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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Форма поиска

Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
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Применить Всего найдено 108114. Отображено 100.
05-01-2012 дата публикации

Anti-inflammatory dissolvable film

Номер: US20120003292A1
Автор: Aron J. Saffer, William Zev Levine, Zvi G. Loewy
Принадлежит: Individual

Provided, among other things, is a slowly dissolvable film comprising: herbal bioactive agent(s); and polymer(s), dissolvable in the aggregate, wherein the film becomes adhesive as it is placed against a mucosal surface and begins to absorb moisture therefrom.

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Номер записи: 1
05-01-2012 дата публикации

Dpp iv inhibitor formulations

Номер: US20120003313A1
Автор: Anja Kohlrausch, Gerd Seiffert, Patrick Romer
Принадлежит: BOEHRINGER INGELHEIM INTERNATIONAL GMBH

The present invention relates to pharmaceutical compositions of DPP IV inhibitors with an amino group, their preparation and their use to treat diabetes mellitus.

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Номер записи: 2
05-01-2012 дата публикации

High affinity antibodies to human il-6 receptor

Номер: US20120003697A1
Автор: Ashique Rafique, Eric Smith, Gang Chen, James P. Fandl, Jeanette L. Fairhurst, Joel H. Martin, Kevin J. Pobursky, Margaret Karow, Nicholas J. Papadopoulos, Sean Stevens, Tammy T. Huang
Принадлежит: Regeneron Pharmaceuticals Inc

A human antibody or an antigen-binding fragment which binds human IL-6 receptor (hIL-6R) with a K D of about 500 pM or less and blocks IL-6 activity with an IC 50 of 200 pM or less, is provided. In preferred embodiments, the antibody the antibody or antigen-binding fragment binds hIL-6R with an affinity at least 2-fold higher relative to its binding monkey IL-6R.

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Номер записи: 3
05-01-2012 дата публикации

Nutritional composition for infants

Номер: US20120004163A1
Автор: Catherine Mace, Etienne Pouteau, Olivier Kevork Aprikian
Принадлежит: Nestec SA

A nutritional composition for infants comprises a protein source, a lipid source and a carbohydrate source wherein the lipid source includes at least 16 wt % linoleic acid and at least 2 wt % α-linolenic acid expressed as a percentage of total fatty acid content in each case and in amounts such that the ratio of linoleic acid:α-linolenic acid is in the range from 1 to 10.

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Номер записи: 4
05-01-2012 дата публикации

Formulation Comprising Bioactive Agents And Method Of Using Same

Номер: US20120004170A1
Автор: Daniel Schwartz, Susan J. Sofia, Wolfgang Friess
Принадлежит: Friedrich Alexander Univeritaet Erlangen Nuernberg FAU

Disclosed are methods of making bioactive BMP-2 microparticles and methods of using the microparticles.

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Номер записи: 5
05-01-2012 дата публикации

NOVEL PIPERAZINE DERIVATIVES AS INHIBITORS OF STEAROYL-CoA DESATURASE

Номер: US20120004213A1
Автор: Alexander Bischoff, Ganesh Prabhu, Hosahalli Subramanya, Kumar Sundaresan, Sandeep N. Raikar, Srinivasa Raju Sammeta
Принадлежит: Forest Laboratories Holdings Ltd

The present invention relates to piperazine derivatives that act as inhibitors of stearoyl-CoA desaturase. The invention also relates to methods of preparing the compounds, compositions containing the compounds, and to methods of treatment using the compounds.

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Номер записи: 6
05-01-2012 дата публикации

N-oxides of 1,4-diaza-bicyclo[3.2.2]nonyl pyrimidinyl derivatives useful as nicotinic acetylcholine receptor ligands

Номер: US20120004214A1
Автор: Dan Peters, Daniel B. Timmermann, Eva Dam Christoffersen
Принадлежит: Neurosearch AS

This invention relates to novel 1,4-diaza-bicyclo[3.2.2]nonyl pyrimidinyl derivatives and their use in the manufacture of pharmaceutical compositions. The compounds of the invention are found to be cholinergic ligands at the nicotinic acetylcholine receptors. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances. Formula (I) a stereoisomer or a mixture of its stereoisomers, or a pharmaceutically acceptable salt thereof, wherein Ar represents an indolyl group, which indolyl may optionally be substituted one or more times with substituents selected from halo, trifluoromethyl, trifluoromethoxy, cyano, nitro, amino, alkyl, hydroxy and alkoxy.

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Номер записи: 7
05-01-2012 дата публикации

Organic compounds

Номер: US20120004247A1
Автор: Brian Cox, Robin Alec Fairhurst, Roger John Taylor
Принадлежит: NOVARTIS AG

A compound of formula (I) or stereoisomers or pharmaceutically acceptable salts thereof, and their preparation and use as pharmaceuticals wherein R 1 , R 2 and R 3 are as defined herein.

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Номер записи: 8
05-01-2012 дата публикации

Bile salt adjuvant for animals for improving fat utilization efficiency in the bodies of animals, and animal feed comprising same

Номер: US20120004304A1
Автор: Kwan-Sik Yun
Принадлежит: KIMIN Inc

The present invention relates to a bile salt adjuvant for animals for improving fat utilization efficiency in the bodies of the animals, and to animal feed comprising same. More particularly, the present invention relates to a bile salt adjuvant for animals comprising sodium stearoyl-2-lactylate. The adjuvant is used in animal feed to improve fat utilization efficiency in the bodies of livestock when ingested by said livestock, thereby reducing the amount of fat required to be used in animal feed and improving productivity.

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Номер записи: 9
12-01-2012 дата публикации

Solid composition containing bacillus-type non-pathogenic bacterial spores

Номер: US20120009167A1
Автор: Tiziano Prato
Принадлежит: Sanofi Aventis SpA

The invention relates to a composition of spores of nonpathogenic bacteria of the Bacillus genus, adsorbed onto a matrix made up of at least one water-insoluble adsorbent compound and a cellulose derivative, which can be obtained by the fluidized air bed technique, useful in the pharmaceutical, veterinary and nutrition fields.

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Номер записи: 10
12-01-2012 дата публикации

Prebiotic Formulations for use with Probiotics to Increase Probiotic Growth Rate and Activity

Номер: US20120009239A1
Автор: Randolph S. Porubcan, Sonja Lea Yonak
Принадлежит: MASTER SUPPLEMENTS Inc

Naturally occurring lecithins and/or oleic acid stimulate the growth and lactic acid producing activity of Lactobacillus and Bifidobacterium species of probiotic bacteria, and replace polysorbate 80 for those products. They can be used in naturally occurring form, or where they are to be combined with probiotics in a carrier, or they can be treated to yield a stable powdered form of these naturally oily compounds. They can be sold as combined prebiotic/probiotic formulations in the same carrier, or sold as separate dietary supplements, e.g., in capsule or tablet form, to be used with the probiotic formulation as desired.

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Номер записи: 11
12-01-2012 дата публикации

Lactoferrin compositions and methods of wound treatment

Номер: US20120010150A1
Автор: Atul Varadhachary, Jose Engelmayer
Принадлежит: Agennix Inc

The present invention relates to lactoferrin compositions and methods of using the compositions to treat wounds. The compositions can be administered alone or in combination with other standard wound healing therapies.

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Номер записи: 12
12-01-2012 дата публикации

Tumor necrosis factor inhibiting peptides and uses thereof

Номер: US20120010158A1
Автор: Rahul Jain, Rajesh Jain, Shudhanand Prasad, Shweta Dubey, Vijay Goel, Virendra Kumar Vinayak
Принадлежит: Panacea Biotec Ltd

The present invention relates to Tumor Necrosis Factor-alpha (TNF-alpha or TNF-α) inhibiting peptides and process for the preparation thereof. The present invention further relates to a pharmaceutical composition comprising TNF-alpha inhibiting peptides of the present invention and uses thereof in treating TNF-alpha mediated inflammatory disorders.

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Номер записи: 13
12-01-2012 дата публикации

11-Beta-Hydroxysteroid Dehydrogenase Type 1 Active Compounds

Номер: US20120010194A1
Автор: Henrik Sune Andersen, Soren Ebdrup
Принадлежит: High Point Pharnaceuticals LLC

The use of substituted amides for modulating the activity of 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1) and the use of these compounds as pharmaceutical compositions, are described. Also a novel class of substituted amides, of the general formula I. Their use in therapy, pharmaceutical compositions comprising the compounds, as well as their use in the manufacture of medicaments are described. The present compounds are modulators and more specifically inhibitors of the activity of 11βHSDI and may be useful in the treatment of a range of medical disorders where a decreased intracellular concentration of active glucocorticoid is desirable.

