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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Применить Всего найдено 39. Отображено 39.
24-10-2019 дата публикации

PHARMACEUTICAL COMPOSITION CONTAINING (R)-N-[1-(3,5-DIFLUORO-4-METHANSULFONYLAMINO-PHENYL)-ETHYL]-3-(2-PROPYL-6-TRIFLUOROMETHYL-PYRIDIN-3-YL)-ACRYLAMIDE AND METHOD FOR INHIBITING CRYSTAL FORMATION THEREOF

Номер: WO2019203461A1
Автор: CHOI, Joonho, CHO, Wonkyung, ROH, Jong Hwa, SHIN, Kwanghyun, WOO, Byoung Young, KIM, Min Soo, PARK, Miyoung, PARK, Youngho, PARK, Eunsil, PARK, Jaehong, LEE, Kiwha
Принадлежит:

The present invention relates to a pharmaceutical composition, containing (R)-N-[1-(3,5-difluoro-4-methansulfonylamino-phenyl)-ethyl]-3-(2-propyl-6-trifluoromethyl-pyridin-3-yl)-acrylamide as a first ingredient and containing a vinylpyrrolidone-based polymer as a second ingredient. The composition of the present invention has a formulation characteristic in which the crystal formation of a compound represented by chemical formula 1 is delayed for a long time.

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Номер записи: 1
03-06-2010 дата публикации

CRYSTAL FORM OF ADEFOVIR DIPIVOXIL, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME

Номер: WO2010062147A3
Автор: LEE, Ki-Wha, JUN, Jai Il, HONG, Deok Ki, WOO, Byoung Young, LEE, Yeongran
Принадлежит:

A crystal form of Adefovir Dipivoxil according to the present invention is an ethyl alcohol solvated form. A method for preparing the crystal form of Adefovir Dipivoxil comprises the steps of: dissolving Adefovir Dipivoxil into an anhydrous ethyl alcohol, and cooling and stirring the Adefovir Dipivoxil solution obtained by the dissolving step to form crystals. The crystal form of Adefovir Dipivoxil according to the present invention has superior solubility and velocity of dissolution, and excellent biosafety, and can be widely used in medical fields.

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Номер записи: 2
16-06-2015 дата публикации

BOLT TO REPAIR GROOVE AND GROOVE REPAIRING METHOD USING SAME

Номер: KR1020150066360A
Автор: LEE, KI HWA, KIM, KYU SIK, CHOI, SANG HO, LEE, SANG HO
Принадлежит:

The present invention relates to a bolt to repair a groove, and a groove repairing method using the same. The groove repairing method comprises: a groove boring step of boring a bolt groove in a damaged pin groove of an object; a bolt insertion step of inserting a bolt to repair a groove having an alternative groove in the bolt groove; a bolt cutting step of separating and removing an exposure part exposed from the bolt to repair a groove such that an insertion part inserted in the bolt groove remains in the bolt to repair the groove; and an alternative groove utilization step of utilizing the alternative groove instead of the damaged pin groove without an additional boring work of the insertion part to replace a damaged pin groove. The present invention increases the accuracy of a position, an inclination, and a depth of the alternative groove and reduces a hazard of safety accidents of the workers by forming the alternative groove, formed in the bolt to repair a groove, in a properly ...

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Номер записи: 3
06-04-2023 дата публикации

(R)-N-[1-(3,5-다이플루오로-4-메테인설폰일아미노-페닐)-에틸]-3-(2-프로필-6-트라이플루오로메틸-피리딘-3-일)-아크릴아마이드를 함유하는 약학 조성물

Номер: KR102518632B1
Автор: 최준호, 조원경, 노종화, 신광현, 우병영, 김민수, 박은실, 박제홍, 이기화, 박미영, 박영호
Принадлежит: (주)아모레퍼시픽

... (R)-N-[1-(3,5-다이플루오로-4-메테인설폰일아미노-페닐)-에틸]-3-(2-프로필-6-트라이플루오로메틸-피리딘-3-일)-아크릴아마이드를 제1 성분으로 포함하고, 비닐피롤리돈계 폴리머를 제2 성분으로 포함하는 약학 조성물에 관한 것으로, 본 발명의 조성물은 화학식 1로 표시되는 화합물의 결정형성이 장기간 지연되는 제형 특성을 가진다.

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Номер записи: 4
14-02-2019 дата публикации

PHARMACEUTICAL COMPOSITION CONTAINING (R)-N-[1-(3,5-DIFLUORO-4-METHANSULFONYLAMINO-PHENYL)-ETHYL]-3-(2-PROPYL-6-TRIFLUOROMETHYL-PYRIDIN-3-YL)-ACRYLAMIDE

Номер: WO2019031902A2
Автор: CHOI, Joon Ho, CHO, Won Kyung, SHIN, Kwang-Hyun, WOO, Byoung Young, LEE, Ki-Wha, KIM, Min-Soo, ROH, Jong Hwa, PARK, Mi Young, PARK, Young-Ho, PARK, Eun Sil, PARK, Jae Hong
Принадлежит:

The present invention relates to a pharmaceutical composition which comprises (R)-N-[1-(3,5-difluoro-4-methansulfonylamino-phenyl)-ethyl]-3-(2-propyl-6-trifluoromethyl-pyridin-3-yl)-acrylamide as a first component and a cellulosic polymer as a second component, wherein the composition of the present invention has a formulation characteristic in which crystal formation is delayed for a long time.

