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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Применить Всего найдено 42. Отображено 42.
10-04-2012 дата публикации

Triazole compounds and uses related thereto

Номер: US0008153631B2

The present invention provides a triazole compound of the following formula: a prodrug thereof or a pharmaceutically acceptable salt thereof. The above-mentioned triazole compound has superior HSD1 inhibitory activity, and is useful as an HSD1 inhibitor, a therapeutic drug of diabetes or a therapeutic drug of obesity or a therapeutic drug of metabolic syndrome.

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23-03-2010 дата публикации

Triazole compounds and uses related thereto

Номер: US0007683059B2
Принадлежит: Amgen Inc., AMGEN INC, AMGEN INC.

The present invention provides a triazole compound of the following formula: a prodrug thereof or a pharmaceutically acceptable salt thereof. The above-mentioned triazole compound is useful as a therapeutic drug for the treatment of diabetes, obesity or metabolic syndrome.

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12-11-2004 дата публикации

GLUCOCORTICOID MIMETICS, METHODS OF MAKING THEM, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF

Номер: KR20040095343A
Принадлежит:

Compounds of Formula (IA) and Formula (IB) wherein R1, R2, R3, R4, R5 and R6 are as defined herein for Formula (IA) or Formula (IB), or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds. © KIPO & WIPO 2007 ...

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11-03-2010 дата публикации

TRIAZOLE COMPOUNDS AND USES RELATED THERETO

Номер: US20100062972A1
Принадлежит: AMGEN INC.

The present invention provides a triazole compound of the following formula: a prodrug thereof or a pharmaceutically acceptable salt thereof. The above-mentioned triazole compound has superior HSD1 inhibitory activity, and is useful as an HSD1 inhibitor, a therapeutic drug of diabetes or a therapeutic drug of obesity or a therapeutic drug of metabolic syndrome.

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11-09-2007 дата публикации

Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof

Номер: US0007268152B2

Compounds of Formula (IA) and Formula (IB) wherein R1, R2, R3, R4, R5, and R6 are as defined herein for Formula (IA) or Formula (IB), or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.

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21-09-2004 дата публикации

Fluorescence polarization assay

Номер: US0006794158B2

This invention is directed to a fluorescence polarization assay useful in the detection and evaluation of soluble epoxide hydrolase (sEH) inhibitors. This invention also relates to novel fluorescent probes used in the fluorescence polarization assay, and methods of manufacturing such fluorescent probes.This fluorescent probe of the invention is a compound having the following formula (I):wherein X is the radical of compound that binds to the active site of soluble epoxide hydrolase, Y is a fluorescent label, and "spacer" and R1 are as defined herein.

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03-04-2007 дата публикации

Antiinflammation agents

Номер: US0007199119B2
Принадлежит: Amgen Inc., AMGEN INC, AMGEN INC.

Compounds, compositions and methods that are useful in the treatment of inflammatory, immunoregulatory, metabolic, infectious and cell proliferative diseases or conditions are provided herein. In particular, the invention provides compounds which modulate the expression and/or function of proteins involved in inflammation, metabolism, infection and cell proliferation. The subject compounds contain a fused heterobicyclic ring.

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09-06-2005 дата публикации

Pyrimidine derivatives useful as inhibitors of PKC-theta

Номер: US2005124640A1
Принадлежит:

Disclosed are novel compounds of formula (I): wherein R1, R2 and R3 are as defined herein, which are useful as inhibitors of PKC-theta and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC-theta, including immunological disorders and type II diabetes. This invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.

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03-07-2012 дата публикации

Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and thereof

Номер: US0008212040B2

Compounds of Formula (IA) wherein R1, R2, R3, R4 and R5 are as defined herein for Formula (IA), or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.

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23-06-2009 дата публикации

Pyrimidine derivatives useful as inhibitors of PKC-theta

Номер: US0007550473B2

Disclosed are novel compounds of formula (I): wherein R 1 , R 2 and R 3 are as defined herein, which are useful as inhibitors of PKC-theta and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC-theta, including immunological disorders and type II diabetes. This invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.