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Номер записи: 14
12-01-2012 дата публикации

5'-modified bicyclic nucleic acid analogs

Номер: US20120010393A1
Автор: Balkrishen Bhat, Eric E. Swayze, Punit P. Seth
Принадлежит: ISIS PHARMACEUTICALS INC

The present invention provides 5′-modified bicyclic nucleoside analogs and oligomeric compounds comprising at least one of these nucleoside analogs. In preferred embodiments the nucleoside analogs have either (R) or (S)-chirality at the 5′-carbon. These bicyclic nucleoside analogs are useful for enhancing properties of oligomeric compounds including for example enhanced nuclease resistance.

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Номер записи: 15
19-01-2012 дата публикации

PYRROLO[2,3-b]PYRIDIN-4-YL-AMINES AND PYRROLO[2,3-b]PYRIMIDIN-5-YL-AMINES AS JANUS KINASE INHIBITORS

Номер: US20120014989A1
Автор: Andrew P. Combs, Haisheng Wang, James D. Rodgers, Richard B. Sparks
Принадлежит: Incyte Corp

The present invention provides pyrrolo[2,3-b]pyridine-4-yl amines pyrrolo[2,3-b]pyrimidin-4-yl amines that modulate the activity of Janus kinases and are useful in the treatment of diseases related to activity of Janus kinases including, for example, immune-related diseases and cancer.

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Номер записи: 16
19-01-2012 дата публикации

Sulfone Compounds Which Modulate The CB2 Receptor

Номер: US20120015988A1
Автор: Christopher Francis Palmer, David Smith Thomson, Doris Riether, Eugene Richard Hickey, Mark Whittaker, Monika Ermann, Patricia Amouzegh, Renee M. Zindell
Принадлежит: BOEHRINGER INGELHEIM INTERNATIONAL GMBH

Compounds which modulate the CB2 receptor are disclosed. Compounds according to the invention bind to and are agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain.

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Номер записи: 17
19-01-2012 дата публикации

Phototherapy methods and devices comprising emissive aryl-heteroaryl compounds

Номер: US20120015998A1
Автор: Amane Mochizuki, Brett T. Harding, Jensen Cayas, Keisaku Okada, Sazzadur Rahman Khan, SHENG Li, Shijun Zheng
Принадлежит: Nitto Denko Corp

Disclosed herein are compounds represented by a formula: R 1 —Ar 1 —X—Ar 2 —Ar 3 -Het, wherein R 1 , Ar 1 , X, Ar 2 , Ar 3 , and Het are described herein. Compositions and light-emitting devices related thereto are also disclosed.

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Номер записи: 18
19-01-2012 дата публикации

Growth factor htter36

Номер: US20120016107A1
Автор: Daniel R. Soppet, Haodong Li
Принадлежит: Human Genome Sciences Inc

The present invention discloses Growth Factor HTTER36 (GDF3) polypeptides and polynucleotides encoding such polypeptides. Also provided are antibodies that bind HTTER36, including chimeric, humanized, and single chain antibodies.

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Номер записи: 19
19-01-2012 дата публикации

Enzymes and methods for producing omega-3 fatty acids

Номер: US20120016144A1
Автор: Anne Maree Mackenzie, Craig Christopher Wood, Dion Matthew Frederick Frampton, James Robertson Petrie, Peter David Nichols, Peter Maged Mansour, Pushkar Shrestha, Qing Liu, Stanley Suresh Robert, Surinder Pal Singh, Susan Irene Ellis Blackburn, Xue-Rong Ziiou
Принадлежит: Individual

The present invention relates generally to the field of recombinant fatty acid synthesis, particularly in transgenic plants. The application describes genes involved in fatty acid synthesis and provides methods and vectors for the manipulation of fatty acid composition of plant oils. In particular, the invention provides constructs for achieving the integration of multiple heterologous genes involved in fatty acid synthesis into the plant genome, such that the resulting plants produce altered levels of polyunsaturated fatty acids. Also described are methods for enhancing the expression of fatty acid biosynthesis enzymes by co-expressing a silencing suppressor within the plant storage organ.

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Номер записи: 20
26-01-2012 дата публикации

Densensitizing dentifrice exhibiting dental tissue antibacterial agent uptake

Номер: US20120020900A1
Автор: Guofeng Xu, Ravi Subramanyam
Принадлежит: Colgate Palmolive Co

An oral composition exhibiting increased uptake by dental tissue of antibacterial compounds contained therein and eliminating or substantially reducing the discomfort and pain associated with dentinal hypersensitivity. The composition includes an orally acceptable vehicle for such composition, an effective therapeutic amount of an antibacterial compound, a mixture of anionic surfactant and amphoteric surfactant, the mixture having 0.1 wt. % to 2.0 wt. % anionic surfactant and 0.8 wt. % to 2.0 wt. % amphoteric surfactant, and a potassium ion releasable compound.

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Номер записи: 21
26-01-2012 дата публикации

Adverse side-effects associated with administration of anti-hyaluronan agents and methods for ameliorating or preventing the side-effects

Номер: US20120020951A1
Автор: Curtis Thompson, Gregory I. Frost, Harold Michael Shepard, Xiaoming Li
Принадлежит: Individual

Provided herein are methods for ameliorating an adverse effect of systemic administration of a PEG hyaluronan degrading enzyme to a subject. The methods involve systemically administering a PEGylated hyaluronan degrading enzyme, particularly a PEGylated hyaluronidase, such as any of the animal or bacterial hyaluronidases, to the subject and administering an amount of a corticosteroid sufficient to ameliorate the adverse effect. Also provided are method of treating a hyaluronan-associated disease or condition for single-agent therapy or combination therapy.

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Номер записи: 22
26-01-2012 дата публикации

Genetically engineered clostridial genes, proteins encoded by the engineered genes, and uses thereof

Номер: US20120021002A1
Автор: Konstantin Ichtchenko, Philip A. Band
Принадлежит: New York University NYU

The present invention relates to an isolated Clostridial neurotoxin propeptide having a light chain region, a heavy chain region, where the light and heavy chain regions are linked by a disulfide bond, and an intermediate region connecting the light and heavy chain regions. An isolated nucleic acid molecule encoding a Clostridial neurotoxin propeptide is also disclosed. Also disclosed is an isolated, physiologically active Clostridial neurotoxin produced by cleaving a Clostridial neurotoxin propeptide, a vaccine or antidote thereof, and methods of immunizing against or treating for toxic effects of Clostridial neurotoxins. Methods of expressing recombinant physiologically active Clostridial neurotoxins are also disclosed. Also disclosed is a chimeric protein having a heavy chain region of a Clostridial neurotoxin and a protein with therapeutic functionality. A treatment method is also disclosed.

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Номер записи: 23
26-01-2012 дата публикации

Dual action dentifrice compositions to prevent hypersensitivity and promote remineralization

Номер: US20120021031A1
Автор: Lynette Zaidel, Michael Prencipe, Suman K. Chopra
Принадлежит: Colgate Palmolive Co

The invention encompasses combinations of bioactive glass composition and potassium salts that are useful in conjunction with delivery agent such as, for example, toothpastes, mouthwashes, and oral gels. In certain embodiments, the compositions of the invention form a rapid and continuous reaction with body fluids (e.g., saliva) to promote the immediate and long-tem release of Ca and P ions to produce a stable crystalline layer deposited onto and into the dentin tubules for the immediate and long term reduction of dentin hypersensitivity and tooth surface remineralization.

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Номер записи: 24
26-01-2012 дата публикации

Axomadol or a Metabolite Thereof for Use in the Treatment of Irritable Bowel Syndrome

Номер: US20120022294A1
Автор: Klaus Schiene, Petra Bloms-Funke, Thomas Christoph, Wolfgang Schroeder
Принадлежит: GRUENENTHAL GmbH

The invention relates to axomadol or a metabolite thereof for use in the treatment of irritable bowel syndrome.

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Номер записи: 25
02-02-2012 дата публикации

Hk1-binding proteins

Номер: US20120027686A1
Автор: Andrew Nixon, Anthony Williams, Daniel J. Sexton, Qi-Long Wu, Robert C. Ladner
Принадлежит: Dyax Corp

The invention features hK1 binding polypeptides as well as compositions comprising such polypeptides and methods of making and using such polypeptides.