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Номер записи: 5
13-07-2017 дата публикации

CHIRAL RESOLUTION METHOD FOR N-[4-(1-AMINOETHYL)-PHENYL]-SULFONAMIDE DERIVATIVE USING POLAR APROTIC SOLVENT

Номер: WO2017119666A1
Автор: WOO, Byoung Young, LEE, Ki-Wha, ROH, Jong Hwa, PARK, Jae Hong, PARK, Miyoung, PARK, Young-Ho
Принадлежит:

The present invention relates to a chiral resolution method for a stereoisomeric mixture, the method comprising a step for mixing a stereoisomeric mixture of a compound, in which an amine group is attached to an asymmetric carbon atom, and a chiral auxiliary. Here, the chiral auxiliary is 2,3-dibenzoyl-tartaric acid or O,O'-di-p-toluoyl tartaric acid. An optical isomer having a high level of optical purity may be obtained by this method. Moreover, according to this method, the ratio of the stereoisomeric mixture contained in a mother liquid may be adjusted through recovery of the optical isomer. Therefore, in the pharmaceutical or medicinal field, a method according to an aspect of the present invention may be usefully used when attempting to obtain at high purity, a compound having a single type of optical isomer, and may be usefully used in the racemization of a mother liquid used in another reaction.

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Номер записи: 6
03-06-2010 дата публикации

CRYSTAL FORM OF ADEFOVIR DIPIVOXIL, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME

Номер: KR2010062147A2
Автор: LEE, Ki-Wha, JUN, Jai Il, HONG, Deok Ki, WOO, Byoung Young, LEE, Yeongran
Принадлежит:

A crystal form of Adefovir Dipivoxil according to the present invention is an ethyl alcohol solvated form. A method for preparing the crystal form of Adefovir Dipivoxil comprises the steps of: dissolving Adefovir Dipivoxil into an anhydrous ethyl alcohol, and cooling and stirring the Adefovir Dipivoxil solution obtained by the dissolving step to form crystals. The crystal form of Adefovir Dipivoxil according to the present invention has superior solubility and velocity of dissolution, and excellent biosafety, and can be widely used in medical fields.

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Номер записи: 7
11-05-2016 дата публикации

Novel compounds, isomer thereof, or pharmaceutically acceptable salts thereof as vanilloid receptor antagonist；and pharmaceutical compositions containing the same

Номер: KR0101619341B1
Автор: 신송석, 김진관, 김선영, 이기화, 우병영, 모주현, 정연수, 임경민, 최진규, 고현주, 박영호
Принадлежит: (주)아모레퍼시픽

... 본 발명은 바닐로이드 수용체(Vanilloid Receptor 1; VR1; TRPV1) 길항제로서의 신규 화합물, 이의 이성질체 또는 이의 약학적으로 허용가능한 염; 및 이를 포함하는 약학 조성물에 관한 것이다. 본 발명은 통증(pain), 편두통(migraine), 관절통(arthralgia), 신경통(neuralgia), 신경장애(neuropathies), 신경손상(nerve injury), 피부 이상(skin disorder), 방광 과민증(urinary bladder hypersensitiveness), 과민성대장 증후군(irritable bowel syndrome), 급성 배변(fecal urgency), 호흡이상(respiratory disorder), 피부, 눈 또는 점막의 자극(irritation of skin, eye or mucous membrane), 위-십이지장 궤양(stomach-duodenal ulcer), 염증성 질환(inflammatory diseases), 귓병(ear disease), 심장질환(heart disease) 등의 질환들을 예방 또는 치료하는 약학 조성물을 제공한다.

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Номер записи: 8
02-11-2015 дата публикации

INTEGRATED FLOATING HONING JIG APPARATUS FOR PERFORMING BOTH ANGLE FLOATING AND POSITION FLOATING SIMULTANEOUSLY

Номер: KR101565112B1
Автор: JANG, HYUN JIN, LEE, KI HWA
Принадлежит: SAEROMPRECISIONTE. CO., JANG, HYUN JIN, LEE, KI HWA

The present invention relates to an integrated floating honing jig apparatus which can perform both angle floating and position floating simultaneously. As a honing jig apparatus for honing by inserting a structure, the apparatus according to the present invention comprises: a jig body (10) for supporting the floor surface; multiple thrust bearings for moving the position (20) inserted into the jig body (10) to provide a space for moving to the sides; a bottom body fixing pin (30) for fixating by being inserted into the jig body (10) downward; a top body fixing pin (40) for combining the top by being inserted in between the thrust bearings for moving the position (20) upward; an escape prevention cover (50) attached to the jig body (10) to prevent an escape of the structure to be processed; and multiple angle floating pins (60) to fixate by giving a space for controlling the angle to both shafts supported in and fixated to the jig body (10). COPYRIGHT KIPO 2016 ...

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Номер записи: 9
14-01-2010 дата публикации

METHOD FOR PREPARING CRYSTAL FORM L OF ADEFOVIR DIPIVOXIL

Номер: KR2010005195A2
Автор: LEE, Ki-Wha, WOO, Byoung Young, HONG, Deok Ki, JUN, Jai Il
Принадлежит:

Disclosed is a method for preparing a crystal form L of adefovir dipivoxil. The method creates crystals by adding an anti-solvent to isopropyl alcohol or an ethyl acetate solution of adefovir dipivoxil and stirring the resultant mixture. The desired crystal form L of adefovir dipivoxil with a uniform and proper size can be easily obtained in a much milder condition by the preparation method of the present invention than by previously known methods.

