupled to first and second ends of the inflatable member.8. The implant of ...

MEDICAL ASSEMBLIES AND METHODS FOR IMPLANTATION OF MULTIPLE MEDICAL LEADS THROUGH A SINGLE ENTRY

Assemblies and methods provide for implantation of multiple medical leads to a defined space within the body, such as the epidural space, through a single entry. A catheter having multiple lumens or alternatively a single oblong lumen may be used. A distal end of the catheter enters the defined space through the single entry such that the distal ends of the multiple lumens or the oblong lumen are present in the defined space. Medical leads are introduced through the multiple lumens or the oblong lumen into the defined space. In some cases, the distal end of the catheter may be deflectable to direct the medical leads within the defined space. In other cases, sheaths may be present within each lumen of the catheter where the sheaths may be extended into the defined space and deflect to direct the medical leads that are being passed through a lumen of the sheaths. 1. A medical assembly comprising:a catheter having a lumen with an oblong lateral cross-section and having a distal end with a pre-formed bend; andan introducer present within the lumen of the catheter, the introducer being positioned within the lumen at the distal end of the catheter such that the pre-formed bend is held straight.2. The medical assembly of claim 1 , wherein a guidewire is present within the lumen of the catheter.3. The medical assembly of claim 2 , wherein the introducer comprises an introducer lumen and wherein the guidewire is also present within the introducer lumen while being present within the lumen of the catheter.4. The medical assembly of claim 1 , wherein the introducer has an oblong lateral cross-section.5. The medical assembly of claim 1 , wherein the catheter comprises a shape memory material.6. The medical assembly of claim 1 , wherein the introducer comprises a conical tip.7. The medical assembly of claim 6 , wherein the conical tip extends beyond the lumen of the catheter.8. The medical assembly of claim 1 , wherein the pre-formed bend of the catheter is achieved once the ...

FLUID COMPRISING METHANE AND A TRACER, AND PROCESSES FOR PRODUCING IT AND THE USE THEREOF

The present invention relates to a liquid comprising methane and a tracer, and to a slush of liquid and solids comprising methane and a tracer. The invention especially relates to LNG comprising a tracer. The LNG may comprise, in addition to the tracer, an odorant and a carrier for the odorant. The odorant is ethyl acrylate and/or ethyl mercaptan. The carrier for the odorant is propane, n-butane, iso-butane, or a mixture of two or more thereof. The present invention also relates to a process for preparing such a liquid or slush by liquefying a gas comprising methane and a tracer. The invention also relates to a process in which a tracer is added to a methane comprising liquid or slush. 3. A labelled methane comprising fluid according to claim 2 , whereby the labelled methane comprising fluid comprises 2 to 10 ppm odorant claim 2 , calculated on the total mass of the labelled methane comprising fluid.4. The labelled methane comprising fluid according to claim 2 , whereby the labelled methane comprising fluid comprises 4 to 6 ppm odorant claim 2 , calculated on the total mass of the labelled methane comprising fluid.5. A The labelled methane comprising fluid according to claim 2 , whereby the carrier is iso-butane.6. The labelled methane comprising fluid according to claim 2 , whereby the odorant is ethyl acrylate or a mixture of ethyl acrylate and ethyl mercaptan.7. A process for preparing a labelled methane comprising fluid comprising in a range of from 1 to 250 ppm claim 2 , the process comprising the following step:a) adding methyl acetate to a methane comprising liquid, or a methane comprising slush of liquid and solids.8. The process according to claim 7 , comprising the following step:a) adding methyl acetate, and in a range of from 1 to 100 ppm of an odorant, and in a range of from 0.1 to 10 m/m % of a carrier to a methane comprising liquid, or a methane comprising slush of liquid and solids,whereby the odorant and carrier are added separately and/or mixed, ...

Deflectable delivery system for implant delivery

An example catheter includes an elongate member having a wall defining a longitudinally extending lumen, a fixation member disposed on an exterior surface of the wall of a distal portion of the elongate member, a pull wire extending axially through the wall of the elongate member and coupled to the fixation member, and a member portion encasing at least a portion of the fixation member, where the fixation member is shaped to engage the distal member in response to a pull force applied to the pull wire to cause the elongate member to deflect from an initial configuration to a deflected configuration.

DEVICES AND METHODS FOR EFFECTUATING PERCUTANEOUS GLENN AND FONTAN PROCEDURES

In some implementations, a radially self-expanding endograft prosthesis is provided that includes (i) distal flange that is self-expanding and configured to flip generally perpendicularly with respect to a body of the prosthesis to help seat the prosthesis against a tissue wall, (ii) a distal segment extending proximally from the distal flange that has sufficient stiffness to maintain a puncture open that is formed through a vessel wall (iii) a compliant middle segment extending proximally from the distal segment, the middle segment being more compliant than the distal segment, and having independently movable undulating strut rings attached to a tubular fabric, the combined structure providing flexibility and compliance to allow for full patency while flexed, the segment being configured to accommodate up to a 90 degree bend, (iv) a proximal segment having a plurality of adjacent undulating strut rings that are connected to each other. 1. A radially self-expanding endograft prosthesis comprising:a distal flange that is self-expanding and configured to flip generally perpendicularly with respect to a body of the prosthesis to help seat the prosthesis against a tissue wall;a distal segment extending proximally from the distal flange that has sufficient stiffness to maintain a puncture open that is formed through a vessel wall;a compliant middle segment extending proximally from the distal segment, the middle segment being more compliant than the distal segment, and having independently movable undulating strut rings attached to a tubular fabric, the combined structure providing flexibility and compliance to allow for full patency while flexed, the segment being configured to accommodate up to a 90 degree bend;a proximal segment having a plurality of adjacent undulating strut rings that are connected to each other, the proximal segment being sufficiently stiff to seat within and urge against a vessel wall; anda proximal end including a plurality of openings around the ...