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27-07-2010 дата публикации

Substituted pyrazolo[3,4-d]pyrimidines as ACK-1 and LCK inhibitors

Номер: US0007763624B2
Принадлежит: Amgen Inc., AMGEN INC, AMGEN INC.

The present invention relates to compounds of Formula I or a stereomer, a tautomer, a solvate, a pharmaceutically acceptable salt, or a prodrug thereof, pharmaceutical formulations containing the compounds, methods of treatments using the compounds, for example, protein tyrosine kinase-associated disorders such as immunologic and oncologic disorders and methods of preparing medicaments comprising the compounds.

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09-06-2005 дата публикации

Method for selecting compounds from a combinatorial or other chemistry library for efficient synthesis

Номер: US2005124002A1
Принадлежит:

A method for determining efficient synthesis of chemical compounds forming a chemical library, such as a library generated using combinatorial chemistry, is described and disclosed involving the generation of ordered sub-sets of compounds from such library in order to rank or choose which compounds to be synthesized based on reagents to be used.

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05-07-2007 дата публикации

Antiinflammation agents

Номер: US2007155777A1
Принадлежит:

Compounds, compositions and methods that are useful in the treatment of inflammatory, immunoregulatory, metabolic, infectious and cell proliferative diseases or conditions are provided herein. In particular, the invention provides compounds which modulate the expression and/or function of proteins involved in inflammation, metabolism, infection and cell proliferation. The subject compounds contain a fused heterobicyclic ring.

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22-12-2009 дата публикации

Antiinflammation agents

Номер: US0007635695B2
Принадлежит: Amgen Inc., AMGEN INC, AMGEN INC.

Compounds, compositions and methods that are useful in the treatment of inflammatory, immunoregulatory, metabolic, infectious and cell proliferative diseases or conditions are provided herein. In particular, the invention provides compounds which modulate the expression and/or function of proteins involved in inflammation, metabolism, infection and cell proliferation. The subject compounds contain a fused heterobicyclic ring.

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29-03-2007 дата публикации

Pyrazolopyridine and pyrazolopyrimidine compounds

Номер: US2007072851A1
Принадлежит:

The present invention relates to compounds of Formula I or a stereomer, a tautomer, a solvate, a pharmaceutically acceptable salt, or a prodrug thereof, pharmaceutical formulations containing the compounds, methods of treatments using the compounds, for example, protein tyrosine kinase-associated disorders such as immunologic and oncologic disorders and methods of preparing medicaments comprising the compounds.

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18-10-2007 дата публикации

Bicyclic carboxylic acid derivatives useful for treating metabolic disorders

Номер: US2007244155A1
Принадлежит:

Compounds having the general formula I and/or the general formula II are useful, for example, for treating metabolic disorders in a subject where the variables are provided herein. Compositions and methods for using the compounds for preparing medicaments and for treating metabolic disorders such as, for instance, type II diabetes are disclosed.

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22-12-2005 дата публикации

Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof

Номер: US2005282881A1
Принадлежит:

Compounds of Formula (IA) wherein R1, R2, R3, R4 and R5 are as defined herein for Formula (IA), or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.