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Номер записи: 10
05-08-2016 дата публикации

바닐로이드 수용체 길항제로 작용하는 신규 화합물, 이의 이성질체 또는 이의 약제학적으로 허용 가능한 염 및 이를 포함하는 약학 조성물

Номер: KR0101645537B1
Автор: 김선영, 김연준, 남미희, 이기화, 신송석, 우병영, 임경민, 정연수, 모주현, 최진규, 고현주, 이정오, 김혁, 윤정훈
Принадлежит: (주)아모레퍼시픽

... 본 발명은 바닐로이드 수용체(Vanilloid Receptor 1; VR1; TRPV1) 길항제로 작용하는 신규 화합물, 이의 이성질체 또는 이의 약제학적으로 허용 가능한 염; 및 이를 포함하는 약학 조성물에 관한 것이다. 본 발명은 통증, 편두통(migraine), 관절통(arthralgia), 신경통(neuralgia), 신경장해(neuropathies), 신경 손상(nerve injury), 피부 질환(skin disorder), 비뇨 방광 과민증(urinary bladder hypersensitiveness), 과민성 대장 증후군(irritable bowel syndrome), 절박배변(fecal urgency), 호흡기 질환(respiratory disorder), 위-십이지장 궤양(stomach-duodenal ulcer), 염증 질병(inflammatory diseases), 귓병(ear disease), 심장병(heart disease) 등과 같은 질병의 예방 또는 치료용 약학 조성물을 제공한다.

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Номер записи: 11
20-06-2019 дата публикации

PHARMACEUTICAL COMPOSITION CONTAINING (R)-N-[1-(3,5-DIFLUORO-4-METHANSULFONYLAMINO-PHENYL)-ETHYL]-3-(2-PROPYL-6-TRIFLUOROMETHYL-PYRIDIN-3-YL)-ACRYLAMIDE

Номер: WO2019031902A3
Автор: CHOI, Joon Ho, CHO, Won Kyung, SHIN, Kwang-Hyun, WOO, Byoung Young, LEE, Ki-Wha, KIM, Min-Soo, ROH, Jong Hwa, PARK, Mi Young, PARK, Young-Ho, PARK, Eun Sil, PARK, Jae Hong
Принадлежит:

The present invention relates to a pharmaceutical composition which comprises (R)-N-[1-(3,5-difluoro-4-methansulfonylamino-phenyl)-ethyl]-3-(2-propyl-6-trifluoromethyl-pyridin-3-yl)-acrylamide as a first component and a cellulosic polymer as a second component, wherein the composition of the present invention has a formulation characteristic in which crystal formation is delayed for a long time.

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Номер записи: 12
15-10-2015 дата публикации

Bolt for repairing hole and Method for repairing hole with the same

Номер: KR0101560904B1
Автор: 이기화, 김규식, 최상호, 이상호
Принадлежит: 주식회사 포스코

... 본 발명에 따른 홈 수리용 볼트를 이용한 홈 수리방법은, 대상물의 손상된 핀홈에 볼트홈을 천공하는 홈천공단계; 대체홈을 가진 홈 수리용 볼트를 상기 볼트홈에 삽입하는 볼트삽입단계; 상기 홈 수리용 볼트에서 상기 볼트홈에 삽입된 삽입부만이 남도록, 상기 홈 수리용 볼트에서 노출된 노출부를 분리제거하는 볼트절단단계; 및 손상된 상기 핀홈을 대체하기 위한 상기 삽입부의 별도 천공작업 없이, 손상된 상기 핀홈을 대신하여 상기 대체홈이 활용되는 대체홈활용단계;를 포함한다. 이와 같이 본 발명의 홈 수리용 볼트를 이용한 홈 수리방법은, 홈 수리용 볼트 내에 형성되는 대체홈을 볼트홈에 홈 수리용 볼트를 삽입하기 전에 먼저 적정 넓이의 장소에서 수작업이 아닌 기계가공을 통하여 형성시킴으로써, 대체홈의 위치, 기울기, 깊이의 정확성을 높이고 이와 함께 작업자 안전사고의 위험성도 낮출 수 있다. 아울러, 상기 대체홈이 형성되는 볼트마련단계에서 홈 수리용 볼트의 노출부 하단 측부를 따라 노치홈을 형성시킴으로써, 볼트절단 시 외력에 의해 홈 수리용 볼트의 노출부 하단에 노치효과가 일어나서 용이하게 볼트가 절단될 수 있다.

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Номер записи: 13
07-03-2019 дата публикации

COMPOSITION FOR PREVENTING OR TREATING SLEEP DISORDERS

Номер: WO2019045215A1
Автор: CHOI, Gyeyoung, NAM, Hyunjin, PARK, Miyoung, JUNG, Kyoungmi, LEE, Jihae, CHOI, Chang Soon, PARK, Youngho, ROH, Jong Hwa, PARK, Eunsil, PARK, Jaehong, SHIN, Kwanghyun, WOO, Byoung Young, LEE, Kiwha, CHO, Wonkyung, CHOI, Joonho
Принадлежит:

Disclosed is a composition for preventing or treating sleep disorders, containing (R)-N-[1-(3,5-difluoro-4-methanesulfonylamino-phenyl)-ethyl]-3-(2-propyl-6-trifluoromethyl-pyridine-3-yl)-acrylamide as an active ingredient. A composition of the present invention can effectively and safely prevent or treat sleep disorders accompanying atopic dermatitis.