AGGREGATION AND GENERATION OF CONFIDENTIAL DATA INSIGHTS WITH CONFIDENCE VALUES

In an example, a plurality of previously submitted confidential data values of a first confidential data type retrieved for a slice having one or more attributes. For a confidential data type, one or more submitted confidential data values of the confidential data type from the slice that are considered outliers based on an external data set or internal data set. A confidence score is calculated by multiplying a support score for the confidential data type in the slice by a non-outlier score for the confidential data type in the slice, the support score being equal to n′/(n′+c), where c is a smoothing constant and n′ is the number of non-excluded submitted confidential data values of the confidential data type in the slice and the non-outlier score being equal to n′/n, where n is the total number of non-null submitted confidential data value of the confidential data type in the slice. 1. A system comprising:a computer-readable medium having instructions stored there on, which, when executed by a processor, cause the system to:retrieve a plurality of previously submitted confidential data values of a first confidential data type for a slice having one or more attributes; exclude one or more submitted confidential data values of the confidential data type from the slice that are considered outliers based on an external data set;', 'exclude one or more submitted confidential data values of the confidential data type from the slice that are considered outliers based on an internal data set;', 'calculate a confidence score for the confidential data type in the slice by multiplying a support score for the confidential data type in the slice by a non-outlier score for the confidential data type in the slice, the support score being equal to n′/(n′+c), where c is a smoothing constant and n′ is the number of non-excluded submitted confidential data values of the confidential data type in the slice and the non-outlier score being equal to n′/n, where n is the total number of ...

EXTERNAL DATASET-BASED OUTLIER DETECTION FOR CONFIDENTIAL DATA IN A COMPUTER SYSTEM

In an example, a plurality of segments of percentile information indicating submitted confidential data values from users matching at least one attribute of a submitting user are retrieved. Then, for each of the segments, an interquartile range is calculated for a first and a second of a plurality of percentiles in the segment, an initial lower limit is computed for the segment by taking a maximum of zero or the difference between the value for the first of the plurality of percentiles and a product of a preset alpha parameter and the interquartile range, and interpolation is performed on values for the plurality of percentiles for the segment to obtain values for a third percentile. The initial lower limits and the interpolated values for the third percentiles are aggregated across the segments. A merged lower limit is determined by applying a function to the aggregated initial lower limits and aggregated interpolated values. 1. A system comprising:a computer-readable medium having instructions stored thereon, which, when executed by a processor, cause the system to:receive, via a first computerized user interface, a submission of a confidential data value of a first confidential data type from a first user;identify one or more attributes of the first user;retrieve, from an external data source, a plurality of segments of percentile information indicating values for confidential data of the first confidential data type for a plurality of users matching the one or more attributes of the first user, each of the plurality of segments including values, for a different combination of attributes of the plurality of users, for data of the first confidential data type for each of a plurality of percentiles; calculate an interquartile range for a first and a second of the plurality of percentiles in the segment, wherein a value for the first of the plurality of percentiles is lower than a value for the second of the plurality of percentiles;', 'compute an initial lower ...

INTERNAL DATASET-BASED OUTLIER DETECTION FOR CONFIDENTIAL DATA IN A COMPUTER SYSTEM

In an example, a submission of a confidential data value of a first confidential data type is received from a first user with one or more attributes. A plurality of previously submitted confidential data values of a first confidential data type for a cohort matching the one or more attributes of the first user are retrieved. A plurality of percentiles for the confidential data values are calculated. Then, an interquartile range is calculated for a first and a second of the plurality of percentiles. A lower limit for the first confidential data type and the cohort is computed by taking a maximum of zero or the difference between the value for the first of the plurality of percentiles and a product of a preset alpha parameter and the interquartile range. Then it is determined if the confidential data value submitted by the user is lower than the lower limit. 1. A system comprising:a computer-readable medium having instructions stored there on, which, when executed by a processor, cause the system to:receive, via a first computerized user interface, a submission of a confidential data value of a first confidential data type from a first user;identify one or more attributes of the first user;retrieve a plurality of previously submitted confidential data values of a first confidential data type for a cohort matching the one or more attributes of the first user;calculate a plurality of percentiles for the plurality of previously submitted confidential data values;calculate an interquartile range for a first and a second of the plurality of percentiles, wherein the value for the first of the plurality of percentiles is lower than the value for the second of the plurality of percentiles;compute a lower limit for the first confidential data type and the cohort by taking a maximum of zero or the difference between the value for the first of the plurality of percentiles and a product of a preset alpha parameter and the interquartile range;determine whether the confidential ...

OUTLIER DETECTION BASED ON DISTRIBUTION FITNESS

In an example, a submission of a confidential data value of a first confidential data type is received from a first user with one or more attributes. A plurality of previously submitted confidential data values of a first confidential data type for a cohort matching the one or more attributes of the first user are retrieved. Then, one or more intermediate cohorts are derived by generalizing each of the one or more attributes of the cohort up at least one level in a different taxonomy corresponding to each of the one or more attributes. One or more of the intermediate cohorts are selected, and a parameterized distribution is fitted to the previously submitted confidential data values that are contained within the selected one or more of the intermediate cohorts, outputting one or more estimated parameters for each of the selected one or more of the intermediate cohorts. A lower limit for the first confidential data type is then set based on the one or more estimated parameters. 1. A system comprising:a computer-readable medium having instructions stored there on, which, when executed by a processor, cause the system to:receive, via a first computerized user interface, a submission of a confidential data value of a first confidential data type from a first user;identify one or more attributes of the first user;retrieve a plurality of previously submitted confidential data values of a first confidential data type for a cohort matching the one or more attributes of the first user;derive one or more intermediate cohorts by generalizing each of the one or more attributes of the cohort up at least one level in a different taxonomy corresponding to each of the one or more attributes;select one or more of the intermediate cohorts;fit a parameterized distribution to the previously submitted confidential data values that are contained within the selected one or more of the intermediate cohorts, outputting one or more estimated parameters for each of the selected one or more of ...

TISSUE EXCISION, CUTTING, AND REMOVAL SYSTEMS AND METHODS

The disclosure provides various embodiments of catheters having articulable ends that can be used for various procedures. Embodiments of methods are also provided that can be performed with catheters in accordance with the present disclosure. 1. A catheter comprising:an elongate member having a collapsible basket mounted thereon having an open distal facing end, the distal facing end being selectively collapsible by applying tension to an actuator; anda deployable cutting snare loop, wherein a user can use the basket to at least partially surround an object attached to a tissue mass, collapse the basket around the object by applying tension to the actuator, and then sever the tissue mass by cutting through the tissue mass with the deployable cutting snare loop.2. The catheter of claim 1 , wherein the cutting step is accomplished at least in part by withdrawing the cutting snare loop into an elongate tubular member claim 1 , wherein the elongate tubular member has a distal end proximate the distal end of the collapsible basket.3. The catheter of claim 1 , wherein the collapsible basket can be moved distally with respect to the cutting snare loop to permit the collapsible basket to be maneuvered around the object.4. The catheter of claim 1 , wherein the elongate member slides along the outside of a tubular member that houses the cutting snare.5. The catheter of claim 1 , wherein the collapsible basket is formed from a laser cut hypotube formed into a stent-like pattern defined by zig-zag rows of struts.6. The catheter of claim 5 , further comprising a cinching tether woven through fenestrations defined about the open distal facing end of the collapsible basket claim 5 , wherein application of tension to the cinching tether causes the collapsible basket to collapse.7. The catheter of claim 1 , wherein a proximal end of the collapsible basket is fastened to the elongate member by a radiopaque marker band and the elongate member further includes a second radiopaque ...