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Номер записи: 26
02-02-2012 дата публикации

Method for alleviating intestinal problems and novel bacterial strains therefor

Номер: US20120027734A1
Автор: Benedikt Sas, Filip Van Immerseel, Frank Pasmans, Freddy Haesebrouck, Richard Ducatelle, Venessa Eeckhaut
Принадлежит: Individual

The present invention relates to butyrate producing bacterial strains related to the species Buty{acute over (η)}coccus pullicaecorum to be used in the prevention and/or treatment of intestinal health problems. The present invention therefore provides methods and compositions that overcome the problems associated with the currently used methods for administering butyric acid in the treatment of intestinal health problems in humans and/or animals.

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Номер записи: 27
02-02-2012 дата публикации

Formulations of Viable Cells for Oral Delivery

Номер: US20120027811A1
Автор: Alexander Edwards, Nigel Slater
Принадлежит: CAMBRIDGE ENTERPRISE LTD, Recipharmcobra Holdings Ltd

This invention relates to solid formulations for the oral delivery of live microbial cells which comprise dried viable cells and small amounts of a bile acid binding agent, for example, an anion exchange resin such as cholestyramine. The presence of bile acid binding agents in the formulation significantly increases the survival of the cells in the intestinal tract and facilitates delivery of the viable cells to the intestine.

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Номер записи: 28
02-02-2012 дата публикации

7-azoniabicyclo[2.2.1]heptane derivatives, methods of production, and pharmaceutical uses thereof

Номер: US20120029044A1
Автор: Gwenaella Rescourio, Jurg R. Pfister, Meenakshi S. Venkatraman, Xiaoming Zhang
Принадлежит: Theron Pharmaceuticals Inc

Muscarinic acetylcholine receptor antagonists and methods of using them for the treatment of muscarinic acetylcholine receptor-mediated diseases, such as pulmonary diseases, are provided.

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Номер записи: 29
02-02-2012 дата публикации

Compositions and methods for treating or preventing radiation injury

Номер: US20120029071A1
Автор: Rajesh K. Thimmulappa, Shyam Biswal
Принадлежит: JOHNS HOPKINS UNIVERSITY

The invention provides compositions and methods featuring Nrf2 activators for treating or preventing radiation-associated tissue damage.

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Номер записи: 30
09-02-2012 дата публикации

Method of Administering an Antibody

Номер: US20120034243A1
Автор: David Edward Allison, Judith A. Fox, Lee R. Brettman
Принадлежит: Genentech Inc, Millennium Pharmaceuticals Inc

Disclosed is a method for treating a human having a disease associated with leukocyte infiltration of mucosal tissues, comprising administering to said human an effective amount of a human or humanized immunoglobulin or antigen-binding fragment thereof having binding specificity for α4β7 integrin. Preferably, no more than 8 mg immunoglobulin or fragment per kg body weight are administered during a period of about one month.

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Номер записи: 31
09-02-2012 дата публикации

Compositions for the treatment of gluten intolerance and uses thereof

Номер: US20120034299A1
Автор: Hugh James Beatty Cornell, Teodor Stelmasiak
Принадлежит: Glutagen Pty Ltd

The present invention provides compositions for use in the prophylaxis or treatment of a condition arising from gluten intolerance, the compositions including at least partially purified caricain (or a biologically active fragment, analogue or variant thereof) alone or in combination with other suitable enzymes including bromelain, and/or an intestinal extract, as herein described. The present invention also provides methods of using such compositions for the prophylaxis or treatment of a condition arising from gluten intolerance.

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Номер записи: 32
16-02-2012 дата публикации

Methods Of Immune Modulation

Номер: US20120039945A1
Автор: Gill Diamond, Richard W. Scott
Принадлежит: Polymedix Inc, UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY

The present invention provides compounds and compositions thereof that modulate the immune system.

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Номер записи: 33
16-02-2012 дата публикации

Isoamyl acetate for weight management

Номер: US20120040046A1
Автор: Alexander Erin, Johannes Le Coutre, Julie Laure Hudry
Принадлежит: Nestec SA

Described is the use of isoamyl acetate in food compositions for weight management and/or weight control. Further described is a beverage containing isoamyl acetate.

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Номер записи: 34
16-02-2012 дата публикации

Collagen peptide composition having good ability to enter the blood and food or beverage containing the same

Номер: US20120040055A1
Автор: Hidetoshi Nishizawa, Hiroki Ohara, Hitoshi Matsumoto, Koichi Terauchi, Masataka Hata
Принадлежит: Meiji Co Ltd

An object of the present invention is to elucidate a collagen peptide effective for causing dipeptides or tripeptides serving as the active component to enter the blood, and thus to reduce the required intake thereof. According to the present invention, a collagen peptide composition obtained by digesting collagen or gelatin with protease is provided, wherein: (a) the ratio of hydroxyproline to total of amino acid residues at the second position from the N terminus of the peptides in the composition is 2 mol % or more and 20 mol % or less, and the ratio of glycine to total of amino acid residues at the third position from the N terminus of the peptides in the composition is 20 mol % or more and 50 mol % or less; and (b) the average molecular weight is 500 or more and 2000 or less.

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Номер записи: 35
16-02-2012 дата публикации

Method of activating regulatory t cells with alpha-2b adrenergic receptor agonists

Номер: US20120041031A1
Автор: Daniel W. Gil, John E. Donello, Lauren M.B. Luhrs, Veena Viswanath
Принадлежит: Allergan Inc

Disclosed herein is a method of upregulating regulatory T-cells, and treating diseases that would benefit from such upregulation, by administering an alpha 2 receptor agonist.

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Номер записи: 36
16-02-2012 дата публикации

Ucp4

Номер: US20120041176A1
Автор: Alan Zhong, James Pan, Sean Adams
Принадлежит: Genentech Inc

The present invention is directed to novel polypeptides having homology to certain human uncoupling proteins (“UCPs”) and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention, and methods for producing the polypeptides of the present invention.

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Номер записи: 37
23-02-2012 дата публикации

TNF-alpha Antagonists Containing IGFBP5

Номер: US20120046217A1
Автор: Jae-ho Huh, Jae-Ryoung Hwang, Je-Ho Lee
Принадлежит: Sungkyunkwan University Foundation For Corporate Collaboration

The present invention relates to: TNF-α antagonists containing IGFBP5 protein, variants thereof, or fragments thereof; and the use of the TNF-α antagonists. More specifically, the present invention relates to: a polynucleotide encoding the protein, variants thereof, or fragments thereof; a vector containing the polynucleotide; a transformant containing the vector; and a method for screening a therapeutic agent for TNF-α overexpression-related diseases by checking whether the mutual reaction thereof is facilitated after treating with candidates to the cell expressing the IGFBP5 protein, variants thereof, or fragments thereof, and the TNER1.

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Номер записи: 38
23-02-2012 дата публикации

Calcium Formate for Use as a Dietary Supplement

Номер: US20120046252A1
Автор: Hector F. DeLuca
Принадлежит: Individual

A calcium formate composition for oral administration to an individual for the purpose of supplementary dietary calcium is disclosed.

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Номер записи: 39
23-02-2012 дата публикации

Diacylethylenediamine compound

Номер: US20120046292A1
Автор: Hiroki Fukudome, Hiroshi Moritani, Takahiro Nigawara, Takeshi Hanazawa, Tomoaki Kawano, Yasuhiro Yonetoku
Принадлежит: Astellas Pharma Inc

[Problem] A compound which is useful as an anti-obesity agent is provided. [Means for Solution] The present inventors have investigated a compound having a DGAT1 inhibitory action, which is promising as an active ingredient of a pharmaceutical composition for treating obesity, type II diabetes mellitus, fatty liver, and diseases associated with these diseases, and as a result, they have found that the diacylethylenediamine compound of the present invention has an excellent DGAT1 inhibitory action, thereby completing the present invention. That is, the diacylethylenediamine compound of the present invention has a DGAT1 inhibitory action, and can be therefore used as an agent for preventing and/or treating obesity, type II diabetes mellitus, fatty liver, and diseases associated with these diseases.

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Номер записи: 40
23-02-2012 дата публикации

Anti-oxidant lozenges for the prevention and treatment of radiation induced mucositis, precancerous lesions, oral cancer and other oral cavity mucosal disorders

Номер: US20120046354A1
Автор: Eli D. Ehrenpreis
Принадлежит: Individual

A method for treating or preventing oral cavity mucosal disorders, comprising a step of providing a lozenge containing an antioxidant selected from the group of Vitamin A, Vitamin C, Vitamin E; and other ingredients and a step of placing the lozenge within the oral cavity for a period of time required for dissolution of the lozenge.

