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Применить Всего найдено 3. Отображено 3.
06-01-2017 дата публикации

ＳＩＲＴ1을 포함하는 ＡＴＦ4 과발현 질환 예방 또는 치료용 약학 조성물

Номер: KR0101693718B1
Автор: 이기호, 우선랑, 신현진, 홍성희, 이은주, 함용호, 김양현, 주현유
Принадлежит: 한국원자력의학원

... 본 발명은 SIRT1 단백질, 상기 SIRT1 단백질을 코딩하는 폴리뉴클레오티드 또는 상기 폴리뉴클레오티드를 포함하는 유전자치료용 발현벡터를 포함하는 ATF4 과발현 질환의 예방 또는 치료용 약학 조성물, ATF4 발현억제용 조성물 및 ATF4 발현을 억제하는 방법에 관한 것이다. 본 발명의 SIRT1을 포함하는 조성물은 세포내에서 ATF4의 축적을 억제하여, 결과적으로는 ER 스트레스를 감소 또는 억제할 수 있으므로, ATF4의 과발현 또는 ER 스트레스에 의해 유발되거나 또는 악화될 수 있는 질환의 예방 또는 치료에 널리 활용될 수 있을 것이다.

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Номер записи: 1
29-07-2010 дата публикации

MARKER FOR LIVER-CANCER DIAGNOSIS AND RECURRENCE AND SURVIVAL PREDICTION, A KIT COMPRISING THE SAME, AND PROGNOSIS PREDICTION IN LIVER-CANCER PATIENTS USING THE MARKER

Номер: WO2010085124A3
Автор: LEE, Kee Ho, PARK, Eun Ran, CHA, Pu Hyeon, KIM, Sang Bum, PARK, Sun Hoo, LEE, Dong Hyoung, WOO, Seon Rang, HAN, Chul Ju, HAM, Yong Ho, LEE, Eun Ju, PARK, Myoung Jin, HWANG, Sang Gu
Принадлежит:

The present invention relates to a composition used in marker detection for liver-cancer diagnosis or prognosis prediction comprising a preparation for measuring the level of expression of UQCRH (ubiquinol-cytochrome c reductase hinge protein), to a kit comprising the composition, to a microarray for diagnosing liver cancer using the marker, to a method for detecting the marker, and to the prediction of recurrence following surgery in liver-cancer patients. According to the present invention, the marker has been judged to be able to greatly contribute to predicting the recurrence and the prognosis for survival following surgery in individuals who have had an early diagnosis and liver resection surgery for liver cancer, and provides significance to treatment targets for subsequent liver-cancer treatment.

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Номер записи: 2
29-07-2010 дата публикации

MARKER FOR LIVER-CANCER DIAGNOSIS AND RECURRENCE AND SURVIVAL PREDICTION, A KIT COMPRISING THE SAME, AND PROGNOSIS PREDICTION IN LIVER-CANCER PATIENTS USING THE MARKER

Номер: KR2010085124A2
Автор: LEE, Kee Ho, PARK, Eun Ran, CHA, Pu Hyeon, KIM, Sang Bum, PARK, Sun Hoo, LEE, Dong Hyoung, WOO, Seon Rang, HAN, Chul Ju, HAM, Yong Ho, LEE, Eun Ju, PARK, Myoung Jin, HWANG, Sang Gu
Принадлежит:

The present invention relates to a composition used in marker detection for liver-cancer diagnosis or prognosis prediction comprising a preparation for measuring the level of expression of UQCRH (ubiquinol-cytochrome c reductase hinge protein), to a kit comprising the composition, to a microarray for diagnosing liver cancer using the marker, to a method for detecting the marker, and to the prediction of recurrence following surgery in liver-cancer patients. According to the present invention, the marker has been judged to be able to greatly contribute to predicting the recurrence and the prognosis for survival following surgery in individuals who have had an early diagnosis and liver resection surgery for liver cancer, and provides significance to treatment targets for subsequent liver-cancer treatment.

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Номер записи: 3