PERCUTANEOUS POTTS SHUNT DEVICES AND RELATED METHODS

The disclosure provides various embodiments of prostheses and delivery systems to permit an interventional cardiologist to create shunts between various blood vessels. Moreover, the disclosed shunts can be used to shunt between various hollow organs, as set forth in the present disclosure. 1. A method of delivering a tubular prosthesis in a Potts procedure , comprising:providing a prosthesis on a percutaneous delivery catheter including:an elongate compliant tubular body having a proximal end and a distal end;a distal sealing flange coupled to the distal end of the elongate compliant tubular body, the distal sealing flange being configured and arranged to facilitate seating the tubular prosthesis against a first concave vessel wall of a first vessel, wherein the tubular prosthesis is configured to extend outwardly through a first ostium formed in the first concave vessel wall when deployed, wherein the distal sealing flange remains inside the ostium after deployment;a proximal sealing flange coupled to the proximal end of the elongate compliant tubular body, the proximal sealing flange being configured and arranged to facilitate seating the tubular prosthesis against a second concave vessel wall of a second vessel, wherein the tubular prosthesis is configured to extend outwardly through a second ostium formed in the second concave vessel wall when deployed, wherein the distal sealing flange remains inside the second ostium after deployment;introducing the prosthesis on the percutaneous delivery catheter into a patient's vasculature;forming an ostium into a wall of the patient's left pulmonary artery and an ostium into a wall of the patient's descending aorta;deploying a first of the proximal sealing flange and distal sealing flange into the ostium formed into the wall of the left pulmonary artery; anddeploying the other of the proximal sealing flange and distal sealing flange into the ostium formed into the wall of the patient's descending aorta.2. The method of ...

RESONANCE TUNING MODULE FOR IMPLANTABLE DEVICES AND LEADS

An implantable medical assist device includes a medical device. The medical device has a housing and electronics contained therein. A lead provides an electrical path to or from the electronics within the medical device. A resonance tuning module is located in the housing and is connected to the lead. The resonance tuning module includes a control circuit for determining a resonant frequency of the implantable medical assist device and an adjustable impedance circuit to change the combined resonant frequency of the medical device and lead. 127-. (canceled)28. A resonance tuning module comprising:a first interface to provide an electrical connection with an implantable medical device having electronics therein;a second interface to provide an electrical connection with an implantable lead;a control and adjustment subsystem configured to determine a combined resonant frequency of the medical device and the lead after implantation; andan adjustable impedance circuit comprising at least one of an adjustable inductive element or an adjustable capacitive element, wherein, based on the combined resonant frequency of the medical device and the lead determined after implantation, the control and adjustment subsystem adjusts at least one of the adjustable inductive element or the adjustable capacitive element to adjust an impedance of the adjustable impedance circuit to change the combined resonant frequency of the medical device and the lead after implantation.29. (canceled)30. The resonance tuning module as claimed in claim 28 , wherein the control and adjustment subsystem operatively controls the impedance of the adjustable impedance circuit to change the combined resonant frequency of the medical device and the lead to be substantially equal to a desired resonant frequency.31. The resonance tuning module as claimed in claim 28 , wherein the control and adjustment subsystem operatively controls the impedance of the adjustable impedance circuit to change the combined ...

RESONANCE TUNING MODULE FOR IMPLANTABLE DEVICES AND LEADS

An implantable medical assist device includes a medical device. The medical device has a housing and electronics contained therein. A lead provides an electrical path to or from the electronics within the medical device. A resonance tuning module is located in the housing and is connected to the lead. The resonance tuning module includes a control circuit for determining a resonant frequency of the implantable medical assist device and an adjustable impedance circuit to change the combined resonant frequency of the medical device and lead. 140-. (canceled)41. An implantable medical assist device system , comprising:a first medical device; a housing,', 'electronics contained within the housing, and', 'a first medical device interface to provide an electrical path to or from the electronics within the housing;, 'the first medical device including,'}a second medical device including a second medical device interface to provide an electrical path to or from the second medical device; anda removable resonance module, operatively connected between the first medical device interface and the second medical device;the removable resonance module providing an impedance such that a combined resonant frequency of the first medical device, the second medical device and the removable resonance module is substantially equal to a predetermined resonant frequency.42. The implantable medical system as claimed in claim 41 , wherein the predetermined resonant frequency is substantially equal to a radio-frequency of a magnetic resonance imaging scanner.43. The implantable medical system as claimed in claim 41 , wherein the predetermined resonant frequency is substantially equal to 64 MHz.44. The implantable medical system as claimed in claim 41 , wherein the predetermined resonant frequency is substantially equal to 128 MHz.45. The implantable medical system as claimed in claim 41 , wherein the predetermined resonant frequency is slightly detuned from a radio-frequency of a magnetic ...

STEERABLE CATHETER HAVING PULL WIRES AFFIXED WITHIN THE DISTAL PORTION OF THE CATHETER

A method and system with enhanced steerability and simplicity of construction for medical devices and a method of manufacturing the same. A steerable medical device may include an elongate body having a distal portion, proximal portion, and central lumen extending therethrough, a distal tip coupled to the distal portion of the elongate body, and at least one pull wire, each of the at least one pull wire having a distal end coupled to the distal tip, the distal portion of the elongate body including at least one pull wire lumen extending proximally from the distal tip through the distal portion of the elongate body, each of the at least one pull wire being within a corresponding pull wire lumen of the at least one pull wire lumen in the distal portion of the elongate body and within the central lumen in the proximal portion of the elongate body. 1. A steerable medical device , comprising:an elongate body having a distal portion, a proximal portion, and a central lumen extending therethrough;a distal tip coupled to the distal portion of the elongate body; andat least one pull wire, each of the at least one pull wire having a distal end coupled to the distal tip;the distal portion of the elongate body including at least one pull wire lumen extending proximally from the distal tip through the distal portion of the elongate body, each of the at least one pull wire being within a corresponding pull wire lumen of the at least one pull wire lumen in the distal portion of the elongate body and within the central lumen in the proximal portion of the elongate body.2. The steerable medical device of claim 1 , wherein the elongate body includes a first layer of material claim 1 , the central lumen and at least one pull wire lumen being defined by the first layer of material.3. The steerable medical device of claim 2 , wherein the elongate body further includes a second layer of material that at least substantially surrounds the first layer of material claim 2 , the second layer ...

