CARD HOLDING MECHANISM AND ELECTRONIC DEVICE

An electronic device includes a housing, and a card holding mechanism for holding an electronic card. The housing defines a through hole, and the card holding mechanism may be inserted into the housing via the through hole. The card holding mechanism includes a tray for receiving the electronic card, an operating component, and a transmission component. The operating component moves from a latched position to an unlatched position, the transmission component is driven by the operating component to rotate and drive the tray to eject from the housing. 1. An electronic device , comprising:a housing comprising a sidewall, the sidewall defining a through hole; anda card holding mechanism being received in the housing, the card holding mechanism comprising:a tray for receiving an electronic card, and capable of being ejected from the housing via the through hole;an operating component capable of moving between a latched position and an unlatched position; anda transmission component arranged between the operating component and the tray;wherein when the operating component moves from the latched position to the unlatched position, the transmission component is driven by the operating component to rotate and drive the tray to eject from the housing such that the electronic card received in the tray can be taken out.2. The electronic device as claimed in claim 1 , wherein when the tray is pushed into the housing claim 1 , the tray drives the transmission component to rotate and drive the operating component moving from the unlatched position to the latched position.3. The electronic device as claimed in claim 2 , wherein the card holding mechanism further comprises an elastic member claim 2 , the elastic member is compressed by the transmission component to generate restoring forces when the operating component moves from the latched position to the unlatched position; the transmission component is driven to rotate via the restoring force generated by the elastic member and ...

Decoding Method for Biphase-Encoded Data

A decoding method for biphase-encoded data is provided. The decoding method includes detecting falling-edge transitions in the biphase-encoded data to decode according to a time difference (Δt) between each two adjacent falling-edge transitions and the logic value of previous bit. When Δt is 1 bit period and previous bit is logic 1, it's determined that present bit is logic 1. When Δt is 1 bit period and previous bit is logic 0, it's determined that present bit is logic 0. When Δt is 1.5 bit periods and previous bit is logic 1, it's determined that present and next bits are both logic 0. When Δt is 1.5 bit periods and previous bit is logic 0, it's determined that present bit is logic 1. When Δt is 2 bit periods and previous bit is logic 1, it's determined that present and next bits are logic 0 and 1 respectively. 1. A decoding method for biphase-encoded data having a plurality of bits wherein the logic value of a first bit of the bits is known , the logic value of one of the bits is a first logic value when the one of the bits has a transition from a first level to a second level at a time within a bit period , and the logic value of one of the bits is a second logic value when the one of the bits has a transition from the second level to the first level at the time within the bit period , the decoding method comprising:detecting specific transitions in the biphase-encoded data to obtain a time difference between each two adjacent specific transitions;when the time difference is 1 bit period and the logic value of a previous bit is the first logic value, determining that the logic value of a present bit is the first logic value;when the time difference is 1 bit period and the logic value of a previous bit is the second logic value, determining that the logic value of a present bit is the second logic value;when the time difference is 1.5 bit periods and the logic value of a previous bit is the first logic value, determining that the logic values of a present bit and ...

SECURING MECHANISM AND ELECTRONIC DEVICE WITH CONNECTOR COVER

An electronic device includes a printed circuit board (PCB), at least one socket mounted to the PCB, at least one connector inserted into the at least one socket, a first member mounted to the PCB, a second member mounted to the PCB, and a first cover. The first cover covers and presses against the at least one connector, the first cover includes a first end for being fixed to the first member and a second end opposite to the first end for being fixed to the second member. At least one of the first member and the second member is soldered to the PCB, and a soldered area of the at least one of the first member and the second member is larger than a predetermined value. 1. An electronic device , comprising:a printed circuit board (PCB);at least one socket mounted to the PCB;at least one connector inserted into the at least one socket;a first member mounted to the PCB;a second member mounted to the PCB; anda first cover for covering and pressing against the at least one connector, the first cover comprising a first end for being fixed to the first member and a second end opposite to the first end for being fixed to the second member;wherein at least one of the first member and the second member is soldered to the PCB, and a soldered area of the at least one of the first member and the second member is larger than a predetermined value.2. The electronic device of claim 1 , further comprising:an integrated circuit mounted to the PCB; anda second cover for covering the integrated circuit and providing an electro-magnetic interference (EMI) shield for the integrated circuit;wherein a first distal end and a second distal end of the second cover are all soldered to the PCB, the second distal end is opposite to the first distal end; the second cover engages with the first cover and presses against the first cover.3. The electronic device of claim 2 , wherein a first protrusion portion extends from the first end claim 2 , a second protrusion portion extends from the second end ...

LOCKING MECHANISM AND ELECTRONIC DEVICE USING SAME

A locking mechanism includes a first locking member positioned on the first object and a second locking member positioned on the second object. The second locking member can be moved to engage with or disengage from the first locking member. The second object defines at least one through hole for allowing insertion of the disassembly tool to push the second locking member, which disengages the second locking member from the first locking member. 1. An electronic device , comprising:an upper cover;a lower cover coupled to the upper cover; andat least one locking mechanism for locking the upper cover to the lower cover, and a disassembly tool capable of being operated to unlock the upper cover from the lower cover, wherein the at least one locking mechanism comprises:a first locking member positioned on the upper cover; anda second locking member positioned on the lower cover, the second locking member is capable of being moved between a locking position for engaging with the first locking member and an unlocking position for disengaging with the first locking member;wherein the lower cover defines at least one through hole for allowing insertion of the disassembly tool, when the disassembly tool extends through the at least one through hole and pushes the second locking member, the second locking member is disengaged from the first locking member for allowing the upper cover be unlocked from the lower cover.2. The electronic device as claimed in claim 1 , wherein a protecting piece positions on an inner surface of the lower cover to cover the at least one through hole claim 1 , the protecting piece comprises at least one breakaway portion corresponding to the at least one through hole claim 1 , when the disassembly tool extends through the at least one through hole and abuts against the corresponding protecting portion claim 1 , the breakaway portion is detachable from the protecting piece to allow the disassembly tool inserting into the electronic device.3. The ...

METHODS AND SYSTEMS FOR UTILIZING VOICE COMMANDS ONBOARD AN AIRCRAFT

Methods and systems are provided for utilizing audio commands onboard an aircraft. A method comprises identifying a flight phase for the aircraft, resulting in an identified flight phase, receiving an audio input, resulting in received audio input, filtering the received audio input in a manner that is influenced by the identified flight phase for the aircraft, resulting in filtered audio input, and validating the filtered audio input as a first voice command of a first plurality of possible voice commands. 1. A method for utilizing voice commands onboard a vehicle , the method comprising:determining a current operating state for the vehicle;recognizing a received voice command as a first voice command of a plurality of possible voice commands, the first voice command being associated with one or more allowed operating states; and invalidating the received voice command if a criterion associated with the first voice command does not allow execution of the first voice command during the current operating state; and', 'executing the first voice command when the current operating state of the vehicle corresponds to an allowed operating state of the one or more allowed operating states., 'in response to recognizing the received voice command2. The method of claim 1 , further comprising validating the first voice command based on one or more criterion associated with the first voice command prior to executing the first voice command.3. The method of claim 1 , further comprising:selecting, from a plurality of different noise models, a first noise model corresponding to the current operating state; andfiltering the received voice command in a manner that is influenced by the first noise model, resulting in a filtered voice command, wherein executing the first voice command comprises executing the first voice command in response to recognizing the filtered voice command as the first voice command.4. The method of claim 1 , further comprising providing feedback in response ...

SPARK PLUG FOR REMOVING RESIDUAL EXHAUST GAS AND ASSOCIATED COMBUSTION CHAMBER

A spark plug, and associated systems, for an internal combustion engine includes a central electrode that terminates at a first distal end surface defined about a central axis. The spark plug also includes at least one outer electrode that terminates at a second distal end surface. The at least one outer electrode at least partially laterally surrounds the central electrode such that the second distal end surface is radially offset relative to the central electrode and a lateral gap is defined between the central electrode and the at least one outer electrode. The spark plug include features that force or redirect movement of the flow of the fresh air-fuel mixture through the lateral gap to help to purge or move the residual exhaust gases left over from a previous combustion event out of the lateral gap. 1. A spark plug for an internal combustion engine , comprising:a central electrode terminating at a first distal end surface defined about a central axis; andat least one outer electrode terminating at a second distal end surface, the at least one outer electrode at least partially laterally surrounding the central electrode such that the second distal end surface is radially offset relative to the central electrode and a lateral gap is defined between the central electrode and the at least one outer electrode;wherein the first distal end surface of the central electrode is axially recessed relative to the second distal end surface of the at least one outer electrode.2. The spark plug of claim 1 , wherein the first distal end surface of the central electrode and the second distal end surface of the at least one outer electrode are substantially co-planar.3. The spark plug of claim 1 , wherein the spark plug comprises a plurality of outer electrodes.4. The spark plug of claim 1 , wherein the first distal end surface of the central electrode is recessed up to about one millimeter relative to the second distal end surface of the at least one outer electrode.5. The ...

METHOD FOR EXPRESSION OF SMALL RNA MOLECULES WITHIN A CELL

The invention provides methods and compositions for the expression of small RNA molecules within a cell using a lentiviral vector. The methods can be used to express doubles stranded RNA complexes. Small interfering RNA (siRNA) can be expressed using the methods of the invention within a cell, which are capable of down regulating the expression of a target gene through RNA interference. A variety of cells can be treated according to the methods of the invention including embryos, embryogenic stem cells, allowing for the generation of transgenic animals or animals constituted partly by the transduced cells that have a specific gene or a group of genes down regulated. 1. A retroviral construct for the expression of an siRNA within a cell , the retroviral construct comprising:a nucleic acid having the R and U5 sequences from a 5′ lentiviral long terminal repeat (LTR);a self-inactivating lentiviral 3′ LTR; anda first RNA Polymerase III promoter configured to operably linked to a first RNA coding region encoding a first siRNA;wherein the first promoter is located between the 5′ LTR and the 3′ LTR.2. The retroviral construct of claim 1 , comprising the first RNA coding region linked to the first RNA Polymerase III promoter claim 1 , wherein the first RNA coding region is followed by at least one termination sequence.3. The retroviral construct of claim 1 , wherein the RNA Polymerase III promoter is inducible.4. The retroviral construct of claim 3 , wherein the inducible RNA Polymerase III promoter is activated with tetracycline.5. The retroviral construct of claim 1 , wherein the first RNA coding region encodes a self-complementary RNA molecule having a sense region claim 1 , an antisense region and a loop region.6. The retroviral construct of claim 5 , wherein the loop region is about 2 to about 10 nucleotides in length.7. The retroviral construct of claim 5 , wherein the sense region and the antisense region are between about 15 and about 30 nucleotides in length.8. The ...

