PROTEINOID COMPOUNDS, PROCESS OF PREPARING SAME AND USES THEREOF

Proteinoid compounds characterized by a molecular weight (Mw) of at least 15,000 Da, processes of preparing such compounds and methods of use thereof, are provided. A method of monitoring the presence and metastases of cancer in a body of an individual is further disclosed. 1. A proteinoid compound comprising a polymeric backbone , wherein said polymeric backbone comprises monomeric units , each of said monomeric units being derived from an amino acid , and wherein said polymeric backbone is characterized by a molecular weight (Mw) of at least 15 ,000 Da.2. The proteinoid compound of claim 1 , wherein said amino acid claim 1 , in each instance claim 1 , is selected from the group consisting of: Glu claim 1 , Lys claim 1 , Asp claim 1 , Arg claim 1 , Tyr claim 1 , His claim 1 , Ala claim 1 , Phe claim 1 , Cys claim 1 , Ile claim 1 , and p-amino benzoic acid.3. The proteinoid compound of claim 1 , wherein said polymeric backbone further comprises polyester.4. The proteinoid compound of claim 3 , wherein said polyester is selected from the group consisting of polylactide claim 3 , polyglycolide claim 3 , and polycaprolactone claim 3 , polyhydroxyalkanoate.5. The proteinoid compound of claim 1 , wherein said polymeric backbone is represented by the following formula [Phe][Arg][His][Lys][A]wherein:{'sub': '4', 'Arepresents a polyester or is absent;'}n, x, y, and z are integers, independently, representing the total numbers of Phe, Arg, His, and Lys, respectively, in the polymeric backbone, such that n+x+y+z has a value of at least 100.6. The proteinoid compound of claim 1 , wherein said polymeric backbone is represented by the following formula: [A][A][A][A]wherein:{'sub': '1', 'a) A, in each instance, is selected from Glu and Lys;'}{'sub': 2', '3, 'b) A, and Aare each, independently, a monomeric unit derived from an amino acid or are each, independently, absent;'}{'sub': '4', 'c) Arepresents the polyester or is absent, and'}{'sub': 1', '2', '3, 'd) x, y and z are ...

POLYAMIDE NANOPARTICLES AND USES THEREOF

Nanoparticles of N-halamine-derivatized crosslinked polyamide. Process of preparing the polymeric nanoparticles per se and incorporated in or on a substrate. Uses of the polymeric nanoparticles and of substrates incorporating same, particularly for reducing a formation of organic based contaminants, e.g., load of a microorganism or of a biofilm.

MULTIMODAL VISIBLE POLYMER EMBOLIZATION MATERIAL

The present invention relates to embolization material for therapeutic use, wherein said material is visible via more than one imaging technique. 1. Embolization material for therapeutic use , wherein said material is visible via more than one imaging technique.2. The embolization material of claim 1 , wherein said material comprises at least one polymer component and at least one inorganic component claim 1 , and wherein said material is visible with high contrast via more than one imaging technique.3. The embolization material of claim 2 , wherein said material is visible via at least one of the following imaging techniques:a) X-ray computed tomography (CT)/projectional radiography and magnetic resonance imaging (MRI),b) X-ray computed tomography (CT)/projectional radiography and ultrasonography (US),c) X-ray computed tomography (CT)/projectional radiography and single photon emission computed tomography (SPECT),d) X-ray computed tomography (CT)/projectional radiography and positron emission tomography (PET),e) magnetic resonance imaging (MRI) and ultrasonography (US),f) magnetic resonance imaging (MRI) and single photon emission computed tomography (SPECT),g) magnetic resonance imaging (MRI) and positron emission tomography (PET),h) X-ray computed tomography (CT)/projectional radiography and magnetic particle imaging, ori) a combination of two or more of said imaging techniques.4. The embolization material of claim 3 , wherein said material is visible via three different imaging techniques at the same time.5. The embolization material of claim 2 , wherein the at least one polymer component is selected from the group of polyacrylate claim 2 , polymethacrylate claim 2 , polyacrylamide claim 2 , polymethacrylamide claim 2 , acrylate polymer claim 2 , polyamide claim 2 , polysiloxane claim 2 , polyester claim 2 , polyurethane claim 2 , polyvinyl ether claim 2 , polyvinyl ester claim 2 , copolymers comprising as monomers a (meth)acrylic-derivative and/or a meth( ...

