SYSTEM Of USE OF the WASTE HEAT

CONTROL UNIT OF ENGINE

Une ECU (40) détecte un couple d'arbre dans une plage de détection de couple spécifiée définie pour chaque cylindre. Le couple d'arbre est généré suite à une combustion du carburant et est appliqué à un vilebrequin du moteur (10). L'ECU (40) calcule une position d'angle de vilebrequin comme une position pic réelle à laquelle un couple de combustion atteint un pic. L'ECU (40) stocke une position de couple maximum précédemment déterminée qui correspond à une position d'angle de vilebrequin à laquelle un couple de combustion atteint un pic. Sur la base de la position pic réelle et de la position de couple maximum préalablement stockée, un allumeur (17) régule un calage de l'allumage. An ECU (40) detects a shaft torque within a specified torque detection range defined for each cylinder. The shaft torque is generated as a result of fuel combustion and is applied to a crankshaft of the engine (10). The ECU (40) calculates a crank angle position as a real peak position at which a combustion torque reaches a peak. The ECU (40) stores a previously determined maximum torque position that corresponds to a crank angle position at which a combustion torque reaches a peak. Based on the actual peak position and the maximum torque position previously stored, an igniter (17) regulates ignition timing.

Gasfeder-Stütze

Engine controller

An ECU detects a shaft torque in a specified torque detection range defined for each cylinder. The shaft torque is generated due to a combustion of the fuel and is applied to a crankshaft of the engine. The ECU computes a crank angle position as an actual peak position at which a combustion torque is peak. The ECU stores a previously determined maximum torque position which corresponds to a crank angle position at which a combustion torque becomes peak. Based on the actual peak position and the previously stored maximum torque position, an igniter controls an ignition timing.

Belt Binder Structure

An improved belt binder structure having a binder body with a flat base and the two sides bended upward to form side panels that constitute a a binder body with a flat base with two sides bended upward to form an enclosure space for enclosing a reel, a ratchet wheel, a handle, a locking plate and a control pulling plate attached to the two side panels of the handle and can move up and down by the connecting points, and whereas the frontal portion of the control pulling plate has locking structure that locks with the positioning slot on the flat base and the bottom of the plate engages with the ratchet wheels.

Optoelectronic semiconductor device with barrier layer

An optoelectronic semiconductor device comprises a barrier layer, a first semiconductor layer on the barrier layer, the first semiconductor layer comprising a first dopant and a second dopant, and a second semiconductor layer beneath the barrier layer, the second semiconductor comprising the second dopant, wherein, in the first semiconductor layer, a concentration of the first dopant is larger than a concentration of the second dopant, and the concentration of the second dopant in the second semiconductor layer is larger than that in the first semiconductor layer.

Semiconductor light-emitting device

A semiconductor light-emitting device comprises an epitaxial structure for emitting a light and comprises an edge, a first portion and a second portion surrounding the first portion, wherein a concentration of a doping material in the second portion is higher than that of the doping material in the first portion, a main light-extraction surface on the epitaxial structure and comprises a first light-extraction region corresponding to the first portion and a second light-extraction region corresponding to the second portion and an edge, wherein the second portion is between the edge and the first portion.

Flexible electrical power strip

An electrical power strip that may be flexibly configured is provided. The power strip includes a power cord having a plug configured to operably couple with a wall socket. A head block is electrically coupled to the power cord on an end opposite the first plug. The head block having a first outlet socket on one end configured to receive a first external power plug. The head block further includes a first, second and third female electrical connector located on different sides. A power block having a first male connector on a side is electrically coupled with one of the first, second or third female connector. The first power block having a second outlet socket configured to receive a second external power plug. The power block further having a fourth, fifth and sixth female connectors located on different sides.

Rab7l1 interacts with lrrk2 to modify intraneuronal protein sorting and parkinson's disease risk

The present invention relates to methods and compositions for treating Parkinson's disease in a subject.

Heterogeneously integrated semiconductor device and manufacturing method thereof

A method of making a semiconductor device includes: providing a substrate; forming an insulating layer on the substrate; forming a first trench in the insulating layer; forming a first semiconductor layer in the first trench; and removing a portion of the insulating layer to expose the first semiconductor layer.

