METHOD FOR MANUFACTURING PRODUCT WITH METALLIC LOGO

The present invention provides a method for manufacturing a product with a metallic logo, which comprises the following steps: preparing a transparent or translucent injection product; disposing a metallic logo on the back side of the product; bonding the metallic logo to the back surface of the product by interposing a transparent or translucent adhesive tape between the product and the metallic logo; and coating a protective layer on the exposed surface of the product and the metallic logo. According to the method for manufacturing the product with the metallic logo, according to the present invention, a product with a complicated metallic logo can be realized with accurate dimensions and shapes, and the yield of a product can be improved. COPYRIGHT KIPO 2018 (AA) Start (BB) End (S10) Preparing a transparent or translucent injection product (S20) Disposing a metallic logo on the back side of the product (S30) Bonding the metallic logo to the back surface of the product by interposing ...

알부민 기반 질환 추적 진단 또는 치료 나노플랫폼

... 본 발명은 알부민에 아자이드(N3)기 또는 사이클로옥테인(Cyclooctyne)기가 수식된, 알부민 나노플랫폼을 제조하는 방법 및 이를 통해 제조된 알부민 나노플랫폼에 관한 것이다. 또한, 본 발명은 상기 알부민 나노플랫폼에 아자이드(N3)기 또는 사이클로옥테인(Cyclooctyne)기를 포함하는 전달물질이 결합된 알부민 나노플랫폼 제조용 키트, 알부민 나노플랫폼을 제조하는 방법 및 이를 통해 제조된 전달물질이 결합된 알부민 나노플랫폼에 관한 것이다. 본 발명에 따른 알부민을 기반의 플랫폼은 혈관내구획에서 존재할 뿐만 아니라 그 크기로 인하여 신장에서의 결합 및 재흡수가 되지 않기 때문에 신장의 섭취를 피할 수 있어 이러한 신독성으로부터 자유로운 약물전달 및 방사성의약품으로서의 넓은 응용이 가능하다. 또한 본 발명은 변형을 최소화하여 오랜 시간 혈관내구획에 존재함으로써 표적 조직 및 장기로의 효과적인 약물 전달이 가능하여 표적 조직으로의 높은 섭취를 용이케 하는 플랫폼 기술이다.

PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING CIRRHOSIS OF LIVER COMPRISING G PROTEIN COUPLED RECEPTOR 119 LIGAND AS ACTIVE INGREDIENT

The present invention relates to a pharmaceutical composition for preventing or treating cirrhosis of liver comprising G protein coupled receptor 119 (GPR119) ligand as an active ingredient. The composition containing GPR119 ligand as an active ingredient according to the present invention significantly inhibits the expression of collagen I, transforming growth factor β(TGFβ), and α-smooth muscle actin (α-SMA) for inhibiting the activation of hepatic stellate cells and significantly inhibiting the multiplication of hepatic stellate cells. Therefore, the composition of the present invention can be effectively utilized for alleviating, preventing, inhibiting, or treating cirrhosis of liver. COPYRIGHT KIPO 2017 ...

ANTIBODY FUNCTIONALIZATION METHOD AND METHOD FOR MANUFACTURING NANOPARTICLE-ANTIBODY CONJUGATED NANO-PLATFORM

The present invention relates to a method for functionalizing an antibody with high efficiency while maintaining bioactivation of the antibody, and a method for manufacturing a nanoparticle-antibody conjugated nano-platform, in which orientation of the antibody is controlled. According to the method for functionalizing an antibody, a disulfide group within an Fc domain of the antibody is only reduced to functionalize the antibody in a state that bioactivation of the antibody is maintained as it is, bind the antibody with nanoparticles with high coupling efficiency and control orientation of the antibody bound with the nanoparticles. In addition, the present invention couples the antibody to surface of the nanoparticles with excellent coupling efficiency to optimize the number of the antibodies and the nanoparticles needed for manufacturing the nanoplatform such that costs are saved, sensitivity of the manufactured nanoplatform is very high, and binding activity with a target molecule is ...

