Method for preparing malonate methylidene nanoparticles, nanoparticles optionally containing one or several biologically active molecules

FORMULATIONS FOR ORAL DELIVERY OF ADSORBENTS IN THE GUT

The invention relates to a formulation for the delayed and controlled delivery of an adsorbent into the lower intestine of mammals. The formulation includes a carrageenan and an adsorbent, such as activated charcoal. The invention further relates to uses of this formulation, in particular to pharmaceutical uses. In one embodiment, the formulation is used to eliminate or reduce the side effects in the intestine, in particular in the colon, of pharmaceutical agents that are administered as a treatment for a disorder, but that have side effects when they reach the late ileum, the caecum or the colon. 1. A formulation comprisinga core containing a composition comprising activated charcoal mixed with carrageenan, anda layer of an external coating comprising an enterosoluble polymer formed around the core such that the activated charcoal is released from the formulation in a desired part of the intestine.2. The formulation according to claim 1 , wherein the activated charcoal is released from the formulation in the lower part of the intestine.3. The formulation according to claim 1 , wherein the external coating is a pH-dependent enterosoluble polymer is selected in the group consisting of cellulose acetate trimellitate (CAT) claim 1 , cellulose acetate phthalate (CAP) claim 1 , anionic copolymers based on methylacrylate claim 1 , methylmethacrylate and methacrylic acid claim 1 , hydroxypropyl methylcellulose phthalate (HPMCP) claim 1 , hydroxypropylmethylcellulose acetate succinate (HPMCAS) claim 1 , methacrylic acid and ethyl acrylate copolymers claim 1 , methacrylic acid and ethyl acrylate copolymer claim 1 , methacrylic acid and methyl methacrylate copolymers (1:1 ratio) claim 1 , methacrylic acid and methyl methacrylate copolymers (1:2 ratio) claim 1 , Polyvinyl acetate phthalate (PVAP) and Shellac resins.4. The formulation according to claim 3 , wherein the polymer dissolves at a pH equal to 6.0 and above claim 3 , and wherein the pH-dependent polymer is selected in ...

Formulations for oral delivery of adsorbents in the gut

The invention relates to a formulation for the delayed and controlled delivery of an adsorbent into the lower intestine of mammals. The formulation includes a carrageenan and an adsorbent, such as activated charcoal. The invention further relates to uses of this formulation, in particular to pharmaceutical uses. In one embodiment, the formulation is used to eliminate or reduce the side effects in the intestine, in particular in the colon, of pharmaceutical agents that are administered as a treatment for a disorder, but that have side effects when they reach the late ileum, the caecum or the colon.

COMPOSITIONS AND METHODS FOR ELIMINATION OF GRAM NEGATIVE BACTERIA

Oral drug delivery formulations which specifically administer antibacterial agents to the ileum, caecum, and/or the colon, without significant administration elsewhere in the gastrointestinal tract, are disclosed. The formulations include, as actives, a combination of a macrolide or aminoglysoside, or quinolone antibacterial and an anti-Gram-negative lipopeptide (polymyxin) antibacterial agent or other peptide antibacterials effective against Gram-negative bacteria. The formulations can be used to treat infections or unwanted colonization in the colon, and to provide effective decontamination of the colonic flora from unwanted or potentially pathogenic bacteria.

FORMULATIONS FOR ORAL DELIVERY OF ADSORBENTS IN THE GUT

The invention relates to a formulation for the delayed and controlled delivery of an adsorbent into the lower intestine of mammals. The formulation includes a carrageenan and an adsorbent, such as activated charcoal. The invention further relates to uses of this formulation, in particular to pharmaceutical uses. In one embodiment, the formulation is used to eliminate or reduce the side effects in the intestine, in particular in the colon, of pharmaceutical agents that are administered as a treatment for a disorder, but that have side effects when they reach the late ileum, the caecum or the colon.

Formulations for oral delivery of adsorbents in the gut

The invention relates to a formulation for the delayed and controlled delivery of an adsorbent into the lower intestine of mammals. The formulation includes a carrageenan and an adsorbent, such as activated charcoal. The invention further relates to uses of this formulation, in particular to pharmaceutical uses. In one embodiment, the formulation is used to eliminate or reduce the side effects in the intestine, in particular in the colon, of pharmaceutical agents that are administered as a treatment for a disorder, but that have side effects when they reach the late ileum, the caecum or the colon.

