08-04-2021 дата публикации
Номер: US20210100919A1
Принадлежит:
Heptamethine cyanines for use as fluorescent markers of the biliary and renal systems are disclosed. Certain heptamethine cyanines exhibit renal system specificity, while others exhibit biliary system specificity. The compounds may be used for diagnostic purposes and/or for visualization of renal or biliary systems during surgery. 2. The compound according to claim 1 , wherein{'sup': 3', '4, 'Rand Rare the same,'}{'sup': 5', '8, 'Rand Rare the same,'}{'sup': 6', '9, 'Rand Rare the same,'}{'sup': 7', '10, 'Rand Rare the same,'}{'sup': 11', '12, 'Rand Rare the same, and'}{'sup': 13', '16, 'R-Rare the same.'}3. The compound according to claim 1 , wherein p is 2 claim 1 , 3 claim 1 , or 4.5. The compound according to claim 1 , wherein at least one of{'sup': 3', '4, 'Rand Rare methyl, and'}{'sup': 13', '16, 'R-Rare methyl.'}7. The compound according to claim 6 , wherein{'sup': 5', '8, 'Rand Rare the same,'}{'sup': 6', '9, 'Rand Rare the same,'}{'sup': 7', '10, 'Rand Rare the same,'}{'sup': 11', '12, 'Rand Rare the same, and'}{'sup': 13', '16, 'R-Rare the same.'}8. The compound according to claim 6 , wherein p is 3 claim 6 , 4 claim 6 , or 5.10. The compound according to claim 6 , wherein at least one of{'sup': '17', 'Ris methyl or ethyl, and'}{'sup': 13', '16, 'Rto Rare methyl.'}11. The compound according to claim 1 , wherein each Rindependently is methyl or ethyl.12. The compound according to claim 6 , wherein each Rindependently is methyl or ethyl.15. A pharmaceutical composition claim 6 , comprising:{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, 'a compound according to ; and'}a pharmaceutically acceptable carrier.16. A pharmaceutical composition claim 6 , comprising:{'claim-ref': {'@idref': 'CLM-00006', 'claim 6'}, 'a compound according to ; and'}a pharmaceutically acceptable carrier.17. A method for visualizing at least a portion of a renal system or a biliary system of a subject claim 6 , the method comprising:administering to the subject a compound;subsequently ...
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