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Номер записи: 41
01-03-2012 дата публикации

Synbiotic Product

Номер: US20120052152A1
Автор: Richard W. Armentrout
Принадлежит: TATE AND LYLE INGREDIENTS AMERICAS LLC

The present invention relates to a synbiotic product composition comprising a blend or mixture of a prebiotic carbohydrate and a probiotic spore-forming Bacillus bacteria. Examples of prebiotic carbohydrates useful in synbiotic product include arabinoxylan, arabinoxylan oligosaccharides, xylose, soluble fiber dextrin, soluble corn fiber, and polydextrose. The present invention also relates to human foodstuffs and animal feed comprising such synbiotic products and methods of increasing the titer of spore-forming bacteria in the intestinal tracts of mammals by administration of symbiotic products.

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Номер записи: 42
01-03-2012 дата публикации

Aqueous nanoemulsion composition containing conjugated linoleic acid

Номер: US20120053241A1
Автор: Hong Geun Ji, Hye Kyeong Woo, Hyo Gyoung Yu, Soo Dong Kim
Принадлежит: Hwail Pharmaceutical Co Ltd

The present invention relates to an aqueous nanoemulsion composition comprising conjugated linoleic acid. More particularly, the present invention relates to an aqueous nanoemulsion composition comprising 5 to 50 wt % of conjugated linoleic acid, 0.01 to 5 wt % of lecithin, 0.01 to 5 wt % of ethanol as a dissolution aid, 1 to 15 wt % of coemulsifier, 10 to 40 wt % of glycerine and the balance of water.

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Номер записи: 43
08-03-2012 дата публикации

Therapeutic or prophylactic agent for dyskinesia

Номер: US20120058186A1
Автор: Kotoe Ohta, Suguru Takaki, Yasuhide Horiuch
Принадлежит: TORAY INDUSTRIES INC

The present invention relates to a stable orally disintegrating coated tablet containing a drug, wherein the tablet is coated with a coating layer containing a water-soluble substance and a polyvinyl alcohol resin of not less than 5% by weight based on the weight of the coating layer, the water-soluble substance dissolving in an amount of 1 g or more in less than 10 mL of water at 20° C., having a hydroxyl group(s) in its molecule, and having a molecular weight of not more than 200 per a unit hydroxyl group. There is provided a stable orally disintegrating coated tablet which does not cause a crack in the coating layer even when the orally disintegrating tablet has been swollen by moisture absorption under high humidity, while ensuring rapid disintegration properties in an oral cavity. In the case of an orally disintegrating tablet containing a light-unstable drug, degradation of the drug can be suppressed by blending a light shading agent in the coating layer.

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Номер записи: 44
08-03-2012 дата публикации

Pharmaceutical formulations comprising substituted benzimidazole derivatives

Номер: US20120058194A1
Автор: Atul Shivaji Shinde, Debashis Dash, Deepti Jain, Harshal Prabhakar Bhagwatwar, Mamta Mishra, Manikandan Ramalingam, Navin Vaya, Rahul Sudhakar Gawande, Srinivas Irukulla, Sushant Dube, Venkateswarlu Vobalaboina, Vishal Lad
Принадлежит: Dr Reddys Laboratories Inc, Dr Reddys Laboratories Ltd

Stabilized substituted benzimidazole modified release pharmaceutical formulations with at least two drug-containing fractions, wherein the release from a first fraction precedes the release from a second fraction, pharmaceutical excipients, processes for preparing the stable formulations, packaging therefor, and their use in treatment of erosive esophagitis and heartburn associated with non-erosive gastroesophageal reflux disease.

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Номер записи: 45
08-03-2012 дата публикации

Microencapsulation of bioactive substances and methods of making the same

Номер: US20120058195A1
Автор: Moti Harel
Принадлежит: Advanced Bionutrtion Corp

The present invention relates to microparticles and methods of making such microparticles that protect a bioactive substance from heat, humidity and oxidation. A microparticle comprising a bioactive substance, an agglomerating agent, an emulsifier and solid fats is disclosed. A method to produce a microparticle comprising an agglomerated bioactive substance enrobed in a double layer of solid fats and emulsifier is also disclosed.

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Номер записи: 46
08-03-2012 дата публикации

METHOD OF DIAGNOSING POOR SURVIVAL PROGNOSIS COLON CANCER USING miR-203

Номер: US20120058914A1
Автор: Aaron J. Schetter, Carlo M. Croce, Curtis C. Harris
Принадлежит: Ohio State University Research Foundation, US Department of Health and Human Services

The present invention provides novel methods and compositions for the diagnosis and treatment of colon cancers. In particular, the present invention provides diagnostics and prognostics for colon (including colon adenocarcinoma) cancer patients, wherein the methods related to measuring miR levels can predict poor survival. The invention also provides methods of identifying inhibitors of tumorigenesis.

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Номер записи: 47
08-03-2012 дата публикации

Nutritional composition inducing a postprandial endocrine response

Номер: US20120058938A1
Автор: Mirian Lansink, Robert Johan Joseph Hageman
Принадлежит: Nutricia NV

The invention concerns the use of a nutritional composition for the treatment of disorders which are associated with malfunctioning in the uptake and use of food-derived energy in the human body. In particular, the invention concerns the use of a nutritional composition for the treatment of a disorder, which is mediated by a postprandial endocrine or neurological response in a human body, wherein the nutritional composition comprises one or more of a specific protein fraction, a specific carbohydrate fraction and a specific nutritional fiber fraction.

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Номер записи: 48
08-03-2012 дата публикации

Neuroprotective iron chelators and pharmaceutical compositions comprising them

Номер: US20120058945A1
Автор: Abraham Warshawsky, Hailin Zheng, Matitiyahu Fridkin, Moussa Youdim, Rivka Warshawsky
Принадлежит: Technion Research and Development Foundation Ltd, Yeda Research and Development Co Ltd

Novel iron chelators exhibiting neuroprotective and good transport properties are useful in iron chelation therapy for treatment of a disease, disorder or condition associated with iron overload and oxidative stress, e.g., a neurodegenerative or cerebrovascular disease or disorder, a neoplastic disease, hemochromatosis, thalassemia, a cardiovascular disease, diabetes, an inflammatory disorder, anthracycline cardiotoxicity, a viral infection, a protozoal infection, a yeast infection, retarding aging, and prevention and/or treatment of skin aging and skin protection against sunlight and/or UV light. The iron chelator function is provided by a 8-hydroxyquinoline, a hydroxypyridinone or a hydroxamate moiety. The neuroprotective function is imparted to the compound, e.g., by a neuroprotective peptide. A combined antiapoptotic and neuroprotective function is provided by a propargyl group.

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Номер записи: 49
08-03-2012 дата публикации

Macrolides with Anti-Inflammatory Activity

Номер: US20120058963A1
Автор: Antun Hutinec, Dubravko Jelic, Goran Kragol, Marija Ribic, Martina Bosnar, Nikola Marjanovic, Ognjen Culic, Sulejman Alihodzic, Vanja Vela, Vesna Erakovic Haber, Zorica Marusic-Istuk
Принадлежит: Glaxo Group Ltd

The present invention relates to novel semi-synthetic macrolides having anti-inflammatory activity. More particularly, the invention relates to 14- and 15-membered macrolides substituted at the 4″ position, to their pharmaceutically acceptable derivatives, to processes and intermediates for their preparation, to pharmaceutical compositions containing them and to their activity and use in the treatment of inflammatory diseases and conditions in humans and animals, especially those diseases associated with excessive secretion of TNF-α, IL-1, IL-8, IL-2 or IL-5; and/or inhibitor of excessive lymphocyte proliferation; and/or excessive granulocyte degranulation.

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Номер записи: 50
08-03-2012 дата публикации

Di-azetidinyl diamide as monoacylglycerol lipase inhibitors

Номер: US20120058986A1
Автор: Bin Zhu, Mark J. Macielag, Peter J. Connolly
Принадлежит: Janssen Pharmaceutica NV

Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I) as follows: wherein Q and Z are defined herein.

