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Применить Всего найдено 2. Отображено 2.
08-11-2012 дата публикации

PYRIDINONE HYDROXYCYCLOPENTYL CARBOXAMIDES: HIV INTEGRASE INHIBITORS WITH THERAPEUTIC APPLICATIONS

Номер: US20120282218A1
Автор: Vasu Nair, Maurice O. Okello, Abdumalik A. Nishonov, Sanjaykumar Mishra, NAIR VASU, OKELLO MAURICE O, NISHONOV ABDUMALIK A, MISHRA SANJAYKUMAR, OKELLO MAURICE O., NISHONOV ABDUMALIK A.
Принадлежит: University of Georgia Research Foundation Inc.

New chiral and achiral oxy-substituted cyclopentyl pyridinone diketocarboxamides and their derivatives and methods for their preparations are disclosed. The compounds include tautomers, regioisomers and geometric isomers. These complex carboxamides are designed as inhibitors of HIV replication through inhibition of HIV integrase. The compounds are useful in the prevention or treatment of infection by HIV and in the treatment of AIDS and ARC, either as the compounds, or as pharmaceutically acceptable salts, with pharmaceutically acceptable carriers, used alone or in combination with antivirals, immunomodulators, antibiotics, vaccines, and other therapeutic agents, especially other anti-HIV compounds (including other anti-HIV integrase agents), which can be used to create combination anti-HIV cocktails. Methods of treating AIDS and ARC and methods of treating or preventing infection by HIV are also described.

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Номер записи: 1
22-04-2014 дата публикации

Pyridinone hydroxycyclopentyl carboxamides: HIV integrase inhibitors with therapeutic applications

Номер: US0008703801B2
Автор: Vasu Nair, Maurice O. Okello, Abdumalik A. Nishonov, Sanjaykumar Mishra, NAIR VASU, OKELLO MAURICE O, NISHONOV ABDUMALIK A, MISHRA SANJAYKUMAR, OKELLO MAURICE O., NISHONOV ABDUMALIK A.
Принадлежит: University of Georgia Research Foundation, Inc., NAIR VASU, OKELLO MAURICE O, NISHONOV ABDUMALIK A, MISHRA SANJAYKUMAR, UNIV GEORGIA, OKELLO MAURICE O., NISHONOV ABDUMALIK A., UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.

New chiral and achiral oxy-substituted cyclopentyl pyridinone diketocarboxamides and their derivatives and methods for their preparations are disclosed. The compounds include tautomers, regioisomers and geometric isomers. These complex carboxamides are designed as inhibitors of HIV replication through inhibition of HIV integrase. The compounds are useful in the prevention or treatment of infection by HIV and in the treatment of AIDS and ARC, either as the compounds, or as pharmaceutically acceptable salts, with pharmaceutically acceptable carriers, used alone or in combination with antivirals, immunomodulators, antibiotics, vaccines, and other therapeutic agents, especially other anti-HIV compounds (including other anti-HIV integrase agents), which can be used to create combination anti-HIV cocktails. Methods of treating AIDS and ARC and methods of treating or preventing infection by HIV are also described.

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Номер записи: 2