Method for preparing malonate methylidene nanoparticles, nanoparticles optionally containing one or several biologically active molecules

The invention relates to a method for the preparation of nanoparticles formed from a random polymer of at least one compound of formula (I) group R1and R2, identical or different, represents a linear or branched C1-C6alkyl group; n=1, 2, 3, 4 or 5, characterised in that the monomer is dissolved beforehand in a water-miscible aprotic organic solvent forming, with the polymerization medium, a non-solvent mixture of the polymer formed. The invention also relates to said nanoparticles, which optionally contain one or more biologically active molecules, and the pharmaceutical compositions containing them.

Formulations for oral delivery of adsorbents in the gut

The invention relates to a formulation for the delayed and controlled delivery of an adsorbent into the lower intestine of mammals. The formulation includes a carrageenan and an adsorbent, such as activated charcoal. The invention further relates to uses of this formulation, in particular to pharmaceutical uses. In one embodiment, the formulation is used to eliminate or reduce the side effects in the intestine, in particular in the colon, of pharmaceutical agents that are administered as a treatment for a disorder, but that have side effects when they reach the late ileum, the caecum or the colon.

FORMULATIONS FOR ORAL DELIVERY OF ADSORBENTS IN THE GUT

The invention relates to a formulation for the delayed and controlled delivery of an adsorbent into the lower intestine of mammals. The formulation includes a carrageenan and an adsorbent, such as activated charcoal. The invention further relates to uses of this formulation, in particular to pharmaceutical uses. In one embodiment, the formulation is used to eliminate or reduce the side effects in the intestine, in particular in the colon, of pharmaceutical agents that are administered as a treatment for a disorder, but that have side effects when they reach the late ileum, the caecum or the colon. 122-. (canceled)23. A composition comprising an adsorbent mixed with carrageenan.24. The composition of claim 23 , in the form of a pellet.25. The composition of claim 23 , wherein the adsorbent is activated charcoal.26. The composition of claim 23 , wherein the carrageenan is a kappa-carrageenan.27. The composition of claim 23 , wherein the amount of carrageenan is between 5% and 25% by weight of the composition.28. A formulation comprising:{'claim-ref': {'@idref': 'CLM-00023', '#text': 'claim 23'}, '#text': 'a core containing a composition according to , and b) a layer of an external coating formed around the core such that the adsorbent is released from the formulation in a desired part of the intestine.'}29. The formulation of claim 28 , wherein the desired part of the intestine is the lower part of the intestine.30. The formulation of claim 28 , wherein the external coating is a pH-dependent enterosoluble polymer.31. The formulation of claim 30 , wherein the pH-dependent enterosoluble polymer is selected from the group consisting of cellulose acetate trimellitate (CAT) claim 30 , cellulose acetate phthalate (CAP) claim 30 , anionic copolymers based on methylacrylate claim 30 , methylmethacrylate and methacrylic acid claim 30 , hydroxypropyl methylcellulose phthalate (HPMCP) claim 30 , hydroxypropylmethylcellulose acetate succinate (HPMCAS) claim 30 , methacrylic acid ...

FLEXIBLE CHUTE, IN PARTICULAR FOR AMMUNITION

In the field of feeding ammunition to a firearm there is disclosed a flexible chute including successive sections () linked by portions of walls () at the transverse faces thereof and including at least one tubular section () of axis G with a first portion of wall () integral with one of the two transverse faces thereof and a second portion () of wall integral with the other transverse face, characterized in that the projections of these portions of wall, perpendicular to a transverse plane of the section, are at least partially separate. 112-. (canceled)13. A flexible chute comprising successive sections linked by wall portions on the transverse faces of the sections and comprising at least one tubular section of axis G , with a first wall portion attached to one the two transverse faces of the sections and a second wall portion attached to the other transverse face of the sections , wherein the projections of the wall portions , perpendicularly to a transverse plane of the section , are at least partly distinct.14. The flexible chute according to claim 13 , wherein said projections are entirely distinct.15. The flexible chute according to claim 14 , wherein said projections are radially offset by an angle between π/9 and 8π/9 claim 14 , and preferably between π/3 and 2π/3 claim 14 , the origin of the radius being the center G.16. The flexible chute according to claim 13 , comprising successive sections linked by wall portions on the transverse faces of the sections claim 13 , wherein the flexible chute comprises at least one tubular section comprising at least an upper long side claim 13 , a lower long side and two smaller lateral sides claim 13 , and in that the section comprises claim 13 , on a first transverse face claim 13 , at least one wall portion only on at least one of the lateral sides and claim 13 , on the second transverse face claim 13 , at least one or more wall portions only on one of the upper and lower long sides.17. The flexible chute according ...

