23-04-2015 дата публикации
Номер: US20150111194A1
A separation material includes a saccharide bound via a linker to a matrix for enabling the separation from a liquid of substances that selectively bind to saccharide moieties. A method for preparing the material, a method for separating from a liquid substances that selective bind to saccharides, and a device including the separation material are also disclosed. 1. A separation material comprising a saccharide-linker-matrix represented by general formula (I){'br': None, 'sup': 1', '2', '1', '3', '1, 'sub': r', 'n', 'm, 'saccharide-X—R—(R—R)—(R—R)-E-F-matrix\u2003\u2003(I)'}wherein{'sub': '2', 'X represents O, S, CHor NR′, wherein R′ represents H, methyl or a protecting group selected from the group consisting of acetyl (Ac), trifluoroacetyl (TFA), trichloroacetyl, benzoyl (Bz), benzyl (Bn), tert-butyloxycarbonyl (BOC), carbobenzyloxy (Cbz), p-methoxybenzyl carbonyl (Moz), 9-fluorenylmethyloxycarbonyl (FMOC), vinyloxycarbonyl (Voc), allyloxycarbonyl (Alloc), p-methoxybenzyl (PMB), 3,4-dimethoxybenzyl (DMB), p-methoxyphenyl (PMP), triphenylmethyl (Tr), tosyl (Ts) and nosyl (Ns),'}{'sup': '1', 'sub': 1', '10, 'Rrepresents, independently of one another, straight-chain or branched C-Calkyl, wherein the alkyl group can be unsubstituted, or substituted with at least one suitable substituent selected from the group of substituents consisting of halogen, alkyl, alkoxy, haloalkyl, cyano, nitro, amino, hydroxy, thiol, acylamino, alkoxycarbonylamino, haloalkoxycarbonylamino or alkylsulfonylamino,'}{'sup': '2', 'Rindependently of one another represents —CO—NH—, —NH—CO—, —C0-NH—NH—, —NH—NH—CO—, —N═CH—, —CH═N—, —NH—N═CH—, —CH═N—NH— or triazolyl,'}{'sup': '3', 'Rindependently of one another represents —O—, —CO—NH—, —NH—CO—, —N═CH— or —CH═N—,'}r represents 0 or an integer from 1-10,n represents 0 or an integer from 1-600,E represents —NH—, —CO—, —O—, —S—, —N═, —CH═, —NH—NH—, —NH—N═ or triazolyl,{'sub': 2', '2, 'F represents —NH—, ═N—, ═CH—, —CO—, —CH—CH(OH)—, —NH—CH—CH(OH)—, —NH—NH ...
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