방사선치료를 위한 다각도 자세 환자 치료 의자

... 본 발명은, 방사선 조사 장치로부터 조사되는 빔의 경로상에 배치가능한 환자 치료 의자로서, 환자의 종아리를 지지할 수 있도록 구성되는 제1 지지부, 환자의 허벅지를 지지할 수 있도록 구성되는 제2 지지부, 환자의 등과 머리를 지지할 수 있도록 구성되는 제3 지지부, 제1 지지부는 제2 지지부와 상대적으로 각도조절이 가능하게 연결되며, 제3 지지부는 제2 지지부와 상대적으로 각도조절이 가능하게 연결되며, 제1 지지부, 제2 지지부 및 제3 지지부는 각도가 조절됨에 따라 환자를 앉은 자세 및 누운 자세로 전환하여 지지할 수 있도록 구성되는 방사선치료를 위한 다각도 자세변형 환자 치료 의자에 관한 것이다. 본 발명에 따른 방사선치료를 위한 다각도 자세 환자 치료 의자는 다양한 각도로 환자를 지지하며, 자동으로 자세를 변환할 수 있으며, 또한 앉은 자세와 누운자세를 기초로 각도를 변화시킬 수 있어 환자의 불편감을 최소화 하면서 치료효과를 극대화할 수 있는 효과가 있다.

PHARMACEUTICAL COMPOSITION COMPRISING THA AS EFFECTIVE INGREDIENT FOR TREATMENT OF PROSTATE CANCER

The present invention relates to a composition comprising 2,4,6-trihydroxyacetophenone (THA) as an effective ingredient for prevention or treatment of prostate cancer. THA in the present invention is a main ingredient of Curcuma comosa. The composition of the present invention effectively inhibits the growth of prostate cancer by regulating in particular the activity of polo-like kinase 1 (PLK1) and thus is expected to find useful applications in use in the prevention, alleviation, and treatment of prostate cancer in future.

PHARMACEUTICAL COMPOSITION COMPRISING GPR119 LIGAND AS ACTIVE INGREDIENT FOR PREVENTING OR TREATING NONALCOHOLIC FATTY LIVER DISEASE

The present invention relates to a pharmaceutical composition comprising a G protein coupled receptor 119 (GPR119) ligand as an active ingredient for preventing or treating a nonalcoholic fatty liver disease. More specifically, according to the present invention, by identifying that the GPR119 ligand which had been developed only as a antidiabetic agent has an excellent effect of treating a nonalcoholic fatty liver disease and the signalling pathways of the GPR119 ligand in liver cells are different from the signalling pathways within a small intestine and a pancreas, which indicates an antidiabetic effect, the GPR119 ligand is demonstrated to be able to be advantageously used in treating a nonalcoholic fatty liver disease. COPYRIGHT KIPO 2015 ...

METHOD FOR SIMULTANEOUSLY DETECTING FLUORESCENCE AND RAMAN SIGNALS FOR MULTIPLE FLUORESCENCE AND RAMAN SIGNAL TARGETS, AND MEDICAL IMAGING DEVICE FOR SIMULTANEOUSLY DETECTING MULTIPLE TARGETS USING THE METHOD

The present invention relates to a method for simultaneously detecting fluorescence and Raman signals for multiple fluorescence and Raman signal targets, and to a medical imaging device for simultaneously detecting multiple targets using the method. The method for simultaneously detecting fluorescence and Raman signals for multiple fluorescence and Raman signal targets according to one embodiment of the present invention comprises the following steps: injecting at least one marker particle consisting of Raman markers and receptors into the body of an animal, such as a human; irradiating a laser beam onto the body of the animal; and detecting the optical signals emitted by the marker particle after the irradiation of the laser beam separately as a fluorescence signal and a Raman signal. According to the present invention, the simultaneous detection of multiple targets may be performed even without individually scanning optical signals emitted by the marker particle. In addition, according ...