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Номер записи: 51
08-03-2012 дата публикации

Use Of Copolymers Based On Amino-Containing Polymers As Matrix Binders In Preparing Active Compound-Containing Granules And Administration Forms

Номер: US20120059054A1
Автор: Karl Kolter, Maximilian Angel
Принадлежит: BASF SE

Described are matrix binders comprising copolymers based on amino-containing polymers, as well as their use in preparing active compound-containing granules and administration forms The copolymers having basic amino groups can be obtained by radical polymerization of: a) N,N-diethylaminoethyl methacrylate, and b) at least one radically polymerizable compound, selected from esters of α,β-ethylenically unsaturated mono- and dicarboxylic acids with C 1 -C 8 alkanols.

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Номер записи: 52
15-03-2012 дата публикации

Pharmaceutical Compositions for the Coordinated Delivery of NSAIDs

Номер: US20120064156A1
Автор: John R. Plachetka
Принадлежит: Individual

The present invention is directed to drug dosage forms that release an agent that raises the pH of a patient's gastrointestinal tract, followed by a non-steroidal anti-inflammatory drug. The dosage form is designed so that the NSAID is not released until the intragastric pH has been raised to a safe level. The invention also encompasses methods of treating patients by administering this coordinated release, gastroprotective, antiarthritic/analgesic combination unit dosage form to achieve pain and symptom relief with a reduced risk of developing gastrointestinal damage such as ulcers, erosions and hemorrhages.

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Номер записи: 53
22-03-2012 дата публикации

Oral composition and method of forming and using same

Номер: US20120070423A1
Автор: Puneet Nanda
Принадлежит: Dr Fresh LLC

An oral composition for the treatment of dry mouth symptoms and other conditions, a method of forming the oral composition, and a method of using the oral composition are disclosed. The oral composition includes a plurality of enzymes to prevent formation of and/or facilitate the break up of biofilm in an oral cavity and a metal ion management system to inhibit growth of gram negative bacteria.

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Номер записи: 54
22-03-2012 дата публикации

Pyrazole oxadiazole derivatives as s1p1 agonists

Номер: US20120071460A1
Автор: Anna Quattropani, Charles Baker-Glenn, Chris KNIGHT, Wesley Blackaby
Принадлежит: MERCK SERONO SA

The present invention relates to pyrazole oxadiazoles derivatives of Formula (I), and their use for treating multiple sclerosis and other diseases, wherein R 1 , R 2 and R 3 are as defined in the description.

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Номер записи: 55
29-03-2012 дата публикации

Use of Toll-like receptor-9 agonists, Toll-like receptor-4 antagonists, and/or nuclear oligomerization domain-2 agonists for the treatment or prevention of Toll-like receptor-4-associated disorders

Номер: US20120077868A1
Автор: David J. Hackam
Принадлежит: Individual

The present invention relates to the use of a TLR9 agonist and/or a TLR4 antagonist and/or a NOD2 agonist for treatment or prevention of disorders involving TLR4 activation, such as systemic sepsis and necrotizing enterocolitis.

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Номер записи: 56
05-04-2012 дата публикации

Soluble il-17ra/rc fusion proteins and related methods

Номер: US20120082668A1
Автор: Gao Zeren, Mark W. Rixon, Steven D. Levin
Принадлежит: Zymogenetics Inc

Disclosed are antagonists of IL-17A and IL-17F. The antagonists are based on soluble IL-17RA and IL-17RC fusion proteins, including hybrid soluble receptors comprising portions of both IL-17RC and IL-17RA (“IL-17RC/IL-17RA”). Such antagonists serve to block, inhibit, reduce, antagonize or neutralize the activity of IL-17F, IL-17A, or both IL-17A and IL-17F. Also disclosed are methods of using such antagonists for treating disease, particularly inflammatory diseases mediated at least in part by IL-17A and/or IL-17F.

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Номер записи: 57
05-04-2012 дата публикации

Botulinum Neurotoxin B Receptors and Use Thereof

Номер: US20120082672A1
Автор: Edwin Raymond Chapman, Min Dong
Принадлежит: Individual

It is disclosed here that synaptotagmin I (syt I) and synaptotagmin II (syt II) are the cellular receptors for botulinum neurotoxin B (BoNT/B) that mediate the cellular entry and toxicity of BoNT/B. The BoNT/B binding domains of syt I and II are also disclosed. While syt I needs gangliosides for BoNT/B binding, syt II can bind to BoNT/B in the absence of gangliosides. Various nucleic acids and polypeptides that relate to the BoNT/B binding domain of syt I or II are disclosed. Further disclosed are methods of reducing BoNT/B toxicity, methods of identifying agents that can block the binding between BoNT/B and syt I or II, methods of identifying agents that can bind to the BoNT/B binding domain of syt I or II, methods of detecting BoNT/B or Clostridium botulinum and kits for use thereof.

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Номер записи: 58
05-04-2012 дата публикации

Human cytokine receptor

Номер: US20120082673A1
Автор: Scott R. Presnell, Steven D. Hughes, Wayne R. Kindsvogel, Wenfeng Xu, Zhi Chen
Принадлежит: Zymogenetics Inc

Cytokines and their receptors have proven usefulness in both basic research and as therapeutics. The present invention provides a new human cytokine receptor designated as “Zcytor16.”

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Номер записи: 59
05-04-2012 дата публикации

Anti-il12rbeta1 antibodies and their use in treating autoimmune and inflammatory disorders

Номер: US20120082681A1
Автор: Andrea Polzer, Christoph Heusser, Christoph Schwaerzler, Gabriela Wochnik-Veltrup, Ingo Klagge, José M. Carballido Herrera, Stefan Hartle
Принадлежит: NOVARTIS AG

The present invention relates to antibodies that specifically bind to IL12Rβ1, the non-signal transducing chain of both the heterodimeric IL12 and IL23 receptors. The invention more specifically relates to specific antibodies that are IL12 and IL23 receptor antagonists capable of inhibiting IL12/1L18 induced IFNγ production of blood cells and compositions and methods of use for said antibodies to treat pathological disorders that can be treated by inhibiting IFNγ production, IL12 and/IL23 signaling, such as rheumatoid arthritis, psoriasis or inflammatory bowel diseases or other autoimmune and inflammatory disorders.

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Номер записи: 60
05-04-2012 дата публикации

Myostatin binding agents

Номер: US20120083442A1
Автор: Hosung Min, Hq Han, Thomas Charles Boone
Принадлежит: AMGEN INC

The present invention provides binding agents comprising peptides capable of binding myostatin and inhibiting its activity. In one embodiment the binding agent comprises at least one myostatin-binding peptide attached directly or indirectly to at least one vehicle such as a polymer or an Fc domain. The binding agents of the present invention produced increased lean muscle mass when administered to animals and decreased fat to muscle ratios. Therapeutic compositions containing the binding agents of the present invention are useful for treating muscle-wasting disorders and metabolic disorders including diabetes and obesity.

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Номер записи: 61
05-04-2012 дата публикации

Novel Compounds, Pharmaceutical Compositions Containing Same, Methods of Use for Same, and Methods for Preparing Same

Номер: US20120083471A1
Автор: Craig A. Townsend, Edward Wydysh, Francis Kuhajda, Gabriele Valeria Ronnett
Принадлежит: JOHNS HOPKINS UNIVERSITY

The present invention relates to novel pharmaceutical compositions containing the same, and methods of use for a variety of therapeutically valuable uses including, but not limited to, treating obesity by inhibiting the activity of Glycerol 3-phosphate acyltransferase (GPAT).

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Номер записи: 62
12-04-2012 дата публикации

1-heterocyclylsulfonyl, 3-aminomethyl, 5- (hetero-) aryl substituted 1-h-pyrrole derivatives as acid secretion inhibitors

Номер: US20120088797A1
Автор: Atsushi Hasuoka, Haruyuki Nishida, Masahiro Kajino
Принадлежит: Takeda Pharmaceutical Co Ltd

The present invention provides a compound having a superior acid secretion inhibitory effect and showing an antiulcer activity and the like. The present invention provides a compound represented by the formula (I) wherein R 1 is a nitrogen-containing monocyclic heterocyclic group optionally condensed with a benzene ring or a heterocycle, the nitrogen-containing monocyclic heterocyclic group optionally condensed with a benzene ring or a heterocycle optionally has substituent(s), R 2 is an optionally substituted C 6-14 aryl group, an optionally substituted thienyl group or an optionally substituted pyridyl group, R 3 and R 4 are each a hydrogen atom, or one of R 3 and R 4 is a hydrogen atom and the other is an optionally substituted lower alkyl pup, an acyl group, a halogen atom, a cyano group or a nitro group, and R 5 is an alkyl group or a salt thereof.