SYNTHESIS AND CHARACTERIZATION OF NEAR IR FLUORESCENT MAGNETIC AND NON-MAGNETIC ALBUMIN NANOPARTICLES FOR BIOMEDICAL APPLICATIONS

The present invention discloses Near Infrared (NIR) fluorescent albumin nanoparticles having a structure selected from a core structure or a core-shell structure. Also disclosed are a process of preparing these NIR fluorescent albumin nanoparticles, and a method of in vivo detection of pathologies, in particular cancer pathology, by using administering these NIR fluorescent albumin nanoparticles to a patient. 1. Near Infrared (NIR) fluorescent albumin nanoparticles having a structure selected from:a. A core structure, said core comprising at least one NIR dye encompassed within albumin nanoparticles and optionally comprising a dyed or non-dyed contrast agent;b. A core-shell structure, said core comprising at least one material selected from a dyed or non-dyed metal or metal oxide, a dyed or non-dyed contrast agent, and a dyed or non-dyed organic compound having a hydrophilic surface, wherein said core is coated by a shell comprising one or more layers of albumin encompassing at least one NIR dye within it.2. The NIR albumin nanoparticles of claim 1 , wherein said NIR dye is a cyanine dye.3. The NIR albumin nanoparticles of claim 2 , wherein said cyanine dye is a dye absorbing in the range of 700-1000 nm.4. The NIR albumin nanoparticles of claim 2 , wherein said cyanine dye is selected from ICG claim 2 , IR-820 claim 2 , IR-806 claim 2 , IR-783 claim 2 , IR-786 claim 2 , DTTCI claim 2 , Cy7 claim 2 , cypate derivatives thereof and carboxylic acid derivatives thereof (CANIR).5. The NIR albumin nanoparticles of claim 1 , wherein said contrast agent is an X-ray contrast agent claim 1 , or a CT contrast agent claim 1 , selected from iron oxide claim 1 , gold (Au) claim 1 , Barium compounds and Bismuth compounds.6. The NIR albumin nanoparticles of claim 1 , wherein said MRI-contrast agent is selected from iron oxide claim 1 , Cobalt claim 1 , Nickel and ferro-fluid.7. The NIR albumin nanoparticles of claim 1 , wherein said organic compound is an organic polymer.8. The NIR ...

POLYAMIDE NANOPARTICLES AND USES THEREOF

Nanoparticles of N-halamine-derivatized crosslinked polyamide. Process of preparing the polymeric nanoparticles per se and incorporated in or on a substrate. Uses of the polymeric nanoparticles and of substrates incorporating same, particularly for reducing a formation of organic-based contaminants, e.g., load of a microorganism or of a biofilm. 2. The article of claim 1 , being selected from the group consisting of a medical device claim 1 , organic waste processing device claim 1 , fluidic device claim 1 , water system device claim 1 , tubing claim 1 , an agricultural device claim 1 , a package claim 1 , a sealing article claim 1 , a fuel container and a construction element.3. The article of claim 1 , wherein said halogen atom claim 1 , in one or more instances claim 1 , is bound to the nitrogen belonging to said Aand/or to said A.5. The method of claim 4 , wherein said load of organic-based contaminant is selected from a load of a microorganism claim 4 , or biofilm claim 4 , said microorganism being selected from the group consisting of: viruses claim 4 , fungi claim 4 , parasites claim 4 , yeast claim 4 , bacteria claim 4 , and protozoa.6. The method of claim 5 , wherein the bacterium is selected from the group consisting of: Gram positive bacteria claim 5 , and Gram negative bacteria.7. The method of claim 6 , wherein the bacterium is selected from the group consisting of Gram negative bacteria.8. The method of claim 4 , wherein said load of organic-based contaminant is maintained substantially reduced over a period of up to at least six months.9. The method of claim 4 , further comprising one or more dehalogenating-rehalogenating cycles with halogen atoms selected from the group consisting of Cl claim 4 , Br claim 4 , and I.10. The method of claim 9 , wherein said load of organic-based contaminant is maintained substantially reduced after at least one dehalogenating-rehalogenating cycle with said halogen atom.11. The method of claim 4 , wherein said Ais ...