METHOD FOR SIMULTANEOUSLY DETECTING FLUORESCENCE AND RAMAN SIGNALS FOR MULTIPLE FLUORESCENCE AND RAMAN SIGNAL TARGETS, AND MEDICAL IMAGING DEVICE FOR SIMULTANEOUSLY DETECTING MULTIPLE TARGETS USING THE METHOD

The present invention relates to a method for simultaneously detecting fluorescence and Raman signals for multiple fluorescence and Raman signal targets, and to a medical imaging device for simultaneously detecting multiple targets using the method. The method for simultaneously detecting fluorescence and Raman signals for multiple fluorescence and Raman signal targets according to one embodiment of the present invention comprises the following steps: injecting at least one marker particle comprising Raman markers and receptors into the body of an animal, which can be a human; irradiating a laser beam onto the body of the animal; and detecting the optical signals emitted by the marker particle after the irradiation of the laser beam separately as fluorescence signals and Raman signals. According to the present invention, the simultaneous detection of multiple targets may be performed even without scanning optical signals emitted by the marker particle individually with different optical ...

SPARC를 발현하는 암의 치료용 조성물

... 본 발명은 알부민 및 이에 결합된 1개 이상의 시스플라틴을 포함하는 SPARC(Secreted Protein Acidic and Rich in Cysteine)를 발현하는 암의 치료용 조성물에 관한 것이다.

PHARMACEUTICAL COMPOSITION COMPRISING THA AS ACTIVE INGREDIENT FOR TREATING BREAST CANCER

The present invention relates to a composition comprising 2,4,6-trihydroxyacetophenone (THA) as an active ingredient for preventing, alleviating, or treating breast cancer. More specifically, the composition of the present invention exhibits an excellent effect in the treatment of breast cancer by inhibiting the activity of polo-like kinase 1 (Plk1), and thus is expected to be used to prevent, alleviate, and treat breast cancer.

NAMEPLATE AND PRODUCTION METHOD THEREOF

According to the present invention, provided are a nameplate and a production method thereof. To this end, the nameplate comprises: a transparent layer; a refractive layer deposited on the back surface of the transparent layer to refract light incident on the transparent layer; and an opaque reflective layer coated on the back surface of the refractive layer to reflect light transmitted through the refractive layer to create various colors on the front surface of the transparent layer. According to the nameplate and the production method, it is possible to create various colors on the front surface of the nameplate. COPYRIGHT KIPO 2018 ...

PIPER AMIDE-BASED COMPOUND AS BOMBESIN RECEPTOR SUBTYPE 3

The present invention relates to: a novel α,β-unsaturated amide compound; a method for preparing a composition for preventing or treating obesity, comprising the steps of selecting a compound showing an obesity prevention or treatment effect from a compound library comprising one or more α,β-unsaturated amide compounds, and preparing a composition for preventing or treating obesity containing the selected compound; and a composition for preventing or treating obesity, containing an α,β-unsaturated amide compound. The α,β-unsaturated amide compound of the present invention has a mother nucleus structure mimicking a piper amide, which is a natural substance showing various activities, and can show various pharmacological activities. In addition, a pure compound can be obtained without carrying out a purification process by column chromatography normally used since soluble by-products are generated using β-phosphono-N-hydroxysuccinimidyl ester as an intermediate. Additionally, it is possible ...

COMPOSITION COMPRISING GOLD COMPOUND AS EFFECTIVE INGREDIENT FOR INHIBITING OSTEOCLAST DIFFERENTIATION

The present invention relates to a composition comprising a gold compound as an effective ingredient for inhibiting osteoclast differentiation, wherein the gold compound can effectively suppress osteoclast differentiation by downregulating the expression of NFATc1 located upstream in the signaling pathway involved in osteoclast differentiation, interfering with the phosphorylation of IKK-IκBα to block NF-κB activation, and inhibiting inflammasome-mediated IL-1β release. In addition, the composition exhibits the effect of repressing bone loss and improving bone density in ovariectomized animal models, and as such, is expected to be used in various fields such as compositions for medicines, quasi-medicines, food additives, and cosmetic materials for use in inhibiting osteoclast differentiation and in alleviating, preventing, or treating osteoclast differentiation-caused metabolic bone disease.

