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Применить Всего найдено 8. Отображено 8.
04-07-2012 дата публикации

Anti-EGFR (epidemic growth factor receptor) humanized antibody L2-H3 and coding gene and application thereof

Номер: CN0102153650B
Автор: YANWEN JIN, WAFER DAVIE, RIDGEWAYTZ MICHELL, CHENG CAO, JIN YANWEN, DAVIE.WAFER, MICHELL.RIDGEWAYTZ, CAO CHENG
Принадлежит:

The invention discloses an anti-EGFR (epidemic growth factor receptor) humanized antibody L2-H3 and a coding gene and application thereof. The antibody is formed by a light chain and a heavy chain, wherein the heavy chain is formed by connection of a heavy chain variable region and a heavy chain constant region; the amino acid sequence of the heavy chain variable region is shown in the 1st-145th positions in the SEQ ID NO:3; the heavy chain constant region is the heavy chain constant region of a humanized antibody IgG1; and the amino acid sequence of the light chain is shown in the SEQ ID NO:1. The experimental results prove that the antibody has good binding activity and capability of inhibiting growth and migration of the tumor cells; and the affinity of the common anti-EGFR human-mouthchimeric antibody, namely cetuximab in the domestic and foreign markets is 1.1*10<9>M. The humanized antibody disclosed by the invention can better bind with the EGFR, thus ensuring the anti-tumor effect ...

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Номер записи: 1
17-08-2011 дата публикации

Anti-EGFR (epidemic growth factor receptor) humanized antibody L3-H3 and coding gene and application thereof

Номер: CN0102153647A
Автор: YANWEN JIN, WAFER DAVIE, RIDGEWAYTZ MICHELL, CHENG CAO, JIN YANWEN, DAVIE.WAFER, MICHELL.RIDGEWAYTZ, CAO CHENG
Принадлежит:

The invention discloses an anti-EGFR (epidemic growth factor receptor) humanized antibody L3-H3 and a coding gene and application thereof. The antibody is formed by a light chain and a heavy chain, wherein the heavy chain is formed by connection of a heavy chain variable region and a heavy chain constant region; the amino acid sequence of the heavy chain variable region is shown in the 1st-145th positions in the SEQ ID NO:3; the heavy chain constant region is the heavy chain constant region of a humanized antibody IgG1; and the amino acid sequence of the light chain is shown in the SEQ ID NO:1. The experimental results prove that the antibody has good binding activity and capability of inhibiting growth and migration of the tumor cells; and the affinity of the common anti-EGFR human-mouth chimeric antibody, namely cetuximab in the domestic and foreign markets is 1.1*10<9>M. The humanized antibody disclosed by the invention can better bind with the EGFR, thus ensuring the anti-tumor effect ...

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Номер записи: 2
17-08-2011 дата публикации

EGFR (epidermal growth factor receptor)-inhibiting humanized antibody L4-H3 and encoding genes and application thereof

Номер: CN0102153648A
Автор: YANWEN JIN, WAFER DAVIE, RIDGEWAYTZ MICHELL, CHENG CAO, JIN YANWEN, DAVIE.WAFER, MICHELL.RIDGEWAYTZ, CAO CHENG
Принадлежит:

The invention discloses an EGFR-inhibiting (epidermal growth factor receptor) humanized antibody L4-H3 and encoding genes and application thereof. The antibody comprises a light chain and a heavy chain, wherein the heavy chain is formed by connecting a variable heavy-chain region with a constant heavy-chain region; the amino acid sequences of the variable heavy-chain region are described as the 1st to the 145th sites in the SEQ ID NO:3, and the constant heavy-chain region is the constant heavy-chain region of the humanized antibody IgG1; the amino acid sequences of the light chain are described as the SEQ ID NO:1. The experimental result confirms that the antibody disclosed by the invention has good combining activity and the capacity of inhibiting the growth and the migration of the tumor cell. The cetuximab which is the foreign common EGFR-inhibiting human-mouse chimeric antibody has the affinity of 1.1*10<-9>M. The humanized antibody disclosed by the invention can be well combined with ...

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Номер записи: 3
04-07-2012 дата публикации

Anti-epidemic growth factor receptor (EGFR) humanized antibody L1-H3 and coded gene and application thereof

Номер: CN0102153649B
Автор: YANWEN JIN, WAFER DAVIE, RIDGEWAYTZ MICHELL, CHENG CAO, JIN YANWEN, DAVIE.WAFER, MICHELL.RIDGEWAYTZ, CAO CHENG
Принадлежит:

The invention discloses an anti-epidemic growth factor receptor (EGFR) humanized antibody L1-H3 and a coded gene and application thereof. The antibody consists of a light chain and a heavy chain, wherein the heavy chain is formed by connecting a heavy chain variable region and a heavy chain constant region; the amino acid sequence of the heavy chain variable region is shown as the 1st-145th sitesin SEQ ID NO: 3; the heavy chain constant region is the heavy chain constant region of a humanized antibody IgG1; and the amino acid sequence of the light chain is shown as SEQ ID NO: 1. Proved by experimental results, the antibody has good bonding activity and capacity of inhibiting tumor cell growth migration; and the affinity of an anti-EGFR human-mouse nested cetuximab antibody common in foreign markets is 1.1*10<-9>M. The humanized antibody can be better combined with the EGFR so as to ensure an anti-tumor effect. A method for preparing the antibody can simultaneously express the light chain ...

