08-10-2020 дата публикации
Номер: US20200316269A1
Принадлежит:
System and methods for stimulating cartilage formation at a first tissue site through a second tissue site is presented. The system includes a fluid source for supplying a therapeutic solution, a reduced pressure source for supplying reduced pressure, a fluid delivery manifold for deploying adjacent the first tissue site, and a vacuum manifold for deploying within the second tissue site. The fluid delivery manifold extends between a proximal end fluidly coupled to the fluid supply and a distal end having at least one aperture for delivering the therapeutic solution to the defect adjacent the articulating surface of the first tissue site. The vacuum manifold extends between a proximal end fluidly coupled to the reduced pressure source and a distal end having at least one aperture for delivering the reduced pressure to the first tissue site adjacent the opposing surface of the first tissue site. 142.-. (canceled)43. A method for treating a defect in cartilage comprising:positioning a vacuum manifold within a subchondral bone;positioning a fluid delivery manifold within an intra-articular space adjacent a surface of the subchondral bone;delivering a therapeutic solution to the defect through the fluid delivery manifold; andapplying reduced pressure to the vacuum manifold to draw the therapeutic solution from the fluid delivery manifold through the defect.44. The method of claim 43 , further comprising the step of creating a hole in the subchondral bone for positioning the vacuum manifold within the subchondral bone.45. The method of claim 43 , wherein the therapeutic solution comprises a cell suspension.46. The method of claim 43 , wherein the therapeutic solution comprises protease inhibitors.47. The method of claim 43 , wherein the therapeutic solution comprises hyaluronic acid.48. The method of claim 43 , wherein the therapeutic solution comprises bioactive factors.49. The method of claim 43 , wherein the therapeutic solution comprises chondrocytes.50. The method of ...
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