Sulfamide derivatives and preparation method and use thereof

The present invention discloses a compound shown in formula I or a stereoisomer, pharmaceutically acceptable salt, crystal form, solvate or isotopologue thereof. The compound of the present invention shows excellent inhibition activity against histone deacetylases, has remarkable inhibition effects on cancer cells, and provides a new choice of drugs used for the clinic treatment and diseases related to the abnormal activity of histone deacetylases.

SULFAMIDE DERIVATIVES AND PREPARATION METHOD AND USE THEREOF

The present invention discloses a compound shown in formula I or a stereoisomer, pharmaceutically acceptable salt, crystal form, solvate or isotopologue thereof. The compound of the present invention shows excellent inhibition activity against histone deacetylases, has remarkable inhibition effects on cancer cells, and provides a new choice of drugs used for the clinic treatment and diseases related to the abnormal activity of histone deacetylases.

INJECTABLE SMART GEL AND METHOD FOR FABRICATING THE SAME

An injectable smart gel and a method for fabricating the same are disclosed. A basic structural stabilizer/polymeric electrolyte and a diluting solution are added to a modified chitosan to regulate the chitosan solution to have a pH value closing to that of the human body and form a flowable chitosan sol. The flowable chitosan sols formed thereby are respectively converted into inflowable chitosan gels via increasing the temperature thereof to the human body temperature, and via adding calcium ion or regulating the chitosan sol into an acidic solution. The injectable smart gel fabricated thereby is injectable and able to function as a carrier of magnetism-sensitive medicine-containing nanocapsules. The medicine can be released to the injectable smart gel with an external non-contact force, such as a magnetic field, an electric field or an ultrasonic wave, for long-acting and multi-stage medicine delivery. The present invention is very useful in biomedical engineering. 1. A method for fabricating an injectable smart gel , comprising steps:providing a hydrophobically-modified or amphiphilically-modified chitosan solution with a concentration of 0.1-10% (w/v); andat a temperature of 4-20° C., adding 0.1-10% (w/v) of a basic structural stabilizer and 80-99.5% (w/v) of a diluting solution to said modified chitosan solution to regulate said modified chitosan solution to have a pH value of 5-9 and form a near-neutrality chitosan sol, which becomes a solid chitosan gel when temperature rises to 30-40° C.2. The method for fabricating an injectable smart gel according to claim 1 , wherein said diluting solution is water or a mixture of water and an oil-like compound claim 1 , and wherein said oil-like compound is selected from a group consisting of DMSO (dimethyl sulfoxide) claim 1 , alcohol claim 1 , glycol and glycerin.3. The method for fabricating an injectable smart gel according to claim 1 , wherein said basic structural stabilizer is selected from a group consisting of ...

Motor sleeve and motor device

A motor sleeve is applied to a motor housing and a motor driver housing. The motor sleeve includes a sleeve base, a second fixing structure, a second coupling structure, a plurality of base fins, a sleeve chassis, a plurality of chassis fins, and a third fixing structure. The second fixing structure is disposed on an inner surface of the sleeve base and correspondingly fixed to a first fixing structure of the motor housing. The sleeve base is installed on a lateral portion of the motor housing. The base fins are separately disposed on an outer surface of the sleeve base and corresponding to a first coupling structure of the motor driver housing. The motor driver housing is coupled to the sleeve base by the first and second coupling structures. The third fixing structure is correspondingly fixed to a fourth fixing structure of the motor housing.

Lighting device

A lighting device includes a light emitting unit, a first hollow tube, a second hollow tube, multiple brackets, multiple supports, and a wire. The first hollow tube has a first pivot portion. The second hollow tube has a second pivot portion and is mounted around the first hollow tube. A first end of at least one bracket is pivotally connected to the first pivot portion. A first end of at least one support is pivotally connected to the second pivot portion. The wire passes through the first hollow tube, and one end of the wire is electrically connected to the light emitting unit. A second end of at least one support is configured with a first connecting portion, a second end of at least one bracket is configured with a second connecting portion, and the first connecting portion is pivotally connected to the second connecting portion.

Pushing force-actuated braking device and rotary table using the same

A pushing force-actuated braking device includes an annular housing that houses a brake disc, a braking piston, plural braking elements, and a brake-releasing piston. When only the braking piston is under the action of a fluid, the braking piston applies an axial pushing force to the brake disc such that the brake disc is kept at a braking position jointly by the braking piston and the braking elements. When only the brake-releasing piston is under the action of a fluid, the brake-releasing piston applies an opposite pushing force to the brake disc to keep it at a brake-releasing position. Should the fluid acting on the braking piston fail, the force of the braking elements still enables the brake disc to produce a braking effect. The pushing force-actuated braking device has a modular design to facilitate assembly and disassembly. A rotary table using the braking device is also provided.

Systems and methods for automated classification of subtyping of leukemia cells

This application relates generally to automated systems and methods for classifying subtypes of leukemia cells and other applications therefrom.