PHENOXYACRYLIC DERIVATIVE AND USE THEREOF

The present invention relates to a phenoxyacrylic derivative and a pharmaceutical composition comprising the same as an active ingredient for preventing or treating a nonalcoholic fatty liver disease. The compound according to the present invention has an excellent inhibitory effect on the activation of SREBP-1c and the expression of FAS, thereby being expected to be advantageously used as an active ingredient of a pharmaceutical composition or a functional food composition for preventing, alleviating or treating a nonalcoholic fatty liver disease. COPYRIGHT KIPO 2015 ...

PHARMACEUTICAL COMPOSITION CONTAINING GPR119 LIGAND AS ACTIVE INGREDIENT FOR PREVENTING OR TREATING NON-ALCOHOLIC FATTY LIVER DISEASE

The present invention relates to a pharmaceutical composition containing a G protein coupled receptor 119 (GPR119) ligand as an active ingredient for preventing or treating non-alcoholic fatty liver disease. More specifically, it was established that the GPR119 ligand, which has been developed as only an anti-diabetic medicine, exhibits an excellent effect in the treatment of non-alcoholic fatty liver, and the signaling pathway in liver cells therefor is different from the signaling pathway in the small intestine or pancreas exhibiting an anti-diabetic effect, and thus it was confirmed that the GPR119 ligand can be useful to treat non-alcoholic fatty liver.

ALBUMIN-BASED DISEASE DIAGNOSTICALLY TRACING OR TREATING NANO-PLATFORM

The present invention relates to a method for producing an albumin nano-platform in which an azide (N_3) group or a cyclooctyne group is modified in albumin, and to an albumin nano-platform produced through the same. Moreover, the present invention relates to an albumin nano-platform producing kit coupled with a transferring material including azide (N_3) group or a cyclooctyne group in the albumin nano-platform; a method for producing an albumin nano-platform; and a transferring material-coupled albumin nano-platform produced through the same. An albumin-based platform according to the present invention exists in an intravascular section and is not coupled and re-absorbed in a kidney, so the albumin-based platform can avoid being absorbed into a kidney. Accordingly, a drug delivery can be performed without being restricted by nephrotoxicity, and the albumin-based platform can be widely applied as a radioactive pharmaceutical product. Moreover, the present invention relates to platform ...

Method for discriminant analysis and standardization of medicinal effect of So-Cheong-Ryoung-Tang

... 본 발명은 (2E,4E,8Z,10E)-N-이소부틸도데카-2,4,8,10-테트라엔아마이드를 표준물질로 하여 소청룡탕의 품질을 판별 및 품질을 표준화하는 방법을 제공한다. 구체적으로, 소청룡탕의 품질을 판별하는 방법으로 소청룡탕 일부를 추출하여 소청룡탕 추출물을 제조하는 단계; 및 상기 소청룡탕 추출물내 포함된 소청룡탕 표준물질의 함량을 측정하는 단계를 포함하고, 상기 판별하고자 하는 품질은 소청룡탕의 항염증 효능이며, 상기 표준물질은 (2E,4E,8Z,10E)-N-이소부틸도데카-2,4,8,10-테트라엔아마이드인 소청룡탕의 품질 판별 방법 및 이를 이용한 품질 표준화 방법을 제공한다. 또한 상기와 같은 품질 표준화 방법을 이용하여 제조한 항염증용 소청룡탕을 제공한다.

AMIDE DERIVATIVE COMPOUND AND USE THEREOF

The present invention relates to an amide derivative compound and a pharmaceutical composition comprising the same as an active ingredient for preventing or treating a nonalcoholic fatty liver disease. The compound according to the present invention suppresses the activity of SREBP-1c and has an excellent inhibitory effect on the FAS expression, thereby being expected to be advantageously used as an active ingredient of a pharmaceutical composition or a functional food composition for preventing, alleviating or treating a nonalcoholic fatty liver disease. COPYRIGHT KIPO 2015 (AA) Compound A ...