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26-12-2000 дата публикации

SRC FAMILY DOMAIN SH2 INHIBITORS

Номер: CO4990963A1
Принадлежит: BOEHRINGER INGELHEIM PHARMA

Un compuesto de la fórmula (I): en donde: el anillo se selecciona del grupo que consiste en cicloalquilo C1 a C10 ; Arilo- Con el arilo seleccionado de fenilo, naftilo; fenilo y/o naftilo que son parcial o completamente halogenados, fenilo y/o naftilo sustituido con flúor, cloro, bromo, yodo, alquilo C1 a C10 , hidroxilo; nitro; -COOH; -COOH; -CO(alcoxi C1 a C6 ), - CO(alquilo C1 a C6 ); amino; alquilamino C1 a C10 ; dialquilamino C1 a C10 , Alcoxi C1 -C10 ; -NCOH; -NCI(alquilo C1 a C6 ); -NSO2 -Ph(halo)0-3 , Ph; -O-Ph; naftilo; -O-naftilo; pirrolilo; pirrolilo sustituido con alquilo C1 a C6 , piridilo; piridinilo; pirazinilo; pirimidinilo y piridazinilo; heterociclilo- con el heterociclilo seleccionado de heterociclos monocíclicos de 5-8 miembros con 1 a 4 heteroátomos seleccionados de nitrógeno, oxígeno, azufre o un heterociclilo bicíclico con 8-11 miembros con 1 a 4 heteroátomos seleccionados de nitrógeno, oxígeno, azufre. A se selecciona del grupo que consiste en alquilo C1 a C10 ; alquenilo C2 a C12 ; alquinilo C2 a C12 ; alcoxi C1 a C10 ; cicloalquilo C1 a C10 ; cicloalquenilo C2 a C12 ; heterocíclilo como en la definición del anillo a; arilo como se definió anteriormente para el anillo a; en donde dicho cicloalquilo, heterociclilo o arilo está opcionalmente enlazado a Q o N a través de un enlazador alcoxi C1 a C10 , -O-amino, alquilo C1 a C6 , alquil amino C1 a C6 , carbonilo, amido amido alquilo C1 a C10 , alcoxicarbonilo C1 a C10 , carbonil alquiloxi C1 a C10 , con el heterociclilo como en la definición para el anillo a, Q se selecciona del grupo que consiste en un enlace, ANDgt;C=O, ANDgt;S(O)2 y ANDgt;C=S; - 2 -B se selecciona de un grupo que consiste en H; alquilo C1 a C6 y un grupo protector de nitrógeno; R es un enlace o un enlazador alquilo C1 a C10 ; arilo como se definió para el anillo a; heterocíclilo con el heterociclilo como se definió para el anillo a o un enlazador cicloalquilo C1 a C10 ; C es una funcionalidad de cáracter ácido que lleva una o ...

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12-08-2004 дата публикации

2,4-diaminopyrimidine derivatives useful as inhibitors of pkc-theta

Номер: CA2514612A1
Принадлежит: Individual

Disclosed are novel compounds of formula (I) wherein R1, R2 and R3 are as defined herein, which are useful as inhibitors of PKC-theta and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC-theta, including immunological disorders and type II diabetes. This invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders and processes for preparing these compounds.

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09-10-2003 дата публикации

Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof

Номер: CA2478156A1
Принадлежит: Individual

Compounds of Formula (IA) and Formula (IB) wherein R1, R2, R3, R4, R5 and R6 are as defined herein for Formula (IA) or Formula (IB), or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing su ch compounds, and methods of modulating the glucocorticoid receptor function an d methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.

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16-08-2007 дата публикации

Acyl hydrazones for treating cardiovascular diseases

Номер: WO2006121684A3

Disclosed are hydrzine compounds useful as soluble epoxide hydrolase (sEH) inhibitors for treating cardiovascular diseases.

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01-03-2007 дата публикации

Pyrazolopyridine and pyrazolopyrimidine compounds useful as kinase enzymes modulators

Номер: CA2619365A1

The present invention relates to compounds of Formula (I) or a stereomer, a tautomer, a solvate, a pharmaceutically acceptable salt, or a prodrug thereof, pharmaceutical formulations containing the compounds, methods of treatments using the compounds, for example, protein tyrosine kinase-associated disorders such as immunologic and oncologic disorders and methods of preparing medicaments comprising the compounds.

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31-10-2003 дата публикации

MIMETICS OF GLUCOCORTICOIDS, PROCEDURES FOR THE PREPARATION, PHARMACEUTICAL COMPOSITIONS AND THEIR USE OF THEM.