Chimeric hemagglutinin protein and a vaccine composition comprising the same

Provided is a chimeric hemagglutinin (HA) protein including an HA1 subunit and an HA2 subunit, in which the HA1 subunit is composed of a first domain derived from a parental HA1 subunit of a first subtype influenza virus and a second domain derived from a parental HA1 subunit of a second subtype influenza virus. The chimeric HA protein has improved thermal stability and can be used in a vaccine composition for preventing influenza virus infection. Also provided is a method of inducing an immune response against an influenza virus in a subject in need thereof that includes administering the chimeric HA protein to the subject, thereby conferring protection against the influenza virus infection on the subject.

Gate driver and liquid crystal display using the same

A gate driver and a liquid crystal display using the same are provided. The gate driver includes a scan signal generating unit and a compensation unit. The scan signal generating unit has a plurality of output channels, and is used for sequentially outputting a scan signal through the output channels according to a basic clock and a start pulse. The compensation unit is coupled to the scan signal generating unit, and used for compensating the total resistance of each of the output channels, and sequentially receiving and transmitting the scan signal to a display panel.

Face tracking method and apparatus, and storage medium

A method of tracking a face includes determining a current frame from video stream data in response to receiving a face tracking instruction; detecting a position of a face in the current frame, and obtaining a historical motion trajectory of the face in the current frame; predicting the position of the face in the current frame based on the historical motion trajectory to obtain a predicted position of the face; obtaining a correlation matrix of the historical motion trajectory and the face in the current frame based on the predicted position and the detected position; and updating the historical motion trajectory based on the correlation matrix, and tracking the face in a next frame based on the updated historical motion trajectory.

Methods of detecting listeria from an environmental sample

Detection of Listeria from an environmental sample is described herein. In particular, the detection can be completed with results available the same day or same work shift, e.g., in about 12 hours or less, or about 6 to 10 hours. The Same Day detection utilizes a short incubation period and/or concentration steps coupled with a rapid detection assay to produce same day results.

Compact bearing system and machine stage system equipping the same

A compact bearing system capable of variable load carrying capability and precision motion on a guideway includes a bearing body, a fluid medium, a sealing bearing member and a pressurizing actuation means installed as an integral part of the bearing body. The bearing body includes an internal pocket with an open side facing a surface of said guideway. The fluid medium is contained inside said internal pocket and is in contact with said surface of said guideway on said open side. The sealing bearing member is in contact with said surface of said guideway and seals a clearance between said bearing body and said surface of said guideway to limit leakage of said fluid medium. The pressurizing actuation means pressurizes the confined fluid medium through a small passage, and the pressurized fluid medium carrying a main portion of a load carried on said compact bearing system.

Stuffed pads for a tape measure housing

Disclosed herein are stuffed pads for a tape measure bonded to surface of a tape measure housing with a binder or with various types of engaging slot made in the form of a recessed slot, a T shaped slot or a pit type slot etc. The inner cavity of the stuffed pad being filled with shock absorption materials is able to buffer a direct impact to the tape measure housing and protect the housing from cracking, breaking or being totally destroyed. Furthermore, the stuffed pad ensures both shock and slip resistant properties of the tape measure housing but never degrades the appearance of the tape measure or affects the grip comfortableness of the surface of a tape measure housing. The life time of a tape measure equipped with such stuffed pads will surely be lengthened.

Nitride light-emitting diode and mthod for manufacturing the same

Systems and methods for frequency domain realization of non-integer fractionally spaced time domain equalization

Various systems and methods are described for performing fractionally spaced time domain equalization (TEQ). One embodiment is a method implemented in a communication system for training a fractionally spaced time domain equalizer (TEQ). The method comprises performing an initialization phase, averaging a received signal in the system to reduce effects of noise in a channel, determining a channel estimate, and aligning an ideal reference signal with the received signal. The method further comprises updating a target response filter according to a non-integer multiple of a base sampling rate, determining an adaptation error based on useful information both inside and outside a Nyquist band of the TEQ, and updating the TEQ according to the adaptation error.

Structure for a tape measure

An improved structure for a tape measure includes a measuring tape, a tape measure framework, and a control apparatus, wherein the control apparatus includes a release key and a stopper. The withdrawal motion of the measuring tape can be performed by simply pressing the release key of the control apparatus with one of the user's fringer. Namely, when measuring length of an object, the user may pull out the measuring tape to a length slightly longer than the estimated value, and does not have to worry about the tape suddenly withdrawing automatically. When the tape is to be withdrawn, the user may presses lightly the release key of the control apparatus. The withdrawal of the tape may be halted by releasing the release key to actuate control function of the control apparatus.