Method for expression of small antiviral rna molecules with reduced cytotoxicity within a cell

In one aspect, the invention provides methods and compositions for the expression of small RNA molecules within a cell using a retroviral vector (FIG. 1 A). Small interfering RNA (siRNA) can be expressed using the methods of the invention within a cell. In a further aspect, the invention provides methods for producing siRNA encoding lentivirus where the siRNA activity may interfere with the lentiviral life cycle. In yet a further aspect, the invention provides methods for expression of a small RNA molecule within a cell, such as an siRNA capable of downregulating CCR5, wherein expression of the small RNA molecule is relatively non-cytotoxic to the cell. The invention also includes small RNA molecules, such as an siRNA capable of downregulating CCR5, that are relatively non-cytotoxic to cells.

METHOD FOR EXPRESSION OF SMALL ANTIVIRAL RNA MOLECULES WITH REDUCED CYTOTOXICITY WITHIN A CELL

In one aspect, the invention provides methods and compositions for the expression of small RNA molecules within a cell using a retroviral vector (FIG. A). Small interfering RNA (siRNA) can be expressed using the methods of the invention within a cell. In a further aspect, the invention provides methods for producing siRNA encoding lentivirus where the siRNA activity may interfere with the lentiviral life cycle. In yet a further aspect, the invention provides methods for expression of a small RNA molecule within a cell, such as an siRNA capable of downregulating CCR5, wherein expression of the small RNA molecule is relatively non-cytotoxic to the cell. The invention also includes small RNA molecules, such as an siRNA capable of downregulating CCR5, that are relatively non-cytotoxic to cells. 120.-. (canceled)21. A retroviral construct for expressing an RNA within a cell , comprising:a nucleic acid having the R and U5 sequences from a 5′ lentiviral long terminal repeat (LTR);a self-inactivating lentiviral 3′ LTR; anda first promoter configured to be operably linked to a first RNA coding region encoding a first RNA,wherein the first promoter is located between the 5′ LTR and the 3′ LTR, and wherein the first RNA comprises a RNA duplex.22. The retroviral construct of claim 21 , wherein the first RNA comprises a sequence that is at least about 90% complementary to a target region of a pathogenic virus genome or genome transcript.23. The retroviral construct of claim 22 , wherein the pathogenic virus is human immunodeficiency virus (HIV) claim 22 , hepatitis A virus (HAV) claim 22 , hepatitis B virus (HBV) claim 22 , hepatitis C virus (HCV) claim 22 , cytomegalovirus (CMV) claim 22 , herpes simplex virus (HSV) claim 22 , influenza virus claim 22 , adeno virus claim 22 , human papillomavirus claim 22 , Coxsackieviruses claim 22 , Measles virus claim 22 , or poliovirus.24. The retroviral construct of claim 23 , wherein the pathogenic virus is HIV-1 or HIV-2.25. The ...

INFORMATION DISPLAY METHOD, TERMINAL, AND SERVER

An information display method, terminal, and server, where the method includes obtaining, by a terminal, content information of at least one content source, where the at least one content source corresponds to at least two pieces of account information stored in the terminal, integrating, by the terminal, the content information into content display information, and displaying, by the terminal, the content display information. Content information of a content source is obtained, integrated, and then displayed to a user by classification, so that it is concise and intuitive for the user to query information without cumbersomeness. 1. An information display method comprising:transmitting, by a terminal, a content information request to a server;receiving, by the terminal, a first content information comprising information regarding a first commodity from a first content source according to a first account information in response to the content information request;receiving, by the terminal, a second content information comprising information regarding a second commodity from a second content source according to a second account information in response to the content information request;classifying the first content information and the second content information into one category; anddisplaying, by the terminal, the classified first content information and second content information, the displaying comprising displaying at least a first level display page and a second level display page, the first level display page displaying a part of the first content information, a part of the second content information, and a link for accessing the second page level display, and the second level display page displaying first content information omitted from the first level display page, or the second level display page displaying second content information omitted from the first level display page.2. The method according to claim 1 , wherein the displaying the classified first ...

ELECTRICAL CONNECTOR WITH IMPROVED HIGH FREQUENCY SIGNAL TRANSMISSION ENVIRONMENT

An electrical connector comprises an insulative housing, a plurality of contacts retained in the insulative housing and including a grounding contact and a first pair of differential signal contacts. The first pair of differential signal contacts have a first signal contact and a second signal contact closing to the grounding contact. Each contact has a contacting portion, a soldering portion, a position portion and a connecting portion. A first distance is defined between a center line of the grounding contact and an inner side edge of the connecting portion of the second signal contact, a second distance is defined between the center line and an inner side edge of the soldering portion, and a third distance is defined between the center line and the position portion, the second distance and the third distance are both smaller than the first distance. 1. An electrical connector , comprising:an insulative housing defining a mating port with a first tongue extending thereinto and a base portion assisting the first tongue, the base portion having a bottom wall; anda plurality of contacts retained in the insulative housing, the contacts having a first grounding contact and a first pair of differential signal contacts, the first pair of differential signal contacts comprising a first signal contact and a second signal contact located between the first signal contact and the first grounding contact, each contact having a contacting portion extending into the mating port, a soldering portion extending downwardly beyond the bottom wall, a position portion extending rearwardly from the contacting portion and a connecting portion extending from the position portion and further downwardly located at a back side of the insulative housing, all the contacting portions disposed in an equal interval;wherein a first distance is defined between a center line of the first grounding contact and an inner side edge of the connecting portion of the second signal contact, a second ...

PORTABLE SPEAKER AND ASSEMBLY THEREOF

A speaker assembly comprises two separate and symmetrical speakers combining together in a reversed manner. Each speaker includes a base surface for seating said speaker and a sound emission surface provided at one front side thereof for an emission of sound derived from the speaker. Wherein each speaker defines a mating surface which the sound emission surface is located at and said two speakers can be secured to each other snugly into an integral unit by jointing two mating surfaces thereof via a magnetic force. 1. A speaker assembly comprising:two separate and symmetrical speakers combining together in a reversed manner, each speaker including a base for seating said speaker and a sound emission surface provided at one front side thereof for an emission of sound derived from the speaker; wherein each speaker defines a mating surface which the sound emission surface is located at and said two speakers can be secured to each other snugly into an integral unit by jointing two mating surfaces thereof via a magnetic force, whereinsaid two speakers combine into a cylinder in shape approximately, each of said speakers is approximately tower-shaped, and the mating surface is formed by cutting in and out of a cylindrical surface of said cylinder obliquely.2. The speaker assembly as claimed in claim 1 , wherein one of said speakers mates to the other one in an upside-down way.3. (canceled)4. The speaker assembly as claimed in claim 2 , wherein the mating surface is S-shaped including a first mating surface curvedly extending backwardly claim 2 , an up-down oblique second mating surface connecting a bottom side of the first mating surface claim 2 , and a third mating surface curvedly extending forwardly connecting a bottom side of the second mating surface.5. The speaker assembly as claimed in claim 1 , wherein each speaker includes a main body having a front cover and assembled to the base downwardly claim 1 , and a plurality of magnets retained in corresponding recessions ...

CARD EDGE CONNECTOR WITH COVERING BLOCK OCCUPYING CONTACT PASSAGEWAYS

A card edge connector includes an insulative housing extending along a lengthwise direction, two rows of (contact) passageways formed in two opposite side walls with a central slot therebetween. Two rows of contacts are disposed within the corresponding passageways, respectively. The contacts include signal contacts and grounding contacts. Each side wall further forms an elongated channel by two sides of central wall under the central slot. A covering block is upwardly assembled into the corresponding channel after the corresponding contacts have been assembled into the corresponding passageways. Each block includes a deflectable latch engaged with the central wall. The covering block occupies at least one half of each passageway in the transverse direction perpendicular to the lengthwise direction. The covering block is optimally made of conductive plastic and forms a plurality of abutment ribs to respectively abut against the corresponding grounding contacts, respectively. 1. An electrical connector comprising:an insulative housing including opposite side walls with a central slot therebetween in a transverse direction, each side wall extending in a longitudinal direction perpendicular to the transverse direction;a bottom wall linked between the pair of side walls in the transverse direction and forming a central wall under the central slot in a vertical direction perpendicular to both the longitudinal direction and the transverse direction;two rows of passageways formed in the corresponding side walls, respectively;two rows of contacts disposed in the corresponding passageways, respectively, said contacts including signal contacts and grounding contacts;each side wall further forming an elongated channel in the bottom wall to extend through the corresponding passageways in the longitudinal direction; andtwo covering blocks received within the corresponding channels, respectively, each covering block including a plurality of fins upwardly extending into the ...

ELECTRICAL CONNECTOR HAVING EMBEDDED GROUNDING MECHANISM

An electrical connector includes an insulative housing forming a mating slot, and the contact module assembled thereto. The contact module includes the insulator and the contacts secured thereto. The insulator is secured to the housing. The contact includes a retaining section secured to the insulator, a contact section extending from one end of the retaining section into a mating slot, a soldering section extending from the other end of the retaining section out of the housing. The contacts include the signal contacts and the grounding contacts. Each contact module further includes at least one conductive plastic block mechanically and electrically connected to the corresponding grounding contacts. 1. An electrical connector comprising:an insulative housing extending along a longitudinal direction and defining a lower receiving cavity and an upper mating slot in a vertical direction perpendicular to said longitudinal direction;a contact module set received within the receiving cavity and including an insulator extending along the longitudinal direction and a plurality of contacts secured therein via insert-molding, the contacts including a plurality of signal contacts and a plurality of grounding contacts;a conductive plastic further attached upon the insulator via an over-molding process to intimately mechanically and electrically connect to each corresponding grounding contact with a length along a length direction of each corresponding grounding contact.2. The electrical connector as claimed in claim 1 , wherein the conductive plastic includes an inner part and an outer part commonly sandwiching each corresponding grounding contact therebetween in a transverse direction perpendicular to both said longitudinal direction and said vertical direction.3. The electrical connector as claimed in claim 2 , wherein each of said contacts including a retaining section secured to the insulator claim 2 , and the retaining section of each corresponding grounding contacts is ...