FORMULATIONS FOR ORAL DELIVERY OF ADSORBENTS IN THE GUT

The invention relates to a formulation for the delayed and controlled delivery of an adsorbent into the lower intestine of mammals. The formulation includes a carrageenan and an adsorbent, such as activated charcoal. The invention further relates to uses of this formulation, in particular to pharmaceutical uses. In one embodiment, the formulation is used to eliminate or reduce the side effects in the intestine, in particular in the colon, of pharmaceutical agents that are administered as a treatment for a disorder, but that have side effects when they reach the late ileum, the caecum or the colon. 122.-. (canceled)23. A formulation comprising:a core containing a composition comprising activated charcoal mixed with carrageenan; andan external coating comprising an enterosoluble polymer formed around the core such that the activated charcoal is released from the formulation in a desired part of the intestine.24. The formulation according to claim 23 , wherein the carrageenan is a kappa-carrageenan.25. The composition according to claim 23 , wherein the amount of carrageenan is comprised between 5% and 25% claim 23 , by weight of the composition.26. The formulation according to claim 23 , wherein the external coating is suitable for releasing the activated charcoal in the lower part of the intestine.27. The formulation according to claim 23 , wherein the external coating is a pH-dependent enterosoluble polymer.28. The formulation according to claim 27 , wherein the pH-dependent enterosoluble polymer is selected in the group consisting of:cellulose acetate trimellitate (CAT);cellulose acetate phthalate (CAP);anionic copolymers based on methylacrylate, methylmethacrylate and methacrylic acid;hydroxypropyl methylcellulose phthalate (HPMCP);hydroxypropylmethylcellulose acetate succinate (HPMCAS);methacrylic acid and ethyl acrylate copolymers;methacrylic acid and ethyl acrylate copolymer;copolymers made of a 1:1 weight ratio mixture of methacrylic acid and methyl ...

Improved percussion device for a firearm.

Dispositif de percussion pour une arme à feu du type comprenant une chambre de chargement d'une munition (M) dont le culot est muni d'une amorce (50), ce dispositif comprenant un équipage mobile en translation constitué d'un percuteur (5) équipé d'une pointe de percussion (17) et associé à une pièce ou soupape (7) dans laquelle il est guidé axialement et qui est elle-même guidée en déplacement axial dans un canal (4) d'un corps (2) de percussion situé à l'arrière de la chambre de chargement. Le percuteur (5) et la soupape (7) sont respectivement montés par les faces avant et arrière du corps (2) de percussion et assemblés l'un à l'autre par un dispositif de liaison démontable (42, 44) du type à baïonnette. Percussion device for a firearm of the type comprising a chamber for loading an ammunition (M), the base of which is provided with a primer (50), this device comprising a mobile unit in translation consisting of a firing pin (5 ) equipped with a percussion tip (17) and associated with a part or valve (7) in which it is guided axially and which is itself guided in axial displacement in a channel (4) of a body (2) percussion box located at the rear of the loading chamber. The striker (5) and the valve (7) are respectively mounted by the front and rear faces of the percussion body (2) and assembled to each other by a removable connecting device (42, 44) of the type with bayonet.

Mechanically controlled torque transmission mechanism and weapon comprising such a mechanism.

IMMUNONANOPARTICLES CARRIING MONOCLONAL ANTI-CD4 ANTIBODIES AND THEIR USE FOR PROPHYLAXIS AND / OR THE TREATMENT OF CONDITIONS DUE TO HIV VIRUS INFECTION.

Safety device for an automatic weapon

The invention relates to a safety device for an automatic continuous-fire weapon, comprising a rotary drum (2) driven by an external motor in order to drive a breech in a reciprocating movement. It comprises means (14) for blocking the rotation of the drum at each cycle, and control means for retracting the blocking means in the event of recoil of the weapon, the said control means being designed to act on the blocking means over a predetermined travel of the recoil, irrespective of the starting position of the recoil.

Flexible chute, in particular for ammunition

Vineyard plow

Automatic weapon with tilting chamber for firing telescoped cylindrical ammunition.

Arme automatique pour le tir de munitions cylindriques télescopées, comprenant un manchon (12) de support d'un tube (10), une culasse (16) et une boîte arrière (38) qui sont reliés rigidement entre eux par des poutres, avec une chambre (20) agencée entre la culasse (16) et le tube (10) et montée basculante par pivotement autour d'un arbre excentré (22), et des moyens (28, 32, 34) portés par la culasse (16) et la boite arrière (38) pour alimenter la chambre en munitions. Automatic weapon for firing telescoped cylindrical ammunition, comprising a sleeve (12) for supporting a tube (10), a breech (16) and a rear box (38) which are rigidly connected to each other by beams, with a chamber (20) arranged between the cylinder head (16) and the tube (10) and tiltably mounted by pivoting around an eccentric shaft (22), and means (28, 32, 34) carried by the cylinder head (16) and the rear box (38) to supply the chamber with ammunition.

