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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
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Применить Всего найдено 11. Отображено 11.
12-10-2017 дата публикации

SMALL MOLECULE REGULATORS OF STEROID RECEPTOR COACTIVATORS AND METHODS OF USE THEREOF

Номер: US20170290830A1
Автор: Bert W. O'Malley, David Michael Lonard, Jin Wang, Jianming Xu, Jianwei Chen, O'MALLEY BERT W, LONARD DAVID MICHAEL, WANG JIN, XU JIANMING, CHEN JIANWEI, O'Malley Bert W., Lonard David Michael, Wang Jin, Xu Jianming, Chen Jianwei
Принадлежит: BAYLOR COLLEGE OF MEDICINE

Small molecule regulators of steroid receptor coactivator (SRC) family proteins are provided, as well as methods for their use in treating or preventing SRC-related diseases. The SRC-related diseases can include cancer, metabolic disorders, human immunodeficiency virus, neurodegenerative disorders, and/or inflammatory diseases. Also provided are methods for regulating SRC family proteins in a cell.

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Номер записи: 1
04-01-2018 дата публикации

BUFALIN PHOSPHATE PRODRUGS AND METHODS OF USE THEREOF

Номер: US20180002371A1
Автор: "OMALLEY Bert W.", Lonard David Michael, Palzkill Timothy Gerald, Wang Jin, XU Jianming
Принадлежит: Baylor College of Medicine

Bufalin phosphate prodrugs are provided herein, as well as methods for their use as small molecule inhibitors of steroid receptor coactivator (SRC) family proteins. Methods for using bufalin phosphate prodrugs in treating or preventing cancer are also provided herein. 5. The compound of claim 4 , wherein the cation is a metal cation.6. The compound of claim 5 , wherein the metal cation is an alkali metal cation or an alkaline earth metal cation.7. The compound of claim 4 , wherein X is selected from the group consisting of Na claim 4 , K claim 4 , Li claim 4 , and NH.10. A composition comprising a compound of and a pharmaceutically acceptable carrier.11. (canceled)12. A method of treating or preventing a steroid receptor coactivator-related disease in a subject claim 1 , comprising:{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, 'administering to the subject an effective amount of a compound of .'}13. The method of claim 12 , wherein the steroid receptor coactivator-related disease is cancer claim 12 , obesity claim 12 , or human immunodeficiency virus.14. The method of claim 13 , wherein the steroid receptor coactivator-related disease is cancer and the cancer is a poor prognosis or invasive cancer claim 13 , breast cancer claim 13 , pancreatic cancer claim 13 , glioblastoma claim 13 , liver cancer claim 13 , lung cancer claim 13 , pancreatic cancer claim 13 , or prostate cancer.15. (canceled)16. The method of claim 14 , wherein the cancer is breast cancer and the breast cancer is triple negative breast cancer.17. (canceled)18. (canceled)19. The method of claim 14 , wherein the cancer is glioblastoma and the glioblastoma is a glioblastoma multiforme tumor.20. The method of claim 19 , wherein the glioblastoma multiforme tumor is a pediatric glioblastoma multiforme tumor.21. (canceled)22. (canceled)23. (canceled)24. (canceled)25. The method of claim 12 , further comprising administering a second compound or composition.26. The method of claim 25 , wherein the ...

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Номер записи: 2
05-03-2020 дата публикации

Small Molecule Stimulators of Steroid Receptor Coactivator-3 and Methods of Their Use as Cardioprotective and/or Vascular Regenerative Agents

Номер: US20200071300A1
Автор: Bert W. O'malley, David Michael LONARD, Yongcheng Song
Принадлежит: Baylor College of Medicine

Small molecule stimulators of steroid receptor coactivator-3 (SRC-3) and methods of their use as cardioprotective agents are provided. The small molecule stimulators are useful for promoting cardiac protection and repair and vascular regeneration after myocardial infarction. The compounds are also useful in preventing cardiac hypertrophy and collagen deposition and improving cardiac post-infarction function.