INTEGRATED GRAPH NEURAL NETWORK FOR SUPERVISED NON-OBVIOUS RELATIONSHIP DETECTION

A method, a computer program product, and a system for non-obvious relationship detection. The method includes receiving a knowledge and inputting a first node and a second node from the knowledge graph into a twin neural network. The method also includes embedding the first node and the second node, aggregating neighborhood information and position information into the node embeddings. The method further includes concatenating the neighborhood information and the position information of the first node and the second node to produce a first output vector and a second output vector. The method also includes generating a final score by comparing the first output vector with the second output vector. The final score indicates a probability of a non-obvious relationship between the first node and the second node. 1. A computer-implemented method for non-obvious relationship detection , the computer-implemented method comprising:inputting a first node and a second node from a knowledge graph into a twin neural network, the twin neural network including two identical neural networks with each having a node attribute embedding layer, at least one neighbor layer, and at least one position layer;embedding attributes of the first node and attributes of the second node separately to generate a first node embedding and a second node embedding using the node attribute embedding layer;aggregating neighborhood information onto the first node embedding and the second node embedding using the neighbor layer;aggregating position information onto the first node embedding and the second node embedding using the position layer;concatenating the neighborhood information and the position information of the first node and the second node, wherein a first output vector and a second output vector is formed; andgenerating a final score by comparing using a cosine distance of the first output vector to the second output vector, wherein the final score indicates a probability of a non-obvious ...

COMBUSTION PRE-CHAMBER ASSEMBLIES FOR AN INTERNAL COMBUSTION ENGINE

A combustion pre-chamber assembly includes pre-chamber device body defining an annular plenum that is in fluid communication with the at least one bore that extends through the spark plug shell. The annular plenum is also in communication with at least one purging passage that extends from the annular plenum to an end surface of the pre-chamber device body. Residual exhaust gases in the annular volume of the spark plug are purged by fresh charge flow from the main combustion chamber as the piston approaches top dead center. The fresh charge flow that is provided to the annular plenum through the at least one purging passage and into the annular volume of the spark plug through the at least one bore through the spark plug shell. 1. A combustion pre-chamber assembly , comprising:a spark plug for an internal combustion engine that includes an insulator nose and a shell around the insulator nose, the spark plug further including an annular volume between the shell and the insulator nose, and at least one bore that extends through the insulator shell from the annular volume; anda pre-chamber device connected to the spark plug, the pre-chamber device including a body defining a pre-chamber volume and at least one nozzle extending through a distal end of the body for communication with a combustion chamber of a cylinder of the internal combustion engine, the body of the pre-chamber device further defining an annular plenum in communication with at least one bore, the body of the pre-chamber device further including at least one passage extending between and opening at the annular plenum and the distal end of the body.2. The combustion pre-chamber assembly of claim 1 , wherein the at least one bore includes a plurality of bores.3. The combustion pre-chamber assembly of claim 2 , wherein the at least one passage includes a plurality of passages.4. The combustion pre-chamber assembly of claim 1 , wherein the annular volume of the spark plug receives charge flow from the ...

METHOD FOR EXPRESSION OF SMALL ANTIVIRAL RNA MOLECULES WITH REDUCED CYTOTOXICITY WITHIN A CELL

In one aspect, the invention provides methods and compositions for the expression of small RNA molecules within a cell using a retroviral vector (FIG. A). Small interfering RNA (siRNA) can be expressed using the methods of the invention within a cell. In a further aspect, the invention provides methods for producing siRNA encoding lentivirus where the siRNA activity may interfere with the lentiviral life cycle. In yet a further aspect, the invention provides methods for expression of a small RNA molecule within a cell, such as an siRNA capable of downregulating CCR5, wherein expression of the small RNA molecule is relatively non-cytotoxic to the cell. The invention also includes small RNA molecules, such as an siRNA capable of downregulating CCR5, that are relatively non-cytotoxic to cells. 1. (canceled)2. A retroviral construct for expressing an siRNA within a cell , comprising:a nucleic acid having the R and U5 sequences from a 5′ lentiviral long terminal repeat (LTR);a self-inactivating lentiviral 3′ LTR; anda first promoter configured to be operably linked to a first RNA coding region encoding a first siRNA,wherein the first promoter is located between the 5′ LTR and the 3′ LTR, and wherein the first siRNA coding region comprises a sequence that is at least about 90% identical to a target region of a pathogenic virus genome or genome transcript, or an endogenous target cell gene encoding a product that is involved in the lifecycle of an infecting pathogenic virus.3. The retroviral construct of claim 2 , wherein the first siRNA coding region comprises a sequence that is at least about 95% identical to a target region of a pathogenic virus genome or genome transcript claim 2 , or an endogenous target cell gene encoding a product that is involved in the lifecycle of an infecting pathogenic virus.4. The retroviral construct of claim 2 , wherein the first promoter is a RNA polymerase III promoter.5. The retroviral construct of claim 2 , wherein the target region of ...

Pressing member and electrical connector assembly

A pressing member is used for downwardly pressing on a chip module. The pressing member has a main body and a central opening going through the main body. The main body has an upper surface and a lower surface opposite to the upper surface. The central opening is provided for a part portion of the chip module going through. The pressing member has a pressing portion protrudes upwardly from the upper surface and provided for an external device pressing downwardly on to make the main body press downwardly on the chip module so as to prevent the chip module from warping.

METHOD FOR EXPRESSION OF SMALL RNA MOLECULES WITHIN A CELL

The invention provides methods and compositions for the expression of small RNA molecules within a cell using a lentiviral vector. The methods can be used to express doubles stranded RNA complexes. Small interfering RNA (siRNA) can be expressed using the methods of the invention within a cell, which is capable of down regulating the expression of a target gene through RNA interference. A variety of cells can be treated according to the methods of the invention including embryos, embryogenic stem cells, allowing for the generation of transgenic animals or animals constituted partly by the transduced cells that have a specific gene or a group of genes down regulated. 1. (canceled)2. A method of modulating gene expression in a cell , comprising: a nucleic acid having the R and U5 sequences from a 5′ lentiviral long terminal repeat (LTR);', 'a self-inactivating lentiviral 3′ LTR; and', 'a first promoter configured to be operably linked to a first RNA coding region encoding a first siRNA,', 'wherein expression of the first siRNA down regulates the expression of a target gene, and wherein the first promoter is located between the 5′ LTR and the 3′ LTR., 'infecting a target cell with a recombinant retrovirus, wherein the recombinant retrovirus comprises3. The method of claim 2 , wherein the infecting step is performed in vivo.4. The method of claim 2 , wherein the infection step is performed ex vivo.5. The method of claim 2 , wherein an activity of the target gene is associated with a pathogen or a disease state.6. The method of claim 5 , wherein the pathogen is HIV.7. The method of claim 5 , wherein the disease state is HIV.8. The method of claim 5 , wherein the down regulation of the target gene results in immunity or resistance to the pathogen.9. The method of claim 2 , wherein the target cell is an embryonic cell claim 2 , a hematopoietic stem cell claim 2 , a hematopoietic precursor cell claim 2 , a central nerve system cell claim 2 , a cell with regenerative capacity ...

Electrical connector having power terminals

An electrical connector includes a terminal module and a plurality of terminals retained in the terminal module. The plurality of terminals are divided into an upper row and a lower row. Each of the terminals has a contacting portion contacting with a complementary connector. Each row of the terminals has a power terminal and a differential pair. The contacting portion of the power terminal in the upper row and the corresponding contacting portion of the power terminal in the lower row mechanically contact with each other to form electrical parallel.

ELECTRICAL CONNECTOR WITH UPPER AND LOWER GROUNDING TERMINALS CONNECTED WITH EACH OTHER

An electrical connector for mounting to a printed circuit board for mating with a plug connector, includes an insulative housing and the upper and lower contacts on the housing, each contact including a contacting section, the contacts including grounding contacts each having a free end of the contacting section, and a mounting leg mounted to the corresponding grounding region of the printed circuit board wherein the free ends of the corresponding paired upper grounding contact and lower grounding contact either abut against each other or against a metallic shielding plate embedded within the mating tongue to form a parallel relation between the paired upper grounding contact and lower grounding contact. 1. A receptacle connector for engagement with a complementary plug connector and mounting to a printed circuit board , comprising:an insulative housing defining a main body and a mating tongue forwardly extending therefrom in a front-to-back direction, said mating tongue defining opposite upper surfaces and lower surfaces in a vertical direction perpendicular to said front-to-back direction;a plurality of contacts disposed in the housing, categorized with grounding contact, power contacts and differential pair contacts, and grouped with upper contacts and lower contacts, each of said contacts including a rear mounting section for mounting to the printed circuit board and a front contacting section exposed upon the mating tongue wherein the contacting section of the upper contact is exposed upon the upper surface and the contacting section of the lower contact is exposed upon the lower surface;a metallic shield enclosing the housing to define a mating cavity in which the mating tongue is disposed; anda metallic shielding plate embedded within the mating tongue and including at least a mounting leg for mounting to the printed circuit board; wherein the grounding contact of the upper contacts and the grounding contact of the lower contacts are symmetrically arranged ...

MULTI-DIMENSIONAL DATA RECOVERY

Provided are a computer-implemented method, system, and computer program product for multidimensional data recover. A snapshot restore request is received with at least one parameter defining at least one dimension for data recovery. At least one snapshot is reconstructed from a single continuous snapshot stream taken for a certain period of time based on the at least one parameter. A selected snapshot is received for data recovery selected from the at least one reconstructed snapshot. The selected snapshot is restored. 1. A computer-implemented method performed by one or more processing units , comprising:receiving a snapshot restore request with at least one parameter defining at least one dimension for data recovery;reconstructing at least one snapshot from a single continuous snapshot stream taken for a certain period of time based on the at least one parameter;receiving a selection of a snapshot for data recovery selected from the at least one reconstructed snapshot; andinstructing a restoration of the selected snapshot.2. The computer-implemented method of claim 1 , wherein the reconstructing the at least one snapshot further comprises:retrieving the at least one parameter from the received snapshot restore request;determining the at least one dimension based on the at least one retrieved parameter; andreconstructing the at least one snapshot for the at least one determined dimension.3. The computer-implemented method of claim 2 , further comprising:verifying the at least one reconstructed snapshot for the at least one determined dimension.4. The computer-implemented method of claim 3 , further comprising:reconstructing at least one further snapshot for the at least one determined dimension responsive to the verification of the at least one reconstructed snapshot for the at least one determined dimension being insufficient.5. The computer-implemented method of claim 1 , further comprising:previewing on a user interface the at least one reconstructed snapshot; ...