TARGETED MAGNETIC VEHICLES AND METHOD OF USING THE SAME

The present invention is directed to a nanoparticle including: a core of a metal chelating polymer, wherein the core is coated with at least two layers of magnetic metal oxide, which are further coated with a protein layer, and at least one active agent bound within or to the nanoparticle, methods for directing or targeting the nanoparticle via a magnetic field to a target tissue, and a computer program for efficiently generating the proper magnetic field for driving the nanoparticle to or into a given target tissue. 1. (canceled)2. (canceled)3. A method for inhibiting growth of a bevacizumab (Bev) non-responsive solid tumor or CRC tumor , comprising: (a) diagnosing a tumor in a subject afflicted with cancer as said Bev non-responsive solid tumor; (b) locally administering to the Bev non-responsive solid tumor or to the tumor's peritumoral tissue a superparamagnetic nanoparticle comprising Bev; and (c) applying a magnetic field on the tumor.4. (canceled)5. (canceled)6. The method of claim 3 , wherein the magnetic field strength is in the range 0.001 to 4 Tesla.7. The method of claim 3 , wherein the magnetic field has a magnetic field gradient of greater than 1 T/m.8. The method of claim 3 , wherein the magnetic field is a pulsating claim 3 , an oscillating or a pulsating-oscillating magnetic field.9. (canceled)10. The method of claim 3 , wherein the magnetic field is applied prior to said administering said nanoparticle.11. The method of claim 3 , wherein said magnetic field is applied in a frequency band from 10Hz to 10Hz.12. The method of claim 3 , wherein said magnetic field is applied for 2 to 8 hours.13. (canceled)14. The method of claim 3 , wherein said nanoparticle comprises a plurality of nanoparticles claim 3 , wherein said magnetic field induces contact between al least 40% of said nanoparticles and said peritumoral tissue claim 3 , said solid tumor claim 3 , said colorectal tumor claim 3 , or any combination thereof.15. (canceled)16. The method of claim 3 ...

UV-ABSORBING POLYMERIC PARTICLES

Microparticles and Nanoparticles crosslinked polymer derived from 2-(2′-hydroxy-5′-methacryloxyethylphenyl)-2H-benzotriazole or a derivative thereof, are disclosed. Process of preparing the polymeric nanoparticles per se and incorporated in or on a substrate are also disclosed. Uses of the polymeric nanoparticles and of substrates incorporating same, particularly for UV absorbing films, are also disclosed. 2. The composition-of-matter of claim 1 , wherein at least one of Rto Ris hydroxyl.4. The composition-of-matter of claim 1 , wherein said cross linker is selected from the group consisting of: tetra(ethylene glycol) diacrylate claim 1 , ethylene glycol and dimethacrylate claim 1 , divinylbenzene.5. The composition-of-matter of claim 1 , being in the form of at least one particle.6. The composition-of-matter of claim 5 , wherein said particle is characterized by at least one dimension thereof having a size selected from (i) a size of less 100 nm; and (ii) a size of 100 nm to 500 nm.7. (canceled)8. The composition-of-matter of claim 5 , wherein at least 80% of a plurality of said particles is characterized by a size that varies within a range of less than 20%.9. The composition-of-matter of claim 6 , further comprising a substrate claim 6 , wherein a plurality of said particles is incorporated or coated in/on at least a portion of said substrate.10. (canceled)11. The composition-of-matter of claim 9 , wherein said substrate is selected from the group consisting of polypropylene (PP) claim 9 , polycarbonate (PC) claim 9 , polyethylene (PE) claim 9 , polyethylene terephthalate (PET) claim 9 , high-density polyethylene (HDPE) claim 9 , low-density polyethylene (LDPE) claim 9 , polyester (PE) claim 9 , and any combination thereof.12. The composition-of-matter of claim 9 , wherein a plurality of said particle forms a layer in/on a surface of said substrate.13. (canceled)14. The composition-of-matter of claim 12 , wherein said layer is provided by a means selected from: ...

ANTIMICROBIAL POLYMERIC PARTICLES

Disclosed methyl styrene farmin compounds, and crosslinked polymeric backbones comprising same. Further disclosed microsized and nanosized polymeric particles comprising polyisothiouronium methylstyrene (PITMS) and/or poly(methyl styrene farmin) or a derivative thereof, and uses thereof in, for example, reducing or preventing growth of microorganisms. 3. (canceled)4. (canceled)6. A polymer comprising a plurality of first monomeric unit claim 1 , wherein said first monomeric unit is derived from the compound of .8. (canceled)9. The polymer of comprising a plurality of polymeric backbone represented by Formula IIIc:{'br': None, 'sub': a', 'b, 'Y—Z;'}wherein:Y represents said first monomeric unit;Z is said second monomeric unit, and wherein a and b, independently, have a value of 0, 1 or more;', 'optionally wherein said second monomeric unit is at least 1%, by weight., 'a and b are integers, each independently in each instance, represents the total numbers of Y and Z, respectively, in the polymeric backbone, and'}10. (canceled)13. (canceled)14. The polymer of claim 11 , wherein any one of:(i) the polymer further comprising a plurality of a second monomeric unit derived from a cross-linking monomer; {'br': None, 'sub': d', 'e-, 'X—F;'}, '(ii) the polymer comprising a plurality of polymeric backbone, represented by Formula Xwherein:X represents said first monomeric unit;F represents second monomeric unit derived from a cross-linking monomer;d and e are integers, each independently in each instance, represents the total numbers of X and F, respectively, in the polymeric backbone, andwherein d and e, independently, have a value of 0, 1 or more; and(iii) the polymer wherein said second monomeric unit is at least 1%, by weight;optionally wherein said cross-linking monomer is selected from the group consisting of tetra(ethylene glycol) diacrylate, ethylene glycol dimethacrylate, and divinylbenzene.1517.-. (canceled)18. A composition-of-matter comprising the polymer of .19. ...