Heterogeneously integrated semiconductor device and manucacturing method thereof

A heterogeneously integrated semiconductor devices includes a base substrate; a Ge-containing film formed on the base substrate; a PMOSFET transistor having a first fin formed on the Ge-containing film; and a NMOSFET transistor having a second fin formed on the Ge-containing film; wherein the PMOSFET transistor and the NMOSFET transistor compose a CMOS transistor, and the first fin comprises Ge-containing material and the second fin comprises a Group III-V compound.

拡散板、照明装置および液晶ディスプレイ

(57)【要約】 【課題】 長時間にわたり明るく美しい表示が得られ る拡散板、バックライトおよび液晶ディスプレイを提供 することを目的とする。 【解決手段】 雲母１０表面に二酸化チタン１２とチタ ン系複合酸化物１５が被覆された有色真珠光沢顔料１１ が均一に分散して存在しており、入射光１４を前記有色 真珠光沢顔料１１が有する干渉色と同系色の散乱光１ ６，１８として透過することを特徴とする拡散板。

反射板並びにそれを用いた反射型液晶表示素子

(57)【要約】 【課題】 鮮やかな色調の反射光が安定して得られる 反射板並びにそれを用いた反射型液晶表示素子を提供す ることを目的とする。 【解決手段】 干渉色を有する粉体１４ａ，１４ｂを少 なくとも２種類含むことを特徴とする反射板２８。

半透過型反射板、照明装置および半透過型液晶表示素子

(57)【要約】 【課題】 鮮やかな色調の透過光および反射光を確実 に得ることができる半透過型反射板、照明装置および半 透過型液晶表示素子を提供することを目的とする。 【解決手段】 干渉色を有する粉体１４ａ，１４ｂを少 なくとも２種類含むことを特徴とする半透過型反射板４ ２。

Diffusion plate, illumination device and liquid crystal display

(57)【要約】 【課題】 光源からの光を効率的に利用することがで きる拡散板、照明装置および液晶ディスプレイを提供す ることを目的とする。 【解決手段】 入射光１４を散乱光として透過する拡散 板３４において、真珠光沢顔料表面１０，１２にポリマ ー１５が被覆された粒子１１が均一に分散して存在して いることを特徴とする拡散板３４。

Cosmetic compositions containing modified powder or particulate material

A modified powder or particulate material having a silicone polymer film coated on substantially the entire surface thereof, this powder or particulate material being produced by bringing at least one silicone compound, in the form of a vapor, having the general formula (I): (R.sup.1 HSiO).sub.a (R.sup.2 R.sup.3 SiO).sub.b (R.sup.4 R.sup.5 R.sup.6 SiO 1/2 ) c (I) wherein R 1 , R 2 , and R 3 represent, independently, hydrogen or a hydrocarbon residue having 1 to 10 carbon atoms, which may be substituted with at least one halogen atom, provided that R 1 , R 2 , and R 3 are not hydrogen at the same time, R 4 , R 5 , and R 6 represent, independently, hydrogen or a hydrocarbon residue having 1 to 10 carbon atoms, which may be substituted with at least one halogen atom, a is zero or an integer of 1 or more, b is zero or an integer of 1 or more, and c is zero or 2, provided that c is 2 when a and b are simultaneously zero and a+b is an integer of 3 or more when c is zero, into contact with a powder or particulate material having an active site on the surface thereof, whereby the silicone compound is polymerized on substantially the entire surface of the powder or particulate material.

Electrically-driven position changing apparatus

A single actuator such as an electric motor is used to actuate a shift range changing mechanism of an automatic transmission. The motor has a plurality of torque generating units each of which is capable of generating a torque sufficient to effect any shift range changes of the shift range changing mechanism. All of the torque generating units are driven electrically normally in response to a shift range change command. Operation of each torque generating unit is monitored separately from each other. When one of the torque generating units fails in operation, the torque generating unit in failure is not driven but the other torque generating units are driven to effect a shift range change. The failure of the torque generating units is indicated on an indicator in a vehicle. The motor may be a brushless type or a reluctance type.