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Номер записи: 14
25-08-2016 дата публикации

CHIRAL RESOLVING METHOD FOR DERIVATIVES OF N-[4-(1-AMINOETHYL)-PHENYL]-METHANESULFONAMIDE

Номер: KR1020160101554A
Автор: WOO, BYOUNG YOUNG, LEE, KI WHA, SHIN, KWANG HYUN, PARK, MI YOUNG, JUNG, KYOUNG MI, CHOI, JOON HO, CHOI, GYE YOUNG, CHO, WON KYUNG, PARK, YOUNG HO
Принадлежит:

The present invention relates to a chiral resolving method for a stereomer mixture comprising a step of mixing the stereomer mixture of a compound, which is made by an amine group coupled with an asymmetric carbon atom, with a chiral auxiliary reagent and a salt-forming auxiliary compound. In the meantime, the chiral auxiliary reagent is a 2,3-dibenzoyl-tartaric acid or an O, O′-di-p-toluoyl tartaric acid. The salt forming auxiliary compound is a mandelic acid or a camphoric sulfonic acid. According to the present invention, an optical isomer having a high degree of optical purity can be obtained. Therefore, the method according to an aspect of the present invention can be usefully utilized in a pharmacy or a pharmaceutical field when a compound having a single type of optical isomers is to be obtained at high purity. COPYRIGHT KIPO 2016 ...

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Номер записи: 15
08-11-2017 дата публикации

SYSTEM AND METHOD FOR HOME DELIVERY SERVICE USING HOME DELIVERY TERMINAL OF APARTMENT HOUSE COMPLEX UNIT

Номер: KR1020170123433A
Автор: LEE, KI HWA, ANN, JEA HYUN
Принадлежит:

The present invention relates to a system and a method for a home delivery service using a home delivery terminal of an apartment house complex unit, providing a dedicated home delivery service by each large-scale apartment house complex, such as an apartment complex, a studio apartment complex, etc., with a predetermined range and, at the same time, performing a work of classifying a home delivery article of each apartment house complex and a delivery work of the classified home delivery article within the corresponding apartment house complex by a home delivery serviceman employed among residents of the corresponding apartment house complex during such dedicated home delivery service. According to the present invention, the system comprises: an apartment house complex home delivery terminal server installed in each apartment house complex with a predetermined range to provide a home delivery service to the corresponding apartment house complex; an apartment house complex home delivery ...

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Номер записи: 16
09-01-2017 дата публикации

METHOD FOR MANUFACTURING N-(4-ACETYL-2,6-DIFLUOROPHENYL)METHANESULFONAMIDE

Номер: KR1020170003261A
Автор: WOO, BYOUNG YOUNG, LEE, KI WHA, SHIN, KWANG HYUN, CHOI, JOON HO, CHO, WON KYUNG, PARK, MI YOUNG, PARK, YOUNG HO
Принадлежит:

The present invention relates to a method for manufacturing N-(4-acetyl-2,6-difluorophenyl)methanesulfonamide comprising the step of conducting the reaction of 3,4,5-trifluoroacetophenone and methanesulfonamide in the presence of a nitrile solvent. According to the present invention, INT-1 can be easily manufactured with high yield. Also, INT-1 can be manufactured by not including a metal catalyst while not generating impurities. Accordingly, by not including a metal catalyst, the method is cost effective compared to other methods and can be used in manufacture fields of INT-1 by obtaining INT-1 with high yield. COPYRIGHT KIPO 2017 ...

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Номер записи: 17
08-12-2016 дата публикации

METHOD FOR PREPARING PYRIDINE INTERMEDIATE

Номер: WO2016195174A1
Автор: WOO, Byoung Young, LEE, Ki-Wha, NAM, Hyun-Jin, PARK, Miyoung, PARK, Young-Ho
Принадлежит:

This specification relates to a method for preparing substituted pyridine by using ammonium carbamate as a nitrogen source to prepare enamine as an intermediate compound, and thereafter reacting the same with other compounds again. According to the method of the present specification, it is possible to prepare substituted pyridine with a high yield in a short reaction time, by a method consisting of at least two steps. In addition, according to this method, the reaction is processed under solvent-free and catalyst-free conditions, and thus the method exhibits a highly efficient arrangement effect. Thus, the present invention can be used widely in the fields of medicine or pharmaceuticals, in fields where substituted pyridine is prepared.

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Номер записи: 18
11-11-2015 дата публикации

COSMETIC COMPOSITION FOR BODY SLIMMING CONTAINING 2-CYCLOPENTENE-1-ONE OXIME DERIVATIVES

Номер: KR0101567571B1
Автор: 김연준, 박미영, 최진규, 이기화, 김선영, 고현주, 우병영, 이은경, 신동욱, 이형호, 이태룡, 임경민
Принадлежит: (주)아모레퍼시픽

... 화학식 1로 나타내어지는 2-사이클로펜텐-1-온 옥심 유도체를 포함하는 슬리밍 화장료 조성물이 개시된다. 구체적으로 상기 화합물은 분화된 지방세포 (3T3-L1)에서의 지방분해를 촉진시켜 결과적으로 체내 지방을 감소시킴으로써, 슬리밍과 같은 미용 목적으로 이용될 수 있다. 화학식 1에서 R1은 선형 또는 분지형 C1-C6 알킬기, 또는 사이클로알킬기, 또는 치환기를 갖거나 갖지 않는 페닐기를 의미하고, R2는 치환기를 갖거나 갖지 않는 방향족기를 의미한다.

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Номер записи: 19
05-01-2017 дата публикации

METHOD FOR PREPARING N-(4-ACETYL-2,6-DIFLUOROPHENYL)METHANESULFONAMIDE

Номер: WO2017003026A1
Автор: WOO, Byoung Young, LEE, Ki-Wha, SHIN, Kwang-Hyun, CHOI, Joonho, CHO, Wonkyung, PARK, Miyoung, PARK, Young-Ho
Принадлежит:

The present invention relates to a method for preparing N-(4-acetyl-2,6-difluorophenyl)methanesulfonamide, the method comprising a step of reacting 3,4,5-trifluoroacetophenone and methanesulfonamide in the presence of a nitrile solvent. The preparation method of the present invention enables a high yield of INT-1 to be prepared easily, particularly without involving a metal catalyst and without producing impurities. Therefore, by being more economical than other methods in that a metal catalyst is not involved and enabling INT-1 to be obtained with high yield, the method can be useful in the field of INT-1 preparation.