Patent TWI366601B

Anti-loose buckle and pipe joint applying the same

本發明係提供一種防鬆扣具及應用其之管接頭，用於安裝在管接頭本體的二側，能夠扣住插入的一接嘴，其包含一樞接在管接頭本體的扣合把手，扣合把手一端具有一扣合凸部，另一端具有一操作柄；一滑動地套設在操作柄的擋止元件，一連接在擋止元件與管接頭本體的連動元件，及一設置在操作柄的限位元件。當扣合把手在扣合狀態下致使擋止元件的下面抵靠在限位元件上，使扣合把手不能反向鬆開，只有當限位元件被拉動離開擋止元件的下面時，才能使扣合把手能夠反向鬆開，藉此使扣合把手具有防鬆功能，且操作方式更簡易。

Programmable control and operation equipment of swing pressure adsorption process

A programmable control and operation system is applied in a swing pressure adsorption process. The system comprises a computer, a driving device, and a plurality of programmable control valve assemblies. The programmable control valve assembly comprises an operating valve with at least one cavity for sealing control, a valve core, a sealing ring, an operation device, a sealing control valve, and a valve position detector. The operation of the sealing control valve is dependent on the open or closed position of the valve and the process of opening and closing the valve. The sealing control valve feeds a sealing control medium at a pressure to the cavity for sealing the operating valve. The sealing control medium acts on the sealing ring to increase the pressure at the valve core to seal the operating valve. The control and operation system provide independent control of the sealing valve and operating valve to increase reliability and durability.

Battery balance circuit

A tape measure structure with improved brake device

The present invention discloses a tape measure structure with improved brake device wherein the tape measure comprises a tape; an enclosure; and a brake device which further includes a release key and two brake shoes. By means of the above combination, the withdrawal motion of the tape can be controlled by the user through simply pressing the release key with his finger. It means that the user may pull out the tape to approximately estimated length he desires for measurement without worrying about that the tape might automatically bounce back. Then afterwards he may press lightly the release key to withdraw the tape gradually and stops pressing the release key as soon as the tape reaches to the accurately desired length, the tape will be halted there by the control effect of the brake device.

Method of inspection for pixel array substrate and inspection apparatus for pixel array substrate

Manufacturing method of platinum nanoparticles solution and self-assembled platinum counter electrode

Sulfonamide derivative and method of preparation and use thereof

La presente invención revela un compuesto que se muestra en la fórmula I o un estereoisómero, sal farmacéuticamente aceptable, forma de cristal, solvatado o isotopólogo del mismo. El compuesto de la presente invención muestra una excelente actividad de inhibición contra las histonas desacetilasas, tiene efectos de inhibición notables en las células cancerosas y proporciona una nueva opción de medicamentos utilizados para el tratamiento clínico y las enfermedades relacionadas con la actividad anormal de las histonas desacetilasas. (Traducción automática con Google Translate, sin valor legal) The present invention discloses a compound shown in formula I or a stereoisomer, pharmaceutically acceptable salt, crystal form, solvate or isotopologue thereof. The compound of the present invention shows excellent inhibition activity against histone deacetylases, has remarkable inhibition effects on cancer cells, and provides a new drug option used for clinical treatment and diseases related to abnormal activity of histone deacetylases. . (Automatic translation with Google Translate, without legal value)

Copper wire bond on gold bump on semiconductor die bond pad

A semiconductor package includes a conductive pad, a semiconductor die with an aluminum bond pad over a dielectric layer of the semiconductor die, a gold bump on the aluminum bond pad, a first intermetallic layer of gold and aluminum between the aluminum bond pad and the gold bump, a copper ball bond on the gold bump, a second intermetallic layer of copper and gold between the copper ball bond and the gold bump, a copper wire extending from the copper ball bond to the conductive pad, a stitch bond between the copper wire and the conductive pad.

Tape measure with innovated brake structure

A tape measure with innovated brake structure characterized in that the brake mechanism comprises a release key, a brake, and a stopper. The upper end of the brake is in connection with the release key, and an intermediate protrusion of the brake directly presses its upper end so as to control the stopper able to be tightly pressing the tape surface against a stop block provided thereunder. By the above described structure, the user may press the release key with a finger to retract the extended tape after measurement work has been completed. When the release key is released, the brake actuates the stopper to directly press the tape surface against the stop block thereby halting the tape therebetween and the braking function is thus performed.

Systems and methods for prognosis prediction of acute myeloid leukemia patients

This application relates generally to a computer implemented method comprising: receiving a medical record data from a patient, wherein said record comprising a static attribute and a time dependent progression attribute; processing the time dependent progression attributes of medical record data using a trained neural network to into time-series representation, and converting the static attributes into static variables; combining the time-series representation and static variables to multiple vectors; providing a prognosis outcome by a trained classifier using said multiple vectors; wherein the neural network is trained by steps of (a) assembling a training data set comprising a retrospective collection of patients' medical record data wherein said record data comprising collected number of static attributes, time dependent progression attributes and patients' mortality and relapse outcomes; (b) processing the time dependent progression attributes of the training data set using a neural network to convert the time dependent progression attributes into time-series representation; (c) processing the static attributes of the training data set into static variables; and (d) combining the time-series representation and static variables to train a classifier based on the combined time-series representation and static variables.