PHARMACEUTICAL COMPOSITIONS COMPRISING GOLD PREPARATIONS FOR PREVENTING OR TREATING FIBROSIS OR CIRRHOSIS OF LIVER

The present invention relates to a pharmaceutical composition for the prevention or treatment of liver fibrosis or liver cirrhosis. More specifically, the composition includes gold preparations. According to the present invention, the pharmaceutical or dietary supplement composition includes the gold preparations as an active ingredient in order to accelerate the transformation of macrophages and increase the expression of TREM-2, thereby suppressing the activation of stellate cells and preventing, alleviating, and treating liver fibrosis or liver cirrhosis. The gold preparations, and more specifically, the sodium aurothiomalate or aurothioglucose similar to auranofin and the auranofin are proven to have little side effects after being used to treat other purposes (rheumatoid arthritis) for an extended period of time. COPYRIGHT KIPO 2016 ...

전극 간격의 변경이 가능한 방사선 검출 장치

... 본 문서에 개시되는 실시예에 따른 방사선 검출 장치는, 일 면에 제1 전극이 구비되는 제1 프레임; 일 면에 상기 제1 전극과 대향하는 제2 전극이 구비되고, 상기 제1 프레임과 제1 축 방향으로 이격되게 배치되는 제2 프레임; 상기 제2 프레임에 연결되고, 상기 제2 프레임을 상기 제1 프레임에 대해 상대적으로 상기 제1 축 방향으로 이동시키도록 구성되는 구동 모듈; 및 상기 제1 프레임과 상기 제2 프레임을 연결하고, 상기 제1 프레임과 상기 제2 프레임 사이의 공간을 밀봉하도록 둘러싸는 측면 커버;를 포함하고, 상기 측면 커버는, 상기 제1 프레임과 상기 제2 프레임 사이에 상기 제1 전극과 상기 제2 전극이 수용되고 기체로 채워지는 이온 챔버를 형성하고, 상기 제1 축을 따라 신축 가능하게 형성될 수 있다. 이 외에도 명세서를 통해 파악되는 다양한 실시예가 가능할 수 있다.

GPR119 리간드를 유효성분으로 포함하는 비알콜성 지방간 질환의 예방 또는 치료용 약학적 조성물

... 본 발명은 GPR119 (G protein coupled receptor 119) 리간드를 유효성분으로 포함하는 비알콜성 지방간 질환의 예방 또는 치료용 약학적 조성물에 관한 것으로, 보다 상세하게는 항당뇨 치료제로서만 개발되고 있는 GPR119 리간드가 비알콜성 지방간의 치료에 우수한 효과를 나타내고, 이를 위한 간 세포 내 신호 전달 체계가 항당뇨 효과를 나타내는 소장 및 췌장 내 신호 전달 체계와 상이함을 밝힘으로써, GPR119 리간드가 비알콜성 지방간 치료에 유용하게 이용될 수 있음을 확인하였다.

PHARMACEUTICAL COMPOSITION FOR TREATING BREAST CANCER OR HORMONE-REFRACTORY BREAST CANCER CONTAINING THA AS ACTIVE INGREDIENT

The present invention relates to a composition for preventing, ameliorating, or treating breast cancer or hormone-refractory breast cancer, containing 2,4,6-trihydroxyacetophenone (THA) as an active ingredient. More specifically, the composition of the present invention suppresses activities of polo-like kinase 1 (Plk1) and shows excellent effectiveness in treating breast cancer or hormone-refractory breast cancer, thereby used for preventing, ameliorating, and treating breast cancer or hormone-refractory breast cancer. COPYRIGHT KIPO 2018 ...

PROCÉDÉ DE DIAGNOSTIC IN VITRO SUR LA BASE DE NANOPARTICULES À LIAISONS NON SPÉCIFIQUES MINIMISÉES ET RÉCIPIENT DE RÉACTION

The present invention relates to an in vitro diagnosis method on the basis of nanoparticles with minimized non-specific binding, wherein a sample substrate is overturned to be mounted on a reaction container, and during the reaction, the reaction container is repeatedly overturned or the flow of a solution is maintained, thereby compensating for the mobility of a biological reaction material by nanoparticles and minimizing the non-specific binding by precipitation. Therefore, the diagnosis with excellent accuracy can be performed even at low costs in a short time.