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Номер записи: 20
19-05-2016 дата публикации

NOVEL COMPOUNDS, ISOMER THEREOF, OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AS VANILLOID RECEPTOR ANTAGONIST AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME

Номер: KR0101621444B1
Автор: 우병영, 김선영, 김연준, 신송석, 김진관, 이기화, 김동현, 임경민, 모주현, 정연수, 최진규, 고현주, 이정오, 김혁, 윤정훈, 리, 푸난, 김지숙, 서영거
Принадлежит: (주)아모레퍼시픽

... 본 발명은 바닐로이드 수용체(Vanilloid Receptor 1; VR1; TRPV1) 길항제로 작용하는 신규 화합물, 이의 이성질체 또는 이의 약제학적으로 허용 가능한 염; 및 이를 포함하는 약학 조성물에 관한 것이다. 본 발명은 통증, 편두통(migraine), 관절통(arthralgia), 신경통(neuralgia), 신경장해(neuropathies), 신경 손상(nerve injury), 피부 질환(skin disorder), 비뇨 방광 과민증(urinary bladder hypersensitiveness), 과민성대장 증후군(irritable bowel syndrome), 절박배변(fecal urgency), 호흡기 질환(respiratory disorder), 피부, 눈 또는 점막 자극(irritation of skin, eye or mucous membrane), 위-십이지장 궤양(stomach-duodenal ulcer), 염증 질병(inflammatory diseases), 귓병(ear disease), 심장병(heartdisease) 등과 같은 질병의 예방 또는 치료용 약학 조성물을 제공한다.

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Номер записи: 21
19-04-2017 дата публикации

N-[4-(1-아미노에틸)-페닐]-술폰아미드 유도체의 카이랄 분할 방법

Номер: KR1020170042548A
Автор: 우병영, 이기화, 신광현, 박미영, 정경미, 최준호, 최계영, 조원경, 박영호
Принадлежит:

... 본 명세서는 비대칭 탄소원자에 아민기가 결합된 화합물의 입체이성질체 혼합물을 카이랄 보조체 및 염-형성 보조 화합물과 혼합시키는 단계를 포함하는 입체이성질체 혼합물의 카이랄 분할 방법에 관한 것이다. 이때, 카이랄 보조체는 O,O'-디아실타르타르산 유도체산, 보다 구체적으로 2,3-디벤조일-타르타르산 또는 O,O'-디-p-톨루오일 타르타르산이고, 염-형성 보조 화합물은 만델산 또는 캄포르술폰산이며, 이러한 방법에 의하면 높은 수준의 광학 순도를 가지는 광학 이성질체를 얻는 것이 가능하다. 따라서, 본 발명의 일 측면에 따른 방법은 약학 또는 화장품 분야에서 높은 광학 순도를 갖는 광학 이성질체를 제조하고자 하는 경우에 유용하게 사용될 수 있다.

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Номер записи: 22
07-03-2019 дата публикации

COMPOSITION FOR PREVENTING OR TREATING ATOPIC DERMATITIS

Номер: WO2019045214A1
Автор: CHOI, Gyeyoung, NAM, Hyunjin, PARK, Miyoung, JUNG, Kyoungmi, LEE, Jihae, CHOI, Chang Soon, PARK, Youngho, ROH, Jong Hwa, PARK, Eunsil, PARK, Jaehong, SHIN, Kwanghyun, WOO, Byoung Young, LEE, Kiwha, CHO, Wonkyung, CHOI, Joonho
Принадлежит:

The present invention relates to an external skin application composition containing a TRPV1 receptor antagonist and, more specifically, to an external skin application composition for preventing and/or treating atopic dermatitis without side effects such as a body temperature increase and epidermal atrophy.

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Номер записи: 23
14-05-2020 дата публикации

SOL-GEL COMPOSITION

Номер: WO2020096217A1
Автор: CHO, Wonkyung, SHIN, Kwanghyun, CHOI, Joonho, LEE, Kiwha, ROH, Jong Hwa, PARK, Miyoung, PARK, Youngho, PARK, Eunsil, PARK, Jaehong, WOO, Byoung Young, KIM, Min Soo, HA, Eun Sol
Принадлежит:

The present invention relates to a sol-gel composition enabling reversible sol-gel transition and, more specifically, to a sol-gel composition of which the viscosity changes by physical force applied from the outside so that reversible sol-gel transition is performed.

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Номер записи: 24
02-07-2018 дата публикации

RACEMIZATION METHOD OF ENANTIOMERS OF N-[4-(1-AMINOETHYL)-2,6-DIFLUORO-PHENYL]-METHANOSULFONAMIDE

Номер: KR1020180073113A
Автор: WOO, BYOUNG YOUNG, LEE, KI WHA, PARK, MI YOUNG, PARK, YOUNG HO
Принадлежит:

The present specification discloses a method which is capable of converting S type enantiomers remained after selectively separating R type enantiomers included in racemates (R/S=1/1) of N-[4-(1-aminoethyl)-2,6-difluoro-phenyl]-methanesulfonamide into the racemates (R/S=1/1) of N-[4-(1-aminoethyl)-2,6-difluoro-phenyl]-methanesulfonamide again through racemization. According to the present invention, the method is economical by enabling the S type enantiomers which have conventionally been discarded to be recycled, and can racemize the S type enantiomers without contamination caused by material change at a high yield compared to an existing recycling technology. COPYRIGHT KIPO 2018 ...