LINKING EXTERNAL PROFESSION DATA TO SOCIAL NETWORK

Generally discussed herein are methods, systems, and apparatuses for harmonizing information from different taxonomies and providing career information based on the harmonized information. A method can include receiving a request for the career information, the request including one or more job titles and one or more job locations associated with the job titles, mapping the one or more job titles to one or more profession titles, mapping the one or more job locations to one or more profession locations, executing a query for statistics associated with the career information, the query including the one or more profession titles and the one or more profession locations to which the one or more job titles and the one or more job locations respectively map, and providing the career information based on the statistics returned from executing the query. 1. A non-transitory machine-readable medium comprising instructions stored thereon which , when executed by a machine , cause the machine to perform operations for providing career information , the operations comprising:receiving a request for the career information, the request including one or more job titles and one or more job locations associated with the job titles, the one or more job titles determined in accord with a first title taxonomy used by entries in a first database and the one or more job locations determined in accord with a first location taxonomy used by entries in the first database;mapping the one or more job titles to one or more profession titles, the one or more profession titles determined in accord with a second, different title taxonomy used by entries in a second database;mapping the one or more job locations to one or more profession locations, the one or more profession locations determined in accord with a second, different location taxonomy used by entries in the second database;executing a query for statistics associated with the career information, the query including the one or more ...

ODORIZED METHANE FLUID AND PROCESSES FOR PRODUCING ODORIZED METHANE FLUIDS AND THE USE THEREOF

The present invention relates to an odorized methane comprising liquid, and to an odorized methane comprising slush of liquid and solids. The invention especially relates to odorized LNG. The odorant is ethyl acrylate and/or ethyl mercaptan. The carrier for the odorant is propane, n-butane, iso-butane, or a mixture of two or more thereof. The present invention also relates to a process for preparing such an odorized liquid or slush by liquefying odorized methane comprising gas. The invention also relates to a process in which odorant is added to a methane comprising liquid or slush. 2. The odorized methane comprising fluid according to claim 1 , whereby the odorized methane comprising fluid comprises 2 to 10 ppm odorant claim 1 , calculated on the total mass of the odorized methane comprising fluid.3. The odorized methane comprising fluid according to claim 2 , whereby the odorized methane comprising fluid comprises 4 to 6 ppm odorant claim 2 , calculated on the total mass of the odorized methane comprising fluid.4. The odorized methane comprising fluid according to claim 1 , whereby the carrier is iso-butane.5. The odorized methane comprising fluid according to claim 1 , whereby the odorant is ethyl acrylate or a mixture of ethyl acrylate and ethyl mercaptan.6. The odorized methane comprising fluid according to claim 1 , whereby the odorized methane comprising fluid additionally comprises in a range of from 1 to 250 ppm claim 1 , calculated on the total mass of the odorized methane comprising fluid.8. A The process according to claim 7 , comprising the following steps:a1) adding odorant to carrier anda2) adding at least a part of the mixture obtained in step a1) to a methane comprising liquid, or a methane comprising slush of liquid and solids.9. The process according to claim 7 , wherein in a range of from 1 to 250 ppm methyl acetate is added separately and/or mixed with odorant and/or carrier to a methane comprising liquid claim 7 , or a methane comprising slush ...

DEVICES AND METHODS FOR CLOSURE OF TRANSVASCULAR OR TRANSCAMERAL ACCESS PORTS

The present disclosure provides a variety of prostheses, delivery systems and techniques to facilitate closure of transvascular or transcameral access ports. Various embodiments of prostheses are provided including a plurality of radially expandable discs that can be filled with material to facilitate coagulation and to reduce or stop leakage from punctures in vessel walls. 1. An implantable prosthesis comprising:a) an inflatable bioresorbable body having a proximal end and a distal end, the body being configured to be expanded radially by directing fluid into the body; andb) at least one radially expandable strut attached to each of the proximal end and distal end of the body, each of the struts being configured to expand outwardly to prevent the prosthesis from being pulled through an anatomical opening into which it has been inserted.2. The prosthesis of claim 1 , further comprising a coupling located at the proximal end of the prosthesis configured to be attached to a delivery system.3. The prosthesis of claim 1 , wherein the coupling is configured to permit inflation fluid to pass therethrough.4. The prosthesis of claim 1 , wherein the prosthesis defines a guidewire lumen therethrough.5. The prosthesis of claim 4 , wherein the guidewire lumen defined in the prosthesis is configured to register with a guidewire lumen in the delivery system.6. The prosthesis of claim 5 , wherein the struts extend from a radially central portion of the prosthesis to a radially outer periphery of the prosthesis.7. A method claim 5 , comprising:a) providing a delivery system having a prosthesis removably attached to a distal end thereof;b) delivering the delivery system over a guidewire routed to a target location within a patient's vasculature;c) deploying the prosthesis at the target location to obstruct a vascular opening to be sealed;d) detaching the prosthesis from the delivery system;e) withdrawing the delivery system over the guidewire after the prosthesis has been detached ...

PREPARATION OF TERTIARY ALCOHOLS, RESOLUTION OF TERTIARY ALCOHOLS AND STEREOSELECTIVE DEUTERATION OR TRITIATION BY RETROALDOLASES

The present invention is directed to methods for catalyzing a chemical reaction by retroaldolases, corresponding uses of retroaldolases and to novel retroaldolases. The methods and retroaldolases have utility in (i) preparing tertiary alcohols, in (ii) chiral resolution of tertiary alcohols by retroaldol cleavage, and in (iii) deuteration or tritiation of carbonyl compounds. 115-. (canceled)16. A method for catalyzing a chemical reaction selected from the group consisting of:(i) preparing tertiary alcohols, optionally chiral tertiary alcohols, by an aldol reaction;(ii) chiral resolution of tertiary alcohols by retroaldol cleavage; and(iii) deuteration or tritiation of carbonyl compounds,comprising the steps of: (aa) a retroaldolase comprising an amino acid sequence selected from the group consisting of SEQ ID NOs: 3 to 28;', '(ab) a retroaldolase comprising an amino acid sequence having an amino acid sequence identity of at least 70% or 80%with an amino acid sequence selected from the group consisting of SEQ ID NOs: 3 to 28;', '(ac) a retroaldolase comprising a functional derivative and/or functional fragment of (aa) and/or (ab); and', '(ad) a retroaldolase according to any of (aa) to (ac), wherein in SEQ ID NOs: 3 to 28, position 50 is tyrosine, position 82 is lysine and position 109 is asparagine and/or position 179 is tyrosine or phenylalanine,', 'for catalyzing the chemical reaction (i), (ii) or (iii),, '(a) providing a retroaldolase selected from the group consisting of (ba) (baa) an aldehyde-comprising substrate and a ketone-comprising substrate, or (bab) two ketone-comprising substrates, which substrates react in the aldol reaction (i) to form a tertiary alcohol;', '(bb) tertiary alcohols for chiral resolution by retroaldol cleavage (ii); and', '(bc) carbonyl compounds, for deuteration or tritiation (iii);, '(b) providing at least one substrate for the chemical reaction (i), (ii) or (iii) selected from the group consisting of'}(c) contacting the retroaldolase ...