PLK1 저해 활성을 갖는 신규 하이드라진 유도체 및 이의 용도

... 본 발명은 PLK1 저해 활성을 갖는 신규 하이드라진 유도체 및 이의 용도에 관한 것으로, 보다 구체적으로 본 발명에 따른 화합물은 PLK1의 활성을 저해하여, 암 세포의 증식을 억제할 수 있어, 이를 유효성분으로 함유하는 약학적 조성물은 암 예방 또는 치료용으로 유용하게 사용될 수 있다.

금제제를 포함하는 간 섬유화 또는 간 경화의 예방 또는 치료용 약학적 조성물

... 본 발명은 간 섬유화 또는 간 경화의 예방 또는 치료용 약학적 조성물에 관한 것으로서, 보다 구체적으로는 금제제를 포함하는 간 섬유화 또는 간 경화의 예방 또는 치료용 약학적 조성물에 관한 것이다. 본 발명의 약학적 조성물은 금(gold)제제를 유효성분으로 포함함으로써, 대식세포의 M2 형질전환을 촉진시킬 뿐만 아니라, TREM-2 발현 증가로 성상세포의 활성화를 억제하여 간 섬유화 또는 간 경화를 예방, 치료 또는 개선하는 약학 조성물, 식품 조성물 등으로 유용하게 이용될 수 있을 것으로 기대된다. 또한, 금(gold)제제, 특히 오라노핀(auranofin)과 이와 유사한 금티오말산 소듐(sodium aurothiomalate) 또는 금티오글루코오스(aurothioglucose)는 타 용도(류마티스 관절염)로 이미 상당 기간 사용되어 왔기 때문에, 약물들에 의한 부작용 가능성이 낮은 장점도 있다.

3차원 다공성 구조체 및 그의 제조방법

... 본 발명은 3차원 다공성 구조체 및 그의 제조방법에 관한 것으로, 오제틱(auxetic) 특성의 준카고메 구조를 갖는 3차원 다공성 구조체 및 그의 제조방법에 대한 것이다. 본 발명의 3차원 다공성 구조체는 신규 구조인 오제틱 특성을 부여한 준카고메 구조를 가져 무게대비 강도가 우수하고, 소성변형 에너지 흡수능력이 탁월하다. 본 발명의 3차원 다공성 구조체의 제조방법을 통해 신규 구조인 오제틱 특성을 부여한 준카고메 구조를 갖는 3차원 다공성 구조체를 제공할 수 있다.

페녹시아크릴 유도체 및 이의 용도

... 본 발명은 페녹시아세틸 유도체 화합물 및 이를 유효성분으로 포함하는 비알콜성 지방간 질환의 예방 또는 치료용 약학적 조성물에 관한 것이다. 본 발명에 따른 화합물은 SREBP-1c의 활성 억제 및 FAS 발현 억제능이 우수한바, 비알콜성 지방간 질환을 예방, 개선 또는 치료하기 위한 약학적 조성물 또는 기능성 식품 조성물의 활성성분으로 유용하게 사용될 수 있을 것으로 기대된다.

INSECT-PROOF CLOTHES

The present invention relates to insect-proof clothes for protecting a user from harmful insects, which is characterized in that a body part and a head part are separated so that a user can conveniently wear the insect-proof clothes respectively on the head and the body; the inside of the insect-proof clothes is filled with air to prevent the harmful insects from touching the skin of a user, thereby improving the safety against the harmful insects; and outside air is introduced into the insect-proof clothes, thereby improving working environment. COPYRIGHT KIPO 2018 ...