Номер: UY27736A1
Принадлежит: BOEHRINGER INGELHEIM PHARMA

Compuestos de fórmula (IA) y fórmula (IB) en las que R1, R2, R3, R4, R5, y R6, son como se definen en la presente memoria para la fórnula (IA) o la fórmula (IB), o uno de sus tautómeros, profármacos, solvatos o sales, composiciones farmacéuticas que contienen dichos compuestos y procedimientos para modular la función del receptor de glucocorticoides y procedimientos para tratar estados de enfermedad o trastornos mediados por la función del receptor de glucocorticoides o caracterizados por procesos inflamatorios, alérgicos o proliferativos en un paciente usando estos compuestos. Compounds of formula (IA) and formula (IB) in which R1, R2, R3, R4, R5, and R6, are as defined herein for the formula (IA) or formula (IB), or one of its tautomers, prodrugs, solvates or salts, pharmaceutical compositions containing said compounds and procedures for modulating the function of the glucocorticoid receptor and procedures for treating disease states or disorders mediated by the function of the glucocorticoid receptor or characterized by inflammatory, allergic processes or proliferative in a patient using these compounds.

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11-10-2010 дата публикации

Glucocorticoid mimetics, pharmaceutical preparations and applications for the manufacture of drugs for the treatment of disease

Номер: NO329386B1
Принадлежит: BOEHRINGER INGELHEIM PHARMA

Forbindelser med Formel (IA) og Formel (IB) hvor R, R, R, R, R5 og Rer som definert heri for Formel (IA) eller Formel (IB) eller en tautomer, prodrug, solvat eller salt derav; farmasøytiske preparater inneholdende slike forbindelser og metoder for å modulere glukocorticoidreseptorfunksjonen og metoder for behandling av sykdomstilstander eller forstyrrelser mediert av glukocorticoidreseptorfunksjonen ellerinflammatoriske, allergiske eller proliferative prosesser hos en pasient ved anvendelse av disse forbindelser.

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24-06-1999 дата публикации

Pyridones as src family sh2 domain inhibitors

Номер: CA2315113A1
Принадлежит: Individual

This invention relates to compounds of formula (I) wherein Ring a, A, B, C, D, E, R and Q are defined herein. These compounds possess the ability to disrupt the interaction between regulatory proteins possessing one or more SH2 domains and their native ligands.

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01-03-2007 дата публикации

Pyrazolopyridine and pyrazolopyrimidine compounds useful as kinase enzymes modulators

Номер: WO2007024680A1
Принадлежит: Amgen Inc.

The present invention relates to compounds of Formula (I) or a stereomer, a tautomer, a solvate, a pharmaceutically acceptable salt, or a prodrug thereof, pharmaceutical formulations containing the compounds, methods of treatments using the compounds, for example, protein tyrosine kinase-associated disorders such as immunologic and oncologic disorders and methods of preparing medicaments comprising the compounds.

Подробнее
19-10-2004 дата публикации

Glucocorticoid mimetics, methods of preparing them, pharmaceutical compositions and applications thereof

Номер: NO20044031L
Принадлежит: BOEHRINGER INGELHEIM PHARMA

Forbindelser med Formel (IA) og Formel (IB) hvor R, R, R, R, Rog Rer ran definert heri for Formel (IA) eller Formel (IB) eller en tautomer, prodrug, solvit eller salt derav; farmasøytiske preparater inneholdende slike forbindelser og metoder for å modulere glukocorticoidieseptorfunksjonen og metoder forfnwg av sykdomstilstander eller forstyrrelser mediert av glukocoiticoidicseptoifunksjonen ellerinflammatoriske, allergiske eller proliferative prosesser hos en pasient ved anvendelse av disse forbindelser.

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21-05-2004 дата публикации

Antiinflammation agents

Номер: CA2502429A1
Принадлежит: Individual

Compounds, compositions and methods that are useful in the treatment of inflammatory, immunoregulatory, metabolic, infectious and cell proliferative diseases or conditions are provided herein. In particular, the invention provides compounds which modulate the expression and/or function of proteins involved in inflammation, metabolism, infection and cell proliferation. The subject compounds contain a fused heterobicyclic ring.