Biothermal power source for implantable devices

An implantable, rechargeable assembly that contains an implantable device within a living organism; an electrical storage device is connected to the implantable device, and a thermoelectric charging assembly is connected to said electrical storage device. A thermoelectric charging assembly contains devices for transferring thermal energy between the living organism and a thermoelectric module, for creating an electrical current of a first polarity from thermal energy, for creating an electrical current with a second polarity from thermal energy, for charging the electrical storage device with the electrical current of said first polarity, and for charging the electrical storage device with the electrical current of the second polarity.

Biothermal power source for implatable devices

An implantable, rechargeable assembly comprised of an implantable device (10) disposed within a living organism, an electrical storage device (20) connected to the implantable device, and a thermoelectric charging assembly (41, 45, 30) operatively connected to the electrical storage device. The thermoelectric charging assembly has devices for transferring thermal energy between the living organism and a thermoelectric module, for generating an electrical current from the thermal energy, for charging the electrical storage device with the electrical current, for determining the extent to which the electrical storage device is being charged with the electrical current, and for generating a signal whenever the extent to which the electrical storage device is being charged with the electrical current falls below a specified value.

sent structure and valve prosthesis.

Prosthetic implants having enhanced utility

A prosthetic implant system connected to the tissue of a living organism. The system contains a first device for measuring the mechanical strain in the implant in an area thereof which is not exposed to tissue regrowth, a second device for measuring the mechanical strain in the implant in an area thereof which is exposed to tissue regrowth, a device for continuously determining the stress/strain relationship of said implant, and a device for treating said tissue.

反応容器

(57)【要約】 【課題】 均質系ＰＣＲを複数の容器で一度に全部実施 可能な反応容器を提供すること。 【解決手段】 反応容器は隣接する複数のチャンバーを 含んで成る。各チャンバーは前壁、後壁、二枚の側壁及 び底壁を含み、該前壁及び該後壁はそれらの最上縁部で 終了し上部開口部を成している。各チャンバーの側壁 は、複数のチャンバーを並べて一体連接するように、隣 接するチャンバーと共通の側壁を含む。各チャンバーの 前壁は液体添加口を含み、その上方の該上部開口部の内 側には、該最上縁部の下方へ移動した時に各チャンバー の添加口を塞ぎ且つ各チャンバーに栓をするように形造 られた弾性プラグが搭載されている。該プラグは、該最 上縁部の下方へ移動した時にすべてのチャンバーについ て同時にその添加口を閉鎖するように、該反応容器内の すべてのチャンバーに差し渡されている。

Magnetically shielded assembly

A sheath assembly with a magnetic shielding factor of at least about 0.9 that contains a sheath. The sheath includes nanomagnetic material, The nanomagnetic material has a mass density of at least about 0.01 grams per cubic centimeter, a saturation magnetization of from about 1 to about 36,000 Gauss, a coercive force of from about 0.01 to about 5,000 Oersteds, a relative magnetic permeability of from about 1 to about 500,000, and an average particle size of less than about 100 nanometers.

Pulse width cardiac pacing apparatus

A cardiac assist system containing a device for delivering a first pacing pulse from said system to a heart, for ceasing the delivery of said first pacing pulse to said heart, for sensing whether the heart is beating, and for delivering a second pacing pulse from said system to the heart. Each of the first pacing pulse and the second pacing pulse are delivered to the heart within a period of less than about 100 milliseconds, and has a voltage of from about 2 to about 5 volts direct current. The time between the delivery of the first pacing pulse and the second pacing pulse is at least about 1 microsecond. The first pacing pulse and the second pacing pulse are delivered to the heart at a frequency of from about 2 kiloherz to about 5 megahertz; and they each have a duration of from about 0.1 microseconds to about 500 milliseconds. The cardiac assist system also contains a device for varying the voltage and/or the frequency of each of the pacing pulses.

Pulsewidth electrical stimulation

A process for stimulating tissue such as cardiac tissue, nerve tissue, and brain tissue. In one step of the process, there is delivered an electrical stimulating signal to the tissue that contains from about 10 to about 1,000 individual pulses. Each individual pulse has a duration of from about one microsecond to about 100 microseconds and is discontinuous, with a spacing between adjacent pulses of at least from about 1 microsecond to about 100 microseconds. The individual pulses have a voltage of from about 10 millivolts to about 100 volts.

Guiding catheter with tungsten loaded band

The present invention comprises a tubular catheter shaft defining at least one catheter shaft lumen and a radiopaque band made of a polymeric material loaded with a radiopaque material of greater than 40% by weight, suitable for visualization under fluoroscopy in catheters in the range of 3 French to 5 French. The distal soft tip is formed of a relatively flexible polymeric material, loaded with radiopaque material which is less radiopaque than the radiopaque band. The radiopaque band's proximal end adjoins the distal end of the catheter shaft. The radiopaque band's distal end adjoins the proximal end of the distal tip to form an attachment junction. A tubular sleeve fits coaxially over the radiopaque band, the distal end of the catheter shaft and the proximal end of the distal soft tip. The tubular sleeve adheres the catheter shaft distal end to the proximal end of the radiopaque band and adheres the soft tip proximal end to the distal end of the radiopaque band thereby aligning the soft tip lumen, the radiopaque band lumen, and the catheter shaft lumen. The proximal end of the tubular sleeve is bonded to a distal portion of the catheter shaft. The distal end of the tubular sheath is bonded to the proximal end of the soft distal tip. The radiopaque band is bonded to the tubular sheath thereby bridging the attachment junction. The tubular sleeve is made of a polymeric material loaded with a radiopaque material which is less radiopaque than the radiopaque band. The tubular sleeve is melt compatible with the radiopaque band, the catheter shaft distal end and the distal soft tip such that the tubular sleeve, the distal end of the catheter shaft, the radiopaque band and the proximal end of the distal soft tip bond.