METHOD FOR SIMULTANEOUSLY DETECTING FLUORESCENCE AND RAMAN SIGNALS FOR MULTIPLE FLUORESCENCE AND RAMAN SIGNAL TARGETS, AND MEDICAL IMAGING DEVICE FOR SIMULTANEOUSLY DETECTING MULTIPLE TARGETS USING THE METHOD

The present invention relates to a method for simultaneously detecting fluorescence and Raman signals for multiple fluorescence and Raman signal targets, and to a medical imaging device for simultaneously detecting multiple targets using the method. The method for simultaneously detecting fluorescence and Raman signals for multiple fluorescence and Raman signal targets according to one embodiment of the present invention comprises the following steps: injecting at least one marker particle comprising Raman markers and receptors into the body of an animal, which can be a human; irradiating a laser beam onto the body of the animal; and detecting the optical signals emitted by the marker particle after the irradiation of the laser beam separately as fluorescence signals and Raman signals. According to the present invention, the simultaneous detection of multiple targets may be performed even without scanning optical signals emitted by the marker particle individually with different optical ...

PHENOXYACRYL DERIVATIVE AND USE THEREOF

The present invention relates to a phenoxyacetyl derivative compound and a pharmaceutical composition comprising the same as an active ingredient for preventing or treating nonalcoholic fatty liver disease. The compound according to the present invention is excellent in the inhibition of SREBP-1c activity and FAS expression, and is thus expected to be able to be usefully used as an active ingredient of a pharmaceutical composition or a functional food composition for preventing, ameliorating or treating nonalcoholic fatty liver disease.

PHARMACEUTICAL COMPOSITION, COMPRISING GOLD COMPOUND, FOR PREVENTING OR TREATING LIVER FIBROSIS OR LIVER CIRRHOSIS

봄베신 수용체 아형-3 조절제로서의 파이퍼 아미드 계열 화합물

... 본 발명은 하기 화학식 1로 표시되는 신규한 α,β-불포화 아미드 화합물; 하나 이상의 α,β-불포화 아미드 화합물을 포함하는 화합물 라이브러리로부터 비만 예방 또는 치료효과를 나타내는 화합물을 선별하는 단계 및 상기 선별된 화합물을 함유하는 비만 예방 또는 치료용 조성물을 제조하는 단계를 포함하는 것이 특징인 비만 예방 또는 치료용 조성물 제조 방법; 및 α,β-불포화 아미드 화합물을 포함하는 비만 예방 또는 치료용 조성물에 관한 것이다. [화학식 1] 본 발명의 α,β-불포화 아미드 화합물은 다양한 활성을 나타내는 천연물인 파이퍼 아미드를 모방하는 모핵구조를 가지는 화합물로서 다양한 약리활성을 나타낼 수 있을 것이며, 중간 산물로서 β-포스포노-N-히드록시숙신이미딜 에스테르(β-phosphono-N-hydroxysuccinimidyl ester)를 이용하여 가용성 부산물(by-products)을 생성하므로 통상적으로 이용되는 컬럼 크로마토그래피 정제과정을 수행할 필요없이 순수한 화합물을 획득할 수 있다. 또한 이렇게 합성된 화합물 라이브러리로부터 약리활성을 테스트하여 BRS-3에 대한 작용제인 화합물들을 스크리닝하여 비만 예방 또는 치료용 조성물로 유용하게 활용할 수 있다.

METHOD FOR EVALUATING QUALITY AND STANDARDIZING QUALITY OF SO CHEONG RYOUNG TANG (ORIENTAL MEDICINE)

The present invention provides a method for evaluating and standardizing quality of So Cheong Ryoung Tang (an oriental medicine) by using (2E, 4E, 8Z, 10E)-N-isobutyldodeca-2,4,8,10-tetraenamide as a standard material. More specifically, the method for evaluating quality of So Cheong Ryoung Tang includes the following steps of: producing a So Cheong Ryoung Tang extract by extracting a portion of the So Cheong Ryoung Tang; and measuring a standard material content of the So Cheong Ryoung Tang included in the extract. The quality to be evaluated is an anti-inflammatory effect of the So Cheong Ryoung Tang. The standard material is (2E, 4E, 8Z, 10E)-N-isobutyldodeca-2,4,8,10-tetraenamide. Further, in the present invention, provided is the So Cheong Ryoung Tang for anti-inflammation manufactured by using the method for standardizing quality. COPYRIGHT KIPO 2016 (AA) Total active ingredients (BB) Medicine boiling pot extraction ...