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Номер записи: 25
14-02-2023 дата публикации

내열성 및 내마모성이 향상된 메탈 하우징

Номер: KR20230021379A
Автор: 이건영, 이기화
Принадлежит:

... 본 발명은 아연도금로 롤러 샤트프 지지 메탈 하우징에 관한 것으로, 본 발명에 의한 메탈하우징은 내열성은 물론 내마모성이 극히 우수하여 메탈하우징의 교체시간을 대폭 연장할 수 있으므로 메탈하우징 교체에 따른 인력소모 및 제 경비 등을 절감할 수 있으며, 교체주기를 장기화하여 생산성도 대폭 향상할 수 있는 효과가 있다.

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Номер записи: 26
25-05-2016 дата публикации

IDLE THROTTLE VALVE OF DIESEL VEHICLE AND FUEL INJECTION CONTROL METHOD

Номер: KR1020160058317A
Автор: LEE, KI HWA, WON, KWANG MIN, NAM, CHUNG GEUN, KIM, HYUNG SHIN, LEE, DONG CHUL, KIM, BO YONG
Принадлежит:

An idle throttle valve of a diesel vehicle and a fuel injection control method are disclosed. To this end, the fuel injection control method comprises: a throttle access condition determination step of determining whether or not a vehicle satisfies an idle throttle access condition under the running of the vehicle; an injection information obtaining step of measuring vehicle information to control injection of a fuel; an idle throttle control step of controlling the throttle valve using a predetermined target air amount map when the vehicle satisfies the throttle access condition determination step, controlling an EGR valve using an EGR map; a step of controlling injection of the fuel by applying the vehicle information measured by the injection information obtaining step to an injection correction map; and a step of determining whether or not the vehicle satisfies a releasing condition of the idle throttle control step. The purpose of the present invention is to provide the idle throttle ...

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Номер записи: 27
14-01-2010 дата публикации

METHOD FOR PREPARING CRYSTAL FORM L OF ADEFOVIR DIPIVOXIL

Номер: WO2010005195A3
Автор: LEE, Ki-Wha, WOO, Byoung Young, HONG, Deok Ki, JUN, Jai Il
Принадлежит:

Disclosed is a method for preparing a crystal form L of adefovir dipivoxil. The method creates crystals by adding an anti-solvent to isopropyl alcohol or an ethyl acetate solution of adefovir dipivoxil and stirring the resultant mixture. The desired crystal form L of adefovir dipivoxil with a uniform and proper size can be easily obtained in a much milder condition by the preparation method of the present invention than by previously known methods.

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Номер записи: 28
05-04-2018 дата публикации

METHOD FOR PREPARING (R)-N-[4-(1-AMINO-ETHYL)-2,6-DIFLUORO-PHENYL]-METHANESULFONAMIDE

Номер: WO2018062799A1
Автор: WOO, Byoung Young, LEE, Ki-Wha, LEE, Jihae, CHOI, Chang Soon, PARK, Miyoung, PARK, Young-Ho, JAYAPRAKASH, Sarva, REGATI, Sridhar, SRINIVAS, Mamidi, PATEL, Krushnakant, RAMAMOHAN, M.
Принадлежит:

Disclosed in the present specification is a method capable of preparing N-[4-[(1R)-1-[[(R)-(1,1-dimethylethyl)sulfinyl]amino]ethyl]-2,6-difluorophenyl]-methanesulfonamide (INT028-2) with high optical purity, through the selection of Ellman-chiral auxiliaries and the re-crystallization and separation of optical isomers. According to the above method, high-purity N-[4-[(1R)-1-[[(R)-(1,1- dimethylethyl)sulfinyl]amino]ethyl]-2,6-difluorophenyl]-methanesulfonamide with excellent quality can be produced at room temperature by improving cryogenic process conditions necessary for realizing high optical purity, and thus the trimming due to the process failure rate can be remarkably reduced.

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Номер записи: 29
14-12-2016 дата публикации

METHOD FOR MANUFACTURING METHYL 2-PROPYL-6-(TRIFLUOROMETHYL)NICOTINATE

Номер: KR1020160143293A
Автор: WOO, BYOUNG YOUNG, LEE, KI WHA, NAM, HYUN JIN, PARK, MI YOUNG, PARK, YOUNG HO
Принадлежит:

The present invention relates to a method for manufacturing enamine as an intermediate compound by using ammonium carbamate as a nitrogen source, reacting with other compounds, and manufacturing substituted pyridine. According to the present invention, substituted pyridine can be manufactured with high yields and in a short reaction time by a method comprising at least two steps. Also, a reaction is performed at solvent-free and noncatalytic conditions, so arrangement efficiency is very high. Accordingly, the method can be widely used in a field of manufacturing substituted pyridine, i.e. medical or pharmaceutical fields. COPYRIGHT KIPO 2016 ...