Fluorometer and method for detecting fluorescent signal

(57)【要約】 【課題】 ＰＭＴ検出器が露光過度にならない蛍光計の 提供。 【解決手段】 フラッシュ照明装置の光出力を非常に低 いレベルから開始してＰＭＴが特定範囲内での蛍光の検 出を記録するまで段階的に強度を増加させる蛍光計及び 方法。二つのランプを設け、その各々に異なる２種のレ ベルでフラッシュするように電力を供給し、それぞれの レベルを最低レベルから最高レベルまでエネルギーを段 階化する。許容できる検出可能なレベルの蛍光がＰＭＴ によって検出された時点でＰＭＴを閉鎖するためのシャ ッターを設ける。

Fluorimeter with intensity-staged excitation light and detection method

A method and fluorimeter for flashing a target at several different levels for detection of fluorescence by a PMT without blinding the PMT at the highest level. Two lamps are provided each of which is powered to flash at two different levels that are staged in energy from the lowest of four to the highest of four levels, and a shutter is provided to close off the PMT from exposure when an acceptable, detectable level of fluorescence is detected by the PMT.

MRI-safe defibrillator electrodes

The present invention reduces patient risks associated with RF-induced thermogenic tissue damage and with pulsed gradient-field-induced arrhythmias by using a defibrillator lead having a self-healing dielectric material that prevents induced voltages from MRI equipment from damaging an ICD or causing unintended defibrillation shocks to a patient. Another aspect of the present invention utilizes a sliding contact arrangement to prevent induced voltages from MRI equipment from being electrically coupled to an ICD thereby reducing patient risks associated with RF-induced thermogenic tissue damage and with pulsed gradient-field-induced arrhythmias.

Biothermal power source for implantable devices

An implantable, rechargeable assembly comprised of an implantable device (10) disposed within a living organism, an electrical storage device (20) connected to the implantable device, and a thermoelectric charging assembly (41, 45, 30) operatively connected to the electrical storage device. The thermoelectric charging assembly has devices for transferring thermal energy between the living organism and a thermoelectric module, for generating an electrical current from the thermal energy, for charging the electrical storage device with the electrical current, for determining the extent to which the electrical storage device is being charged with the electrical current, and for generating a signal whenever the extent to which the electrical storage device is being charged with the electrical current falls below a specified value.

Odorized methane fluid and processes for producing odorized methane fluids and the use thereof

The present invention relates to an odorized methane comprising liquid, and to an odorized methane comprising slush of liquid and solids. The invention especially relates to odorized LNG. The odorant is ethyl acrylate and/or ethyl mercaptan. The carrier for the odorant is propane, n-butane, iso-butane, or a mixture of two or more thereof. The present invention also relates to a process for preparing such an odorized liquid or slush by liquefying odorized methane comprising gas. The invention also relates to a process in which odorant is added to a methane comprising liquid or slush.

Nuclear magnetic resonance spectrometer assembly

An implantable nuclear magnetic resonance spectrometer comprised of a first input lead and a second output lead, wherein each of said first input lead and said second output lead comprise a photonic lead (585).

Helical guidewires and related systems

In accordance with some implementations, various embodiments of a guidewire or catheter having an elongate core with a helical section are provided. In accordance with one implementation, a guidewire is provided. The guidewire includes a core wire having a proximal end, a distal end and is defined by an outer surface between the proximal end and the distal end of the core wire. The core wire has a centerline that traverses the length of the core wire from the proximal end to the distal end of the core wire. The centerline is located approximately at the center of mass along the core wire within the outer surface of the core wire. Preferably, the core wire has a substantially straight proximal portion and a helically curved segment located distally with respect to the proximal portion. The centerline of the core wire is substantially straight along the straight proximal portion, and, the centerline is helically curved along the helically curved segment. The disclosure similarly provides a catheter having the aforementioned attributes.

Optical mri catheter system

Electromagnetic interference immune tissue invasive system

An electromagnetic immune tissue invasive system includes a primary device housing. The primary device housing having a control circuit therein. A shielding is formed around the primary device housing to shield the primary device housing and any circuits therein from electromagnetic interference. A lead system transmits and receives signals between the primary device housing. The lead system is either a fiber optic system or an electrically shielded electrical lead system.

Improved wash technique for immunoassay

The present invention provides an improved wash technique for an immunoassay. The improved wash technique provides a more effective displacement of unbound label away from the detection area, thereby providing an assay having greater sensitivity. The improved wash technique of the invention comprises applying 8-10 νL of the wash liquid at a point up to 43 % of the distance in betweenthe center of the sample spot and the inner periphery of the area wetted by the sample. When applying the wash fluid in this manner, the central portion of the spot will be adequately washed of unbound label, while the excess label at the periphery will not be redistributed back towards the center.

Integrally attached and operable multiple reaction vessels

Failure detection in automated clinical analyzers

The invention is a method for detecting failures in an analyzer for conducting clinical assays. Potential errors that can result in assay failures in an analyzer are identified, as are their potential sources. The probability that an error source so identified will result in a clinically significant error is also determined. Available potential detection measures corresponding to the source of potential errors are identified with a combination of such measures selected and implemented based on their probability of detecting such errors within an acceptable limit with a concomitant low probability of the false detection of an assay failure. Each of the measures selected are functionally independent of others chosen to address the source of the error and are not subject to the same inherent means of failed detection. Applications of the method in a clinical analyzer are also presented.

Method and apparatus for minimally invasive direct mechanical ventricular actuation

A device for assisting the function of a heart can be deployed using minimally invasive procedures. The device is collapsible to facilitate insertion into the chest cavity and deployment on the heart. The device includes a cup-shaped shell. The wall of the shell extends from a hole at an apex of the shell to a rim. A support cage is disposed within the shell. The support cage comprises a port and a plurality of flexible radial struts extending from the base contiguously along the inner surface to the rim of the shell. A liner is joined to the rim of the shell at upper and lower regions. It has a tapered seal and an elastic central region, forming an inflatable cavity between the outer surface of the liner and the inner surface of the shell. A first fitting is connectable to a first lumen and a second fitting is in communication with the inflatable cavity.

Integrally attached and operable multiple reaction vessels

Book stand

A collapsible stand (1) for a book has, when erected for use, an upper member (7) that provides a support surface for a book, first and second side wall members (8) that are hingedly connected to the upper member (7), and front and rear wall members (10,11), that are hingedly connected to the side wall members (8). The upper member (7) and the front and rear wall members (10,11) are each foldable laterally about substantially the center line of the stand (1). The arrangement is such that folding the upper member (7) upwards from the erected position causes the first and second side wall members (8) to collapse towards one another and the front and rear wall members (10,11) to fold inwards.