ELECTRICAL CONNECTOR FOR HIGH FREQUENCY USE WITH DUAL ORIENTATION

An electrical connector includes an insulative housing with a rear base and a mating tongue extending forwardly from the base. Two rows of contacts are retained in the housing. A metallic shielding plate is embedded within the housing and between the two rows of contacts. Each row of contacts defines positions from one to twelve in the transverse direction wherein positions 2&3 and 10&11 are designated for high frequency signal transmission. In the shielding plate the space between corresponding positions 4 and 6, and that between corresponding positions 7 and 9, are of a complete or enlarged hole being essentially fully empty along the front-to-back direction for achieving the high frequency transmission without undesired crosstalk among the corresponding contacts. 1. An electrical connector comprising:a metallic shield;a contact module received within the metallic shield to commonly form a mating cavity for receiving a complementary plug connector,the contact module including an insulative housing with a base and mating tongue extending forwardly from the base in a front-to-back direction with a stepped portion at a root thereof to the base;a plurality of contacts including a row of lower contacts and a row of upper contacts with a metallic shielding plate therebetween integrally formed within the insulative housing in a vertical direction perpendicular to the front-to-back direction; andthe upper contacts as well as the lower contacts defining twelve positions in sequence along a transverse direction perpendicular to both the front-to-back direction and the vertical direction; whereinthe contacts at positions 2/3, 6/7 and 10/11 are high speed differential pairs, and the shielding plate forms a pair of independent elongated holes generally respectively aligned with and corresponding to positions 5 and 8 and extending along the front-to-back direction.2. The electrical connector as claimed in claim 1 , wherein the elongated hole corresponding to the position 5 is ...

AAV VARIANTS WITH ENHANCED TROPISM

The disclosure relates to compositions, methods, and processes for the preparation, use, and/or formulation of adeno-associated virus capsid proteins, wherein the capsid proteins comprise targeting peptide inserts for enhanced tropism to a target tissue. 1. An AAV capsid protein comprising(i) a parent VP1 amino acid sequence selected from the group consisting of SEQ ID NO: 2 or SEQ ID NO: 3, and (ii) at least one targeting peptide inserted into the parent VP1 amino acid sequence of (i),wherein the targeting peptide comprises at least 4 contiguous amino acids of any member of a group consisting of SEQ ID NO: 43073-43341.2. The AAV capsid protein of claim 1 , wherein the parent VP1 amino acid sequence comprises at least one of a VP2 region and a VP3 region.3. The AAV capsid protein of claim 2 , wherein the targeting peptide is inserted within the VP2 region of the parent VP1 amino acid sequence.4. The AAV capsid protein of claim 2 , wherein the targeting peptide is inserted within the VP3 region of the parent VP1 amino acid sequence.5. The AAV capsid protein of claim 1 , wherein the targeting peptide is inserted at any amino acid position between amino acids 586-592 claim 1 , inclusive claim 1 , of the parent VP1 amino acid sequence.6. The AAV capsid protein of claim 5 , wherein the targeting peptide is inserted between amino acids 588-589 of the parent VP1 amino acid sequence.7. The AAV capsid protein of claim 1 , wherein the targeting peptide comprises at least 7 contiguous amino acids of any member of the group consisting of SEQ ID NO: 43073-43341.8. The AAV capsid protein of claim 7 , wherein the at least 7 contiguous amino acids comprise amino acids at positions 3 through 9 claim 7 , inclusive claim 7 , of any member of the group consisting of SEQ ID NO: 43073-43341.9. A peptide comprising an amino acid sequence selected from the group consisting of SEQ ID NO: 43073-43341.10. A peptide comprising an amino acid sequence claim 7 , said amino sequence comprising at ...

METHOD FOR EXPRESSION OF SMALL RNA MOLECULES WITHIN A CELL

The invention provides methods and compositions for the expression of small RNA molecules within a cell using a lentiviral vector. The methods can be used to express doubles stranded RNA complexes. Small interfering RNA (siRNA) can be expressed using the methods of the invention within a cell, which are capable of down regulating the expression of a target gene through RNA interference. A variety of cells can be treated according to the methods of the invention including embryos, embryogenic stem cells, allowing for the generation of transgenic animals or animals constituted partly by the transduced cells that have a specific gene or a group of genes down regulated. 120.-. (canceled)21. A retroviral construct for the expression of an siRNA within a cell , comprising:a nucleic acid having the R and U5 sequences from a 5′ lentiviral long terminal repeat (LTR);a self-inactivating lentiviral 3′ LTR; anda first promoter configured to be operably linked to a first RNA coding region encoding a first siRNA, wherein expression of the first siRNA results in the down regulation of a target gene whose activity is associated with a disease or disorder;wherein the first promoter is located between the 5′ LTR and the 3′ LTR.22. The retroviral construct of claim 21 , comprising the first RNA coding region linked to the first promoter claim 21 , wherein the first RNA coding region is followed by at least one termination sequence.23. The retroviral construct of claim 21 , wherein the first promoter is a RNA Polymerase III promoter.24. The retroviral construct of claim 21 , wherein the first RNA coding region encodes a self-complementary RNA molecule having a sense region claim 21 , an antisense region and a loop region.25. The retroviral construct of claim 24 , wherein the loop region is about 2 to about 10 nucleotides in length.26. The retroviral construct of claim 24 , wherein the sense region and the antisense region are between about 15 and about 30 nucleotides in length.27. The ...

METHOD FOR EXPRESSION OF SMALL ANTIVIRAL RNA MOLECULES WITH REDUCED CYTOTOXICITY WITHIN A CELL

In one aspect, the invention provides methods and compositions for the expression of small RNA molecules within a cell using a retroviral vector (FIG. A). Small interfering RNA (siRNA) can be expressed using the methods of the invention within a cell. In a further aspect, the invention provides methods for producing siRNA encoding lentivirus where the siRNA activity may interfere with the lentiviral life cycle. In yet a further aspect, the invention provides methods for expression of a small RNA molecule within a cell, such as an siRNA capable of downregulating CCR5, wherein expression of the small RNA molecule is relatively non-cytotoxic to the cell. The invention also includes small RNA molecules, such as an siRNA capable of downregulating CCR5, that are relatively non-cytotoxic to cells. 1a nucleic acid having the R and U5 sequences from a 5′ lentiviral long terminal repeat (LTR);a self-inactivating lentiviral 3′ LTR;an RNA Polymerase III promoter; andat least one RNA coding region operably linked to the RNA Polymerase III promoter;wherein the RNA coding region encodes SEQ ID NO: 16, andwherein the RNA coding region is substantially complementary to a target region that is from about 10 to about 50 nucleotides in length.. A retroviral construct for the expression of an siRNA within a cell, the retroviral construct comprising: The present application is a continuation of U.S. patent application Ser. No. 13/749,319, filed Jan. 24, 2013, which is a continuation of U.S. patent application Ser. No. 12/769,157, now U.S. Pat. No. 8,361,982, filed Apr. 28, 2010, which is in turn a continuation of U.S. patent application Ser. No. 11/683,962, now U.S. Pat. No. 7,737,124, filed Mar. 8, 2007, which is in turn a continuation-in-part of U.S. application Ser. No. 10/319,341, now U.S. Pat. No. 7,195,916, filed Dec. 12, 2002 which is in turn a continuation-in-part of U.S. application Ser. No. 10/243,553, now U.S. Pat. No. 7,919,309, filed Sep. 13, 2002, which in turn claims ...

ELECTRICAL CONNECTOR WITH SHIELDING PLATE SECURED THEREIN

An electrical connector includes a first terminal module, a second terminal module, a shielding shell and a metallic shielding plate. The first terminal module includes a first mating tongue and first terminals insert molded thereamong. The first mating tongue has a first mating face on which the first terminals are exposed. The first terminals have first connecting sections extending in a vertical direction. The second terminal module includes a second mating tongue and second terminals insert molded thereamong. The second mating tongue has a second mating face directly facing to the first mating face and a third mating face. The second terminals are disposed in the second and third mating faces and have second connecting sections extending in the vertical direction. The metallic shielding plate is disposed between the first and second connecting sections and has a plurality of hooked shrapnels elastically contacting with the shielding shell. 1. A receptacle connector comprising:an insulating housing having a mating cavity, the mating cavity having a first mating cavity and a second mating cavity communicating with each other, the insulating housing having a first mating tongue extending into the first mating cavity and a second mating tongue extending into the second mating cavity, the first and second mating tongues being parallel with each other, the insulating housing having a base portion located behind the mating tongue, the base portion having a lower wall, two side walls disposed at two sides of the mating cavity, a rear wall located in a rear side and connecting the two side walls and an accommodating room recessed forwardly from the rear wall, the base portion having a supporting wall located in a front of the accommodating room and being parallel to the rear wall and a plurality of terminal limiting slots recessed forwardly from the supporting wall;a plurality of conductive terminals, the conductive terminals having a plurality of first terminals secured ...

METHOD FOR EXPRESSION OF SMALL RNA MOLECULES WITHIN A CELL

The invention provides methods and compositions for the expression of small RNA molecules within a cell using a lentiviral vector. The methods can be used to express doubles stranded RNA complexes. Small interfering RNA (siRNA) can be expressed using the methods of the invention within a cell, which is capable of down regulating the expression of a target gene through RNA interference. A variety of cells can be treated according to the methods of the invention including embryos, embryogenic stem cells, allowing for the generation of transgenic animals or animals constituted partly by the transduced cells that have a specific gene or a group of genes down regulated. 176.-. (canceled)77. A retroviral construct for the expression of an RNA in a cell , the retroviral construct comprising:a nucleic acid having the R and U5 sequences from a 5′ lentiviral long terminal repeat (LTR);a self-inactivating lentiviral 3′ LTR; anda first RNA Polymerase III promoter configured to operably linked to a first RNA coding region encoding a first desired RNA, wherein the first RNA Polymerase III promoter is located between the 5′ LTR and the 3′ LTR.78. The retroviral construct of claim 77 , wherein the first desired RNA is a small RNA molecule with regulatory function.79. The retroviral construct of claim 77 , wherein the first desired RNA is a RNA marker claim 77 , an antisense RNA claim 77 , a ribozymes claim 77 , or a small interfering RNA (siRNA).80. The retroviral construct of claim 77 , wherein the RNA Polymerase III promoter is inducible.81. The retroviral construct of claim 80 , further comprising a second RNA Polymerase III promoter operably linked to a second RNA coding region encoding a second desired RNA.82. The retroviral construct of claim 81 , wherein the second desired RNA is substantially complementary to the first desired RNA.83. The retroviral construct of claim 77 , wherein the first RNA coding region is followed by at least one termination sequence.84. The ...

Facial interfaces for head-mounted displays and related systems and methods

A head-mounted display may include a frame for supporting an electronic display for viewing by an intended user donning the head-mounted display. The frame may include a flange disposed on a perimeter area of the frame and a facial interface configured to abut against an intended user's face wherein the facial interface comprises a foam body and an undercut region in the foam body that is sized and shaped for detachably engaging with the flange of the frame. Various other apparatuses, systems, and methods are also disclosed.