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12-02-2004 дата публикации

Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof

Номер: US20040029932A1

Compounds of Formula (IA) and Formula (IB) wherein R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 are as defined herein for Formula (IA) or Formula (IB), or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.

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17-12-2008 дата публикации

Bicyclic carboxylic acid derivatives useful for treating metabolic disorders

Номер: EP2001844A2
Принадлежит: AMGEN INC

Compounds having the general formula I and/or the general formula II are useful, for example, for treating metabolic disorders in a subject formula (I) (II) where the variables are provided herein. Compositions and methods for using the compounds for preparing medicaments and for treating metabolic disorders such as, for instance, type II diabetes are disclosed.

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16-11-2023 дата публикации

Lrrk2 inhibitors

Номер: WO2023220238A1
Принадлежит: Interline Therapeutics, Inc.

The present invention relates to imidazo[4,5-c]quinoline compounds of Formula (I), and pharmaceutically acceptable salts thereof. The invention is also directed to pharmaceutical compositions comprising the compounds of Formula (I) and to use of the compounds in the treatment of diseases associated with LRRK2, such as neurodegenerative diseases including Parkinson's disease or Alzheimer's disease, or inflammatory bowel disease such as Crohn's disease.

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16-11-2023 дата публикации

Lrrk2 inhibitors

Номер: WO2023220247A1
Принадлежит: Interline Therapeutics, Inc.

The present invention relates to imidazo[4,5-c]quinoline compounds of Formula (I), and pharmaceutically acceptable salts thereof. The invention is also directed to pharmaceutical compositions comprising the compounds of Formula (I) and to use of the compounds in the treatment of diseases associated with LRRK2, such as neurodegenerative diseases including Parkinson's disease or Alzheimer's disease, or inflammatory bowel disease such as Crohn's disease.

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14-12-2023 дата публикации

Imidazo(1,2-a)pyridine derivatives as ripk2 inhibitors

Номер: WO2023239941A1
Принадлежит: Interline Therapeutics Inc.

The present application relates to compounds of Formula (I), as defined herein, and pharmaceutically acceptable salts thereof, and compositions comprising same. Also described are methods of treating the diseases and disorders disclosed herein, with the compounds of Formula (I), and pharmaceutically acceptable salts thereof, and the compositions comprising same.

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15-09-2017 дата публикации

Clucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof

Номер: MY163491A

COMPOUNDS OF FORMULA (IA) AND FORMULA (IB) WHEREIN R1,R2,R3,R4,R5, AND R6 ARE AS DEFINED HEREIN FOR FORMULA (IA) OR FORMULA (IB), OR A TAUTOMER, PRODRUG, SOLVATE, OR SALT THEREOF; PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH COMPOUNDS, AND METHODS OF MODULATING THE GLOCOCORTICOID RECEPTOR FUNCTION AND METHODS OF TREATING DISEASE-STATES OR CONDITIONS MEDIATED BY THE GLUCOCORTICOID RECEPTOR FUNCTION OR CHARACTERIZED BY INFLAMMATORY, ALLERGIC, OR PROLIFERATIVE PROCESSES IN A PATIENT USING THESE COMPOUNDS.

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14-11-2024 дата публикации

Lrrk2 inhibitors

Номер: AU2023269061A1
Принадлежит: Interline Therapeutics Inc

The present invention relates to imidazo[4,5-c]quinoline compounds of Formula (I), and pharmaceutically acceptable salts thereof. The invention is also directed to pharmaceutical compositions comprising the compounds of Formula (I) and to use of the compounds in the treatment of diseases associated with LRRK2, such as neurodegenerative diseases including Parkinson's disease or Alzheimer's disease, or inflammatory bowel disease such as Crohn's disease.

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