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Применить Всего найдено 12. Отображено 12.
17-01-2019 дата публикации

NOVEL 1H-PYRAZOLOPYRIDINE DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING SAME

Номер: WO2019013562A1
Принадлежит:

The present invention relates to a novel 1H-pyrazolopyridine derivative and a pharmaceutical composition containing the same. The 1H-pyrazolopyridine derivative and the pharmaceutical composition containing the same can be effectively used for prevention or treatment of an autoimmune disease or cancer.

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21-07-2011 дата публикации

METHOD FOR PREPARING TETRAZOLE METHANESULFONIC ACID SALTS, AND NOVEL COMPOUND USED IN SAME

Номер: WO2011087316A2
Принадлежит:

According to the present invention, a method for preparing tetrazole methanesulfonic acid salts comprises an acylation reaction using a novel 4-iodine-4H-chromene-2-carbothionic acid S-benzothiazole-2-yl ester. The method of the present invention can shorten a reaction time and improve safety as compared to conventional methods, and can prepare high-purity tetrazole methanesulfonic acid salts at a high yield rate without using a column chromatography method.

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16-05-2018 дата публикации

NOVEL PYRROLOPYRIMIDINE DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING SAME

Номер: KR1020180051220A
Принадлежит:

The present invention relates to a compound represented by chemical formula 1, or a pharmaceutically acceptable salt thereof. According to the present invention, the compound has effective inhibitory functions against Briton′s tyrosine kinase (BTK) and is able to be useful for preventing or treating diseases. In the chemical formula 1, X, L, and R are the same as defined in the present specification. COPYRIGHT KIPO 2018 ...

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08-02-2019 дата публикации

1-(4-(4-(3,4-디클로로-2-플루오로페닐아미노)-7-메톡시퀴나졸린-6-일옥시)피페리딘-1-일)프로프-2-엔-1-온의 제조방법

Номер: KR1020190012245A
Автор: 방극찬, 정재혁, 문영호
Принадлежит:

... 본 발명은 화학식 2의 화합물을 비활성 극성 비양성자성 용매 중에서 염기의 존재 하에 화학식 3의 화합물과 반응시킴으로써 목적하는 1-(4-(4-(3,4-디클로로-2-플루오로페닐아미노)-7-메톡시퀴나졸린-6-일옥시)피페리딘-1-일)프로프-2-엔-1-온을 종래 방법에 비해 훨씬 간편하게 제조하는 방법에 관한 것이다.

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18-04-2019 дата публикации

NOVEL PHENYLPYRIDINE DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING SAME

Номер: WO2019074275A1
Принадлежит:

The present invention relates to a novel phenylpyridine derivative represented by chemical formula 1 and a pharmaceutical composition containing the same. The compound according to the present invention can be favorably used in the prevention or treatment of an autoimmune disease or cancer.

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07-04-2022 дата публикации

PROTEIN KINASE INHIBITOR AND USE THEREOF

Номер: WO2022071772A1
Принадлежит:

Provided are: a compound of chemical formula 1, having protein kinase inhibitory activity; a stereoisomer thereof or a pharmaceutically acceptable salt thereof; and a use thereof.

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22-02-2019 дата публикации

1-(4-(4-(3,4-디클로로-2-플루오로페닐아미노)-7-메톡시퀴나졸린-6-일옥시)피페리딘-1-일)프로프-2-엔-1-온의 제조방법

Номер: KR0101950942B1
Автор: 방극찬, 정재혁, 문영호
Принадлежит: 한미약품 주식회사

... 본 발명은 화학식 2의 화합물을 비활성 극성 비양성자성 용매 중에서 염기의 존재 하에 화학식 3의 화합물과 반응시킴으로써 목적하는 1-(4-(4-(3,4-디클로로-2-플루오로페닐아미노)-7-메톡시퀴나졸린-6-일옥시)피페리딘-1-일)프로프-2-엔-1-온을 종래 방법에 비해 훨씬 간편하게 제조하는 방법에 관한 것이다.

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05-03-2020 дата публикации

NOVEL HETEROCYCLIC AMINE DERIVATIVE AND PHARMACEUTICAL COMPOSITION COMPRISING SAME

Номер: WO2020045941A1
Принадлежит:

The present invention relates to a novel heterocyclic amine derivative represented by chemical formula 1 stated below and a pharmaceutical composition comprising same, and a compound according to the present invention may be utilized for prevention or treatment of autoimmune diseases or cancer. [Chemical formula 1] In chemical formula 1, explanations for R1, R2, X1, X2, L, Y, A, and B are as defined in the description.

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21-07-2011 дата публикации

METHOD FOR PREPARING TETRAZOLE METHANESULFONIC ACID SALTS, AND NOVEL COMPOUND USED IN SAME

Номер: WO2011087316A3
Принадлежит:

According to the present invention, a method for preparing tetrazole methanesulfonic acid salts comprises an acylation reaction using a novel 4-iodine-4H-chromene-2-carbothionic acid S-benzothiazole-2-yl ester. The method of the present invention can shorten a reaction time and improve safety as compared to conventional methods, and can prepare high-purity tetrazole methanesulfonic acid salts at a high yield rate without using a column chromatography method.

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17-01-2018 дата публикации

NOVEL 4-AMINOPYRAZOLO[3,4-d]PYRIMIDINYL AZABICYCLO DERIVATIVE AND PHARMACEUTICAL COMPOSITION COMPRISING SAME

Номер: KR1020180006334A
Принадлежит:

The present invention relates to a novel 4-aminopyrazolo[3,4-d]pyrimidinyl azabicyclo derivative and a pharmaceutical composition comprising the same. The 4-aminopyrazolo[3,4-d]pyrimidinyl azabicyclo derivative and the pharmaceutical composition comprising the same have a BTK inhibitory activity as well as a remarkably high inhibitory activity selectivity against BTK compared to ITK, thereby being useful for the prevention and treatment of autoimmune diseases or cancer as a BTK inhibitor. COPYRIGHT KIPO 2018 ...

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28-04-2022 дата публикации

PROTEIN KINASE INHIBITOR AND USE THEREOF

Номер: WO2022086284A1
Принадлежит:

Provided are: a compound of chemical formula 1, having inhibitory activity against protein kinase, a stereoisomer thereof, or a pharmaceutically acceptable salt thereof; and a use thereof.

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22-01-2019 дата публикации

신규한 1H-피라졸로피리딘 유도체 및 이를 포함하는 약학 조성물

Номер: KR1020190007391A
Автор: 방극찬, 엄덕기, 박준석
Принадлежит:

... 본 발명은 신규한 1H-피라졸로피리딘 유도체 및 이를 포함하는 약학 조성물에 관한 것으로, 상기 1H-피라졸로피리딘 유도체 및 이를 포함하는 약학 조성물은 자가 면역 질환 또는 암의 예방 또는 치료에 유용하게 사용될 수 있다.

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