29-08-2013 дата публикации
Номер: US20130225797A1
Provided is an oligonucleotide containing an azobenzene derivative, represented by Formula (1) or (2) below: 2. The oligonucleotide according to claim 1 , wherein Rto Rand Rto Rare hydrogen atoms.3. The oligonucleotide according to claim 1 , wherein Rand Rare methyl groups.5. The oligonucleotide according to claim 4 , wherein Rand Rbind with each other to represent a cyclohexyl group or adamantyl group together with a carbon atom for linking to a sulfur atom.6. The oligonucleotide according to claim 4 , wherein{'sup': 31', '32, 'sub': '1-4', 'Rand Reach independently represent a Calkyl group, and'}{'sup': 33', '40, 'Rto Rare hydrogen atoms.'}7. The oligonucleotide according to claim 6 , wherein Rand Rare methyl groups.8. A photo-switching agent claim 1 , by which the formation and dissociation of a double strand can be controlled by visible light irradiation claim 1 , and which is provided with the oligonucleotide according to .10. The photo-switching agent according to claim 9 , wherein Rand Rrepresent methyl groups or hydrogen atoms claim 9 , and R claim 9 , R claim 9 , and Rto Rare hydrogen atoms.11. The photo-switching agent according to claim 9 , wherein each of the pair of oligonucleotides has two or more of the azobenzene derivative adjacent to one another on either side of two or more nucleotides. The present invention relates to an oligonucleotide, and to a photo-switching agent using the oligonucleotide. The priority claim for the present application is based on Japanese Patent Application No. 2010-194942, submitted on Aug. 31, 2010, and the entire contents of the Description of that Japanese Patent Application are incorporated by reference in this Description.Techniques have been developed for controlling hybridization between oligonucleotides with complementary structures by an external stimulus. If hybridization control could be achieved, it could contribute to more precise gene detection, identification and assay, and to the development of molecular ...
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