17-11-2016 дата публикации
Номер: US20160335412A1
Принадлежит:
The method and system of this invention provides for the use of the Simcyp Simulator to identify the characteristics of a Virtual Twin to a real patient based on physiological data and demographic characteristics of the real patient. The Virtual Twin can be used to estimate appropriate dosage levels for a real patient undergoing pharmaceutical treatment and to indicate drug interactions that can occur during the administration of multiple drugs. 1. A method of using the Simcyp Simulator to identify a Virtual Twin to a real patient to identify drug treatment parameters and possible drug interactions comprising the following steps:entering a chosen dosage, dosage interval, route of administration, and dosage form (where relevant) for the drug of interest (the primary drug). The name of the drug is matched with the compound libraries within the Simulator to determine if a file for that drug has been established. If so, the next step will be initiated;b) entering age, sex, weight, race of the patient and relevant genotypes (for enzymes and transporters, receptors), smoking habit (number of cigarettes smoked per day), and relevant biomarker data (e.g. markers of specific drug metabolizing enzyme activity—such as salivary caffeine level for CYP1A2, plasma 6 beta-hydroxycortisol level for CYP3A4). The prescriber is also requested to enter the names of any other drugs (and their dosage) that the patient is already taking or that the doctor wishes them to take simultaneously with the primary drug. The names of these drugs are matched with compound libraries within the Simcyp Simulator® to determine if files for those drugs have been established. If so, the degree of any interaction with the primary drug will subsequently be determined;c) determining on the patient's demographics and relevant information on disease state, the Simcyp Simulator® defines his or her tissue volumes and blood flows, renal function, and gut characteristics (gastric emptying rate, segmental volumes ...
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