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Номер записи: 63
19-04-2012 дата публикации

Oral medicinal composition and oral medicinal capsule having the composition encapsulated therein

Номер: US20120093925A1
Автор: Tsuyoshi Shimoo
Принадлежит: Morishita Jintan Co Ltd

The present invention relates to an oral medicinal composition comprising (a) a medical agent that is low in solubility in both water and oils but is soluble in a polyethylene glycol, (b) a polyethylene glycol that is solid at temperatures of 40° C. or lower, and (c) an oily or aqueous auxiliary agent. The oral medicinal composition cannot provide any stimulus or unpleasant feeling during being dissolved in the mouth, and is improved in the solubility of the medicinal agent in the mouth, and is also improved in the absorbability of the medicinal agent in the mouth.

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Номер записи: 64
19-04-2012 дата публикации

Derivatives of apf and methods of use

Номер: US20120094933A1
Автор: Christopher Michejda, Maria Michejda, Piotr Kaczmarek, Susan K. Keay, Zoltan Szekely
Принадлежит: University of Maryland at Baltimore, US Department of Health and Human Services

Derivatives of bladder epithelial antiproliferative factor and methods of using them are disclosed. In specific embodiments, the glycopeptide compositions are useful for the treatment and/or prevention of medical conditions, including cancer. In other embodiments, there are compositions and methods related to treatment of bladder conditions. In particular embodiments, the glycopeptide comprises D-pipecolic acid or L-pipecolic acid.

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Номер записи: 65
19-04-2012 дата публикации

5-ht receptor modulating compounds

Номер: US20120094989A1
Автор: Bjame Brudeli, Finn Olav Levy, Jo Klaveness, Lise Roman Moltzau, Trygve Gulbrandsen
Принадлежит: SERODUS AS

The present invention relates to compounds having 5-hydroxytryptamine receptor modulating activity, in particular compounds having an acidic moiety held distant from the 5-HT pharmacophore by a rigid linker group, to compositions containing such compounds and methods of treatment using them. Such compounds have an increased affinity for the 5-HT receptor and a reduced hERG effect. Certain compounds of the invention further exhibit an angiotensin II receptor modulating activity. Claimed are compounds of formula (I): HT-L-A. HT is a 5-HT receptor modulating moiety containing a basic nitrogen atom; A is an acid moiety; L is a linker moiety.

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Номер записи: 66
26-04-2012 дата публикации

Thiadiazole derivatives and their use for the treatment of disorders mediated by s1p1 receptors

Номер: US20120101086A1
Автор: Christian Alan Paul Smethurst, Emmanuel Hubert Demont, Gail Astra Lorraine Seal, James Matthew Bailey, Jason Witherington, John Alexander Brown, Lee Andrew Harrison
Принадлежит: Glaxo Group Ltd

The present invention relates to novel compounds having pharmacological activity, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders.

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Номер записи: 67
26-04-2012 дата публикации

Anti-Emetic Substance

Номер: US20120101089A1
Автор: Ankit Bharat, Ashwani Agarwal
Принадлежит: Individual

The present invention provides a therapeutic solution for effective control of symptoms related to nausea and vomiting. The therapeutic solution is a pharmaceutical composition which combines anti-emetics of different classes. These classes include dopamine receptor antagonists, serotonin receptor antagonists, butyrphenones, and neurokinin receptor antagonists. The combination of different anti-emetics mitigates adverse affects of a single anti-emetic alone while increasing drug efficacy and decreasing cost of administration to the individual patient.

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Номер записи: 68
03-05-2012 дата публикации

Anti bone-loss and anti attachment-loss effects of an oral composition

Номер: US20120107843A1
Автор: Emi Shimizu, Harsh M. Trivedi, Nicola C. Partridge, Tao Xu, Virginia Barnes, Wei Wang
Принадлежит: Colgate Palmolive Co

Methods for identifying compounds useful for treating diseases and conditions of the oral cavity are described herein.

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Номер записи: 69
03-05-2012 дата публикации

Carbamoyl Compounds as DGAT1 Inhibitors 190

Номер: US20120108602A1
Автор: Alan Martin Birch, Alexander Tobias Noeske, Andrew Leach, Annika Ulrika Petersson, Clive Green, Jan Magnus Johansson, Jonas Gunnar Barlind, Petra Johannesson, Ragnar Hovland, Roger John Butlin, Udo Andreas Bauer
Принадлежит: AstraZeneca AB

DGAT-1 inhibitor compounds of formula (1), pharmaceutically-acceptable salts and pro-drugs thereof are described, together with pharmaceutical compositions, processes for making them and their use in treating, for example, obesity wherein, for example, Ring A is optionally substituted 2,6-pyrazindiyl; X is ═0; Ring B is optionally substituted 1,4-phenylene; Y 1 is a direct bond or —O—; Y 2 is —(CH 2 ) r — wherein r is 2 or 3; n is 0 or n is 1 when Y 1 is a direct bond between Ring B and Ring C and when Ring B is 1,4-phenylene and Ring C is (4-6C)cycloalkane; Ring C is optionally substituted (4-6C)cycloalkane, (7-10C)bicycloalkane, (8-12C)tricycloalkane, phenylene or pryidindiyl; L is a direct bond or —O—; p is 0, 1 or 2 and when p is 1 or 2 R A1 and R A2 are each independently hydrogen or (1-4C)alkyl; Z is carboxy or a mimic or bioisostere thereof.

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Номер записи: 70
10-05-2012 дата публикации

Bismuth-containing compounds, coordination polymers, methods for modulating pharmacokinetic properties of biologically active agents, and methods for treating patients

Номер: US20120115823A1
Автор: John D. Price, Michaela E. Mulhare, Robert A. Oberlender, Scott B. Palmer, Thomas Piccariello
Принадлежит: Synthonics Inc

Bismuth-containing compounds include bismuth and a biologically active agent coordinated to the bismuth. The biologically active agent includes at least one heteroatom configured for coordination with the bismuth. Coordination polymers include a polymer matrix that contains a bismuth-containing compound. Methods for modulating a pharmacokinetic property of a biologically active agent include coordinating the biologically active agent to bismuth to form a bismuth-containing compound, and administering the bismuth-containing compound orally to a patient. Methods for treating Parkinson's disease, methods for treating hypothyroidism, methods for treating ulcerative colitis, and methods for treating cancer each include administering a bismuth-containing compound to a patient.

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Номер записи: 71
10-05-2012 дата публикации

Aryl- and Heteroarylcarbonyl derivatives of substituted nortropanes, medicaments containing such compounds and their use

Номер: US20120115853A1
Автор: Bradford S. Hamilton, Frank Himmelsbach, Matthias Eckhardt, Stefan Peters
Принадлежит: BOEHRINGER INGELHEIM INTERNATIONAL GMBH

The present invention relates to compounds defined by formula (I) wherein the groups R 1 and R 2 are defined as in claim 1 , possessing valuable pharmacological activity. Particularly the compounds are inhibitors of 11 β-hydroxysteroid dehydrogenase (HSD) 1 and thus are suitable for treatment and prevention of diseases which can be influenced by inhibition of this enzyme, such as metabolic diseases, in particular diabetes type 2, obesity, and dyslipidemia.

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Номер записи: 72
10-05-2012 дата публикации

Xanthan gum and swellable particulate containing composition and uses thereof

Номер: US20120115964A1
Автор: John Richard Mitchell, Mitaben Dhirajlal Lad, Timothy John Foster
Принадлежит: UNIVERSITY OF NOTTINGHAM

This invention relates to a composition comprising at least about 0.2% w/w xanthan gum and at least about 6% w/w of a swellable particulate, and to uses thereof.

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Номер записи: 73
10-05-2012 дата публикации

Rifaximin

Номер: US20120116071A1
Автор: Dharmaraj Ramachandra Rao, Manjinder Singh Phull, Maruti Ghagare, Rajendra Narayanrao Kankan
Принадлежит: Cipla Ltd

Amorphous rifaximin, methods of making it, and pharmaceutical compositions containing it. Also described are methods of converting amorphous rifaximin to crystalline rifaximin and vice versa.

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Номер записи: 74
17-05-2012 дата публикации

Dry whole milk preparations containing probiotic micro-organisms

Номер: US20120121561A1
Автор: Annick Mercenier, Guénolée Prioult, Sophie Nutten
Принадлежит: Nestec SA

The present invention relates to the field of nutrition for young children. In particular, the present invention relates to dry whole milk preparations comprising probiotic micro-organisms to be administered to young children older than 12 months. These probiotic micro-organisms may be non-replicating probiotic micro-organisms such as bioactive heat treated probiotic micro-organisms, for example.