Variable volume pipette

There is disclosed a pipette useful with disposable tips, comprising a plurality of differently-sized pistons and a piston chamber for each piston. Each piston chamber has a vent passageway extending to the exterior surface of the pipette. The pipette is improved in that the mounting means for mounting a disposable tip comprises, not one surface, but a plurality of differently-sized surfaces. Furthermore, the vent passageway for all but the smallest piston chamber exits at a location in between the mounting surface for the tip of that particular piston chamber and the next smaller mounting surface, whereby the larger disposable tips seal over the vent passageways of the smaller disposable tips.

Mri-safe defibrillator electrodes

The present invention reduces patient risks associated with RF-induced thermogenic tissue damage and with pulsed gradient-field-induced arrhythmias by using a defibrillator lead having a self-healing dielectric material that prevents induced voltages from MRI equipment from damaging an ICD or causing unintended defibrillation shocks to a patient. Another aspect of the present invention utilizes a sliding contact arrangement to prevent induced voltages from MRI equipment from being electrically coupled to an ICD thereby reducing patient risks associated with RF-induced thermogenic tissue damage and with pulsed gradient-field-induced arrhythmias.

Electromagnetic interference immune tissue invasive system

An electromagnetic immune tissue invasive system includes a primary device housing. The primary device housing having a control circuit therein. A shielding is formed around the primary device housing to shield the primary device housing and any circuits therein from electromagnetic interference. A lead system transmits and receives signals between the primary device housing. The lead system is either a fiber optic system or an electrically shielded electrical lead system.

Reflectometer featuring an integrating cavity of enhanced efficiency

REFLECTOMETER FEATURING AN INTEGRATING CAVITY OF ENHANCED EFFICIENCY Abstract There is disclosed a reflectometer which uses an integrating cavity interposed between a pulsed light source and a test element. The cavity has enhanced efficiency by reason of its construction wherein a diffusely-reflecting surface is connected at opposite edges to mirrored surfaces that reflect back to the diffusely-reflecting surface, at least the majority of diffusely-reflected rays that are non-aligned with selected rays from the diffusely-reflecting surface that impinge unimpeded on the test element.

Integrally attached and operable multiple reaction vessels

A reaction vessel for confined amplification and detection of nucleic acid material. The vessel features a plurality of adjacent chambers, each chamber comprising a front wall, a back wall, two side walls, and a bottom wall, the front and back walls terminating in an upper opening at a top edge of said front and back walls, a side wall of each chamber comprising a side wall in common with an adjacent chamber so as to integrally connect the chambers side-by-side; the front wall of each chamber including a liquid access port spanning all of the chambers below the top edge, the common side walls terminating at the port; and a movable elastomeric plug mounted within the upper opening above the port, shaped to block the port of each of the chambers and to stopper each the chamber when moved below the top edge, the plug spanning across all of the chambers in the vessel so as to close off the port simultaneously for all of the chambers when moved below the top edge.

An electromagnetic interference immune tissue invasive system

An electromagnetic immune tissue invasive system includes a primary device housing (1100 of Figure 30). The primary device housing having a control circuit therein (1110 of Figure 30). A shielding (1160 of Figure 30) is formed around the primary device housing (1100 of Figure 30) to shield the primary device housing and any circuits therein from electromagnetic interference. A lead system (1150 of Figure 30) transmits and receives signals between the primary device housing (1100 of Figure 30). The lead system (1150 of Figure 30) is either a fiber optic system or an electrically shielded electrical lead system.

Multi-layer armor having lateral shock transfer

Armor includes a projectile impermeable material layer and a shock stiffening layer. The shock stiffening layer has opposing shock stiffening sublayers wherein each shock stiffening sublayer has a plurality of shock stiffening sublayer elements. The plurality of shock stiffening sublayer elements of opposed shock stiffening sublayers are interdigitated. The armor includes a foam layer wherein the shock stiffening layer is positioned between the foam layer and the projectile impermeable material layer. The plurality of shock stiffening sublayer elements of opposed shock stiffening sublayers may momentarily or permanently fuse in response to a projectile’s impact. The shock stiffening layer spreads the energy laterally, thereby effectively mitigating the transfer of kinetic energy from a ballistic projectile directly to a region to be protected.

Electromagnetic interference immune tissue invasive system

An electromagnetic immune tissue invasive system includes a primary device housing. The primary device housing having a control circuit therein. A shielding is formed around the primary device housing to shield the primary device housing and any circuits therein from electromagnetic interference. A lead system transmits and receives signals between the primary device housing. The lead system is either a fiber optic system or an electrically shielded electrical lead system.

Electromagnetic interference immune tissue invasive system

An electromagnetic immune tissue invasive system includes a primary device housing. The primary device housing having a control circuit therein. A shielding is formed around the primary device housing to shield the primary device housing and any circuits therein from electromagnetic interference. A lead system transmits and receives signals between the primary device housing. The lead system is either a fiber optic system or an electrically shielded electrical lead system.

Machine learning technique for recommendation of courses in a social networking service based on confidential data

In an example, each of a plurality of members of social networking service is mapped to a weighted skill vector, each weighted skill vector including a list of skills for the member with an associated weight indicating strength of the skill. Members of the social networking service that belong to an industry are aggregated to obtain a weighted matrix of members and skills along with compensation vectors indicating compensation for each of the members in the matrix. The weighted matrix of users and skills and corresponding compensation vectors is used to train a machine learning skill monetary value prediction model to output a predicted monetary value for one or more skills contained in a candidate vector fed to the machine learning skill monetary value prediction model.

Integrally attached and operable multiple reaction vessels

A reaction vessel for confined amplification and detection of nucleic acid material. The vessel features a plurality of adjacent chambers, each chamber comprising a front wall, a back wall, two side walls, and a bottom wall, the front and back walls terminating in an upper opening at a top edge of said front and back walls, a side wall of each chamber comprising a side wall in common with an adjacent chamber so as to integrally connect the chambers side-by-side; the front wall of each chamber including a liquid access port spanning all of the chambers below the top edge, the common side walls terminating at the port; and a movable elastomeric plug mounted within the upper opening above the port, shaped to block the port of each of the chambers and to stopper each the chamber when moved below the top edge, the plug spanning across all of the chambers in the vessel so as to close off the port simultaneously for all of the chambers when moved below the top edge.