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Номер записи: 4
04-07-2012 дата публикации

EGFR (epidermal growth factor receptor)-inhibiting humanized antibody L4-H3 and encoding genes and application thereof

Номер: CN0102153648B
Автор: YANWEN JIN, WAFER DAVIE, RIDGEWAYTZ MICHELL, CHENG CAO, JIN YANWEN, DAVIE.WAFER, MICHELL.RIDGEWAYTZ, CAO CHENG
Принадлежит:

The invention discloses an EGFR-inhibiting (epidermal growth factor receptor) humanized antibody L4-H3 and encoding genes and application thereof. The antibody comprises a light chain and a heavy chain, wherein the heavy chain is formed by connecting a variable heavy-chain region with a constant heavy-chain region; the amino acid sequences of the variable heavy-chain region are described as the 1st to the 145th sites in the SEQ ID NO:3, and the constant heavy-chain region is the constant heavy-chain region of the humanized antibody IgG1; the amino acid sequences of the light chain are described as the SEQ ID NO:1. The experimental result confirms that the antibody disclosed by the invention has good combining activity and the capacity of inhibiting the growth and the migration of the tumor cell. The cetuximab which is the foreign common EGFR-inhibiting human-mouse chimeric antibody has the affinity of 1.1*10<-9>M. The humanized antibody disclosed by the invention can be well combined with ...

Подробнее
Номер записи: 5
17-08-2011 дата публикации

Anti-epidemic growth factor receptor (EGFR) humanized antibody L1-H3 and coded gene and application thereof

Номер: CN0102153649A
Автор: YANWEN JIN, WAFER DAVIE, RIDGEWAYTZ MICHELL, CHENG CAO, JIN YANWEN, DAVIE.WAFER, MICHELL.RIDGEWAYTZ, CAO CHENG
Принадлежит:

The invention discloses an anti-epidemic growth factor receptor (EGFR) humanized antibody L1-H3 and a coded gene and application thereof. The antibody consists of a light chain and a heavy chain, wherein the heavy chain is formed by connecting a heavy chain variable region and a heavy chain constant region; the amino acid sequence of the heavy chain variable region is shown as the 1st-145th sites in SEQ ID NO: 3; the heavy chain constant region is the heavy chain constant region of a humanized antibody IgG1; and the amino acid sequence of the light chain is shown as SEQ ID NO: 1. Proved by experimental results, the antibody has good bonding activity and capacity of inhibiting tumor cell growth migration; and the affinity of an anti-EGFR human-mouse nested cetuximab antibody common in foreign markets is 1.1*10<-9>M. The humanized antibody can be better combined with the EGFR so as to ensure an anti-tumor effect. A method for preparing the antibody can simultaneously express the light chain ...

Подробнее
Номер записи: 6
17-08-2011 дата публикации

Anti-EGFR (epidemic growth factor receptor) humanized antibody L2-H3 and coding gene and application thereof

Номер: CN0102153650A
Автор: YANWEN JIN, WAFER DAVIE, RIDGEWAYTZ MICHELL, CHENG CAO, JIN YANWEN, DAVIE.WAFER, MICHELL.RIDGEWAYTZ, CAO CHENG
Принадлежит:

The invention discloses an anti-EGFR (epidemic growth factor receptor) humanized antibody L2-H3 and a coding gene and application thereof. The antibody is formed by a light chain and a heavy chain, wherein the heavy chain is formed by connection of a heavy chain variable region and a heavy chain constant region; the amino acid sequence of the heavy chain variable region is shown in the 1st-145th positions in the SEQ ID NO:3; the heavy chain constant region is the heavy chain constant region of a humanized antibody IgG1; and the amino acid sequence of the light chain is shown in the SEQ ID NO:1. The experimental results prove that the antibody has good binding activity and capability of inhibiting growth and migration of the tumor cells; and the affinity of the common anti-EGFR human-mouth chimeric antibody, namely cetuximab in the domestic and foreign markets is 1.1*10<9>M. The humanized antibody disclosed by the invention can better bind with the EGFR, thus ensuring the anti-tumor effect ...

Подробнее
Номер записи: 7
04-07-2012 дата публикации

Anti-EGFR (epidemic growth factor receptor) humanized antibody L3-H3 and coding gene and application thereof

Номер: CN0102153647B
Автор: YANWEN JIN, WAFER DAVIE, RIDGEWAYTZ MICHELL, CHENG CAO, JIN YANWEN, DAVIE.WAFER, MICHELL.RIDGEWAYTZ, CAO CHENG
Принадлежит:

The invention discloses an anti-EGFR (epidemic growth factor receptor) humanized antibody L3-H3 and a coding gene and application thereof. The antibody is formed by a light chain and a heavy chain, wherein the heavy chain is formed by connection of a heavy chain variable region and a heavy chain constant region; the amino acid sequence of the heavy chain variable region is shown in the 1st-145th positions in the SEQ ID NO:3; the heavy chain constant region is the heavy chain constant region of a humanized antibody IgG1; and the amino acid sequence of the light chain is shown in the SEQ ID NO:1. The experimental results prove that the antibody has good binding activity and capability of inhibiting growth and migration of the tumor cells; and the affinity of the common anti-EGFR human-mouthchimeric antibody, namely cetuximab in the domestic and foreign markets is 1.1*10<9>M. The humanized antibody disclosed by the invention can better bind with the EGFR, thus ensuring the anti-tumor effect ...

Подробнее
Номер записи: 8