FLEXIBLE CORRIDOR FOR AMMUNITION

Compositions and methods for elimination of gram-negative bacteria.

Se dan a conocer formulaciones de suministro de fármacos orales que administran específicamente agentes antibacterianos al íleo, ciego, y/o el colon, sin la administración significativa en alguna otra parte del tracto gastrointestinal. Las formulaciones incluyen, como agentes activos, una combinación de un agente antibacteriano de macrólido o aminoglicósido, o quinolona y un agente antibacteriano de lipopéptido anti-Gram-negativo (polimixina) u otros agentes antibacterianos de péptido efectivos contra bacterias Gram-negativas. Las formulaciones se pueden usar para tratar infecciones o colonización no deseada en el colon, y para proporcionar una descontaminación efectiva de la flora colónica de bacterias no deseadas o potencialmente patogénicas.

Formulations for oral delivery of adsorbents in the gut

SECURITY DEVICE FOR AN AUTOMATIC WEAPON.

Method for preparing malonate methylidene nanoparticles, nanoparticles optionally containing one or several biologically active molecules

The invention concerns a method for preparing nanoparticles formed of a statistic polymer of at least one compound of formula (I) in which A represents a group (a) or a group (b); R1 and R2, identical or different, represent a C1-C6 alkyl group linear or branched; n = 1, 2, 3, 4, or 5, characterised in that the monomer is previously made soluble in an organic aprotic solvent miscible in water forming with the polymerisation medium a mixture non-solvent of the formed polymer. The invention also concerns said nanoparticles, containing optionally one or several biologically active molecules, and the pharmaceutical compositions containing them.

Mechanically controlled torque transmission mechanism and weapon having such a mechanism.

La présente invention se rapporte principalement à un mécanisme de transmission de couple à commande mécanique de déphasage entre des arbres et à une arme, notamment montée sur tourelle, comportant un tel mécanisme. Un mécanisme selon l'invention comporte un arbre moteur et un arbre de sortie reliés par une pièce de liaison ayant un débattement important ainsi que des moyens de commande du débattement de la pièce de liaison. The present invention relates mainly to a torque transmission mechanism with mechanical phase shift control between shafts and to a weapon, in particular mounted on a turret, comprising such a mechanism. A mechanism according to the invention comprises a motor shaft and an output shaft connected by a connecting piece having a large clearance as well as means for controlling the clearance of the connecting piece.

Automatic weapon with tilting chamber for firing telescoped cylindrical ammunition.

Formulations for oral delivery of adsorbents in the gut

The invention relates to a formulation for the delayed and controlled delivery of an adsorbent into the lower intestine of mammals. The formulation includes a carrageenan and an adsorbent, such as activated charcoal. The invention further relates to uses of this formulation, in particular to pharmaceutical uses. In one embodiment, the formulation is used to eliminate or reduce the side effects in the intestine, in particular in the colon, of pharmaceutical agents that are administered as a treatment for a disorder, but that have side effects when they reach the late ileum, the caecum or the colon.

CONTROL AND SECURITY DEVICE FOR AN AUTOMATIC EXTERNAL ENERGY WEAPON.

Drive device for inserting a flexible object into a conduit

Formulations for oral delivery of adsorbents in the gut

The invention relates to a formulation for the delayed and controlled delivery of an adsorbent into the lower intestine of mammals. The formulation includes a carrageenan and an adsorbent, such as activated charcoal. The invention further relates to uses of this formulation, in particular to pharmaceutical uses. In one embodiment, the formulation is used to eliminate or reduce the side effects in the intestine, in particular in the colon, of pharmaceutical agents that are administered as a treatment for a disorder, but that have side effects when they reach the late ileum, the caecum or the colon.

