07-11-2013 дата публикации
Номер: US20130296165A1
Принадлежит:
Dry stabilizing compositions for bioactive materials include sugars and hydrolyzed proteins, and may be formed into tablets or other forms providing enhanced stability for the bioactive material. Compositions containing the bioactive materials may be produced by a method that includes (a) combining the bioactive material with other ingredients in an aqueous solvent to form a viscous slurry; (b) snap-freezing the slurry in liquid nitrogen to form solid frozen particles, beads, droplets or strings; (c) primary drying by water removal under vacuum of the product of step (b) while maintaining it at a temperature above its freezing temperature; and (d) secondary drying of the product of step (c) at maximum vacuum and a temperature of 20° C. or higher for a time sufficient to reduce the water activity to below 0.3 Aw. 1. A dry stabilizing composition for a bioactive material , comprising a carbohydrate component comprising between about 10% and 80% oligosaccharide , between about 5% and 30% disaccharide and between about 1% and 10% polysaccharide; and a protein component comprising between about 0.5% and 40% hydrolyzed animal or plant proteins; based on the total weight of the composition.2. The composition of claim 1 , wherein the hydrolyzed protein component comprises hydrolyzed casein claim 1 , hydrolyzed whey protein claim 1 , hydrolyzed pea protein claim 1 , hydrolyzed soy protein or a mixture thereof.3. The composition of claim 2 , wherein the hydrolyzed casein claim 2 , hydrolyzed whey protein claim 2 , hydrolyzed pea protein and hydrolyzed soy protein are extensively hydrolyzed proteins.4. The composition of claim 1 , wherein the polysaccharide comprises cellulose acetate phthalate (CAP) claim 1 , carboxy-methyl-cellulose claim 1 , pectin claim 1 , sodium alginate claim 1 , salts of alginic acid claim 1 , hydroxylpropyl methyl cellulose (HPMC) claim 1 , methyl cellulose claim 1 , carrageenan claim 1 , gellan gum claim 1 , guar gum claim 1 , gum acacia claim 1 , ...
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