22-08-2013 дата публикации
Номер: US20130217762A1
The present invention provides novel selective androgen receptor modulators and their salts and pharmaceutical compositions thereof. 6. A compound of that is 2-chloro-4-[[(1R claim 5 ,2R)-2-hydroxy-2-methyl-cyclopentyl]amino]-3-methyl-benzonitrile.8. A compound of that is 2-Chloro-4-[[(1S claim 7 ,2R)-2-hydroxy-2-methyl-cyclopentyl]amino]-3-methyl-benzonitrile.9. A pharmaceutical composition comprising a compound of any of claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , and one or more pharmaceutically acceptable carriers claim 1 , diluents claim 1 , or excipients.10. A pharmaceutical composition comprising a compound of any of claim 5 , or a pharmaceutically acceptable salt thereof claim 5 , and one or more pharmaceutically acceptable carriers claim 5 , diluents claim 5 , or excipients.11. A pharmaceutical composition comprising a compound of any of claim 7 , or a pharmaceutically acceptable salt thereof claim 7 , and one or more pharmaceutically acceptable carriers claim 7 , diluents claim 7 , or excipients.12. A pharmaceutical composition according to which is formulated as a patch.13. A pharmaceutical composition according to which is formulated as a topical gel.14. A pharmaceutical composition according to which is formulated as a topical cream.15. A pharmaceutical composition according to which is formulated as a topical spray.16. A pharmaceutical composition according to comprising a solvate.17. A pharmaceutical composition according to which is 2-chloro-4-[[(1R claim 16 ,2R)-2-hydroxy-2-methyl-cyclopentyl]amino]-3-methyl-benzonitrile•ethanol solvate in crystalline form characterized by an X-ray powder diffraction pattern obtained from a CuKα source (λ=X Å) which comprises peaks at:a) 7.00, 17.26, 12.30, and 23.34+/−−0.2 in 2θ; orb) 7.00, 8.59, 12.30, 16.76, 17.26, and 23.34+/−−0.2 in 2θ; orc) 7.00, 8.59, 10.13, 11.89, 12.30, 12.91, 13.95, 16.76, 17.26, 23.34+/−−0.2 in 2θ.18. A method for the treatment of muscle atrophy in a patient ...
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