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Номер записи: 30
20-11-2017 дата публикации

N-[4-(1-아미노에틸)-페닐]-술폰아미드 유도체의 카이랄 분할 방법

Номер: KR0101791119B1
Автор: 우병영, 이기화, 신광현, 박미영, 정경미, 최준호, 최계영, 조원경, 박영호
Принадлежит: (주)아모레퍼시픽

... 본 명세서는 비대칭 탄소원자에 아민기가 결합된 화합물의 입체이성질체 혼합물을 카이랄 보조체 및 염-형성 보조 화합물과 혼합시키는 단계를 포함하는 입체이성질체 혼합물의 카이랄 분할 방법에 관한 것이다. 이때, 카이랄 보조체는 O,O'-디아실타르타르산 유도체산, 보다 구체적으로 2,3-디벤조일-타르타르산 또는 O,O'-디-p-톨루오일 타르타르산이고, 염-형성 보조 화합물은 만델산 또는 캄포르술폰산이며, 이러한 방법에 의하면 높은 수준의 광학 순도를 가지는 광학 이성질체를 얻는 것이 가능하다. 따라서, 본 발명의 일 측면에 따른 방법은 약학 또는 화장품 분야에서 높은 광학 순도를 갖는 광학 이성질체를 제조하고자 하는 경우에 유용하게 사용될 수 있다.

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Номер записи: 31
22-07-2015 дата публикации

APPARATUS FOR SEALING PIPE

Номер: KR0101538868B1
Автор: 김규식, 이기화
Принадлежит: 주식회사 포스코

... 폐열회수보일러 설비 내의 고온의 가스가 외부로 배출되는 것을 방지하도록 폐열회수보일러의 내부와 외부를 동시에 밀폐할 수 있는할 수 있는 배관 실링장치에 관한 것이다.본 발명의 배관 실링장치는, 폐열회수보일러 설비의 설비케이스와 이 설비케이스를 관통하는 배관 사이의 틈새부위를 실링하는 배관 실링장치로서,상기 설비케이스 내부에 형성된 상기 틈새부위를 둘러싸며 구비되어 상기 설비케이스 내부에서 발생된 고온의 가스가 상기 틈새부위를 따라 외부로 유출되는 것을 방지하는 1차 실링부; 및상기 설비케이스 외부에 상기 배관을 둘러싸며 구비되어 상기 배관의 팽창 또는 수축시 상기 배관과 동일하게 거동하여 상기 틈새부위를 실링하는 2차 실링부를 포함하고,상기 2차 실링부는, 상기 설비케이스 상면에 구비되어 상기 배관을 둘러싸는 제1밀착부재와, 상기 제1밀착부재를 둘러싸며 구비되는 제2밀착부재와, 상기 제2밀착부재를 둘러싸며 구비되는 고정플레이트를 포함하며,상기 제1밀착부재 및 제2밀착부재는 상기 배관의 수축 또는 팽창시 상기 배관과 동일하게 거동할 수 있도록 탄성을 가지는 것을 특징으로 한다.

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Номер записи: 32
05-07-2018 дата публикации

필름 절단 장치

Номер: KR0101875078B1
Автор: 김준섭, 진태준, 이기화, 장종민
Принадлежит: (주)피엔티

... 권취된 원단 필름을 풀어내면서 엣지(edge) 제거 작업과 폭 방향 횡단 절개 작업을 연속적으로 수행하여 필름 시트(film sheet)를 형성하는 필름 절단 장치가 개시된다. 개시된 필름 절단 장치는, 권취된 원단 필름을 풀어 공급하는 원단 필름 언와인딩 롤러(unwinding roller)과, 원단 필름에서 그 폭 방향 양 측 단부의 엣지(edge)를 잘라내는 엣지 커팅 유닛과, 엣지가 제거된 원단 필름을 미리 정해진 간격을 두고 절단하여 필름 시트를 형성하는 필름 시트 커팅 유닛(film sheet cutting unit)과, 엣지 커팅 유닛과 필름 시트 커팅 유닛 사이에 마련되어 엣지가 제거된 원단 필름을 필름 시트 커팅 유닛으로 공급하나, 필름 시트 커팅 유닛에 의해 원단 필름이 절단되는 동안에는 원단 필름을 정지시키는 원단 필름 공급 유닛과, 엣지 커팅 유닛에서 잘려진 엣지를 권취하여 수거하는 엣지 와인딩 롤러와, 원단 필름 언와인딩 롤러와 엣지 커팅 유닛 사이, 또는 엣지 커팅 유닛과 원단 필름 공급 유닛에 마련되고, 원단 필름의 텐션(tension) 변화에 감응하여 승강하는 댄서 롤러(dancer roller)를 구비하는 원단 필름 텐션 조절 유닛과, 원단 필름 언와인딩 롤러, 원단 필름 공급 유닛, 필름 시트 커팅 유닛, 및 엣지 와인딩 롤러의 동작을 제어하는 제어 유닛을 구비한다.

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Номер записи: 33
17-10-2017 дата публикации

SYSTEM AND METHOD FOR PROVIDING PARCEL INFORMATION USING WIDGET

Номер: KR1020170115298A
Автор: LEE, KI HWA, ANN, JEA HYUN
Принадлежит:

The present invention relates to a system and a method for providing parcel information using widgets of electronic devices on which a parcel delivery state is displayed for example a departure and destination such as smartphones and tablet PCs on the basis of a current location of a parcel, such that a user who sends the parcel and a user who receives the parcel can easily check the current parcel delivery state in real time. The system for providing parcel information using a widget, according to one embodiment of the present invention, comprises: a delivery information notifying service operating server which makes a parcel application for displaying a parcel delivery state as departures and destinations for each delivery step through a widget, and provides the parcel application for a terminal which is going to use the parcel application; a parcel delivery providing terminal which has the parcel application, generates either or both a destination signal and a departure signal of a parcel ...