Tape measure structure with improved brake device

A tape measure structure includes a tape, an enclosure, and a brake device which further includes a release key and a first and second brake shoes. By means of the above combination, the retraction motion of the tape can be controlled by the user through simply pressing the release key with his finger. It means that the user may pull out the tape to approximately estimated length he desires for measurement without worrying about that tape might automatically bounce back. Then, afterwards, he may press lightly the release key for retracting the tape gradually and stop pressing the release key as soon as the tape reaches to the accurately desired length, the tape will be halted there by the control effect of the brake device.

Piercing tools

Manufacturing method of platinum nanoparticles solution and self-assembled platinum counter electrode

一種鉑奈米粒子溶液及自組裝鉑對電極之製備方法，採用多元醇還原法並搭配適當的酸鹼值條件，便能調控還原反應的進行，來製作出尺寸極小且均勻分散之鉑奈米粒子及其溶液，接著，即可利用常溫浸泡方式，讓鉑奈米粒子自組裝吸附於經由表面官能化處理後的導電基材表面，來形成鉑奈米粒子單層結構，藉以獲得具有均勻單層表面的自組裝鉑對電極。由於本發明製程簡易，鉑的使用量極低，過程中不需添加任何穩定劑，且後續無需再進行熱處理，將有助於降低應用至染料敏化太陽能電池商業量產化的成本。

Methods of detecting listeria from an environmental sample

Detection of Listeria from an environmental sample is described herein. In particular, the detection can be completed with results available the same day or same work shift, e.g., in about 12 hours or less, or about 6 to 10 hours. The Same Day detection utilizes a short incubation period and/or concentration steps coupled with a rapid detection assay to produce same day results.

Supporting stand and portable device with the supporting stand

Electronic game machine

Delivery and deployment of a prostatic implant

Devices and methods are disclosed for managing and/or treating body tissues obstructing a hollow body lumen, including the prostatic lobe tissues obstructing the urethra, for example conditions including benign prostatic hyperplasia (BPH), bladder outlet obstruction (BOO), benign prostatic obstruction (BPO) and associated lower urinary tract symptoms (LUTS). A prostatic implant deployment and delivery system may have a controlled release mechanism, a handle mechanism and an irrigation system. The controlled release mechanism includes a disengageable connection between a pusher member and the prostatic implant with a control member. The handle mechanism includes a plunger for advancing the pusher member and an actuator for withdrawing the control member. The irrigation system may define two fluid paths.

Information display method and apparatus, electronic device, and computer storage medium

Embodiments of the disclosure provide an information display method and apparatus, an electronic device, and a computer storage medium. The method includes: obtaining a motion status of a target object at a current moment in a virtual scene and a first operation for controlling the target object to move in the virtual scene; predicting a first moving track along which the target object is to move within a period of time after the current moment based on the motion status of the target object at the current moment and the first operation; and displaying the first moving track and a second moving track, the second moving track being a moving track along which the target object has moved before the current moment.

Information display method and apparatus, electronic device, and computer storage medium

Embodiments of the disclosure provide an information display method and apparatus, an electronic device, and a computer storage medium. The method includes: obtaining a motion status of a target object at a current moment in a virtual scene and a first operation for controlling the target object to move in the virtual scene; predicting a first moving track along which the target object is to move within a period of time after the current moment based on the motion status of the target object at the current moment and the first operation; and displaying the first moving track and a second moving track, the second moving track being a moving track along which the target object has moved before the current moment.

10H-phenothiazine ferroptosis inhibitor and preparation method therefor and application thereof

Disclosed are 10H-phenothiazine derivatives capable of inhibiting ferroptosis, or pharmaceutically acceptable salts thereof, or crystal forms thereof, or solvates thereof as shown in formula (I), and a preparation method therefor and applications thereof. The derivatives take a good inhibitory effect on ferroptosis, show a good therapeutic effect on a rat model of focal cerebral ischemia and thus can be used as a main active ingredient in the preparation of ferroptosis inhibitors. All the derivatives have good medicinal potential and are expected to be used as drug candidates for the treatment of stroke. The preparation method is simple, the reaction condition is mild, the operation and the control are convenient, the energy consumption is small, the yield is high, the cost is low, and the product is thus suitable for industrial production.

