25-07-2013 дата публикации
Номер: US20130190256A1
The invention relates to novel curcumin derivatives in which one or two of the phenolic groups have been modified. 2. A curcumin derivative according to claim 1 , with the proviso that if Yis —C≡CH claim 1 , then m1 is 0.3. A curcumin derivative according to claim 1 , with the proviso that if Yis —C≡CH claim 1 , then m2 is 0.7. A curcumin derivative according to claim 6 , wherein the saccharide is a monosaccharide.8. A curcumin derivative according to claim 7 , wherein the monosaccharide is glucose or galactose.12. A curcumin derivative according to claim 11 , wherein the saccharide is a monosaccharide.13. A curcumin derivative according to claim 12 , wherein the monosaccharide is glucose or galactose.14. A curcumin derivative according to claim 1 , wherein Yor Yis a saccharide.15. A curcumin derivative according to claim 1 , wherein Y or Yis a disaccharide or a trisaccharide.16. A curcumin derivative according to claim 1 , wherein the saccharide is a monosaccharide.17. A curcumin derivative according to claim 1 , wherein the monosaccharide is glucose or galactose. This application claims the benefit of U.S. Provisional Application No. 61/308,362, filed Feb. 26, 2010, which is incorporated herein by reference.There is a vital need to find drugs that halt or reverse Alzheimer's disease (AD). AD presently affects 18 million people worldwide. The human and financial costs of AD in the US is expected to exceed $150 billion in 2005. FDA approved medications treat symptoms, but do not alter AD progression.The hallmarks of AD are inter-neuronal plaques consisting of precipitates or aggregates of amyloid beta protein (Aβ), and intra-neuronal neurofibrillary tangles (NFTs) of tau protein. The major target for drug discovery for AD has been Aβ that forms insoluble senile plaques. Although the etiology of AD is not fully understood, the Aβ amyloid cascade hypothesis is the most common view of the pathological pathway of AD in which the generation of Aβ and accumulation of Aβ ...
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