28-03-2019 дата публикации
Номер: US20190092724A1
Принадлежит:
A compound of Formula (I), or a pharmaceutically acceptable salt thereof, is provided that has been shown to be useful for the treatment of lysine (K)-specific demethylase 1A (LSD1)-mediated diseases or disorders: 5. A compound or a pharmaceutically acceptable salt thereof claim 1 , according to claim 1 , wherein:{'sup': 1', 'd', 'b', 'b, 'sub': 4', '6, 'Ris independently selected from: C-Ccycloalkyl substituted with one R, phenyl substituted with one to two R, and pyridyl substituted with one to two R;'}{'sup': '5', 'sub': '3', 'Ris independently selected from: H, F, Cl, and CH;'}{'sup': '6', 'sub': '3', 'Ris independently selected from: H and CH;'}Y is independently selected from: CH and N;{'sup': b', 'c', 'c, 'sub': 3', '2', '3', '2', '1', '4', '1', '4, 'Ris independently selected from: F, Cl, OH, OCF, CN, COCH, CONH, C-Calkyl substituted with zero to one R, and C-Calkoxy substituted with zero to one R;'}{'sup': 'c', 'sub': 3', '2', '3', '2, 'Ris independently selected from: OH, OCH, COCH, and CONH; and'}{'sup': 'd', 'sub': '3', 'Ris independently selected from: OH, ═O, and NHCH.'}6. A compound or a pharmaceutically acceptable salt thereof claim 1 , according to claim 1 , wherein:{'sup': 1', 'd', 'b, 'sub': 4', '6, 'Ris independently selected from: C-Ccycloalkyl substituted with one Ror phenyl substituted with one to two R;'}{'sup': '5', 'sub': '3', 'Ris independently selected from: H, F, Cl, and CH;'}{'sup': '6', 'sub': '3', 'Ris independently selected from: H and CH;'}Y is independently selected from: CH and N;{'sup': 'b', 'sub': 3', '1', '4', '1', '4, 'Ris independently selected from: F, Cl, OH, OCF, C-Calkyl and C-Calkoxy; and'}{'sup': 'd', 'sub': '3', 'Ris independently selected from: OH and NHCH.'}7. A compound or a pharmaceutically acceptable salt thereof claim 1 , according to claim 1 , wherein said compound is selected from Examples 1 to 102.10. A pharmaceutical composition claim 1 , comprising one or more pharmaceutically acceptable carriers and a ...
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