AAV VARIANTS WITH ENHANCED TROPISM

The disclosure relates to compositions, methods, and processes for the preparation, use, and/or formulation of adeno-associated virus capsid proteins, wherein the capsid proteins comprise targeting peptide inserts for enhanced tropism to a target tissue. 1. An AAV capsid protein comprising (i) a parent VP1 amino acid sequence selected from the group consisting of SEQ ID NO: 2 or SEQ ID NO: 3 , and (ii) at least one targeting peptide inserted into the parent VP1 amino acid sequence of (i) , wherein the targeting peptide is selected from any member of the group consisting of SEQ ID NO: 4-14326 and any member of the group consisting of SEQ ID NO: 42973-42999.2. The AAV capsid protein of claim 1 , wherein the parent VP1 amino acid sequence comprises a VP2 region and/or a VP3 region.3. The AAV capsid protein of claim 2 , wherein the targeting peptide is inserted within the VP2 region of the parent VP1 amino acid sequence.4. The AAV capsid protein of claim 2 , wherein the targeting peptide is inserted within the VP3 region of the parent VP1 amino acid sequence.5. The AAV capsid protein of claim 1 , wherein the targeting peptide is inserted at any amino acid position between amino acids 586-592 claim 1 , inclusive claim 1 , of the parent VP1 amino acid sequence.6. The AAV capsid protein of claim 1 , wherein the targeting peptide is inserted between amino acids 588-589 of the parent VP1 amino acid sequence.7. A peptide comprising an amino acid sequence selected from the group consisting of SEQ ID NO: 4-14326 and SEQ ID NO: 42973-42999.8. A nucleic acid sequence encoding the peptide of claim 7 , selected from the group consisting of SEQ ID NO: 14327-42972 and SEQ ID NO: 4300-43053.9. An AAV particle comprising an AAV capsid protein of any of - and a viral genome.10. The AAV particle of claim 9 , wherein the viral genome comprises a nucleic acid sequence encoding a payload.11. The AAV particle of claim 10 , wherein the payload is an RNAi agent.12. The AAV particle of claim 11 ...

HEMOSTATIC MATERIAL

Disclosed is a hemostatic material, wherein a thrombin receptor activating agent is covalently coupled to a biocompatible matrix. 1. A hemostatic material , wherein a thrombin receptor activating agent is covalently coupled to a biocompatible matrix.2. The hemostatic material according to claim 1 , wherein the biocompatible matrix is a hemostatic matrix and is selected from the group consisting of a biomaterial claim 1 , preferably a protein claim 1 , a biopolymer or a polysaccharide matrix claim 1 , especially a collagen claim 1 , gelatin claim 1 , fibrin claim 1 , starch or chitosan matrix; and a synthetic polymer claim 1 , preferably a polyvinyl alcohol claim 1 , polyethylene glycol claim 1 , or poly(N-isopropylacrylamide).3. The hemostatic material according to claim 1 , wherein the thrombin receptor activating agent is a thrombin receptor activating peptide (TRAP) claim 1 , preferably TRAP8 claim 1 , TRAP7 claim 1 , TRAP6 claim 1 , TRAP1-41 claim 1 , SLIGKV (for PAR-2 (human)) claim 1 , TFRGAP (for PAR-3 (human)) claim 1 , GYPGQV (for PAR-4 (human)) claim 1 , or amidated forms thereof claim 1 , as well as mixtures thereof.4. The hemostatic material according to claim 1 , wherein the biocompatible matrix is a sponge claim 1 , a woven or non-woven fabric claim 1 , a preformed shape claim 1 , preferably as a cylinder or cone for tooth extraction claim 1 , a particulate or granulate material or a sheet.5. The hemostatic material according to claim 1 , wherein the biocompatible matrix comprises polyvinyl alcohol.6. A method for producing the hemostatic material according to claim 1 , wherein a thrombin receptor activating agent in covalently coupled to a biocompatible matrix.7. The method according to claim 6 , wherein the thrombin receptor activating agent is a thrombin receptor activating peptide (TRAP) claim 6 , preferably TRAP8 claim 6 , TRAP7 claim 6 , TRAP6 claim 6 , TRAP1-41 claim 6 , SLIGKV (for PAR-2 (human)) claim 6 , TFRGAP (for PAR-3 (human)) claim 6 , ...

Information Display Method, Terminal, and Server

Embodiments of the present invention provide an information display method, terminal, and server. In one embodiment, the information display method includes obtaining, by a terminal, content information of at least one content source. The at least one content source corresponds to at least two pieces of account information stored in the terminal. The method further includes integrating, by the terminal, the content information into content display information; and displaying, by the terminal, the content display information.

Electrical connector having better electrical performance

An electrical connector includes a base seat, a plurality of contacts fixed in the base seat, and a shielding shell surrounding the base seat. The shielding shell defines a body portion retained in the base seat, a rear wall attached a rear face of the base seat and a plurality of soldering portions extending outside of the body portion. The electrical connector defines a mounting surface, a lower edge of the rear wall is higher than the mounting surface and defines at least one board-lock portion to improve the resonant frequency.

MODULATORY POLYNUCLEOTIDES

The present invention relates to adeno-associated viral (AAV) particles modulatory polynucleotides encoding at least one siRNA molecules and methods of use thereof. 1112-. (canceled)113. An adeno-associated virus (AAV) vector genome comprising a nucleic acid sequence positioned between two inverted terminal repeats (ITRs) , wherein the nucleic acid sequence comprises a first polynucleotide and a second polynucleotide; wherein the first polynucleotide comprises a first region encoding a first sense strand sequence which comprises at least 15 nucleotides , and a second region encoding a first antisense strand sequence which comprises at least 15 nucleotides , and wherein the first sense strand sequence and the first antisense strand sequence share a region of complementarity of at least seven nucleotides in length; and wherein the second polynucleotide comprises a third region encoding a second sense strand sequence which comprises at least 15 nucleotides , and a fourth region encoding a second antisense strand sequence which comprises at least 15 nucleotides , and wherein the second sense strand sequence and the second antisense strand sequence share a region of complementarity of at least seven nucleotides in length.114. The AAV vector genome of claim 113 , wherein the nucleic acid sequence of the AAV vector genome comprises a third polynucleotide; wherein the third polynucleotide comprises a fifth region encoding a third sense strand sequence which comprises at least 15 nucleotides claim 113 , and a sixth region encoding a third antisense strand sequence which comprises at least 15 nucleotides claim 113 , and wherein the third sense strand sequence and the third antisense strand sequence share a region of complementarity of at least seven nucleotides in length.115. The AAV vector genome of claim 114 , wherein the nucleic acid sequence of the AAV vector genome comprises a fourth polynucleotide; wherein the fourth polynucleotide comprises a seventh region encoding a ...

SPARK PLUG FOR AN INTERNAL COMBUSTION ENGINE HAVING A COMBUSTION PRE-CHAMBER

A spark plug is disclosed that includes at least one bore extending through a shell of the spark plug in order to form a passageway between an annular volume around the spark plug insulator nose and a pre-chamber volume of a pre-chamber device, thus directing a purge of exhaust gases trapped in the annular volume to a space formed by the exterior of the spark plug body and the interior of the pre-chamber device. 1. A spark plug for an internal combustion engine , comprising:a distal end portion comprising a center cathode electrode and at least one ground electrode;an insulator nose extending around the center cathode electrode, the insulator nose having a distal end that is spaced proximally from a distal end of the center cathode electrode;a shell extending around a body of the spark plug, the shell defining an annular volume around the insulator nose; andat least one bore extending through the shell, wherein the at least one bore extends between an inner end that opens into the annular volume and an outer end that opens on an outer side of the shell.2. The spark plug of claim 1 , wherein the inner end of the bore is located such that a distance between the inner end of the bore and the distal end of the center cathode electrode is greater than a distance between the distal end of the insulator nose and the distal end of the center cathode electrode.3. The spark plug of claim 1 , wherein the at least one ground electrode includes at least four ground electrodes that surround the center cathode electrode.4. The spark plug of claim 1 , wherein the body of the spark plug extends along a central longitudinal axis and the at least one bore extends along a bore axis that is angled relative to the central longitudinal axis so the at least one bore diverges from the central longitudinal axis in a distal direction.5. The spark plug of claim 4 , wherein the bore axis of the at least one bore intersects the central longitudinal axis.6. The spark plug of claim 4 , wherein the ...

COMPUTING DEVICE, NON- TRANSITORY STORAGE MEDIUM, AND METHOD FOR CALCULATING VEHICLE INSURANCE FEE

In a method for calculating vehicle insurance fee, core data transmitted from an electronic device in a vehicle is received. The core date includes information as to how the vehicle is driven, by recording the driving style of the driver e, purchase price of the vehicle, and other basic information. A driving risk level of the vehicle is determined according to the received core data. A comprehensive risk coefficient associated with the driving risk level is obtained. An insurance fee of the vehicle is calculated based on the comprehensive risk coefficient and a preset sheet of parameters. 1. A method for calculating vehicle insurance fee executable by at least one processor of a computing device , the method comprising:receiving core data transmitted from an electronic device, wherein the electronic device is associated with a vehicle, the core date comprises driving data of the vehicle, driving style of a driver of the vehicle, and purchase price of the vehicle, the core data is obtained by the electronic device;determining a driving risk level of the vehicle according to the received core data;obtaining a comprehensive risk coefficient associated with the driving risk level; andcalculating an insurance fee of the vehicle based on the comprehensive risk coefficient and information stored in a look up table, wherein the information in the look up table comprises relationships between preset risk coefficients, purchase prices of vehicles, and insurance fees associated with the preset risk coefficients and the purchase prices of vehicles.2. The method according to claim 1 , wherein the driving data of the vehicle comprises locations where the vehicle is driven and accelerations which are greater than a preset acceleration claim 1 , the driving style of the driver are deemed to be dangerous.3. The method according to claim 2 , wherein the driving data of the vehicle comprises images of a driver captured by the electronic device in the process of driving the vehicle.4. ...

COMBUSTION PRE-CHAMBER DEVICE FOR AN INTERNAL COMBUSTION ENGINE

A combustion pre-chamber device for a spark ignition internal combustion engine is configured to engage a spark plug and be mounted to a cylinder head in communication with a combustion chamber of a cylinder of the engine. The combustion pre-chamber device includes any one or combination of a number of features to improve operating effectiveness, including extending the combustion operating range by improving cooling and optimizing the flow field inside the combustion pre-chamber device. 1. An apparatus , comprising:a combustion pre-chamber device for engaging a cylinder head of an internal combustion engine, the combustion pre-chamber device including a body with an outer surface extending between a first proximal end and an opposite second distal end of the body, the first end of the body including an opening to an inner passage defined by the body for receiving a spark plug, the body defining a combustion pre-chamber distally of the spark plug and at least one nozzle in communication with the combustion pre-chamber that opens through a dome-shaped distal end wall at the second end of the body, the dome-shaped distal end wall extending across a substantial portion of an opening in the cylinder head to which the combustion pre-chamber device is engaged.2. The apparatus of claim 1 , wherein the dome-shaped distal end wall extends at least partially into a combustion chamber of a cylinder of the internal combustion engine with the body engaged to the cylinder head claim 1 , wherein the at least one nozzle includes at least one axial nozzle that extends along a longitudinal axis of the body and at least one swirl nozzle that is obliquely oriented to the longitudinal axis.3. The apparatus of claim 2 , wherein a ratio of a swirl flow component to an axial flow component of the swirl and axial nozzles ranges from 1.55 to 1.85.4. The apparatus of claim 2 , wherein a ratio of a volume of the combustion pre-chamber to a cross-sectional area of the least one axial nozzle and ...