Bisphosphonates vinylic monomers and polymers and uses thereof

A compound or a polymer is claimed. A first formula can be wherein X is H, CH 3 , CN, phenyl, substituted phenyl, (CH 2 ) m Z, or phenyl(CH 2 ) m Z; T is O, N, S or NH; m equals 1 to 20; n equals 1-100; and Z is CN, NH 2 , Thiol, OH, or CO 2 H. The second formula is: wherein X is H, CH 3 , CN, phenyl, substituted phenyl, (CH 2 ) m Z, or phenyl(CH 2 ) m Z; and Z is CN, NH 2 , Thiol, OH, or CO 2 H. The third formula is wherein: R 1 , R 2 , R 3 , and R 4 are independently: H, CH 3 , OH, or a halogen.

Bisphosphonates vinylic monomers and polymers and uses thereof

The present invention provides novel bisphosphonates vinylic monomers, polymers and particles that have utility as biologically active molecule (such as drugs) carriers, medical device coatings and for imaging/radiology applications, especially in bone and dental applications. The invention also provides methods of synthesizing the monomers, polymerizing the polymers, and assembling the particles of the invention.

IN-SITE THIN COATING OF SILICA PARTICLES ONTO PLASTIC FILMS AND THEIR APPLICATIONS

A composition comprising nano- or micro-particles grafted onto a surface are disclosed. Process of preparing the compositions and methods of using the same, such as for anti-fogging, anti-fouling and anti-scratching are provided. 1. A process for coating a substrate with a plurality of oxide particles , comprising the steps of (i) providing a substrate selected from an hydrophilic substrate , or an at least partially oxidized substrate; and (ii) contacting one or more oxide monomers with said substrate , under conditions suitable for said one or more oxide monomers to polymerize into oxide particles bound to said substrate , thereby forming a first layer of a plurality of oxide particles coating a substrate.2. The process of claim 1 , further comprising a step (iii) of washing the substrate to remove non-bound oxide particles.3. The process of claim 1 , further comprising a step (iv) of contacting one or more oxide monomers with said substrate under conditions suitable for said one or more oxide monomers to polymerize into oxide particles bound to said first layer claim 1 , thereby forming a second layer.4. The process of claim 1 , wherein said contacting is via dipping claim 1 , spraying claim 1 , spreading claim 1 , curing claim 1 , or printing.5. The process of claim 1 , wherein said one or more oxide monomers are selected from having a general formula of M(OR) claim 1 , M(R′)(OR) claim 1 , or a combination thereof claim 1 , wherein M is a metal selected from Si claim 1 , Ti claim 1 , Zn claim 1 , or Fe claim 1 , and R and R′ are each independently selected from hydrogen claim 1 , methyl claim 1 , alkyl claim 1 , alkenyl claim 1 , alkynyl claim 1 , cycloalkyl claim 1 , heteroalicyclic claim 1 , aryl claim 1 , heteroaryl claim 1 , hydroxy claim 1 , alkoxy claim 1 , aryloxy claim 1 , thiohydroxy claim 1 , thioalkoxy claim 1 , thioaryloxy claim 1 , halide claim 1 , amine claim 1 , amide claim 1 , carbonyl claim 1 , thiocarbonyl claim 1 , carboxy claim 1 , ...