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Номер записи: 34
12-07-2017 дата публикации

METHOD FOR CHIRAL RESOLUTION OF N-[4-(1-AMINOETHYL)-PHENYL]-SULFONAMIDE DERIVATIVES BY USING POLAR APROTIC SOLVENT

Номер: KR1020170081315A
Автор: WOO, BYOUNG YOUNG, LEE, KI WHA, ROH, JONG HWA, PARK, JAE HONG, PARK, MI YOUNG, PARK, YOUNG HO
Принадлежит:

The present specification relates to a method for chiral resolution of the stereoisomeric mixture. The method comprises the step of mixing a chiral auxiliary with a stereoisomeric mixture of compounds in which amine groups are bonded to asymmetric carbon atoms. In this case, the chiral auxiliary is 2,3-dibenzoyl-tartaric acid or O,O′-di-p-toluoyl tartaric acid, and it is possible to obtain optical isomers with high optical purity levels by the method. Further, the method enables a ratio of the stereoisomeric mixture included in a mother liquid to be controlled by recovering the optical isomers. Accordingly, the method according to one aspect of the present invention can be usefully used when obtaining high purity compounds having single conformational optical isomers in a pharmacy or pharmaceutical field. Further, the method can be usefully used in performing a racemization process on mother liquids used in other reactions. COPYRIGHT KIPO 2017 ...

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Номер записи: 35
25-08-2016 дата публикации

CHIRAL RESOLUTION METHOD OF N-[4-(1-AMINOETHYL)-PHENYL]-SULFONAMIDE DERIVATIVES

Номер: WO2016133317A1
Автор: WOO, Byoung Young, LEE, Ki-Wha, SHIN, Kwang-Hyun, PARK, Miyoung, JUNG, Kyoungmi, CHOI, Joonho, CHOI, Gyeyoung, CHO, Wonkyung, PARK, Young-Ho
Принадлежит:

The present specification relates to a chiral resolution method of a stereoisomer mixture, comprising a step of mixing a stereoisomer mixture of compounds, in which an amine group is bound to an asymmetric carbon atom, with a chiral auxiliary and salt-forming auxiliary compound, wherein the chiral auxiliary is an O,O'-diacyltartaric acid derivative, more specifically, a 2,3-dibenzoyl-tartaric acid or an O,O'-di-p-toluoyl tartaric acid, the salt-forming auxiliary compound is mandelic acid or camphorsulfonic acid, and an optical isomer having a high level of optical purity can be obtained by using the method. Therefore, according to one aspect of the present invention, the method can be useful in the pharmaceutical or cosmetic field when preparing an optical isomer having a high optical purity.

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Номер записи: 36
28-06-2018 дата публикации

METHOD FOR RACEMIZING ENANTIOMERS OF N-[4-(1-AMINO-ETHYL)-2,6-DIFLUORO-PHENYL]-METHANESULFONAMIDE

Номер: WO2018117467A1
Автор: WOO, Byoung Young, LEE, Ki-Wha, PARK, Miyoung, PARK, Young-Ho
Принадлежит:

Disclosed in the specification is a method which selectively separates an R type enantiomer contained in a racemate (R/S=1/1) of N-[4-(1-amino-ethyl)-2,6-difluoro-phenyl]-methanesulfonamide, and then can convert the same back into the racemate (R/S=1/1) of N-[4-(1-amino-ethyl)-2,6-difluoro-phenyl]-methanesulfonamide through racemization of the remaining S type enantiomer. According to the method, S type enantiomers which were discarded in the past can be recycled, which is economical, and the S type enantiomers can be racemized without contamination due to material changes at a higher yield than the existing recycling technology.

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Номер записи: 37
06-07-2015 дата публикации

APPARATUS FOR SEALING PIPE

Номер: KR1020150075555A
Автор: KIM, KYU SIK, LEE, KI HWA
Принадлежит:

The present invention relates to an apparatus for sealing a pipe which can seal the inside and outside of a waste heat recovering boiler simultaneously to prevent high-temperature gas in the facility of the waste heat recovering boiler from being discharged to the outside. The apparatus for sealing a pipe according to the present invention is an apparatus for sealing a pipe which seals a gap between the facility case of the facility of a waste heat recovering boiler and a pipe penetrating the facility case. The apparatus for sealing a pipe comprises: a first sealing part enveloping the gap formed inside the facility case to prevent high-temperature gas, which is generated inside the facility case, from leaking through the gap to the outside; and a second sealing part enveloping the pipe outside the facility case to seal the gap by behaving identically to the pipe during the expansion and contraction of the pipe. COPYRIGHT KIPO 2015 (DD) Right (CC) Left (BB) Contraction (AA) Expansion ...

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Номер записи: 38
27-04-2017 дата публикации

PIPE CLEANING APPARATUS

Номер: KR101726762B1
Автор: KIM, KYU SIK, KIM, KYUNG HA, LEE, KI HWA, CHOI, SANG HO, LEE, SANG HO
Принадлежит: POSCO

The present invention relates to a pipe cleaning apparatus, which can effectively clean a pipe. The pipe cleaning apparatus according to an embodiment of the present invention comprises: a pipe member which provides a path for a fluid, and which contains a filter member configured to filter out impurities included in the fluid; a spray unit which selectively sprays cleaning fluid to the filter member; a pressure measurement unit which measures pressure inside the pipe member, particularly pressure in front of the filter member and pressure in back of the filer member based on the direction in which the fluid moves; and a control unit which is connected to the pressure measurement unit, which calculates the ratio of the pressure in back of the filer member to the pressure in front of the filter member by using the pressures measured by the pressure measurement unit, and which controls the spray unit to spray the cleaning fluid when the pressure ratio is less than a reference pressure ratio ...

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Номер записи: 39