掃描裝置

一種掃描裝置係用於掃描混合螢光染料的生物樣本，其包含機殼、樣本平台、光源模組、影像擷取單元、驅動單元與濾波單元。該機殼係提供容置空間用以容置該樣本平台，而該光源模組係產生短波長光源入射至該生物樣本，用於激發該螢光染料並藉由螢光共振能量轉移使該螢光染料產生相對的螢光波長光源，而該影像擷取單元係透過該驅動單元與該濾波單元擷取該螢光波長光源的影像，以供使用者根據該影像分析該生物樣本。故本發明係可用以達到對該生物樣本進行全部或局部的影像掃描。

Wagon for burn-in board

A 10h-phenothiazine ferroptosis inhibitor as well as the preparative method and the use thereof

Disclosed are 10H-phenothiazine derivatives capable of inhibiting ferroptosis, or pharmaceutically acceptable salts thereof, or crystal forms thereof, or solvates thereof as shown in formula (I), and a preparation method therefor and applications thereof. The derivatives take a good inhibitory effect on ferroptosis, show a good therapeutic effect on a rat model of focal cerebral ischemia and thus can be used as a main active ingredient in the preparation of ferroptosis inhibitors. All the derivatives have good medicinal potential and are expected to be used as drug candidates for the treatment of stroke. The preparation method is simple, the reaction condition is mild, the operation and the control are convenient, the energy consumption is small, the yield is high, the cost is low, and the product is thus suitable for industrial production.

Gate driver and liquid crystal display using the same

Methods of Detecting Listeria from an Environmental Sample

Detection of Listeria from an environmental sample is described herein. In particular, the detection can be completed with results available the same day or same work shift, e.g., in about 12 hours or less, or about 6 to 10 hours. The Same Day detection utilizes a short incubation period and/or concentration steps coupled with a rapid detection assay to produce same day results.

Chip carrier of pin grid array

Packing case structure for hardware tool

Chimeric hemagglutinin protein and a vaccine composition comprising the same

Provided is a chimeric hemagglutinin (HA) protein including an HA1 subunit and an HA2 subunit, in which the HA1 subunit is composed of a first domain derived from a parental HA1 subunit of a first subtype influenza virus and a second domain derived from a parental HA1 subunit of a second subtype influenza virus. The chimeric HA protein has improved thermal stability and can be used in a vaccine composition for preventing influenza virus infection. Also provided is a method of inducing an immune response against an influenza virus in a subject in need thereof that includes administering the chimeric HA protein to the subject, thereby conferring protection against the influenza virus infection on the subject.

LED and manufacturing method thereof

Automated classification of immunophenotypes represented in flow cytometry data

Introduced here is an approach to improving the automatic identification of hematological diseases using computer-implemented models that are trained to rapidly distinguish between different collections of immunophenotypes that represent different disease types or disease states. Understanding the different patterns of immunophenotype collections contained in a given sample may permit a proposed diagnosis for a given hematological disease to be produced for the corresponding patient. For example, the proposed diagnoses may be output by a classification model based on the distribution of immunophenotypes across the given sample.

5-substituted indole 3-amide derivatives, preparation method and use thereof

Provided are a 5-substituted indole 3-amide derivative, a preparation method and a use thereof, belonging to the field of medicine. A compound represented by formula I or a pharmaceutically acceptable salt thereof is provided. This type of compound can significantly inhibit the activity of RIPK1 kinase, has high selectivity and excellent safety, serves as a RIPK1 kinase inhibitor, and can be used as a potential therapeutic drug for inflammation, immune diseases, tumors and neurodegenerative diseases. TNFα-induced SIRS model experiments proved that the compound can inhibit a RIPK1 kinase in vivo. Pharmacokinetic results showed that this series of compounds has excellent pharmacokinetic properties, thus providing a novel strategy and means for disease treatments targeting RIPK1.

Pdgf-d prodomain and its mutant and fusion

Provided is directed to PDGF-D prodomain or its mutant or fusion. Provided is also directed to a process or use of the PDGF-D prodomain or its mutant or fusion for inhibiting PDGFR phosphorylation, for inhibiting cell proliferation stimulated by PDGF, or for preventing and/or treating diseases associated therewith.

Improvement of frame materiel structure for mounting frame

Gate driver and liquid crystal display using the same

A gate driver and a liquid crystal display using the same are provided. The gate driver includes a scan signal generating unit and a compensation unit. The scan signal generating unit has a plurality of output channels, and is used for sequentially outputting a scan signal through the output channels according to a basic clock and a start pulse. The compensation unit is coupled to the scan signal generating unit, and used for compensating the total resistance of each of the output channels, and sequentially receiving and transmitting the scan signal to a display panel.

Electronic device

An electronic device is provided. The electronic device includes a substrate, a first wire, a first semiconductor element and a second semiconductor element. The substrate has a display region and a peripheral region adjacent to the display region. The first wire is disposed in the display region and the peripheral region. The first semiconductor element is disposed in the display region. The second semiconductor element is disposed in the peripheral region and adjacent to the first semiconductor element. The first semiconductor element and the second semiconductor element cross the first wire in two parts respectively and the two parts of the second semiconductor element is less than the two parts of the first semiconductor element in distance.

Electronic device capable of adjusting light emitting frequency, computer system having the same and method for adjusting light emitting frequency of electronic device

An electronic device capable of adjusting light emitting frequency includes an oscillator used to generate an oscillation signal, a microcontroller connected to the oscillator, and a light emitting module connected to the microcontroller. The microcontroller is used to define that an oscillation times of the oscillator within a unit time period is an original oscillation times. The microcontroller sets a correspondence between a switching period and the original oscillation times. The microcontroller is further used to receive the oscillation signal to calculate a time elapse. The microcontroller is configured to control on or off of the light emitting module according to the switching period and the time elapse.