PROTEINOID COMPOUNDS, PROCESS OF PREPARING SAME AND USES THEREOF

Proteinoid compounds characterized by a molecular weight (Mw) of at least 15,000 Da, processes of preparing such compounds and methods of use thereof, are provided. A method of monitoring the presence and metastases of cancer in a body of an individual is further disclosed. 1. A proteinoid compound comprising a polymeric backbone , wherein said polymeric backbone comprises monomeric units , each of said monomeric units being derived from an amino acid , and wherein said polymeric backbone is characterized by a molecular weight (Mw) of at least 15 ,000 Da.2. The proteinoid compound of claim 1 , wherein said amino acid claim 1 , in each instance claim 1 , is selected from the group consisting of: Glu claim 1 , Lys claim 1 , Asp claim 1 , Arg claim 1 , Tyr claim 1 , His claim 1 , Ala claim 1 , Phe claim 1 , Cys claim 1 , Ile claim 1 , and p-amino benzoic acid.3. The proteinoid compound of claim 1 , wherein said polymeric backbone further comprises polyester.4. The proteinoid compound of claim 3 , wherein said polyester is selected from the group consisting of polylactide claim 3 , polyglycolide claim 3 , and polycaprolactone claim 3 , polyhydroxyalkanoate.5. The proteinoid compound of claim 1 , wherein said polymeric backbone is represented by the following formula [Phe][Arg][His][Lys][A]wherein:{'sub': '4', 'Arepresents a polyester or is absent;'}n, x, y, and z are integers, independently, representing the total numbers of Phe, Arg, His, and Lys, respectively, in the polymeric backbone, such that n+x+y+z has a value of at least 100.6. The proteinoid compound of claim 1 , wherein said polymeric backbone is represented by the following formula: [A][A][A][A]wherein:{'sub': '1', 'a) A, in each instance, is selected from Glu and Lys;'}{'sub': 2', '3, 'b) A, and Aare each, independently, a monomeric unit derived from an amino acid or are each, independently, absent;'}{'sub': '4', 'c) Arepresents the polyester or is absent, and'}{'sub': 1', '2', '3, 'd) x, y, and z are ...

ANTI-FOGGING PROTEINOIDS AND COMPOSITION COMPRISING SAME

Anti-fogging proteinoid compounds are disclosed. Processes of preparing the antifogging proteinoid compositions and incorporating thereof in or on a substrate are also disclosed. Articles of manufacturing incorporating such compositions are also disclosed. 1. (canceled)2. A composition comprising: (i) at least one proteinoid compound comprising a polymeric backbone , wherein said polymeric backbone comprises monomeric units , each of said monomeric units being derived from an amino acid , and wherein said polymeric backbone is characterized by a molecular weight (Mw) of at least 5 ,000 Da , and (ii) wherein any one of:at least one proteinoid compound further encapsulates or is attached to at least one antifogging agents;the composition further comprises a substrate having incorporated in and/or on a portion thereof at least one proteinoid compound, optionally wherein the proteinoid compound encapsulates or is attached to at least one antifogging agent; andthe composition further comprises a crosslinker, and wherein the proteinoid compound comprises at least one activated double bond, at least one primary amine, or a combination thereof.3. (canceled)4. The composition of claim 2 , wherein the composition comprises a crosslinker selected from: (i) a crosslinker comprising an acrylate polymer (ii) an acrylate polymer having an average molecular weight in the range of 200 Da to 1000 Da; (iii) a crosslinker comprising a diacrylate monomer claim 2 , triacrvlate monomer or a combination thereof.5. (canceled)6. (canceled)7. The composition of claim 2 , wherein the composition comprises a crosslinker and further comprising a photo-initiator.8. The composition of claim 2 , wherein said amino acid is claim 2 , in each instance claim 2 , selected from the group consisting of: Glu claim 2 , Lys claim 2 , Asp claim 2 , Arg claim 2 , Tyr claim 2 , His claim 2 , Ala claim 2 , Ser claim 2 , Trp and Phe claim 2 , Ile claim 2 , and p-amino benzoic acid.9. The composition of claim 2 , ...

Polyglutaraldehyde microspheres

Suspension polymerization of aqueous glutaraldehyde in basic conditions in presence of surfactants such as isobutoxy acrylamide copolymers and/or cross-linking agents yield cross-linked, water insoluble glutaraldehyde polymer microspheres ranging in size from 200 A to 10μ. Addition of fluorochromes, e.g., FITC, during polymerization yields microspheres of high fluorescent intensity and addition of a suspension of metal containing particles such as Fe 3 O 4 during polymerization yields magnetic microspheres. Immunopolyglutaraldehyde microspheres can be obtained by interacting the polyglutaraldehyde microspheres with antibodies. The immunomicrospheres were used to label and separate cell subpopulations. The labeling specificity is considerably improved by increasing the amount of isobutoxy polyacrylamide incorporated in the microspheres.