DATA-DRIVEN HVAC OPTIMIZATION

A system and method for data-driven HVAC optimization for outputting HVAC setpoints to a thermostat and determining a predicted HVAC usage of an HVAC unit based on the HVAC setpoints and an outdoor temperature. The system may further determine and output a predicted cost of the HVAC unit heating or cooling a structure based on the HVAC setpoints. The system may further select optimized HVAC setpoints such that the predicted cost is less than or equal to a user defined cost constraint and minimize deviation from user-preferred HVAC setpoints. 1. A heating ventilation and air conditioning (HVAC) management system , comprising:a monitor configured to receive a user defined cost constraint and one or more user-preferred HVAC setpoints and to output one or more optimized HVAC setpoints for a thermostat to control an HVAC unit in a structure;an HVAC prediction engine configured to determine a predicted HVAC usage of the HVAC unit based on an outdoor temperature for a geographic area that includes the structure and one or more HVAC setpoints,a cost modeling unit configured to determine, based on the predicted HVAC usage and energy costs, a predicted cost to control the HVAC unit based on the one or more HVAC setpoints; andan HVAC optimization engine configured to select one or more optimized HVAC setpoints such that the predicted cost to control the HVAC unit based on the one or more optimized HVAC setpoints is less than or equal to the user define cost constraint and temperature distance between the one or more user-preferred HVAC setpoints and the one or more optimized HVAC setpoints is minimized.2. (canceled)3. (canceled)4. The system of claim 1 , wherein the temperature distance is an absolute value of a difference between each of the one or more optimized HVAC setpoints and one or more user-preferred HVAC setpoints.5. The system of claim 1 , wherein the optimization engine is further configured to select the one or more optimized HVAC setpoints such that a number of ...

ELECTRICAL CONNECTOR AND METHOD MAKING THE SAME

An electrical connector includes an insulative housing having a tongue portion with opposite upper and lower surfaces, a plurality of upper terminals and a plurality of lower terminals with contacting sections exposed upon the corresponding upper surface and lower surface, respectively. A metallic shielding plate located between upper terminals and the lower terminals. The tongue portion forms a first type hole in which the upper power terminal mechanically and electrically connects to the lower power terminal, and a second type hole in which either the upper grounding terminal mechanically and electrically connects to an upper face of the shielding plate or the lower grounding terminal mechanically and electrically connects to the lower face of the shielding plate. 1. An electrical connector comprising:a metallic shielding shell;a contact module disposed in the metallic shielding shell and including:an insulative housing including a base and a tongue portion extending forwardly form the base in a front-to-back direction, said tongue portion forming opposite upper surface and lower surface in a vertical direction perpendicular to the front-to-back direction;a metallic shielding plate disposed in the tongue portion between the upper surface an the lower surface;a plurality upper terminals disposed in the housing with corresponding contacting sections exposed upon the upper surface, said upper terminals including upper grounding terminals and upper power terminals, each of said upper grounding terminals including a front abutting section and each of said upper power terminals including a front abutment section;a plurality of lower terminals dispose din the housing with corresponding contacting sections exposed upon the lower surface, said lower terminals including lower grounding terminals and lower power terminals, each of said lower grounding terminals including a front abutting section and each of said lower power terminals including a front abutment section; ...

Method for expression of small rna molecules within a cell

The invention provides methods and compositions for the expression of small RNA molecules within a cell using a lentiviral vector. The methods can be used to express doubles stranded RNA complexes. Small interfering RNA (siRNA) can be expressed using the methods of the invention within a cell, which are capable of down regulating the expression of a target gene through RNA interference. A variety of cells can be treated according to the methods of the invention including embryos, embryogenic stem cells, allowing for the generation of transgenic animals or animals constituted partly by the transduced cells that have a specific gene or a group of genes down regulated.

Light - emitting diode drive system and control module

Methods and compositions for therapies using genes encoding secreted proteins such as interferon-beta

Methods and pharmaceutical compositions for modifying cells of a mammalian recipient with DNA encoding a secreted protein such as human interferon in situ are provided. The methods include forming a secreted protein expression system in vivo or ex vivo and administering the expression system to the mammalian recipient. The expression system and methods are useful for the localized and systemic delivery of interferons in situ.

Macroscopic ordered assembly of carbon nanotubes

The present invention is directed to the creation of macroscopic materials and objects comprising aligned nanotube segments. The invention entails aligning single-wall carbon nanotube (SWNT) segments that are suspended in a fluid medium and then removing the aligned segments from suspension in a way that macroscopic, ordered assemblies of SWNT are formed. The invention is further directed to controlling the natural proclivity or nanotube segments to self assemble into or ordered structures by modifying the environment of the nanotubes and the history of that environment prior to and during the process. The materials and objects are "macroscopic" in that they are large enough to be seen without the aid of a microscope or of the dimensions of such objects. These macroscopic ordered SWNT materials and objects have the remarkable physical, electrical, and chemical properties that SWNT exhibit on the microscopic scale because they are comprised of nanotubes, each of which is aligned in the same direction and in contact with its nearest neighbors. An ordered assembly of closest SWNT also serves as a template for growth of more and larger ordered assemblies. An ordered assembly further serves as a foundation for post processing treatments that modify the assembly internally to specifically enhance selected material properties such as shear strength, tensile strength, compressive strength, toughness, electrical conductivity, and thermal conductivity.

Using a metered size press to produce lightweight coated rotogravure paper

A method for producing paper suitable for rotogravure printing by using a metered size press process to apply a coating formulation to a paper and then calendering the coated paper. In one aspect, the coating formulation comprises a pigment mixture containing engineered delaminated kaolin clay, and a latex binder. In another aspect, the pigment mixture comprises delaminated kaolin clay, engineered delaminated kaolin clay and calcined clay. Alternatively, talc is used in place of the calcined clay. In a further aspect, the pigment mixture comprises delaminated kaolin clay, platey kaolin clay, coarse kaolin clay and calcined clay.

Process for producing super high bulk, light weight coated papers

The present invention relates to a process of manufacturing a high bulk, low weight paper product produced by using a high level of groundwood containing sheet, blade coating with specifically formulated coatings then passing the paper web between two extended-nip calenders, one calender for each side of paper. As a result, densification of the resulting coated paper product is reduced, while maintaining stiffness and opacity comparable to heavier weight sheets.

Method for expression of small antiviral rna molecules with reduced cytotoxicity within a cell

In one aspect, the invention provides methods and compositions for the ex pression of small RNA molecules within a cell using a retroviral vector (Fig . IA). Small interfering RNA (siRNA) can be expressed using the methods of t he invention within a cell. In a further aspect, the invention provides meth ods for producing siRNA encoding lentivirus where the siRNA activity may int erfere with the lentiviral life cycle. In yet a further aspect, the inventio n provides methods for expression of a small RNA molecule within a cell, suc h as an siRNA capable of downregulating CCR5, wherein expression of the smal l RNA molecule is relatively non-cytotoxic to the cell. The invention also i ncludes small RNA molecules, such as an siRNA capable of downregulating CCR5 , that are relatively non-cytotoxic to cells.

Method for expression of small antiviral rna molecules within a cell

In one aspect, the invention provides methods and compositions for the expression of small RNA molecules within a cell using a retroviral vector. T he methods can be used to express double stranded RNA complexes. Small interfering RNA (siRNA) can be expressed using the methods of the invention within a cell, that interfere with a viral life cycle by down regulating either the viral genome, a viral genome transcript, or a host cell that . In another aspect the invention provides methods for treating patients having suffering from infection, particularly infection with HIV.

Electrical connector and circuit board used in the connector

An electrical connector includes a terminal module having a circuit board having first through eighth conductive traces sequentially arranged in a transverse direction and corresponding first through eighth terminals, the third terminal and the sixth terminal being configured for transmitting a pair of differential signals, the fourth terminal and the fifth terminal being configured for transmitting another pair of differential signals, the first through eighth conductive traces being respectively electrically connected to corresponding first through eighth terminals, each of the third conductive trace and the fifth conductive trace including a coupling portion, a size of the coupling portion in the transverse direction is larger than a size of the other part of the corresponding conductive trace in the transverse direction, wherein the coupling portion of the third conductive trace and the coupling portion of the fifth conductive trace overlap in an up and down direction to increase mutual coupling.

Method for expression of small antiviral rna molecules with reduced cytotoxicity within a cell

In one aspect, the invention provides methods and compositions for the expression of small RNA molecules within a cell using a retroviral vector (FIG. 1 A). Small interfering RNA (siRNA) can be expressed using the methods of the invention within a cell. In a further aspect, the invention provides methods for producing siRNA encoding lentivirus where the siRNA activity may interfere with the lentiviral life cycle. In yet a further aspect, the invention provides methods for expression of a small RNA molecule within a cell, such as an siRNA capable of downregulating CCR5, wherein expression of the small RNA molecule is relatively non-cytotoxic to the cell. The invention also includes small RNA molecules, such as an siRNA capable of downregulating CCR5, that are relatively non-cytotoxic to cells.

High-frequency guided wave detection capability verification reference block

本实用新型公开了一种高频导波检测能力验证对比试块，包括截面呈圆环形的试块，所述试块的内壁设有第一刻槽区和第二刻槽区，所述第一刻槽区内包括若干沿所述试块内壁倾斜布置的第一矩形刻槽，所述第二刻槽区内包括若干沿所述试块内壁倾斜且相互重叠布置的第二刻槽，所述第一矩形刻槽与所述第二刻槽的倾斜方向相反，本装置结构简单，能够全面模拟管道内壁缺陷。

Methods and compositions for cancer therapies using genes encoding interferon-beta

Methods and pharmaceutical compositions for modifying cells of a mammalian recipient with DNA encoding a secreted protein such as human interferon in situ are provided. The methods include forming a secreted protein expression system in vivo or ex vivo and administering the expression system to the mammalian recipient. The expression system and methods are useful for the localized and systemic delivery of interferons in situ.