Systems and methods for automated hematological abnormality detection

This application relates generally to automated systems and associated methods for identifying hematological abnormalities. An automated system can include at least one processor that, in operation, is configured to: receive, from a flow cytometer, a flow cytometry data matrix characterizing a tube that is associated with a sample; convert the flow cytometry data matrix into a high dimensional vector; produce a single sample high dimensional vector including a concatenation of multiple high dimensional vectors associated with the sample, wherein the multiple high dimensional vectors comprise the tube high dimensional vector; assemble a training data set including multiple sample high dimensional vectors; receive, from a datastore, outcome information including respective labels associated with each of the multiple sample high dimensional vectors; and train a classifier based on the training data set and the outcome information.

Transfer learning across hematological malignancies

Introduced here is an approach to improving the automatic identification of hematological malignancies by taking advantage of established databases through transfer learning. At a high level, this approach attempts to address the cross-domain gap by preserving knowledge of the source domain for better optimization of the target domain.

模擬輸入方法及其模擬輸入系統

一模擬輸入方法及其模擬輸入系統，適用於電腦主機，其模擬輸入系統包括一第一輸入裝置及一第二輸入裝置，第一輸入裝置被致動而產生至少一輸入訊號，第二輸入裝置分別與電腦主機及第一輸入裝置電性連接。第二輸入裝置儲存有巨集指令，係對應第一輸入裝置所產生之輸入訊號。第二輸入裝置接收第一輸入裝置之輸入訊號，當第二輸入裝置判斷輸入訊號為熱鍵指令，第二輸入裝置呼叫對應之巨集指令，並轉換為指令訊號傳送至電腦主機，當第二輸入裝置判斷輸入訊號非屬熱鍵指令，第二輸入裝置直接傳送輸入訊號至電腦主機。

A 10h-phenothiazine ferroptosis inhibitor as well as the preparative method and the use thereof

Disclosed are 10H-phenothiazine derivatives capable of inhibiting ferroptosis, or pharmaceutically acceptable salts thereof, or crystal forms thereof, or solvates thereof as shown in formula (I), and a preparation method therefor and applications thereof. The derivatives take a good inhibitory effect on ferroptosis, show a good therapeutic effect on a rat model of focal cerebral ischemia and thus can be used as a main active ingredient in the preparation of ferroptosis inhibitors. All the derivatives have good medicinal potential and are expected to be used as drug candidates for the treatment of stroke. The preparation method is simple, the reaction condition is mild, the operation and the control are convenient, the energy consumption is small, the yield is high, the cost is low, and the product is thus suitable for industrial production.

Improved transformer structure

Delivery and deployment of a prostatic implant

Devices and methods are disclosed for managing and/or treating body tissues obstructing a hollow body lumen, including the prostatic lobe tissues obstructing the urethra, for example conditions including benign prostatic hyperplasia (BPH), bladder outlet obstruction (BOO), benign prostatic obstruction (BPO) and associated lower urinary tract symptoms (LUTS). A prostatic implant deployment and delivery system may have a controlled release mechanism, a handle mechanism and an irrigation system. The controlled release mechanism includes a disengageable connection between a pusher member and the prostatic implant with a control member. The handle mechanism includes a plunger for advancing the pusher member and an actuator for withdrawing the control member. The irrigation system may define two fluid paths.

Delivery and deployment of a prostatic implant

Devices and methods are disclosed for managing and/or treating body tissues obstructing a hollow body lumen, including the prostatic lobe tissues obstructing the urethra, for example conditions including benign prostatic hyperplasia (BPH), bladder outlet obstruction (BOO), benign prostatic obstruction (BPO) and associated lower urinary tract symptoms (LUTS). A prostatic implant deployment and delivery system may have a controlled release mechanism, a handle mechanism and an irrigation system. The controlled release mechanism includes a disengageable connection between a pusher member and the prostatic implant with a control member. The handle mechanism includes a plunger for advancing the pusher member and an actuator for withdrawing the control member. The irrigation system may define two fluid paths.

Broad-spectrum antiviral pharmaceutical composition and manufacturing method thereof

A broad-spectrum antiviral pharmaceutical composition includes total organic and phenolic acid glycosides and/or their condensate compounds and/or salts of total organic and phenolic acid glycosides extracted from a Stellaria plant by a method including the steps of cleaning, powdering and extracting a Stellaria plant to form a water extraction, producing a liquid from the water extraction, absorbing the total organic and phenolic acid glycosides and/or their condensate compounds and/or the salts of total organic and phenolic acid glycosides of the liquid on a resin column by passing the liquid through the resin column, cleaning the resin column by water, washing the resin column by adding an agent to the resin column to obtain and collect a brownish or dark red liquid from the resin column, and collecting the ethanol from the brownish or dark red liquid.

