04-11-2016 дата публикации
Номер: KR1020160127568A
Автор:
CHOI SOONGYU,
PARK, EUN JUNG,
SEO, HEE JEONG,
KONG, YOUNG GYU,
SON, ICK HWAN,
MA, SANG HO,
CHA, MAN YOUNG,
KIM, MI SOON,
PARK, KI SOO
Принадлежит:
The present invention relates to a compound represented by chemical formula (I) as Traf2- and NCK-interacting kinase (TNIK), I-kappa-B kinase epsilon (IKKε) and TANK-binding kinase 1 (TBK1) inhibitors. The compound according to the present invention effectively inhibits the TNIK, IKKε and TBK1, and thus is useful not only as an anticancer agent for the treatment of various cancers including colorectal cancer, breast cancer, CNS cancer, colon cancer, non-small cell lung cancer, kidney cancer, prostate cancer, ovarian cancer, uterus cancer, stomach cancer, liver cancer, skin cancer, lung cancer, brain cancer, bladder cancer, esophageal cancer, pancreatic cancer, thyroid cancer, head and neck cancer, squamous cell carcinoma, osteosarcoma, B-cell or T-cell lymphoma, acute or chronic leukemia and multiple myeloma, but as a therapeutic agent for chronic inflammation. COPYRIGHT KIPO 2016 ...
Подробнее