Supported Microspheres

A composition of matter which comprises a solid substrate having covalent bonds to either (a) substantially a single layer of at least one species of microspheres containing residual reactive functions, or (b) a multiplicity of layers of at least one species of microspheres, wherein adjoining layers of the multiplicity of layers are covalently linked together, the innermost layer of the multiplicity of layers having the above-mentioned covalent bonds to the solid substrate connected thereto, while at least the outermost layer of the multiplicity of layers contains residual reactive functions. The covalent bonds may be provided by the same or different ligands. The compositions find potential applications not only where the use of microspheres is already known per se , but may also be used to immobilize drugs, prodrugs, enzymes, proteins, antibodies, biological cells and other controllably releasable substances.

Polymer nanoparticle coated by magnetic metal oxide and use thereof

【課題】特には腫瘍及び炎症の検出及び治療のために使用されるための、ナノ粒子及びそれを含有する医薬組成物。 【解決手段】本発明は、磁性金属酸化物で被覆された金属キレート剤であるポリマーからなるナノ粒子を提供し、ここで、少なくとも１種の活性薬剤が、該ポリマーに共有結合で結合し、前記ナノ粒子は、磁性金属酸化物の外表面に物理的に又は共有結合で結合している少なくとも１種の活性薬剤を任意選択でさらに含むことができる。 【選択図】なし

New core and core-shell nanoparticles containing iodine for x-ray imaging

Nanoparticles having an average particle size of less than 2000nm, wherein said nanoparticles comprise a polymer having pendant cleavable iodine substituted groups are provided. Processes for preparing the nanoparticles and their use as a contrast agent for X-ray imaging are also described.

Agarose-polyaldehyde beads, process for their production and their use

There are provided magnetic and non-magnetic agarose (or agar) - polyaldehyde beads with diameters ranging from 40 microns up to 1 cm, and processes for the synthesis of such beads. The polyaldehyde compounds, e.g. polyacrolein, polymethacrolein or polyglutaraldehyde, were ued as microspheres or as powders. The agarosepolyaldehyde beads are capable of covalently binding in a single step, through their aldehyde groups, compounds containing primary amino groups or thiol groups, such as proteins, antibodies, enzymes and drugs. The beads are useful for various biological applications, e.g. affinity chromatography, hemoperfusion, ion exchange resins, cell labeling, diagnostic purposes and cell separation.

Core and core-shell nanoparticles containing iodine for X-ray imaging

Nanoparticles having an average particle size of less than 2000 nm, wherein said nanoparticles comprise a polymer having pendant cleavable iodine substituted groups are provided. Processes for preparing the nanoparticles and their use as a contrast agent for X-ray imaging are also described.

Phosphonates and n-halamines compositions for tartar removal

Provided herein are compositions and methods comprising phosphonates, N-halamines or combination thereof for dental care. Specifically, for removing tartar (calculus), including mature tartar.

New core and core-shell nanoparticles containing iodine for x-ray imaging

Nanoparticles having an average particle size of less than 2000nm, wherein said nanoparticles comprise a polymer having pendant cleavable iodine substituted groups are provided. Processes for preparing the nanoparticles and their use as a contrast agent for X-ray imaging are also described.

Bioactive conjugates of polyhydroxy-polymers with amines

An article comprising immobilized protein which has been manufactured from at least one polymer containing a plurality of free hydroxy groups which is selected from the group consisting of cellulose and its functional derivatives, polysaccharides other than cellulose and their functional derivatives, and other polymers containing a plurality of free hydroxy groups, the at least one polymer being conjugated with at least one amine function of a biologically active protein which is cross-linked, provided that said manufacture includes the sequential steps of: contacting the at least one polymer in absence of reactants for hydroxy groups, with at least one N-heterocyclic compound; derivatizing the at least one polymer by reaction with at least one reactant for free hydroxy groups in the polymer, such that the resultant derivative is reactive with the at least one amine function; reacting the resultant derivative with at least one amine function in a non-cross-linked protein to form polymer-non-cross-linked protein conjugate; and cross-linking the polymer-conjugated protein in presence of non-conjugated protein by reacting conjugated and non-conjugated protein together in at least one step with cross-linking agent; further provided that the at least one amine function of a cross-linked biologically active protein includes at least one N-H bond, and still further provided that the contacting step is effected for a period of time sufficient to increase the capacity of the at least one polymer for reaction with the at least one reactant, in comparison with an analogous sequence of steps in which the contacting step is omitted.