倉儲管理系統

一種倉儲管理系統，包含一儲存單元及一處理單元。儲存單元儲存有複數個貨品條碼資料、複數個貨架條碼資料、一電子地圖、一起點位置、一終點位置、複數個貨架位置、一揀貨清單及一對應性資料。對應性資料定義各貨品條碼資料對應於其中一貨架條碼資料，且定義每一貨架條碼資料對應於其中一貨架位置。揀貨清單包括該等貨品條碼資料中的至少一者。處理單元能產生一揀貨路線，揀貨路線起始於起點位置，並經過揀貨清單中的貨品條碼資料對應的貨架位置，且結束於終點位置。藉此，揀貨人員可依照揀貨路線進行揀貨，從而提升揀貨作業的效率。

Heterojunction bipolar transistor structure having current clamping layer

A heterojunction bipolar transistor structure is provided, including a substrate and a multi-layer structure formed on the substrate. The multi-layer structure includes a current clamping layer, and the current clamping layer can be disposed in a collector layer, disposed in a sub-collector layer, or interposed between a collector layer and a sub-collector layer. An electron affinity of the current clamping layer is less than an electron affinity of an epitaxial layer formed on the current clamping layer.

Plastic aspheric wide-angle lens

黏貼後腫脹會裂開警示的貼紙

取像裝置

遮光陣列透鏡及其製造方法

一種遮光陣列透鏡包含一本體、複數光學有效區及一遮光區，該本體為塑膠材質並包括一頂面及一底面，該等光學有效區設置於該本體中且自該頂面延伸至該底面，光線可通過該等光學有效區，該遮光區設置於該本體中且圍繞界定該等光學有效區，該遮光區包括一由雷射加工形成且能阻擋光線的碳化層，由於該遮光區的碳化層是由施打雷射形成，定位容易且膜厚容易控制，在非平面區域也容易成型，且雷射加工屬於乾性製程，能降低成本與提高良率。

Digital lens apparatus

Light-emitting diode

A light-emitting diode (LED) is provided. An LED die includes a first semiconductor layer, a light-emitting layer, a second semiconductor layer, a first electrode and a second electrode. At least a part of the first semiconductor is exposed from the light emitting layer and the second semiconductor layer. The first electrode and the second electrode is disposed on top of the exposed first semiconductor layer and the second semiconductor layer respectively. At least two metal pads are disposed on top of the first electrode and the second electrode of the LED die respectively. Each of the metal pads has a side surface. A fluorescent layer is disposed on a surface of the LED die. The fluorescent layer directly contacts with the side surfaces of the metal pads and fills a gap between the metal pads.

Methods and devices of processing cytometric data

Disclosed are methods and devices of processing cytometric data. The present disclosure provides a method of processing cytometric data. The method comprises: dividing a first data matrix into a first plurality of first submatrices; encoding each of the first submatrices into one corresponding vector representation to acquire a first plurality of vector representations; and aggregating the first plurality of vector representations into a first ensemble representation. The first data matrix is indicative of a first plurality of properties of a first set of cells.

Process and structure of combining tape of tape measure with covering film

5-substituted indole 3-amide derivative, preparation method and use thereof

Provided are a 5-substituted indole 3-amide derivative, a preparation method and a use thereof, belonging to the field of medicine. A compound represented by formula I or a pharmaceutically acceptable salt thereof is provided. This type of compound can significantly inhibit the activity of RIPK1 kinase, has high selectivity and excellent safety, serves as a RIPK1 kinase inhibitor, and can be used as a potential therapeutic drug for inflammation, immune diseases, tumors and neurodegenerative diseases. TNFα-induced SIRS model experiments proved that the compound can inhibit a RIPK1 kinase in vivo. Pharmacokinetic results showed that this series of compounds has excellent pharmacokinetic properties, thus providing a novel strategy and means for disease treatments targeting RIPK1.

Improved structure of slant support frame

浴巾晾曬架

衣架結構

本創作為一種衣架結構，其包括有第一衣架及第二衣架；其中，第一衣架包括有卡扣孔，第二衣架包括有第二卡扣結構，第二卡扣結構包括有二彈性勾扣，且各彈性勾扣包括有勾部，第二卡扣結構穿置於卡扣孔，兩彈性勾扣的兩勾部卡制於第一卡扣結構；本創作讓第二衣架能拆裝地結合於第一衣架，且讓第二衣架與第一衣架之間形成夾角，而在晾曬衣物時能展開衣物；可解決現有衣架無法充分撐起衣物的問題，提供一種充分撐開衣物而縮短衣物晾曬時間的衣架結構。

自動炒菜裝置

Novel braking structure of measuring tape

Improved actuating structure of tape measure

Polymorphic forms of 6-11 bicyclic ketolide derivatives

The present invention includes EP-13420 polymorphic crystalline forms: Form I, Form II, Form Ia, and monohydrate and amorphous EP-13420 which posses distinct physical properties. In another embodiment of the present invention, there are provided methods of producing the various polymorphic forms in pure form or in combination with one another. The present invention also provides pharmaceutical compositions and formulations comprising the polymorphic and amorphous forms and methods of treating bacterial infections by administering the pharmaceutical compositions to a subject in need of such treatment.

