11-03-2021 дата публикации
Номер: US20210070731A1
Принадлежит:
The present application provides novel compounds that are inhibitors of kinases, including AMPK-related kinases like NUAK1, NUAK2, SIK1, SIK2, SIK3, MARK1, MARK2, MARK3, MARK4, as well as AURKA, AURKB, AURKC, CLK1, CLK2, DCAMKL2, MAPK7, MKNK2, PIK3CD, PKN3, RET, TAOK1, TAOK2, TAOK3, ULK2 and their mutants. The application also provides compositions, including pharmaceutical compositions, kits that include compounds, and methods of making and using compounds. The compounds provided herein are useful in treating diseases, disorders, or conditions that are mediated by these kinases. 1. A compound of formula:{'sup': 1', '2', '3', '4', '7', '8', '9', '10', '10, 'Each G, G, G, G, G, G, Gand Gis independently selected from N and CR;'}{'sup': 5', 'a', 'a', 'a', 'a', '100, 'sub': 2', '2', '1-6', '2-6', '2-6', '1-6', '2-6', '2-6, 'Gis selected from —S—, —O—, —NR—, —C(O)—, —C(O)O—, —C(O)NR—, S(O)NR—, —S(O)NR—, —S(O)—, —S(O)—, Calkylene, Calkenylene and Calkynylene; wherein each Calkylene, Calkenylene and Calkynylene is substituted with one to six R;'}{'sup': 6', '100, 'sub': 4-7', '6-10', '6-10, 'Gis selected from Cmembered heterocycloalkyl, Caryl, 5-10 membered heteroaryl containing 1 to 4 heteroatoms selected from the group consisting of N, O, and S, and 4-10 membered heterocyclyl containing 1 to 4 heteroatoms selected from the group consisting of N, O, and S; wherein each Caryl, 5-10 membered heteroaryl and 4-10 membered heterocyclyl is optionally substituted with one to four R;'}{'sup': 1', 'a', 'b', 'b', 'a', 'a', 'a', 'b', 'a', 'b', 'a', 'a', 'a', 'b', 'a', 'b', '100, 'sub': 2', '2', '1-6', '2- 6', '2-6', '3-8', '6-10', '1-6', '2-6', '2-6', '3-8', '6-10, 'Ris selected from absent, hydrogen, cyano, hydroxy, amino, —C(O)R, —C(O)OR, —C(O)NR, —N(R)C(O)R, —S(O)NRR, —S(O)NRR, —S(O)R, —S(O)R, — NRR, —OR, —SR, Calkyl, Calkenyl, Calkynyl, Ccycloalkyl, Caryl, 5-10 membered heteroaryl containing 1 to 4 heteroatoms selected from the group consisting of N, O, and S and 4-10 membered ...
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