04-02-2016 дата публикации
Номер: US20160031875A1
Автор:
BELARDI Justin K.,
BOYD Steven A.,
CUI Wenge,
DECORNEZ Helene,
FLENTGE Charles A.,
HADDEN Mark,
HALE James S.,
HARRIED Scott S.,
Heap Charles R.,
LIU Shuang,
MARESKA David A.,
RESNICK Lynn,
TOPALOV George T.,
ZHANG KAI
Принадлежит:
Compounds represented by formula 1 can be potent and/or partially selective for the Kv7.2/7.3 heteromultimer. They may be useful in treating disorders related to seizures, pain, neurotransmitter release, etc. 140.-. (canceled)42. The compound of claim 41 , wherein the compound is active at a homotetrameric Kv7.2 bearing potassium channel claim 41 , a Kv7.3 homotetrameric bearing potassium channel claim 41 , a heterotetrameric Kv7.2/7.3 bearing channel claim 41 , a heterotetrameric Kv7.3/7.5 bearing channel claim 41 , a homotetrameric Kv7.4 bearing potassium channel claim 41 , or a homotetrameric Kv7.5 bearing potassium channel at a concentration below about 10 μM.43. The compound of claim 41 , wherein claim 41 , if Ris substituted claim 41 , all substituents of Rare R claim 41 , F claim 41 , Cl claim 41 , CN claim 41 , OR claim 41 , CF claim 41 , NRR claim 41 , COR claim 41 , COR claim 41 , OCORA claim 41 , NRCOR claim 41 , CONRR claim 41 , wherein Rand Rare independently H or Calkyl.44. The compound of claim 41 , wherein claim 41 , if R claim 41 , R claim 41 , R claim 41 , or Ris substituted claim 41 , all substituents of R claim 41 , R claim 41 , R claim 41 , and Rare independently F claim 41 , Cl claim 41 , Br claim 41 , I claim 41 , CN claim 41 , Calkyl claim 41 , C—O-alkyl claim 41 , Camino claim 41 , Caminoalkyl claim 41 , Caminoacyl claim 41 , Cacylamino claim 41 , Calkylthio claim 41 , or Calkylsulfonyl.45. The compound of claim 41 , wherein Ris optionally substituted CH claim 41 , optionally substituted cyclic CH claim 41 , optionally substituted cyclic CH claim 41 , Coptionally substituted aryl claim 41 , or Coptionally substituted heterocyclyl.46. The compound of claim 45 , wherein Ris optionally substituted CH claim 45 , optionally substituted cyclic CH claim 45 , or optionally substituted cyclic CH.47. The compound of claim 45 , wherein Ris optionally substituted phenyl claim 45 , or Coptionally substituted heterocyclyl.48. The compound of claim 41 , ...
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