COMPOSITION FOR PREVENTING OR TREATING ALLERGIC DISEASES CONTAINING MIXED EXTRACT OF TWO OR MORE AMONG ASIASARUM ROOT, PLATYCODON ROOT, AND CINNAMOMI RAMULUS AS ACTIVE INGREDIENTS

The present invention pertains to: a pharmaceutical composition for preventing or treating allergic diseases, the pharmaceutical composition containing a mixed extract of two or more selected from the group consisting of asiasarum root, platycodon root, and Cinnamomi Ramulus as active ingredients; a method for preventing or treating allergic diseases by using the pharmaceutical composition; and a health functional food and a feed composition for alleviating allergic diseases. The composition containing a mixed extract of two or more selected from the group consisting of asiasarum root, platycodon root, and Cinnamomi Ramulus as active ingredients according to the present invention specifically inhibits Th2 cell differentiation, and can thus be useful as a composition for preventing or treating allergic diseases.

항체 작용화 방법 및 나노입자-항체 결합 나노플랫폼의 제조 방법

... 본 발명은 항체의 생체활성을 유지하면서도 높은 효율로 항체를 작용화하는 방법 및 항체의 배향이 제어된 나노입자-항체 결합 나노플랫폼의 제조방법에 관한 것으로, 본 발명의 항체 작용화 방법은 항체의 Fc 도메인 내의 디설파이드기만을 환원시키기 때문에, 항체의 생체활성이 그대로 유지된 상태에서 항체를 작용화할 수 있고, 높은 결합 효율로 항체를 나노입자와 결합시킬 수 있으며, 나노입자와 결합된 항체의 배향을 제어하는 것이 가능하다. 또한, 우수한 결합 효율로 항체가 나노입자의 표면에 결합되기 때문에, 나노플랫폼을 제조하기 위해 필요한 항체 및 나노입자의 수가 최적화되어 비용이 절감되고, 제조된 나노플랫폼의 민감성이 매우 높고, 표적 분자와의 결합 활성도 매우 우수하다. 나아가, 결합된 항체의 개수 및 표적 결합 능력을 정량적/실험적으로 측정하는 것이 가능하여, 고비용 진단 및 치료 용도에 적용하기에 적합하고, 진단 키트 등과 같이 상업화하는 것이 용이하다.

PHARMACEUTICAL COMPOSITION COMPRISING THA AS ACTIVE INGREDIENT FOR TREATING BREAST CANCER

The present invention relates to a composition comprising 2,4,6-trihydroxyacetophenone (THA) as an active ingredient for preventing, alleviating, or treating breast cancer. More specifically, the composition of the present invention exhibits an excellent effect in the treatment of breast cancer by inhibiting the activity of polo-like kinase 1 (Plk1), and thus is expected to be used to prevent, alleviate, and treat breast cancer.

NOVEL HYDRAZINE DERIVATIVE HAVING PLK1 INHIBITORY ACTIVITIES AND USE THEREOF

The present invention relates to a novel hydrazine derivative having polo-like kinase 1 (PLK1) inhibitory activities, and a use thereof. More specifically, the compound, according to the invention, inhibits activities of PLK1 and suppresses proliferation of cancer cells. Thus, a pharmaceutical composition containing the same as an active ingredient can be useful for preventing or treating cancer. COPYRIGHT KIPO 2018 ...

PRODUCING METHOD OF ASIASARUM ROOT AND RHIZOME EXTRACT REMOVING TOXIC SUBSTANCE, AND PREPARATION COMPRISING EXTRACT AS ACTIVE INGREDIENT

The present invention relates to a producing method of an Asiasarum root and rhizome extract removing toxic substances and herbal preparation comprising the extract as an active ingredient. The producing method obtaining the Asiasarum root and rhizome extract removing toxic substances comprises: a first step of obtaining a first Asiasarum root and rhizome extract; a second step of obtaining an alkalized suspension; a third step of a second extract; and fourth step of depressurizing and concentrating the second extraction. COPYRIGHT KIPO 2016 ...