Method for expression of small antiviral rna molecules within a cell

In ones aspect, the invention provides methods and compositions for the expression of small RNA molecules within a cell using a retroviral vector. The methods can be used to express double stranded RNA complexes. Small interfering RNA (siRNA) can be expressed using the methods of the invention within a cell, that interfere with a viral life cycle by down regulating either the viral genome, a viral genome transcript, or viral replication in a host cell. In another aspect, the invention provides methods for treating patients suffering from infection, particularly infection with HIV.

Information display method, terminal, and server

Embodiments of the present invention provide an information display method, terminal, and server, where the method includes: obtaining, by a terminal, content information of at least one content source, where the at least one content source corresponds to at least two pieces of account information; integrating, by the terminal, the content information into content display information; and displaying, by the terrninal, the content display information. According to the embodiments of the present invention, content information of a content source is obtained, integrated, and then displayed to a user by classification, so that it is concise and intuitive for the user to query information without cumbersomeness.

Combustion pre-chamber assemblies for an internal combustion engine

A combustion pre-chamber assembly includes pre-chamber device body defining an annular plenum that is in fluid communication with the at least one bore that extends through the spark plug shell. The annular plenum is also in communication with at least one purging passage that extends from the annular plenum to an end surface of the pre-chamber device body. Residual exhaust gases in the annular volume of the spark plug are purged by fresh charge flow from the main combustion chamber as the piston approaches top dead center. The fresh charge flow that is provided to the annular plenum through the at least one purging passage and into the annular volume of the spark plug through the at least one bore through the spark plug shell.

Method for expression of small rna molecules within a cell

The invention provides methods and compositions for the expression of small RNA molecules within a cell using a lentiviral vector. The methods can be used to express doubles stranded RNA complexes. Small interfering RNA (siRNA) can be expressed using the methods of the invention within a cell, which are capable of down regulating the expression of a target gene through RNA interference. A variety of cells can be treated according to the methods of the invention including embryos, embryogenic stem cells, allowing for the generation of transgenic animals or animals constituted partly by the transduced cells that have a specific gene or a group of genes down regulated.

Interactive pet caring system

一種互動式寵物照護系統，由一遠端設備搭配一主機設備，使用在一網際網路的環境中。遠端設備包括一螢幕、一輸入單元及一寵物照護單元，寵物照護單元被輸入單元啟動，通過網際網路傳輸一電子資訊。主機設備包括一處理單元、一收發單元、一影像擷取單元及一互動單元，以收發單元接收所述的電子資訊，經過處理單元的邏輯演算，命令影像擷取單元收集一寵物的影音檔，回傳遠端設備且顯示於螢幕，判斷寵物的心情，以互動單元陪寵物玩耍，取得互動式照護效果。

Method for expression of small rna molecules within a cell

The invention provides methods and compositions for the expression of small RNA molecules within a cell using a lentiviral vector. The methods can be used to express doubles stranded RNA complexes. Small interfering RNA (siRNA) can be expressed using the methods of the invention within a cell, which are capable of down regulating the expression of a target gene through RNA interference. A variety of cells can be treated according to the methods of the invention including embryos, embryogenic stem cells, allowing for the generation of transgenic animals or animals constituted partly by the transduced cells that have a specific gene or a group of genes down regulated.

Method for expression of small antiviral RNA molecules with reduced cytotoxicity within a cell

In one aspect, the invention provides methods and compositions for the expression of small RNA molecules within a cell using a retroviral vector (FIG. 1 A). Small interfering RNA (siRNA) can be expressed using the methods of the invention within a cell. In a further aspect, the invention provides methods for producing siRNA encoding lentivirus where the siRNA activity may interfere with the lentiviral life cycle. In yet a further aspect, the invention provides methods for expression of a small RNA molecule within a cell, such as an siRNA capable of downregulating CCR5, wherein expression of the small RNA molecule is relatively non-cytotoxic to the cell. The invention also includes small RNA molecules, such as an siRNA capable of downregulating CCR5, that are relatively non-cytotoxic to cells.

METHOD FOR PRODUCING SUPER THICK-GRAFT LWC PAPERS

Method for expression of small RNA molecules within a cell

The invention provides methods and compositions for the expression of small RNA molecules within a cell using a lentiviral vector. The methods can be used to express doubles stranded RNA complexes. Small interfering RNA (siRNA) can be expressed using the methods of the invention within a cell, which is capable of down regulating the expression of a target gene through RNA interference. A variety of cells can be treated according to the methods of the invention including embryos, embryogenic stem cells, allowing for the generation of transgenic animals or animals constituted partly by the transduced cells that have a specific gene or a group of genes down regulated.

Hemostatic material

Disclosed is a hemostatic material, wherein a thrombin receptor activating agent is covalently coupled to a biocompatible matrix.

Method for measuring visual effect of non-colored target in different light environments and system thereof

Electrical connector

一種電連接器，包括絕緣本體及收容於絕緣本體內之複數導電端子。所述絕緣本體設定有底壁，所述導電端子包括第一接地端子，第一訊號端子及位於第一訊號端子及第一接地端子之間之第二訊號端子。所述導電端子均設有接觸部，向下延伸之焊接腳，連接接觸部與焊接腳之連接部。第二訊號端子之連接部與第一接地端子之中軸線之間具有第一間距，第二訊號端子之焊接腳與中軸線之間具有第二間距，所述第二間距小於第一間距。如是排配，降低了差分訊號端子之間的相互串擾。

Emi shield spring device

An electro-magnetic interference device attached to a surface of an object by soldering is disclosed. The device comprises a base comprising a surface defining at least one recessed portion. The at least one recessed portion comprises a side wall. An angle between the side wall and the surface of the base is equal to or greater than 90 degrees.

Floating photovoltaic power plant and anchor system for floating photovoltaic power plant

【課題】水底に配置される基部と、浮体と、ケーブルとを含む、新規な浮体式太陽光発電所のアンカシステムを提供すること。【解決手段】浮体１１には複数の浮体プーリ１１１が設けられ、基部１２には複数の基部プーリ１２１が設けられ、ケーブル１３は浮体プーリと基部プーリとに連続的に巻かれ、その後に浮体式太陽光発電所に接続され、基部と浮体式太陽光発電所との間の距離は水位の変化とともに変化することが可能であり、基部プーリの数は浮体プーリの数以上であり、これにより、水位が変化する際に浮体式太陽光発電所が常に水面に浮遊することが確実になり、さらに、水位が激しく変化する環境にアンカシステムが適用可能になる。【選択図】図２

Information display method, terminal, and server

Embodiments of the present invention provide an information display method, terminal, and server. In one embodiment, the information display method includes obtaining, by a terminal, content information of at least one content source. The at least one content source corresponds to at least two pieces of account information stored in the terminal. The method further includes integrating, by the terminal, the content information into content display information; and displaying, by the terminal, the content display information.

Method for expression of small antiviral RNA molecules within a cell

In one aspect, the invention provides methods and compositions for the expression of small RNA molecules within a cell using a retroviral vector. The methods can be used to express double stranded RNA complexes. Small interfering RNA (siRNA) can be expressed using the methods of the invention within a cell, that interfere with a viral life cycle by down regulating either the viral genome, a viral genome transcript, or a host cell that. In another aspect the invention provides methods for treating patients having suffering from infection, particularly infection with HIV. In a further aspect, the invention provides methods for producing siRNA encoding lentivirus where the siRNA activity may interfere with the lentiviral life cycle.

Method for expression of small antiviral rna molecules with reduced cytotoxicity within a cell

In one aspect, the invention provides methods and compositions for the expression of small RNA molecules within a cell using a retroviral vector (FIG. 1 A). Small interfering RNA (siRNA) can be expressed using the methods of the invention within a cell. In a further aspect, the invention provides methods for producing siRNA encoding lentivirus where the siRNA activity may interfere with the lentiviral life cycle. In yet a further aspect, the invention provides methods for expression of a small RNA molecule within a cell, such as an siRNA capable of downregulating CCR5, wherein expression of the small RNA molecule is relatively non-cytotoxic to the cell. The invention also includes small RNA molecules, such as an siRNA capable of downregulating CCR5, that are relatively non-cytotoxic to cells.

Electrical connector and method making the same

An electrical connector includes an insulative housing having a tongue portion with opposite upper and lower surfaces, a plurality of upper terminals and a plurality of lower terminals with contacting sections exposed upon the corresponding upper surface and lower surface, respectively. A metallic shielding plate located between upper terminals and the lower terminals. The tongue portion forms a first type hole in which the upper power terminal mechanically and electrically connects to the lower power terminal, and a second type hole in which either the upper grounding terminal mechanically and electrically connects to an upper face of the shielding plate or the lower grounding terminal mechanically and electrically connects to the lower face of the shielding plate.

PREPARATION OF LWC LOW PRINTED PAPER IN A ROLL RAKELLE IMPRESS

Method for expression of small antiviral rna molecules with reduced cytotoxicity within a cell

In one aspect, the invention provides methods and compositions for the expression of small RNA molecules within a cell using a retroviral vector (Fig. IA). Small interfering RNA (siRNA) can be expressed using the methods of the invention within a cell. In a further aspect, the invention provides methods for producing siRNA encoding lentivirus where the siRNA activity may interfere with the lentiviral life cycle. In yet a further aspect, the invention provides methods for expression of a small RNA molecule within a cell, such as an siRNA capable of downregulating CCR5, wherein expression of the small RNA molecule is relatively non-cytotoxic to the cell. The invention also includes small RNA molecules, such as an siRNA capable of downregulating CCR5, that are relatively non-cytotoxic to cells.

Method for expression of small antiviral rna molecules within a cell

Modulatory polynucleotides

The present invention relates to adeno-associated viral (AAV) particles modulatory polynucleotides encoding at least one siRNA molecules and methods of use thereof.

Using a metered size press to produce lightweight coated rotogravure paper

A method for producing paper suitable for rotogravure printing by using a metered size press process to apply a coating formulation to a paper and then calendering the coated paper. In one aspect, the coating formulation comprises a pigment mixture containing engineered delaminated kaolin clay, and a latex binder. In another aspect, the pigment mixture comprises delaminated kaolin clay, engineered delaminated kaolin clay and calcined clay. Alternatively, talc is used in place of the calcined clay. In a further aspect, the pigment mixture comprises delaminated kaolin clay, platey kaolin clay, coarse kaolin clay and calcined clay.

Driving system of LED and control module

一種發光二極體的驅動系統包含一升壓電路及一控制模組。該升壓電路根據一控制信號選擇性將一直流的電源電壓轉換成一大於該電源電壓且直流的輸出電壓，並提供一輸出電流以驅動一發光二極體發光。該控制模組根據一相關於該電源電壓的輸入電壓，產生該脈寬調變的控制信號。該控制信號的佔空比隨著該輸入電壓的變大而單調改變。當該電源電壓越小時，該控制信號的佔空比越小，使該升壓電路所提供的該輸出電壓及該輸出電流越小，進而使提供該電源電壓的電池的使用時間能夠延長。

Efficient water injection method for low-permeability coal seam

Method for expression of small antiviral rna molecules within a cell

In one aspect, the invention provides methods and compositions for the expression of small RNA molecules within a cell using a retroviral vector. The methods can be used to express double stranded RNA complexes. Small interfering RNA (siRNA) can be expressed using the methods of the invention within a cell, that interfere with a viral life cycle by down regulating either the viral genome, a viral genome transcript, or a host cell that . In another aspect the invention provides methods for treating patients having suffering from infection, particularly infection with HIV.

