15-01-2018 дата публикации
Номер: KR1020180005113A
Принадлежит:
The present invention relates to a psoriasis-induced animal model and a use thereof, and more particularly, to a psoriasis-induced animal model transformed such that a Pellino homolog 1 (Peli1) gene is overexpressed according to the administration of doxycycline; and a use thereof. The Peli1 gene is overexpressed according to the administration of doxycycline in the transgenic animal model of the present invention, showing similarity to the phenotype exhibited in a patient with psoriasis, and thus the transgenic animal model can be useful in clinical research, such as screening for candidate drugs for psoriasis treatment. Further, the transgenic animal model can be useful in the development of new drugs for psoriasis-associated diseases through a Peli1 FHA domain-derived peptide, which interferes with the normal substrate binding of a substrate protein and a Peli1 protein and targets the FHA binding motif. Furthermore, the model can be useful in evaluating the severity of disease of patients ...
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