07-02-2019 дата публикации
Номер: US20190040102A1
Принадлежит:
The present invention is directed to somatostatin receptor antagonist compounds having the structure of Formula I, compositions comprising the same, and methods of using such compounds and compositions. The compounds may be useful in the prevention or treatment of hypoglycemia. 2. The compound or salt of claim 1 , wherein Ris selected from the group consisting of:{'sub': 1-6', '1-6', '6-10', '1-6, 'sup': 53', '51', '52', '51', '52', '53, '(i) —Calkylene-N(R)C(O)NRR, wherein each of Rand Ris independently selected from the group consisting of H, Calkyl, Caryl, and 5- to 10-membered heteroaryl, and wherein Ris H or Calkyl;'}{'sub': 1-6', '6-10', '1-6', '6-10', '1-6', '6-10, 'sup': 56', '57', '56', '57, '(ii) —Calkylene-(Carylene)-C(O)NRR, wherein each of Rand Ris independently selected from the group consisting of H, Calkyl, Caryl, and 5- to 10-membered heteroaryl, wherein the Calkyl is optionally substituted with one or more substituents, and wherein the Caryl and 5- to 10-membered heteroaryl are optionally substituted with one or more substituents;'}{'sub': 1-6', '6-10', '1-6', '6-10', '1-6, 'sup': 59', '58', '58', '59, '(iii) —Calkylene-(Carylene)-N(R)C(O)R, wherein Ris selected from the group consisting of Calkyl, Caryl, and 5- to 10-membered heteroaryl, and wherein Ris H or Calkyl;'}{'sub': 1-6', '6-10', '1-6', '6-10', '1-6', '6-10', '1-6', '6-10', '1-6, 'sup': 62', '60', '61', '60', '61', '60', '61', '60', '61', '62, '(iv) —Calkylene-(Carylene)-N(R)C(O)NRR, wherein Ris selected from the group consisting of H, Calkyl, Caryl, and 5- to 10-membered heteroaryl, Ris selected from the group consisting of Calkyl, Caryl, and 5- to 10-membered heteroaryl, wherein the Calkyl of Ror Ris optionally substituted with one or more substituents, and wherein the Caryl and 5- to 10-membered heteroaryl of Ror Rare optionally substituted with one or more substituents, and wherein Ris H or Calkyl;'}{'sub': 1-6', '6-10', '2', '1-6', '6-10', '1-6, 'sup': 64', '63', '63', '64, '(v) — ...
Подробнее
