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Применить Всего найдено 4. Отображено 4.
25-06-2014 дата публикации

Chemical synthesis method of methyl 3-methyl-5-pyrazolylformate

Номер: CN103880749A
Автор: TANG YANFENG, DING XINYU, SHAN JIAHUI, YU HONGMEI, WANG SHUQING, MAO JIARONG, GUO XIAOQING
Принадлежит:

The invention relates to a chemical synthesis method of methyl 3-methyl-5-pyrazolylformate.3-methylpyrazole used as the raw material is subjected to reactive hydrogen protection, carboxylation, esterification and deprotection to prepare the methyl 3-methyl-5-pyrazolylformate. The chemical synthesis method comprises the following steps: adding 3-methylpyrazole, p-methoxycyclite and sodium hydride into an N,N-dimethylformamide or dimethylsulfoxide organic solvent, and reacting to prepare 1-(4'-methoxybenzyl)-3-methylpyrazole; adding into a tetrahydrofuran organic solvent, reacting at certain temperature, and adding into dry ice after the reaction finishes to prepare 1-(4'-methoxybenzyl)-3-methyl-5-pyrazolylformic acid; adding thionyl chloride to react to obtain methyl 1-(4'-methoxybenzyl)-3-methyl-5-pyrazolylformate; and adding trifluoroacetic acid, and reacting at certain temperature to obtain the methyl 3-methyl-5-pyrazolylformate. The invention provides a high-efficiency synthesis method ...

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Номер записи: 1
25-06-2014 дата публикации

Chemical synthetic method for (s)-3-(Boc-amino)azacycloheptane

Номер: CN103880746A
Автор: TANG YANFENG, WANG MIAO, DING JINJIN, ZHU JINLI, SUN TONGMING, MAO JIARONG, GUO XIAOQING
Принадлежит:

The invention relates to a chemical synthetic method for (s)-3-(Boc-amino)azacycloheptane. The (s)-3-(Boc-amino)azacycloheptane is synthesized through esterification, cyclization, reduction, protection and deprotection by taking L-lysine as a raw material. The method comprises the steps of adding L-lysine into ethanol, adding a catalyst concentrated sulfuric acid, reacting to a reflux state, and esterifying to prepare L-lysine ester; adding the L-lysine ester into ethanol, and reacting to synthesize (s)-3-aminocyclocaprolactam; adding (s)-3-aminocyclocaprolactam and lithium aluminum hydride into a tetrahydrofuran solvent, reacting and controlling to be in a reflux state, and performing reduction reaction to obtain (s)-3-amino-azacycloheptane; reacting to prepare (s)-3-(N'-cbz-amino)-1-N-cbz-azacycloheptane; reacting to obtain (s)-3-(N'-Boc-N'-cbz-amino)-1-N-cbz-azacycloheptane; reacting to obtain the (s)-3-(Boc-amino)azacycloheptane. The synthesis method utilizes the chirality of amino ...

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Номер записи: 2
02-07-2014 дата публикации

2-Cyano-3-cyclobutylpyridine and chemical synthesis method thereof

Номер: CN103896834A
Автор: TANG YANFENG, SUN TONGMING, WANG MIAO, DING JINJIN, ZHU JINLI, MAO JIARONG, GUO XIAOQING
Принадлежит:

The invention relates to a 2-cyano-3-cyclobutylpyridine and a chemical synthesis method thereof. According to the method, The 2-cyano-3-cyclobutylpyridine is prepared from 3-bromo-2-methylpyridine by virtue of four steps of reactions. The method is high in synthesis route yield and simple and convenient to operate.

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Номер записи: 3
25-06-2014 дата публикации

Chemical synthesis method of 3-cyclobutylmorpholine

Номер: CN103880768A
Автор: TANG YANFENG, DING JINJIN, ZHU JINLI, SUN TONGMING, WANG MIAO, MAO JIARONG, GUO XIAOQING
Принадлежит:

The invention relates to a chemical synthesis method of 3-cyclobutylmorpholine. The method comprises the following steps: adding cyclobutyl formaldehyde, ammonium sulfate, aqua ammonia and cyanide into a methanol or ethanol solvent, and reacting at controlled temperature to obtain aminocyclobutyl acetonitrile; adding the aminocyclobutyl acetonitrile into hydrochloric acid, and hydrolyzing to obtain aminocyclobutyl acetic acid; adding the aminocyclobutyl acetic acid into hydrochloric acid ethanol, and reacting to prepare ethyl aminocyclobutyl acetate; dissolving the ethyl aminocyclobutyl acetate and triethylamine in a tetrahydrofuran solvent, adding chloracetyl chloride, and reacting at controlled temperature to obtain ethyl 2-cyclobutyl-2-chloropropionamidoacetate; obtaining N-(1-cyclobutyl-2-hydroxymethylethyl)chloropropanamide; obtaining 5-cyclobutylmorpholinyl-3-one; and obtaining the 3-cyclobutylmorpholine. The cyclobutyl formaldehyde used as the raw material is subjected to seven reactions ...

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Номер записи: 4