TUMOR TARGETED ANTIBODIES AND METHOD FOR USING THE SAME

Isolated and recombinant antibodies, such as EGFR-binding antibodies. Antibodies can comprising the sequence of an immunoglobulin heavy constant gamma-1 region encoded by a human G1M3 allele. For example, antibodies of the embodiments can comprise an immunoglobulin heavy constant gamma-1 region wherein position 214 is arginine; position 356 is glutamic acid; position 358 is methionine and/or position 431 is alanine. Methods for treating diseases, such as cancer, in a human subject with such antibodies are also provided. 1. A pharmaceutical composition comprising a purified EGFR-binding antibody which has a human immunoglobulin heavy constant gamma-1 region with arginine at position 214 and a pharmaceutically acceptable carrier.2. The composition of claim 1 , wherein the human immunoglobulin heavy constant gamma-1 region has glutamic acid claim 1 , methionine claim 1 , and alanine at positions 356 claim 1 , 358 claim 1 , and 431 claim 1 , respectively.3. The composition of claim 1 , wherein the human immunoglobulin heavy constant gamma-1 region is encoded by a human G1M3 allele.4. The composition of claim 1 , wherein the antibody is a humanized antibody.5. The composition of claim 1 , wherein the antibody is a human antibody.6. The composition of claim 1 , wherein the antibody is a chimeric antibody.7. The composition of claim 1 , wherein the EGFR is HER2 (human epidermal growth factor receptor 2).8. The composition of claim 1 , wherein the EGFR is HER1 (human epidermal growth factor receptor 1).9. The composition of claim 1 , wherein the antibody is coupled to a therapeutic claim 1 , a reporter claim 1 , or a targeting moiety.10. The composition of claim 9 , wherein the therapeutic is a nucleotide claim 9 , a peptide claim 9 , a small molecule claim 9 , a therapeutic radionuclide claim 9 , a chemotherapeutic claim 9 , a tumor suppressor claim 9 , an apoptosis inducer claim 9 , an enzyme claim 9 , a second antibody claim 9 , an siRNA claim 9 , a hormone claim 9 , a ...