04-04-2013 дата публикации
Номер: US20130085156A1
The present invention relates to a compound which has a glucokinase-activating effect and is useful as a therapeutic agent for diabetes mellitus, being represented by a formula (I): 138-. (canceled)40. The compound according to claim 39 , or a pharmaceutically acceptable salt thereof claim 39 , wherein D is S.41. The compound according to claim 39 , or a pharmaceutically acceptable salt thereof claim 39 , wherein both of Rand Rare hydrogen atoms.42. The compound according to claim 39 , or a pharmaceutically acceptable salt thereof claim 39 , wherein Xis selected from the group consisting of: a nitrogen atom claim 39 , sulfur atom claim 39 , oxygen atom claim 39 , —CH— claim 39 , —N—CH— claim 39 , —S—CH— claim 39 , —O—CH— claim 39 , —CH—N— claim 39 , —CH—O— claim 39 , and —CH—S—.43. The compound according to claim 39 , or a pharmaceutically acceptable salt thereof claim 39 , wherein the substituent on ring A is a hydrogen atom claim 39 , lower alkyl group claim 39 , lower alkoxy group claim 39 , hydroxy group claim 39 , or hydroxy lower alkyl group (the hydrogen atom of the hydroxy group of the hydroxy lower alkyl group may further be substituted by a lower alkyl group).44. The compound of claim 39 , or a pharmaceutically acceptable salt thereof claim 39 , wherein the substituent on ring B is a hydrogen atom claim 39 , lower alkyl group claim 39 , halogen atom claim 39 , hydroxyalkyl group claim 39 , aminoalkyl group claim 39 , or alkanoyl group.45. The compound according to claim 39 , or a pharmaceutically acceptable salt thereof claim 39 , wherein Rrepresents a pyridyl group.46. The compound according to claim 39 , or a pharmaceutically acceptable salt thereof claim 39 , wherein the substituent in Ris hydrogen atom claim 39 , hydroxyalkyl group claim 39 , lower alkyl group claim 39 , lower alkoxy group claim 39 , carbamoyl group claim 39 , alkylcarbamoyl group claim 39 , dialkylcarbamoyl group claim 39 , cyano group claim 39 , trifluoromethyl group claim 39 , ...
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