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Номер записи: 75
17-05-2012 дата публикации

Biodegradable immunomodulatory formulations and methods for use thereof

Номер: US20120121622A1
Автор: Dino Dina, Gary Van Nest, Karen L. Fearon, Stephen Tuck
Принадлежит: Dynavax Technologies Corp

The invention provides new compositions and methods for immunomodulation of individuals. Immunomodulation is accomplished by administration of immunomodulatory polynucleotide/microcarrier (IMP/MC) complexes. The IMP/MC complexes may be covalently or non-covalently bound, and feature a polynucleotide comprising at least one immunostimulatory sequence bound to a biodegradable microcarrier or nanocarrier.

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Номер записи: 76
17-05-2012 дата публикации

Reduction of Side Effects From Aromatase Inhibitors Used for Treating Breast Cancer

Номер: US20120122824A1
Автор: Stephen N. Birrell
Принадлежит: Chavah Pty Ltd

The present invention is directed generally to pharmaceutical compositions, methods, and kits for improving side effects associated with aromatase inhibitor treatment in a subject diagnosed with breast cancer. More specifically, the present invention provides compositions, methods, and kits comprising an aromatase inhibitor and an androgenic agent.

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Номер записи: 77
17-05-2012 дата публикации

Aurora kinase modulators and method of use

Номер: US20120122847A1
Автор: Bingfan Du, Hanh Nho Nguyen, Holly Deak, Issac Marx, Karina Romero, Kathleen Panter, Laurie Schenkel, Matthew Martin, Philip Olivieri, Ryan White, Stephanie Geuns-Meyer, Victor Cee, Zihao Hua
Принадлежит: AMGEN INC

The present invention relates to chemical compounds having a general formula I wherein A 1-8 , D′, L 1 , L 2 , R 1 , R 6-8 and n are defined herein, and synthetic intermediates, which are capable of modulating various protein kinase receptor enzymes and, thereby, influencing various disease states and conditions related to the activities of such kinases. For example, the compounds are capable of modulating Aurora kinase thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of Aurora kinase.

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Номер записи: 78
17-05-2012 дата публикации

Tricyclic n-heteroaryl-carboxamide derivatives containing a benzimidazole unit, method for preparing same and their therapeutic use

Номер: US20120122852A1
Автор: Andre Malanda, Catherine Gille, David Machnik, Laurent Dubois, Luc Even, Nathalie Rakotoarisoa, Yannick Evanno
Принадлежит: Sanofi Aventis France

The invention concerns tricyclic N-heteroaryl-carboxamide derivatives containing a benzimidazole unit of general formula (I): Wherein A, P, Y, R 1 , R 2 and R 3 are as defined herein. The invention also concerns a method of preparing the compounds and their therapeutic use.

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Номер записи: 79
17-05-2012 дата публикации

Pharmaceutical composition combining tenatoprazole and a histamine h2-receptor antagonist

Номер: US20120122919A1
Автор: Alain Taccoen, Francois Schutze, Herve Ficheux, Michel Homerin, Nathalie Taccoen, Suzy Charbit, Yoshio Inaba
Принадлежит: Mitsubishi Pharma Corp, Sidem Pharma SA

The invention relates to a novel pharmaceutical combination. The inventive pharmaceutical composition, which is intended for the treatment of pathologies linked to gastric hyperacidity, comprises a combination of tenatoprazole and one or more histamine H2-receptor antagonists preferably selected from cimetidine, ranitidine, famotidine and nizatidine. The invention is particularly suitable for the treatment of duodenal and gastric ulcers and the symptoms of, and lesions caused by, gastroesophageal reflux.

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Номер записи: 80
17-05-2012 дата публикации

Polyunsaturated fatty acids for the treatment of diseases related to cardiovascular, metabolic and inflammatory disease areas

Номер: US20120122940A1
Автор: Anne Kristin Holmeide, Morten Braendvang, Ragnar Hovland, Tore Skjæret
Принадлежит: Individual

The present disclosure relates to lipid compounds of the general formula (I): R1-O—C(R2)(R3)-X  (I) wherein R 1 is a C 10 -C 22 alkyl group, a C 10 -C 22 alkenyl group having 1-6 double bonds, or a C 10 -C 22 alkynyl group having 1-6 triple bonds; R 2 and R 3 are the same or different and may be chosen from different substituents; and X is a carboxylic acid or a derivative thereof, such as a carboxylic ester, a carboxylic anhydride, a phospholipid, triglyceride, or a carboxamide; or a pharmaceutically acceptable salt, solvate, solvate of such salt or a prodrug thereof. The present disclosure also relates to pharmaceutical compositions and lipid compositions comprising at least one compound according to the present disclosure, and to such compounds for use as medicaments or for use in therapy, in particular for the treatment of diseases related to the cardiovascular, metabolic, and inflammatory disease area.

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Номер записи: 81
17-05-2012 дата публикации

Treatment of disorders associated with g protein-coupled receptor 35 (gpr35)

Номер: US20120122987A1
Автор: Herbert H. Seltzman, Lawrence S. Barak, Mary E. Abood, Pingwei Zhao
Принадлежит: Duke University, Research Triangle Institute, Temple University of Commonwealth System of Higher Education

Compounds are provided having agonistic activity against G protein-coupled receptor 35 (GPR35). The compounds are useful for providing antinociception, providing neuroprotection in case of stroke or ischemia, or treating gastric inflammation.

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Номер записи: 82
17-05-2012 дата публикации

Oleoylethanolamide based functional mesophases

Номер: US20120122990A1
Автор: Matthieu Pouzot, Rafaele Mezzenga, Sayed Mohammady
Принадлежит: Nestec SA

The present invention relates to the field of liquid crystals. Embodiments of the present invention relate to liquid crystals comprising at least one molecule within N-acyl ethanolamide (NAE) family, for example oleoylethanolamide (OEA), compositions comprising them and their possible uses.

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Номер записи: 83
24-05-2012 дата публикации

Oral care composition

Номер: US20120128599A1
Автор: Andre Michelle Morgan, Davide Miksa, Evangelia S. Arvanitidou, Gregory Szewczyk, Laurence Du-Thumm, Lyndsay Schaeffer-Korbylo, Michael Prencipe
Принадлежит: Colgate Palmolive Co

Disclosed are oral care compositions and the use of such oral care compositions for treating conditions caused by biofilm formation. Also disclosed are methods for inhibiting biofilm formation and/or degrading biofilm. The oral care composition includes a sesquiterpenoid and an antimicrobial agent, in which the sesquiterpenoid and the antimicrobial agent are present in an amount effective to inhibit and/or degrade a biofilm in the oral cavity.

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Номер записи: 84
24-05-2012 дата публикации

Novel antibody formulation

Номер: US20120128687A1
Автор: Christine Wurth, Michael Adler
Принадлежит: Hoffmann La Roche Inc

Pharmaceutical liquid formulation of an antibody against human OX40L, a process for the preparation and uses of the formulation.

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Номер записи: 85
24-05-2012 дата публикации

Compositions and methods for the removal of biofilms

Номер: US20120128701A1
Автор: Lauren O. Bakaletz, Steven D. Goodman
Принадлежит: Nationwide Childrens Hospital Inc, University of Southern California USC

Methods of breaking down a biofilm or inhibiting, preventing or treating a microbial infection that produces a biofilm are disclosed, which involves administration of a polypeptide that has one or more HMG-box domains to a subject suffering from the infection or having the biofilm. By competing with microbial proteins that bind to DNA scaffold in the biofilm, these polypeptides destabilize the biofilm leading to destruction and removal of the biofilm by the immune system.

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Номер записи: 86
24-05-2012 дата публикации

Infant feeding formulas comprising probiotic micro-organisms

Номер: US20120128726A1
Автор: Annick Mercenier, Guénolée Prioult, Sophie Nutten
Принадлежит: Nestec SA

The present invention relates to the field of infant nutrition. In particular, the present invention relates to infant feeding formulas comprising probiotic micro-organisms. These probiotic micro-organisms may be non-replicating probiotic micro-organisms such as bioactive heat treated probiotic micro-organisms, for example.

