18-02-2021 дата публикации
Номер: US20210047279A1
Принадлежит:
A salt compound of 4-(2-((4-bromophenyl)thio)acetamido)-1-phenethyl-1H-pyrazole-3-carboxylic acid is disclosed. Also disclosed are methods for making the salt compound and formulations of the salt compound into dosage forms for clinical use. 2. The salt compound of in which X is a potassium ion claim 1 , sodium ion claim 1 , calcium ion or a substituted ammonia molecule.3. The salt compound of claim 1 , in which X is a quaternary amine claim 1 , wherein the amine is selected from the group consisting of choline claim 1 , diethylamine claim 1 , dimethylamine claim 1 , L-lysine claim 1 , N claim 1 ,N′-dibenzylethylenediamine claim 1 , N-ethylglucamine claim 1 , 1-(2-hydroxyethyl)pyrrolidine claim 1 , N-(phenylmethyl)benzeneethaneamine claim 1 , ammonia claim 1 , magnesium acetate claim 1 , N-methylglucamine claim 1 , tromethamine claim 1 , 4-(2-hydroxyethyl)morpholine claim 1 , 2-(diethylamino)ethanol claim 1 , 2-dimethylamino-ethanol.4. The salt compound of in which X is potassium ion claim 1 , sodium ion or quaternary dimethylamine or quaternary diethylamine.5. The salt compound of claim 1 , in which m is 0.5 or 1.6. The salt compound of claim 4 , in which m is 0.5 or 1.7. The salt compound of claim 1 , that is a solvate further including 4-methyl-pentan-2-one claim 1 , ethanol or diisopropyl ether.8. The salt compound of claim 4 , that is a solvate further including ethanol or diisopropyl ether.10. The process of claim 9 , in which the organic solvent is 1 claim 9 ,1-dimethoxyethane claim 9 , acetonitrile claim 9 , ethanol claim 9 , 1 claim 9 ,2-dichloroethane claim 9 , benzonitrile claim 9 , ethyl acetate claim 9 , 1 claim 9 ,4-dioxane claim 9 , anisole claim 9 , heptane claim 9 , 2-butanol claim 9 , cumene claim 9 , hexane claim 9 , 2-propanol claim 9 , cyclohexane claim 9 , isopropyl acetate claim 9 , 4-methyl-pentan-2-one claim 9 , dichloromethane claim 9 , methanol claim 9 , acetone claim 9 , diisopropyl ether (DIPE) claim 9 , isobutyl acetate claim 9 , ...
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