Optical MRI catheter system

An assembly for delivering optical signals comprising a nuclear magnetic resonance system comprised of magnets, an NMR programmable logic unit, a signal input channel, and a command output channel; an optical interface assembly electrically connected to the nuclear magnetic resonance system, the optical interface assembly comprising a first laser modulated so as to produce laser optical signals, an interface optical to electrical signal convertor; and a catheter assembly connected to said optical interface assembly, the catheter assembly comprising a proximal end, a distal end, a fiber optic cable assembly, an electronics assembly disposed at the distal end comprised of a catheter electrical to optical signal convertor and a catheter optical to electrical signal convertor, and a first receiving coil disposed at the distal end.

Improved fluorimeter and detection method

A method and fluorimeter for flashing a target at several different levels for detection of fluorescence by a PMT without blinding the PMT at the highest level. Two lamps are provided each of which is powered to flash at two different levels that are staged in energy from the lowest of four to the highest of four levels, and a shutter is provided to close off the PMT from exposure when an acceptable, detectable level of fluorescence is detected by the PMT.

Cardiac annuloplasty and pacing procedures, related devices and methods

Devices and methods are disclosed for the treatment or repair of regurgitant cardiac valves, such as a mitral valve. An illustrative annuloplasty device can be placed in the coronary sinus to reshape the mitral valve and reduce mitral valve regurgitation. The disclosure also provides improved techniques for cardiac pacing.

Fluid comprising methane and a tracer, and processes for producing it and the use thereof

The present invention relates to a liquid comprising methane and a tracer, and to a slush of liquid and solids comprising methane and a tracer. The invention especially relates to LNG comprising a tracer. The LNG may comprise, in addition to the tracer, an odorant and a carrier for the odorant. The odorant is ethyl acrylate and/or ethyl mercaptan. The carrier for the odorant is propane, n-butane, iso-butane, or a mixture of two or more thereof. The present invention also relates to a process for preparing such a liquid or slush by liquefying a gas comprising methane and a tracer. The invention also relates to a process in which a tracer is added to a methane comprising liquid or slush.

Improved fluorimeter and detection method

Biothermal power source for implantable devices

An implantable, rechargeable assembly that contains an implantable device (22) within a living organism; an electrical storage device (20) is connected to the implantable device, and a thermoelectric charging assembly (12, 40, 14, 18) is connected to said electrical storage device. A thermoelectric charging assembly contains devices for transferring thermal energy between the living organism and a thermoelectric module (12), for creating an electrical current of a first polarity from thermal energy, for creating an electrical current with a second polarity from the thermal energy, for charging the electrical storage device with the electrical current of said first polarity, and for charging the electrical storage device with the electrical current of the second polarity.

Stented heart valve devices

A stent frame (10) including an annular portion (12) having first and second ends, a central longitudinal axis, and a wire portion with at least two extending posts (18) the wire portion having a generally sinusoidal series of peaks and valleys be-tween each of the at least two extending posts; an atrial portion (14) extending from the first end of the annular portion, wherein the atrial portion includes a plurality of flares (20) that extend radially outward relative to the longitudinal axis of the annular por-tion; and a ventricular portion (16) extending from the second end of the annular portion, wherein the ventricular portion includes at least one flare (24) that extends radially outward relative to the longitudinal axis of the annular portion.

Devices for effectuating percutaneous glenn and fontan procedures

Electromagnetic interference immune pacing/defibrillation lead

An electromagnetic interference immune defibrillator lead has a first electromagnetic insulating layer. A first layer is formed on the first electromagnetic insulating layer, the first layer having a plurality of first conductive rings composed of first conductive material, each first conductive ring being separated by first insulating material. A second electromagnetic insulating layer is formed on the first layer. A second layer is, formed on the second electromagnetic insulating layer, the second layer having a plurality of second conductive rings composed of second conductive material, each second conductive ring being separated by second insulating material. A third electromagnetic insulating layer is formed on the second layer. The second conductive rings of second conductive material are positioned such that a second conductive ring overlaps a portion of a first conductive ring and overlaps a portion of a second conductive ring, the second conductive ring being adjacent to the first conductive ring. The second electromagnetically insulating layer is composed of a self-healing dielectric material.

Biothermal power source for implantable devices

An implantable, rechargeable assembly that contains an implantable device (22) within a living organism; an electrical storage device (20) is connected to the implantable device, and a thermoelectric charging assembly (12, 40, 14, 18) is connected to said electrical storage device. A thermoelectric charging assembly contains devices for transferring thermal energy between the living organism and a thermoelectric module (12), for creating an electrical current of a first polarity from thermal energy, for creating an electrical current with a second polarity from the thermal energy, for charging the electrical storage device with the electrical current of said first polarity, and for charging the electrical storage device with the electrical current of the second polarity.

Improved fluorimeter and detection method

A method and fluorimeter for flashing a target at several different levels for detection of fluorescence by a PMT without blinding the PMT at the highest level. Two lamps are provided each of which is powered to flash at two different levels that are staged in energy from the lowest of four to the highest of four levels, and a shutter is provided to close off the PMT from exposure when an acceptable, detectable level of fluorescence is detected by the PMT.

Failure detection in automated clinical analyzers

The invention is a method for detecting failures in an analyzer for conducting clinical assays. Potential errors that can result in assay failures in an analyzer are identified, as are their potential sources. The probability that an error source so identified will result in a clinically significant error is also determined. Available potential detection measures corresponding to the source of potential errors are identified with a combination of such measures selected and implemented based on their probability of detecting such errors within an acceptable limit with a concomitant low probability of the false detection of an assay failure. Each of the measures selected are functionally independent of others chosen to address the source of the error and are not subject to the same inherent means of failed detection. Applications of the method in a clinical analyzer are also presented.

Resonance tuning module for implantable devices and leads

An implantable medical assist device includes a medical device. The medical device has a housing and electronics contained therein. A lead provides an electrical path to or from the electronics within the medical device. A resonance tuning module is located in the housing and is connected to the lead. The resonance tuning module includes a control circuit for determining a resonant frequency of the implantable medical assist device and an adjustable impedance circuit to change the combined resonant frequency of the medical device and lead.

Multi-component substances and processes for preparation thereof

Devices and methods for closure of transvascular or transcameral access ports

The present disclosure provides a variety of prostheses, delivery systems and techniques to facilitate closure of transvascular or transcameral access ports. Various embodiments of prostheses are provided including a plurality of radially expandable discs that can be filled with material to facilitate coagulation and to reduce or stop leakage from punctures in vessel walls.

Devices for closure of transvascular or transcameral access ports