24-03-2022 дата публикации
Номер: US20220089583A1
Compounds and a method of treating a retinal disease that leads to photoreceptor loss or outer-retina degeneration, including administering compound of the formula (I) 2. A compound according to wherein B is selected from the group consisting of a residue of formula (II) claim 1 , (III) or (IV).5. The compound according to claim 1 , wherein Ror Ris selected from the group consisting of methoxy claim 1 , chloro claim 1 , and fluoro.6. The compound according to claim 1 , wherein A is selected from the group consisting a 5-oxazolyl residue claim 1 , pyridine-4-yl residue and a triazolyl residue.8. The compound according to wherein R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , Rand Ris selected from the group consisting of hydrogen claim 1 , methoxy and ethoxy claim 1 , and R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , and Rare hydrogen.9. The compound according to claim 1 , wherein R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , Rand Ris selected from the group consisting of hydrogen claim 1 , fluoro and chloro claim 1 , and R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , and Rare hydrogen.11. Compound according to for use as a medicament.12. Compound according to for use in the treatment and/or prevention of a retinal disease that leads to photoreceptor loss or outer retina degradation.13. Compound according to for use in the treatment and/or prevention of a retinal disease selected from the group consisting of inherited retinal dystrophies claim 12 , acquired degeneration claim 12 , vascular ...
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