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Номер записи: 87
24-05-2012 дата публикации

Trace Elements

Номер: US20120128792A1
Автор: William Alfred Smith
Принадлежит: Individual

The inventions discloses a trace element solution, which comprises at least the following metals: zinc; manganese; selenium; and copper; and which comprises a concentration of the metals of at least 90 mg/ml. The solution may comprise the following concentrations: at least 60 mg/ml zinc; at least 10 mg/ml manganese; at least 5 mg/ml selenium; and at least 15 mg/ml copper. The solution may comprise chromium, iodine and chromium.

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Номер записи: 88
24-05-2012 дата публикации

Methods and compositions for diagnosing ankylosing spondylitis using biomarkers

Номер: US20120129185A1
Автор: Robert L. Wong, Walter P. Maksymowych
Принадлежит: Abbott Biotech Ltd Bermuda

The invention provides a method for determining the efficacy of a TNFα inhibitor, such as a TNFα antibody, or an antigen-binding portion thereof, for treating ankylosing spondylitis (AS), using a collagen degradation biomarker and/or a synovitis biomarker.

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Номер записи: 89
24-05-2012 дата публикации

Pyridyl-thiazolyl inhibitors of pro-matrix metalloproteinase activation

Номер: US20120129843A1
Автор: Aihua Wang, Brett Andrew Tounge, Joseph Kent Barbay, Kristi Anne Leonard, Michael Hawkins, Umar S.M. Maharoof, Yan Zhang
Принадлежит: Janssen Pharmaceutica NV

This invention relates to thiazole I and its therapeutic and prophylactic uses, wherein the variables R z , Q, J, R 1 , R 3 , R 5 , and R 6 are defined in the specification. Disorders treated and/or prevented include rheumatoid arthritis.

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Номер записи: 90
31-05-2012 дата публикации

Application and Uses of PRG4 and Therapeutic Modulation Thereof

Номер: US20120134925A1
Автор: Benjamin Sullivan, David Sullivan, Edward R. Truitt, Nicole Barbara Justis Truitt, Tannin Schmidt
Принадлежит: Lubris Llc, Schepens Eye Research Institute Inc

The present invention relates to the uses of the protein PRG4 and therapeutic modulation thereof. In particular, the present invention relates compositions and methods utilizing PRG4 and therapeutic modulation thereof, including, use as a surgical lubricant, use in a treatment for prevention or reduction of post-surgical adhesions, use in a treatment for oral ulcerations, use as an athletic lubricating patch, use as a dermal filler, use in a treatment for dry mouth, use in a drug delivery method or composition, and use in nursing lubrication.

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Номер записи: 91
31-05-2012 дата публикации

Instant thickener comprising probiotics for hot or cold foods and beverages to be administered to dysphagic patients

Номер: US20120135044A1
Автор: Annick Mercenier, Guénolée Prioult, Sophie Nutten
Принадлежит: Nestec SA

The present invention relates to the fields of hydration and nutrition for dysphagic patients. In particular, the present invention relates to thickeners comprising probiotic microorganisms and to compositions comprising such thickeners. The probiotic micro-organisms may be non-replicating probiotic micro-organisms such as bioactive heat treated probiotic microorganisms.

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Номер записи: 92
31-05-2012 дата публикации

Compositions containing mixtures of fermentable fibers

Номер: US20120135957A1
Автор: Annick Bernalier, Béatrice MORIO, Christian Fougnies, Heidi Jacobs, Veronique Coxam, Yann Dugenet
Принадлежит: COSUCRA GROUPE WARCOING SA, DF3 SAS

The present invention relates to synergistic compositions comprising mixtures of fermentable fibers. The present invention specifically relates to composition comprising inulin and arabinoxylan for use in reducing, preventing and/or treating inflammation, wherein said arabinoxylan is partially hydrolyzed arabinoxylan and wherein the ratio of said inulin to said arabinoxylan and/or partially hydrolyzed arabinoxylan is between 65%/35% by weight and 90%/10% by weight.

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Номер записи: 93
31-05-2012 дата публикации

Hydroxy fatty acid compounds and uses thereof for disease treatment and diagnosis

Номер: US20120136057A1
Автор: Dayan Goodenowe, M. Amin Khan, Pearson W.K. Ahiahonu, Shawn Ritchie
Принадлежит: Phenomenome Discoveries Inc

A compound of formula (I): wherein R represents a hydroxy substituted C 24 -C 40 straight chain aliphatic group containing at least one double bond in the carbon chain; and at least one carbon in the chain is substituted with a hydroxy group. Such compounds are useful for detecting inflammation, inflammatory disorders and cancer in a subject, and can also be used in therapeutic applications including treatment and/or prevention of these conditions. Pharmaceutical compositions, combinations and supplements, as well as methods of treatment using the described compounds are therefore also described.

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Номер записи: 94
07-06-2012 дата публикации

Insoluble dietary fiber-containing materials derived from cereal seeds

Номер: US20120141455A1
Автор: Hideo Ohmae, Hiroshi Murayama, Hiroyuki Watanabe, Mikio Katayama, Naohiro Takimoto, Osamu Kanauchi, Yuji Sakamoto, Yuta Komano
Принадлежит: Kirin Holdings Co Ltd

This invention provides a product safe for treating, improving or preventing an inflammatory bowel disease such as ulcerative colitis, and provides a product comprising an insoluble dietary fiber obtained by enzymatic treatment of seeds of a grain plant(s) or germinated young seeds thereof, as well as a food or drink or medicament comprising the product.

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Номер записи: 95
07-06-2012 дата публикации

Method of increasing immunological effect

Номер: US20120141512A1
Автор: Harvey Brandwein, James E. Egan, John W. Hadden, Kathy L. Signorelli, Margareta Czytowska, Theresa L. Whiteside
Принадлежит: IRX Therapeutics Inc

A method of increasing immunological effect in a patient by administering an effective amount of a primary cell derived biologic to the patient, inducing immune production, blocking immune destruction, and increasing immunological effect in the patient. Methods of treating an immune target, treating a tumor, immune prophylaxis, and preventing tumor escape.

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Номер записи: 96
07-06-2012 дата публикации

Liquid enteral nutritional composition with a low monovalent metal ion content

Номер: US20120142587A1
Автор: Hilde Ruis, Marcel Minor, Suzanne VAN STEENIS
Принадлежит: Nutricia NV

Heat-treated liquid enteral nutritional composition with a low monovalent metal ion content are provided that contain micellar casein and optionally caseinate, and in which the total amount of monovalent metal ions is less than 25 mg/g of protein. Also, heat-treated liquid enteral nutritional compositions are disclosed comprising 10 to 20 g of protein per 100 ml of the composition, in which all or a major part of said protein comprises micellar casein. Also, a method is disclosed for producing the composition according to the invention, comprising a step wherein an aqueous protein solution in which all or a major part of said protein comprises micellar casein, is subjected to an evaporation step.

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Номер записи: 97
07-06-2012 дата публикации

Azetidine 2-Carboxamide Derivatives Which Modulate The CB2 Receptor

Номер: US20120142666A1
Автор: David Smith Thomson, Doris Riether, Eugene Richard Hickey, Lifen Wu, Renee M. Zindell
Принадлежит: BOEHRINGER INGELHEIM INTERNATIONAL GMBH

Compounds of the formula (I), (II) and (III) which modulate the CB2 receptor are disclosed. Compounds according to the invention bind to and are agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain.

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Номер записи: 98
07-06-2012 дата публикации

4-substituted-cyclohexylamino-4-piperidinyl-acetamide antagonists of ccr2

Номер: US20120142733A1
Автор: James C. Lanter, Nalin Subasinghe, Thomas P. Markotan, Xuqing Zhang, Zhihua Sui
Принадлежит: Janssen Pharmaceutica NV

The present invention comprises compounds of Formula (I). wherein: R 1 , R 2 , R 3 , R 4 , X, Y, and Z are as defined in the specification. The invention also comprises a method of preventing, treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is type II diabetes, obesity and asthma. The invention also comprises a method of inhibiting CCR2 activity in a mammal by administration of a therapeutically effective amount of at least one compound of Formula (I).

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Номер записи: 99
07-06-2012 дата публикации

Novel complexes of fatty acid esters of polyhydroxyalkanes and pyridine carboxy derivatives

Номер: US20120142744A1
Автор: Morten SLOTH WEIDNER
Принадлежит: Astion Dermatology AS

The present invention relates to novel combinations of fatty acid derivatives and pyridine carboxy derivatives, including fatty acid esters with glycerol and 3-carboxy pyridine derivates such as niacinamide. Such combinations have surprisingly shown antiviral and anti-microbial activity and the use for the treatment of inflammatory conditions and infections is disclosed herein.

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Номер записи: 100