Electronic device

An electronic device is provided. The electronic device includes a substrate, first, second, and third wires, first and second semiconductor elements, and a conductor. The first, second, and third wires are disposed on the substrate. The third wire is adjacent to the second wire. The second and third wires cross the first wire, and a width of the third wire is less than that of the second wire. The first semiconductor element is overlapped the first and third wires. The second semiconductor element is overlapped the first wire and adjacent to the first semiconductor element. The conductor is disposed below the second semiconductor element. The first and the second semiconductor element each crosses the first wire in two parts and the two parts of the second semiconductor element is less than the two parts of the first semiconductor element in distance.

導光元件組合體及其成型方法

一種導光元件組合體及其成型方法，其主要係包含有一第一導光元件及一第二導光元件，其中該第一導光元件之成型方法係以擠押成型或塗佈成型等方式製作該第一導光元件，再以射出成型或塗佈方式等製作該第二導光元件，並以結合成型或組裝方式結合該第一導光元件與該第二導光元件，藉此，除了可利用該第二導光元件增加第一導光元件之入光效益，增加該第一導光元件之光利用率外，更可獲得同時具有薄型化及大尺寸優點之導光元件。

Improved structure for refrigerant processing machine

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無鹵高頻樹脂組合物

本發明公開一種無鹵高頻樹脂組合物，該無鹵高頻樹脂組合物，以重量份計，其組分包括雙環戊二烯型環氧樹脂20~50重量份、苯乙烯-馬來酸酐共聚物10-40重量份、苯並惡嗪樹脂10~30重量份、多官能基環氧樹脂5~20重量份以及至少一種含磷阻燃劑20~40重量份。用所述無鹵高頻樹脂組合物製成的覆銅板具有低介電常數、低介電損耗，高耐熱性，低吸水率，低膨脹係數，PCB加工性好等優異性能。

安全帽之溫度調節及除霧裝置

Massage pad for bath

Delivery and deployment of a prostatic implant

Devices and methods are disclosed for managing and/or treating body tissues obstructing a hollow body lumen, including the prostatic lobe tissues obstructing the urethra, for example conditions including benign prostatic hyperplasia (BPH), bladder outlet obstruction (BOO), benign prostatic obstruction (BPO) and associated lower urinary tract symptoms (LUTS). A prostatic implant deployment and delivery system may have a controlled release mechanism, a handle mechanism and an irrigation system. The controlled release mechanism includes a disengageable connection between a pusher member and the prostatic implant with a control member. The handle mechanism includes a plunger for advancing the pusher member and an actuator for withdrawing the control member. The irrigation system may define two fluid paths.

Blinker light for road construction

Embedded-insertion type data protection device

透皮吸收皮脂膜組合物乳液保養品結構

Mechanism for modulating wireless communication signals

Mechanism for modulating wireless communication signals

Grocery bag

多功能戶外遮陽餐桌

Feedback acoustic signal mechanism of computer input device

Improved structure of fireproof door

環控、消防自動導引裝置

Capacitance-type sensing system and wearable device for indirect contact

A capacitance-type sensing system for indirect contact includes a capacitance-type sensor and a grounding conductor. The capacitance-type sensor includes a sensing electrode and a driving circuit electrically connected to the sensing electrode. The driving circuit has a grounding terminal. The grounding conductor is electrically connected to the grounding terminal and configured to contact a grounding surface. A contact area of the grounding conductor is greater than or equal to 3000 mm 2 .

Methods and devices of processing cytometric data

Disclosed are methods and devices of processing cytometric data. The present disclosure provides a method of processing cytometric data. The method comprises: dividing a first data matrix into a first plurality of first submatrices; encoding each of the first submatrices into one corresponding vector representation to acquire a first plurality of vector representations; and aggregating the first plurality of vector representations into a first ensemble representation. The first data matrix is indicative of a first plurality of properties of a first set of cells.

防水表蓋

本創作提供一種防水表蓋，尤其是作為電表之外罩使用之防水表蓋。本創作之防水表蓋1具備可旋轉開闔之通訊模組外蓋3，有易於開啟以進行維修更新等作業之便利性，且由於連接本體2與通訊模組外蓋3之旋轉軸203和本體2係一體成型，可避免習知以熔接或黏合方式固接之旋轉軸於長期使用下因應力拉扯或黏著性降低而從本體脫落之情形，再者，藉由本體2之第一卡扣部210與扣體4之突出部42相互抵靠，即便無螺栓鎖合也能提供足以使通訊模組外蓋3與本體2密合之力量，可有效避免雨水等外部液體滲入表蓋內。