01-08-2013 дата публикации
Номер: US20130197121A1
Принадлежит:
A method for making a crosslinked polymeric material for use in an orthopaedic device is described. The method may include the use of one or more crosslinking enhancers to enhance the crosslinking process. 1. A method of making crosslinked UHMWPE , comprising:contacting UHMWPE with a crosslinking enhancer; and crosslinking the UHMWPE by exposing the UHMWPE to a radiation dose from about 1 Mrad to about 50 Mrad.2. The method of claim 1 , wherein:the crosslinking enhancer includes at least one of the following, acrylic, methacrylic, ethacrylic, citraconic, maleic, malonic, mesaconic acids and ester and amide derivatives thereof.3. The method of claim 1 , wherein:the crosslinking enhancer includes at least one of the following, hydroxyethyl methacrylate, allyl acrylate, allyl methacrylate, diallyl fumarate, ethylene glycol dimethacrylate, tetraethylene glycol dimethacrylate, butanedioldimethacrylate, 1,6-hexanediol dimethacrylate, 1,4-butylene glycol dimethacrylate, trimethylolpropane-trimethacrylate, pentaerythritol tetramethacrylate, tripropylene glycol diacrylate, neopentyl glycol diacrylate, tetraethylene glycol diacrylate, trimethylol propane triacrylate, trimethylol propane ethoxylate triacrylate, pentaerythritol tetraacrylate, diallyl phthalate, triallyl cyanurate, divinyl benzene, triallyl isocyanurate, diacetylene(2,4-hexadiyn-1,6-bis(n-butyl urethane), 2,4-hexadiyn-1,6-bis(ethyl urethane).4. The method of claim 1 , wherein: {'br': None, 'sub': 2', '2', 'n', '2, 'HC═CH—(CH)—CH═CH'}, 'the crosslinking enhancer includes a compound having the formula'}wherein n is from 10 to 26.6. The method of claim 1 , wherein:the crosslinking enhancer includes at least one vinyl ester having one or more non-terminal double bond.7. The method of claim 1 , wherein: {'br': None, 'sub': 2', 'n, 'HS—(CH)—SH'}, 'the crosslinking enhancer includes a compound having the formula'}wherein n is from 6 to 30.8. The method of claim 7 , wherein:the crosslinking enhancer includes at least ...
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