14-04-2016 дата публикации
Номер: US20160102065A1
Provided are a novel compound having skin-whitening, anti-oxidizing and PPAR activities and a medical use thereof, and the compound has skin-whitening activities for the suppression of tyrosinase, and accordingly, is useful for use in skin-whitening pharmaceutical composition or cosmetic products; has anti-oxidant activities, and accordingly, is useful for the prevention and treatment of skin-aging; and has PPAR activities, and in particular, PPARα and PPARγ activities, and accordingly, is useful for use in pharmaceutical compositions or health foods which are effective for the prevention and treatment of obesity, metabolic disease, or cardiovascular disease. 3. The compound of claim 2 , wherein the compound is any one selected from the group consisting of 5-(4-hydroxybenzylidene)pyrimidine-2 claim 2 ,4 claim 2 ,6(1H claim 2 ,3H claim 2 ,5H)-trione (Compound 14); 5-(3 claim 2 ,4-dihydroxybenzylidene)pyrimidine-2 claim 2 ,4 claim 2 ,6(1H claim 2 ,3H claim 2 ,5H)-trione (Compound 15); 5-(2 claim 2 ,4-dihyroxybenzylidene)pyrimidine-2 claim 2 ,4 claim 2 ,6(1H claim 2 ,3H claim 2 ,5H)-trione (Compound 16); 5-(4-hydroxy-3-methoxybenzylidene)pyrimidine-2 claim 2 ,4 claim 2 ,6(1H claim 2 ,3H claim 2 ,5H)-trione (Compound 17); 5-(3-ethoxy-4-hydroxybenzylidene)pyrimidine-2 claim 2 ,4 claim 2 ,6(1H claim 2 ,3H claim 2 ,5H)-trione (Compound 18); 5-(3-hydroxy-4-methoxybenzylidene)pyrimidine-2 claim 2 ,4 claim 2 ,6(1H claim 2 ,3H claim 2 ,5H)-trione (Compound 19); 5-(4-methoxybenzylidene)pyrimidine-2 claim 2 ,4 claim 2 ,6(1H claim 2 ,3H claim 2 ,5H)-trione (Compound 20); 5-(3 claim 2 ,4-dimethoxybenzylidene)pyrimidine-2 claim 2 ,4 claim 2 ,6(1H claim 2 ,3H claim 2 ,5H)-trione (Compound 21); 5-(2 claim 2 ,4-dimethoxybenzylidene)pyrimidine-2 claim 2 ,4 claim 2 ,6(1H claim 2 ,3H claim 2 ,5H)-trione (Compound 22); 5-(3 claim 2 ,4 claim 2 ,5-trimethoxybenzylidene)pyrimidine-2 claim 2 ,4 claim 2 ,6(1H claim 2 ,3H claim 2 , 5H)-trione (Compound 23); and 5-(4-hydroxy-3 claim 2 ,5- ...
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