Metal-containing polyaldehyde microspheres

A metal-containing polyaledehyde microsphere com­ posed of a polyaldehyde microsphere to which a transition metal, e.g. Au, Ag, Pt, Pd, Tc, Fe, Ni or Co, is bound may be obtained in accordance with this invention. The polyaldehy­ de, e.g. polyacrolein or polyglutaraldehyde, may be encapsu­ lated in agarose, and the mocrosphere may be radioactive or magnetic. The microphere may additionally have a com­ pound having at least one amine group, e.g. a drug, antibody, antigen, enzyme or other protein, bound to its surface. In one embodiment a transition metal is bound to a polyaldehyde microsphere by contacting the polyaldehyde microsphere with a suitable amount of an appropriate salt or acid of the transition metal under suitable conditions so as to cause the salt or acid to be reduced to a lower valence state and to bind to the microsphere. Some salts or acids may thus be reduced to the elemental state; others are further reduced with an appropriate reducing agent. In another embodiment, a transition metal in elemental form is bound to a polyaldehyde microsphere by contacting the polyaldehyde microsphere with a suitable amount of a compound capable of complexing with a salt or acid of the transition metal under suitable conditions permitting binding of the compound to the microsphere, contacting the com­ pound with an appropriate amount of an appropriate salt or acid of a transition metal under appropriate conditions permitting the compound to bind to the salt or acid, and reducing the salt or acid to the corresponding elemental metal by contacting it under effective reducing conditions and for a sufficient period of time with a sufficient amount of an effective reducing agent. The metal-containing microsphere of the invention is useful for such applications as cell labeling, cell separation, diagnostic methods, catalysis and coating methods.

Polyamide nanoparticles and uses thereof

Nanoparticles of N-halamine-derivatized crosslinked polyamide. Process of preparing the polymeric nanoparticles per se and incorporated in or on a substrate. Uses of the polymeric nanoparticles and of substrates incorporating same, particularly for reducing a formation of organic-based contaminants, e.g., load of a microorganism or of a biofilm.

NUCLEAR GENERATION AND GROWTH OF METAL OXIDE NANOPARTICLES AND USE

A method for preparing nanoparticles coated with magnetic metal oxide, comprising the following steps: a) contacting an aqueous solution containing a soluble polymeric metal chelating agent with one or more soluble metal salts providing metal ions, wherein at least one of said metal ions is capable of forming an oxide which is magnetic, said metal ions being in amounts which do not exceeed substantially the binding capacity of said chelating agent; b) causing said metal ions to be present in the oxidation states required for the formation of the oxide which is magnetic; c) maintaining the pH of the solution at the range of at least 7; d) introducing into the solution additional amounts of said metal salts; e) causing said additional metal ions to be present in the oxidation states required for the formation of the oxide which is magnetic; f) maintaining the pH of the solution at the range of at least 7; g) successively repeating the operations of steps d) to f) as many times as required to obtain monodispersed nanoparticles coated with magnetic metal oxide.

Proteinoid compounds, process of preparing same and uses thereof

Proteinoid compounds characterized by a molecular weight (Mw) of at least 15,000 Da, processes of preparing such compounds and methods of use thereof, are provided. A method of monitoring the presence and metastases of cancer in a body of an individual is further disclosed.

Aufgetragene mikrokugeln

Uv-blocking coatings and anti-fogging and superhydrophobic coatings

Compositions comprising a substrate and a silane-based polymer are disclosed. Coated substrates and articles comprising the compositions are also disclosed. Process of preparing the compositions and methods of using the same, such as for UV-blocking coatings are provided. Compositions comprising a substrate, a silane compound and a surfactant wherein a weight per weight (w/w) ratio of the silane compound and the surfactant is between 10:1 (w/w) to 40:1 (w/w) are disclosed. Coated substrates and articles comprising the compositions are also disclosed. Process of preparing the compositions and methods of using the same, such as for anti-fogging and superhydrophobic coatings are provided.

Uv-absorbing polymeric particles

Microparticles and Nanoparticles crosslinked polymer derived from 2-(2' -hydroxy-5 '-methacryloxyethylphenyl)-2H-benzotriazole or a derivative thereof, are disclosed. Process of preparing the polymeric nanoparticles per se and incorporated in or on a substrate are also disclosed. Uses of the polymeric nanoparticles and of substrates incorporating same, particularly for UV absorbing films, are also disclosed.

Biodegradable pva/pvp hydrogels, uses and preparation thereof

A hydrogel comprising a cross-linked or a non-crosslinked PVA/PVP mixed polymer hydrogel is provided, Further, articles comprising the hydrogel optionally including an active agent incorporated therewithin are also provided.

