19-09-2013 дата публикации
Номер: US20130245270A1
The present invention describes tripodal catechol derivatives with a flexible basic framework for the functionalisation of surfaces, and methods for their production and use. The central atom of the flexible framework is hereby a tertiary aliphatic carbon atom. The remaining fourth bridgehead position is easily suitable to be further functionalised via so-called click reactions, e.g. with biomolecules, dyes, radiomarkers, polyethylene glycol or active agents. 2. The compound according to claim 1 , wherein Y is a bond claim 1 , —CH— claim 1 , —NH—(C═O)— claim 1 , —(C═O)—NH— claim 1 , or —NR—.3. The compound according to claim 1 , wherein n is an integer between 0 and 3.4. The compound according to claim 1 , m is an integer between 0 and 3.7. The compound according to claim 1 , wherein X is —(CH)—R claim 1 , and p is an integer between 0 and 3.8. The compound according to claim 1 , wherein{'sub': 2', 'p, 'sup': '5', 'X is —(CH)—R,'}{'sup': 5', '6', '6', '7', '6, 'sub': 2', '2', '2', '2, 'Ris —H, —OH, —NH, —NO, —NH—NH, —NHR, —NRR, —O—NH, —NH—(C═O)—C≡CH, —C≡CH, —N═C═S, —N═C═O, —COOH, —(C═O)H, or —(C═O)R, and'}p is an integer between 0 and 3.10. The method according to claim 9 , wherein X is a hydrogen atom.11. The method according to claim 9 , wherein{'sub': 2', 'p, 'sup': '5', 'X is —(CH)—R,'}{'sup': 5', '6', '6', '7', '6, 'sub': 2', '2', '2', '2, 'Ris —OH, —NH, —NO, —NH—NH, —NHR, —NRR, —O—NH, —NH—(C═O)—C≡CH, —C≡CH, —N═C═S, —N═C═O, —COOH, —(C═O)H, or —(C═O)R, and'}p is an integer between 0 and 3.12. The method according to claim 11 , wherein Ris protected by a protective group (Pg) prior to reacting the compound with the reagent Y″Z claim 11 , so that the compound Pg-X—C[(CH)—Y′]is reacted with the reagent Y″Z to produce a corresponding compound Pg-X—C[(CH)—YZ].13. (canceled)14. (canceled)15. (canceled) The present invention describes tripodal catechol derivatives with a flexible basic framework for the functionalisation of surfaces, and methods for their production ...
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