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Номер записи: 3
19-03-2020 дата публикации

SMALL MOLECULE REGULATORS OF STEROID RECEPTOR COACTIVATORS AND METHODS OF USE THEREOF

Номер: US20200085824A1
Автор: "OMALLEY Bert W.", Chen Jianwei, Lonard David Michael, Wang Jin, XU Jianming
Принадлежит: Baylor College of Medicine

Small molecule regulators of steroid receptor coactivator (SRC) family proteins are provided, as well as methods for their use in treating or preventing SRC-related diseases. The SRC-related diseases can include cancer, metabolic disorders, human immunodeficiency virus, neurodegenerative disorders, and/or inflammatory diseases. Also provided are methods for regulating SRC family proteins in a cell. 3. The compound of claim 2 , wherein each R is hydrogen or substituted or unsubstituted alkyl.5. The compound of claim 4 , wherein R claim 4 , R claim 4 , and Rare each independently selected from hydrogen and halogen.6. A tautomer of the compound of .13. The compound of claim 1 , wherein the compound is isotopically substituted with a stable isotope.14. The compound of claim 13 , wherein the stable isotope is selected from the group consisting of deuterium claim 13 , C claim 13 , N claim 13 , and O.15. A composition comprising a compound of and a pharmaceutically acceptable carrier.16. A kit comprising a compound of .17. A method of treating or preventing a steroid receptor coactivator-related disease in a subject claim 1 , comprising:{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, 'administering to the subject an effective amount of a compound of .'}18. The method of claim 17 , wherein the steroid receptor coactivator-related disease is cancer claim 17 , a metabolic disorder claim 17 , human immunodeficiency virus claim 17 , a neurodegenerative disorder claim 17 , or an inflammatory disease.19. The method of claim 17 , wherein the steroid receptor coactivator is SRC-1 claim 17 , SRC-2 claim 17 , or SRC-3.20. The method of claim 17 , further comprising administering a second compound or composition.21. The method of claim 20 , wherein the second compound or composition is a chemotherapeutic agent.22. A method of regulating a steroid receptor coactivator protein in a cell claim 20 , comprising:{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, 'contacting a cell with an ...

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Номер записи: 4
18-07-2019 дата публикации

Small molecule regulators of steroid receptor coactivators and methods of use thereof

Номер: US20190216810A1
Автор: Bert W. O'malley, David Michael LONARD, Jianming Xu, Jianwei Chen, JIN Wang
Принадлежит: Baylor College of Medicine

Small molecule regulators of steroid receptor coactivator (SRC) family proteins are provided, as well as methods for their use in treating or preventing SRC-related diseases. The SRC-related diseases can include cancer, metabolic disorders, human immunodeficiency virus, neurodegenerative disorders, and/or inflammatory diseases. Also provided are methods for regulating SRC family proteins in a cell.

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Номер записи: 5
20-09-2018 дата публикации

SMALL MOLECULE STIMULATORS OF STEROID RECEPTOR COACTIVATOR PROTEINS AND THEIR USE IN THE TREATMENT OF CANCER

Номер: US20180265444A1
Автор: "OMALLEY Bert W.", Li Xiaonan, Lonard David Michael, Palzkill Timothy Gerald, Song Yongcheng, Wang Lei, XU Jianming
Принадлежит: Baylor College of Medicine

Small molecule stimulators of steroid receptor coactivator (SRC) family proteins are provided, as well as methods for their use in treating or preventing cancer. Also provided are methods for stimulating SRC family proteins in a cell. 5. The method of claim 1 , wherein the cancer is glioblastoma.6. The method of claim 5 , wherein the glioblastoma is a glioblastoma multiforme tumor.7. The method of claim 6 , wherein the glioblastoma multiforme tumor is a pediatric glioblastoma multiforme tumor.8. The method of claim 1 , wherein the cancer is selected from the group consisting of breast cancer claim 1 , liver cancer claim 1 , lung cancer claim 1 , pancreatic cancer claim 1 , and prostate cancer.13. The method of claim 11 , wherein the steroid receptor coactivator protein is SRC-1.14. The method of claim 11 , wherein the steroid receptor coactivator protein is SRC-2.15. The method of claim 11 , wherein the steroid receptor coactivator protein is SRC-3.16. The method of claim 9 , wherein the method is performed in vitro.17. The method of claim 9 , wherein the method is performed in vivo. This application claims priority to U.S. Provisional Application No. 62/097,995, filed Dec. 30, 2014, which is incorporated herein by reference in its entirety.This invention was made with government support under Grant No. DOD BC120894, awarded by the Department of Defense, and Grant Nos. DK059820 and HD076596, awarded by the National Institutes of Health. The government has certain rights in the invention.Members of the p160 steroid receptor coactivator (SRC) family, SRC-1, SRC-2/TIF2/GRIP1, and SRC-3/AM1/RAC3/ACTR/pCIP, interact with nuclear receptors and other transcription factors to drive target gene expression while also functioning as integrators of upstream cell signaling pathways. Although the proteins share homology with each other, they have distinct and important roles in multiple physiological processes, including growth and development, reproduction, and metabolism. All ...