Immunoparticles bearing monoclonal anti-cd4 antibodies and utilisation/thereof

Actuation and safety device for an externally powered automatic weapon

Actuation and safety device for an externally powered automatic weapon, comprising a rotor (10) driven by a motor and carrying a stop (14) co-operating with a blocking piece (18), this device comprising, on the one hand, a trigger lever (24) for controlling the fire and a lever (64) subjected to the action of a rotating finger (72) driven by the recoil of the weapon, the trigger lever (24) and the lever (64) being connected to the blocking piece (18) by means of a system of slides (34, 36) and of links (50, 54), ensuring that the rotor (10) is stopped automatically by means of the blocking piece (18) in the event that ammunition functions incorrectly. <IMAGE>

Drive device for inserting a flexible object into a conduit

The present invention relates to a driving band (15 1 , 152, 153, 154, 155) for inserting a flexible ammunition belt (13) with links into a conduit, comprising a flexible longitudinal column (31, 51) having a thickness and width at least 10 times less than the length thereof, and transverse branches (33, 35, 37, 39, 53, 55, 57) each comprising an end secured to said flexible longitudinal column (31, 51) and arranged successively along the flexible longitudinal column (31, 51), making a non-zero angle α with said flexible longitudinal column (31, 51), said band (151, 152, 153, 154, 155) being characterised in that it comprises, at one of the transverse ends thereof, called rear portion, engaging means (20, 41, 62) which protrude longitudinally, at least partially, from the driving band and are capable of engaging an ammunition belt.

Compositions and methods for elimination of gram-negative bacteria

Oral drug delivery formulations which specifically administer antibacterial agents to the ileum, caecum, and/or the colon, without significant administration elsewhere in the gastrointestinal tract, are disclosed. The formulations include, as actives, a combination of a macrolide or aminoglysoside, or quinolone antibacterial and an anti-Gram-negative lipopeptide (polymyxin) antibacterial agent or other peptide antibacterials effective against Gram-negative bacteria. The formulations can be used to treat infections or unwanted colonization in the colon, and to provide effective decontamination of the colonic flora from unwanted or potentially pathogenic bacteria.

PROCESS FOR THE PREPARATION OF METHYLIDENE MALONATE NANOPARTICLES, NANOPARTICLES CONTAINING ONE OR MORE BIOLOGICALLY ACTIVE MOLECULES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

CONTROL AND SECURITY DEVICE FOR AN AUTOMATIC EXTERNAL ENERGY WEAPON.

Dispositif de commande et de sécurité pour une arme automatique à énergie externe, comprenant un rotor (10) entraîné par un moteur et portant une butée (14) coopérant avec une pièce de blocage (18), ce dispositif comprenant d'une part un levier de détente (24) pour la commande du tir et un levier (64) soumis à l'action d'un doigt tournant (72) entraîné par le recul de l'arme, le levier de détente (24) et le levier (64) étant reliés à la pièce de blocage (18) par un système de coulisseaux (34, 36) et de biellettes (50, 54) assurant automatiquement l'arrêt du rotor (10) par l'intermédiaire de la pièce de blocage (18) en cas de mauvais fonctionnement d'une munition. Control and safety device for an automatic weapon with external energy, comprising a rotor (10) driven by a motor and carrying a stop (14) cooperating with a locking part (18), this device comprising on the one hand a lever trigger (24) for firing control and a lever (64) subjected to the action of a rotating finger (72) driven by the recoil of the weapon, the trigger lever (24) and the lever (64 ) being connected to the blocking piece (18) by a system of slides (34, 36) and rods (50, 54) automatically stopping the rotor (10) by means of the blocking piece (18 ) in the event of an ammunition malfunction.

Tool carrier lifting device for agricultural tractors and others

Safety device for an automatic firearm

"composition comprising a drug dispensing system, a first and a second composition set, and a kit."

Eljárás metilidén-malonát nanorészecskék előállítására, és adott esetben egy vagy több biológiai hatással rendelkező molekulát tartalmazó nanorészecskék

A találmány tárgya eljárás legalább egy (I) általánős képletűvegyületek statisztikűs pőlimerjéből álló nanőrészecskékelőállítására, ahől A jelentése (a) általánős képletű csőpőrt vagy (b) általánős képletűcsőpőrt, R1 és R2 jelentése egymástól függetlenül egyenes vagy elágazószénláncú 1-6 szénatőmős alkilcsőpőrt, n értéke 1, 2, 3, 4 vagy 5,amelyet úgy végeznek, hőgy az egy vagy több mőnőmert a pőlimerizációelőtt őlyan aprőtikűs szerves őldószerben őldják, amely vízzelelegyedő, és amely a pőlimerizációs közeggel a képződött pőlimert nemőldó elegyet alkőt,. A találmány az előállítőtt, adőtt esetben egyvagy több, biőlógiailag hatásős mőlekűlát is tartalmazónanőrészecskékre és az ezeket tartalmazó gyógyszerkészítményekre isvőnatkőzik. (I) (a) ŕ

Methyliden-malonat nanopartikel, verfahren zu deren herstellung, und diese enthaltende pharmazeutische praeparate

Sicherheitsvorrichtung für automatische Feuerwaffen.