Antimicrobial polymeric particles

Disclosed methyl styrene farmin compounds, and crosslinked polymeric backbones comprising same. Further disclosed microsized and nanosized polymeric particles comprising polyisothiouronium methylstyrene (PITMS) and/or poly(methyl styrene farmin) or a derivative thereof, and uses thereof in, for example, reducing or preventing growth of microorganisms.

Biodegradable pva/pvp hydrogels, uses and preparation thereof

A hydrogel comprising a cross-linked or a non-crosslinked PVA/PVP mixed polymer hydrogel is provided, Further, articles comprising the hydrogel optionally including an active agent incorporated therewithin are also provided.

Phosphonates and n-halamines compositions for tartar removal

Provided herein are compositions and methods comprising phosphonates, N-halamines or combination thereof for dental care. Specifically, for removing tartar (calculus), including mature tartar.

Anti-fogging proteinoids and composition comprising same

Anti-fogging proteinoid compounds are disclosed. Processes of preparing antifogging proteinoid compositions and incorporating thereof in or on a substrate are disclosed. Articles of manufacturing incorporating such compositions are also disclosed.

Phosphonates and n-halamines compositions for tartar removal

Composiciones de fosfonatos y n-halaminas para eliminacion del sarro.

En la presente se proporcionan composiciones y métodos que comprenden fosfonatos, N-halaminas o una combinación de los mismos para el cuidado dental. Específicamente, para la eliminación del sarro (cálculos), incluyendo sarro maduro.

Phosphonates and n-halamines compositions for tartar removal

Provided herein are compositions and methods comprising phosphonates, N-halamines or combination thereof for dental care. Specifically, for removing tartar (calculus), including mature tartar.

Anti-fogging proteinoids and composition comprising same

Biodegradable pva/pvp hydrogels, uses and preparation thereof

A hydrogel comprising a cross-linked or a non-crosslinked PVA/PVP mixed polymer hydrogel is provided, Further, articles comprising the hydrogel optionally including an active agent incorporated therewithin are also provided.

Biodegradable pva/pvp hydrogels, uses and preparation thereof

A hydrogel comprising a cross-linked or a non-crosslinked PVA/PVP mixed polymer hydrogel is provided, Further, articles comprising the hydrogel optionally including an active agent incorporated therewithin are also provided.

Antimicrobial polymeric particles

Disclosed methyl styrene farmin compounds, and crosslinked polymeric backbones comprising same. Further disclosed microsized and nanosized polymeric particles comprising polyisothiouronium methylstyrene (PITMS) and/or poly(methyl styrene farmin) or a derivative thereof, and uses thereof in, for example, reducing or preventing growth of microorganisms.

Bisphosphonates vinylic monomers and polymers and uses thereof

The present invention provides novel bisphosphonates vinylic monomers, polymers and particles that have utility as biologically active molecule (such as drugs) carriers, medical device coatings and for imaging/radiology applications, especially in bone and dental applications. The invention also provides methods of synthesizing the monomers, polymerizing the polymers, and assembling the particles of the invention.

Engineered multifunctional particles and thin durable coatings comprising crosslinked silane polymers containing urea

Keimbildung und wachstum von metalloxid- nanopartikeln und verwendung

Engineered multifunctional particles and thin durable coatings comprising crosslinked silane polymers containing urea

Compositions comprising a silane-based polymer comprising a urea functional group and having a binding affinity to a biocide are disclosed. Coated substrates, particles and articles comprising the silane-based polymer are also disclosed. Process of preparing the compositions and methods of using the same, such as for inhibiting or reducing the formation of load of a microorganism in a plant or food product are provided.

Polyamide nanoparticles and uses thereof

Nanoparticles of N-halamine-derivatized crosslinked polyamide are disclosed. Process of preparing the polymeric nanoparticles per se and incorporated in or on a substrate are also disclosed. Uses of the polymeric nanoparticles and of substrates incorporating same, particularly for reducing a formation of organic -based contaminants, e.g., load of a microorganism or of a biofilm, are also disclosed.

Biodegradable pva/pvp hydrogels, uses and preparation thereof

A hydrogel comprising a cross-linked or a non-crosslinked PVA/PVP mixed polymer hydrogel is provided, Further, articles comprising the hydrogel optionally including an active agent incorporated therewithin are also provided.

Bisphosphonates vinylic monomers and polymers and uses thereof

The present invention provides novel bisphosphonates vinylic monomers, polymers and particles that have utility as biologically active molecule (such as drugs) carriers, medical device coatings and for imaging/radiology applications, especially in bone and dental applications. The invention also provides methods of synthesizing the monomers, polymerizing the polymers, and assembling the particles of the invention.