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Номер записи: 6
12-10-2017 дата публикации

Small molecule regulators of steroid receptor coactivators and methods of use thereof

Номер: CA3019948A1
Автор: Bert W. O'malley, David Michael LONARD, Jianming Xu, Jianwei Chen, JIN Wang
Принадлежит: Baylor College of Medicine

Small molecule regulators of steroid receptor coactivator (SRC) family proteins are provided, as well as methods for their use in treating or preventing SRC-related diseases. The SRC-related diseases can include cancer, metabolic disorders, human immunodeficiency virus, neurodegenerative disorders, and/or inflammatory diseases. Also provided are methods for regulating SRC family proteins in a cell.

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Номер записи: 7
07-07-2021 дата публикации

Small molecule stimulators of steroid receptor coactivator-3 and methods of their use as cardioprotective and/or vascular regenerative agents

Номер: EP3843843A1
Автор: Bert W. O'malley, David Michael LONARD, Yongcheng Song
Принадлежит: Baylor College of Medicine

Small molecule stimulators of steroid receptor coactivator-3 (SRC-3) and methods of their use as cardioprotective agents are provided. The small molecule stimulators are useful for promoting cardiac protection and repair and vascular regeneration after myocardial infarction. The compounds are also useful in preventing cardiac hypertrophy and collagen deposition and improving cardiac post-infarction function.

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Номер записи: 8
24-12-2019 дата публикации

Small molecule regulators of steroid receptor coactivators and methods of use thereof

Номер: US10512647B2
Автор: Bert W. O'malley, David Michael LONARD, Jianming Xu, Jianwei Chen, JIN Wang
Принадлежит: Baylor College of Medicine

Small molecule regulators of steroid receptor coactivator (SRC) family proteins are provided, as well as methods for their use in treating or preventing SRC-related diseases. The SRC-related diseases can include cancer, metabolic disorders, human immunodeficiency virus, neurodegenerative disorders, and/or inflammatory diseases. Also provided are methods for regulating SRC family proteins in a cell.

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Номер записи: 9
13-02-2019 дата публикации

Small molecule regulators of steroid receptor coactivators and methods of use thereof

Номер: EP3440074A1
Автор: Bert W. O'malley, David Michael LONARD, Jianming Xu, Jianwei Chen, JIN Wang
Принадлежит: Baylor College of Medicine

Small molecule regulators of steroid receptor coactivator (SRC) family proteins are provided, as well as methods for their use in treating or preventing SRC-related diseases. The SRC-related diseases can include cancer, metabolic disorders, human immunodeficiency virus, neurodegenerative disorders, and/or inflammatory diseases. Also provided are methods for regulating SRC family proteins in a cell.

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Номер записи: 10
09-11-2023 дата публикации

Small molecule stimulators of steroid receptor coactivator-3 and methods of their use as cardioprotective and/or vascular regenerative agents

Номер: US20230357200A1
Автор: Bert W. O'malley, David Michael LONARD, Yongcheng Song
Принадлежит: Baylor College of Medicine

Small molecule stimulators of steroid receptor coactivator-3 (SRC-3) and methods of their use as cardioprotective agents are provided. The small molecule stimulators are useful for promoting cardiac protection and repair and vascular regeneration after myocardial infarction. The compounds are also useful in preventing cardiac hypertrophy and collagen deposition and improving cardiac post-infarction function.

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Номер записи: 11