Method for expression of small antiviral rna molecules within a cell

In ones aspect, the invention provides methods and compositions for the expression of small RNA molecules within a cell using a retroviral vector. The methods can be used to express double stranded RNA complexes. Small interfering RNA (siRNA) can be expressed using the methods of the invention within a cell, that interfere with a viral life cycle by down regulating either the viral genome, a viral genome transcript, or viral replication in a host cell. In another aspect, the invention provides methods for treating patients suffering from infection, particularly infection with HIV.

Electrical connector having overlapping coupling portions

An electrical connector includes an insulating body and first through eighth terminals sequentially arranged in a lateral direction in the insulating body, wherein the first and second terminals, the third and sixth terminals, the fourth and fifth terminals, and the seventh and eighth terminals are respectively used to transmit a pair of differential signals, each terminal including: a mating portion for mating to a mating connector; a tail portion opposite to the mating portion; and a connecting portion connected therebetween, the connecting portions of the third terminal to the fifth terminal are all provided with a coupling portion; wherein the coupling portions of the third through fifth terminals are in three different planes, respectively, and the coupling portion of the fifth terminal and the coupling portion of the third terminal at least partially overlap in a longitudinal direction perpendicular to the lateral direction.

Method, apparatus and device for generating image processing interface, and storage medium

A method and an apparatus for generating an image processing interface, a device, and a storage medium, including: receiving (S101) a first instruction, where the first instruction is used to characterize an image parameter of a target image; determining (S102) an image template corresponding to the first instruction, where the image template is used to characterize a processing flow of the target image; and generating (S103) a processing interface of the target image according to the image template. Since the image template standardizes the process and steps of image processing, the specific operation steps for generating an image processing interface are simplified, while standardizing the generated image processing interface, reducing the using and maintenance cost of the image processing interface, and improving the security of the image processing interface.

鞋墊

【物品用途】;本物品用於墊在鞋內，給腳提供按摩、減震、透氣、防滑的效果。;【設計說明】;圖式不主張色彩，本物品用於墊在鞋內，給腳提供按摩、減震、透氣、防滑的效果。

音箱

【物品用途】;本創作係提供一種音箱，尤其涉及一種攜帶型音箱。;【設計說明】;請參閱附圖，本創作音箱包括本體部及支撐本體部的底座，底座具有圓形底面且圓形底面的局部向內凹陷，本體部呈圓筒狀，音箱的出音面設置在本體部上且呈S型曲面狀，從後視圖看，音箱的上側呈光滑的曲線狀，從右側視圖看，音箱的左側呈S型曲線狀，而右側呈直線狀，從俯視圖和仰視圖看，音箱呈圓面狀。;綜觀本創作，其整體造型醒目別緻，予人以全新之視感，誠為一新穎、獨特之式樣。

Collagen visualization on microfluidic device

The invention relates to a method for generating an in-vitro cell culture model of cell development or cell differentiation, comprising a) providing a microfluidic chamber through which a stream of cell culture medium can be conducted; b) providing a plurality of primary cells embedded in a synthetic macroporous hydrogel, the macroporous hydrogel comprising polymer chains crosslinked by linker molecules amenable to cleavage by an extracellular endopeptidase, c) applying a flow of cell culture medium to said plurality of stem cells inside of the microfluidic chamber, thereby subjecting said cells to fluid shear stress in order to trigger functional maturation and collagen secretion. Another aspect of the invention relates to a microfluidic device, comprising a microfluidic chamber that comprises a macroporous hydrogel wherein cells are present. The macroporous hydrogel is composed of polymer chains crosslinked by linker molecules amenable to cleavage by an extracellular endopeptidase.

Método, terminal e servidor de exibição de informação

MÉTODO, TERMINAL E SERVIDOR DE EXIBIÇÃO DE INFORMAÇÃO. Modalidades da presente invenção fornecem um método, terminal e servidor de exibição de informação, onde o método inclui: obter (102), por um terminal, informação de conteúdo de pelo menos uma fonte de conteúdo, onde a pelo menos uma fonte de conteúdo corresponde a pelo menos duas peças de informação de conta; integrar (104), pelo terminal, a informação de conteúdo à informação de exibição de conteúdo; e exibir (106), pelo terminal, a informação de exibição de conteúdo. De acordo com as modalidades da presente invenção, informação de conteúdo de uma fonte de conteúdo é obtida, integrada e então exibida para um usuário por meio de classificação, de maneira que é conciso e intuitivo para o usuário consultar informação sem ser problemático.

服務派送伺服器及依據資料內容特徵碼提供服務之控管方法

本發明提供一種服務派送伺服器及依據資料內容特徵碼提供服務之控管方法。該方法包含下列步驟：自一服務要求端接收一服務要求(Service request)，其中該服務要求包含有該資料內容特徵碼以及至少一服務資料，該資料內容特徵碼與該至少一服務資料係對應於一應用服務；依據該服務要求，解析出該資料內容特徵碼與該至少一服務資料；以及將該服務要求傳送給對應該資料內容特徵碼與該至少一服務資料之一處理單元，以允許該處理單元執行該應用服務。

Compositions and methods for the treatment of tauopathy

The disclosure provides compositions and methods for the preparation, manufacture and therapeutic use of viral vectors, such as adeno-associated virus (AAV) particles having viral genomes encoding one or more antibodies or antibody fragments or antibody-like polypeptides, for the prevention and/or treatment of diseases and/or disorders.

按壓式水閥

本創作的目的在於提供一種具有緩衝結構的按壓式水閥，其具有：上座，其具有第一流道及第二流道；位於上座下方的下座，且下座與上座間形成一流通空間；位於流通空間的活動塞；以及控制機構，其根據使用者控制而封閉或開啟下座的穿孔。當控制機構開啟穿孔時，活動塞位於流通空間內的下方；當控制機構封閉穿孔時，活動塞漸進式貼靠於上座的下表面，並封閉第二流道。因此，本創作的透過活動塞於關水時會被水壓漸進式地推抵至封閉第二流道的位置可以有效降低流水於瞬間停止時會產生的正負壓力波。

Method and apparatus for generating image processing interface, device, and storage medium

A method and an apparatus for generating an image processing interface, a device, and a storage medium, including: receiving a first instruction, where the first instruction is used to characterize an image parameter of a target image; determining an image template corresponding to the first instruction, where the image template is used to characterize a processing flow of the target image; and generating a processing interface of the target image according to the image template. Since the image template standardizes the process and steps of image processing, the specific operation steps for generating an image processing interface are simplified, while standardizing the generated image processing interface, reducing the using and maintenance cost of the image processing interface, and improving the security of the image processing interface.

Compositions and methods for the vectored augmentation of protein destruction, expression and/or regulation

The disclosure provides compositions and methods for the Vectored Augmentation of the Destruction, Expression and/or Regulation of proteins, e.g., VA-DER systems and methods.

Makroskopische geordnete anordnung von kohlenstoffnanoröhren

Verfahren zur expression von kleinen antiviralen rna-molekülen innerhalb einer zelle

Verfahren zur herstellung von superdickgriffigen lwc-papieren

Electric torch with magnetic-induction switch

Herstellung von lwc tiefdruckpapier in einer rollrakelleimpresse

Modulatory polynucleotides

The present invention relates to adeno-associated viral (AAV) particles modulatory polynucleotides encoding at least one siRNA molecules and methods of use thereof.

調節性ポリヌクレオチド

【課題】疾患の治療または予防等のための少なくとも１つのｓｉＲＮＡ分子をコードする調節性ポリヌクレオチド、調節性ポリヌクレオチドを含むＡＡＶ粒子、及びＡＡＶ粒子を含む組成物を提供する。【解決手段】アデノ随伴ウイルス（ＡＡＶ）ウイルスゲノムは、２つの末端逆位配列（ＩＴＲ）の間に、発現すると細胞における標的遺伝子の発現を阻害または抑制する核酸配列を含む。核酸配列は、５’から３’の順に、第１のセンス鎖配列、第１のアンチセンス鎖配列、第２のセンス鎖配列、および第２のアンチセンス鎖配列をコードする領域を含む。第１および第２のアンチセンス鎖配列は、標的遺伝子によって産生されるｍＲＮＡに相補的である。第１のセンス鎖配列及び第１のアンチセンス鎖配列、並びに第２のセンス鎖配列及び第２のアンチセンス鎖配列は、それぞれ相補性の領域を有する。【選択図】なし

Aav variants with enhanced tropism

The disclosure relates to compositions, methods, and processes for the preparation, use, and/or formulation of adeno-associated virus capsid proteins, wherein the capsid proteins comprise targeting peptide inserts for enhanced tropism to a target tissue.

音箱組合

【物品用途】;本創作係提供一種音箱組合，尤其涉及一種攜帶型音箱組合。;【設計說明】;請參閱附圖，本創作音箱組合呈圓柱體，且可拆分成兩個形狀、圖案完全一樣的音箱，從前視圖看，音箱組合表面具有偏下的U型曲線，從後視圖看，音箱組合表面具有偏上的倒U型曲線，從右側視圖看，音箱組合表面具有類S型曲線，從左側視圖看，音箱組合表面具有左右翻轉的類S型曲線。;綜觀本創作，其整體造型醒目別緻，予人以全新之視感，誠為一新穎、獨特之式樣。

Μεθοδοι και συνθεσεις για θεραπειες καρκινου χρησιμοποιωντας γονιδια που κωδικοποιουν εκκρινομενες πρωτεϊνες οπως ιντερφερονη-βητα

Παρέχονται μέθοδοι και φαρμακευτικές συνθέσεις για τροποποίηση κυττάρων ενός δέκτου θηλαστικού με DNA που κωδικοποιεί εκκρινόμενη πρωτεΐνη, όπως ανθρώπινη ιντερφερόνη, in situ. Οι μέθοδοι περιλαμβάνουν σχηματισμό συστήματος έκφρασης εκκρινόμενης πρωτεΐνης in vivo ή ex vivo και χορήγηση του συστήματος έκφρασης στο δέκτη θηλαστικό. Το σύστημα έκφρασης και οι μέθοδοι είναι χρήσιμοι για την εντοπισμένη και συστημική απελευθέρωση ιντερφερονών in situ.