Mutants of interleukin-1 receptor antagonist

The invention provides an isolated polypeptide comprising a variant amino acid sequence of SEQ ID NO: 1, or a fusion or derivative of said polypeptide, or a fusion of a said derivative thereof, wherein the polypeptide, fusion or derivative retains a biological activity of wild type IL-IRa. In one embodiment, the isolated polypeptide, fusion or derivative is or comprises a polypeptide variant of amino acid sequence SEQ ID NO: 1 comprising or consisting of substitutions at one or more of the following amino acid mutations of SEQ ID NO: 1: Q29K, P38Y, P38R, L42W, D47N, E52R, H54R, E90Y, Q129L, Q129N, M136N, M136D and Q149K. Also provided are pharmaceutical compositions of the above polypeptide, fusion or derivative, as well as uses of the same for treating a disease or condition capable of being treated by an agent which inhibits the function of IL-1 receptors.

Mutants of interleukin-1 receptor antagonist

The invention provides an isolated polypeptide comprising a variant amino acid sequence of SEQ ID NO: 1, or a fusion or derivative of said polypeptide, or a fusion of a said derivative thereof, wherein the polypeptide, fusion or derivative retains a biological activity of wild type IL-IRa. In one embodiment, the isolated polypeptide, fusion or derivative is or comprises a polypeptide variant of amino acid sequence SEQ ID NO: 1 comprising or consisting of substitutions at one or more of the following amino acid mutations of SEQ ID NO: 1: Q29K, P38Y, P38R, L42W, D47N, E52R, H54R, E90Y, Q129L, Q129N, M136N, M136D and Q149K. Also provided are pharmaceutical compositions of the above polypeptide, fusion or derivative, as well as uses of the same for treating a disease or condition capable of being treated by an agent which inhibits the function of IL-1 receptors.

Composite powder and color composition containing the same

Diffusion plate, illuminating device and liquid crystal display

(57)【要約】 【課題】 光源からの光を効率的に利用することがで きると共に、美しい映像が得られる拡散板、照明装置お よび液晶ディスプレイを提供することを目的とする。 【解決手段】 入射光を拡散させると共に、その吸収波 長域と略同一波長域の干渉光を有する粉体１４を均一に 含むことを特徴とする拡散板３８。

Production of a test card

Transgenic mice expressing human TREM proteins and methods of use thereof

Provided herein are transgenic non-human animals whose genomes comprise two or more human genes selected from TREM1, TREML1, TREM2, TREML2, and TREML4, to methods of screening candidate agents that bind to and/or modulate the function and/or activity of at least one of the human genes in the transgenic non-human animals, and to methods of screening candidate agents to determine their effect on one or more activities and/or functions associated with expression of at least one of the human genes in the transgenic non-human animals. Further provided herein are methods of recapitulating a human TREM immune system in a non-human animal, and methods of generating a non-human animal disease model comprising a human TREM repertoire.

Cable connection

Wireless roaming using a distributed store

Systems, methods, and computer-readable storage media for wireless roaming are disclosed. An access point receives a communication request from a wireless device and determines a home broadcast domain associated with the wireless device. The access point determines that the home broadcast domain is different than the broadcast domain associated with the access point and proceeds to identify a second access point that is associated with the home broadcast domain of the wireless device. The access point establishes a tunnel between the access point and the second access point for routing traffic associated with the wireless device.

Titanium-mica composite material

A titanium-mica composite material including (i) mica, (ii) a first coating composed of a titanium compound or a mixture thereof containing titanium dioxide coated on the surface of the mica, and (iii) a second coating composed of titanium dioxide coated on the first coating. The titanium compound in the first coating is at least one compound selected from the group consisting of low oxides of titanium and titanium oxynitrides. This mica composite material exhibits excellent color tone (e.g., chroma and brightness), good consistency of an appearance color and an interference color, excellent stability, safety, light resistance, acid resistance, alkali resistance, solvent resistance, and heat resistance.

Aluminum electrolytic capacitor and manufacturing process

Refrigerating apparatus and fluid machine therefor

A complex fluid machine has an expansion-compressor device, a pump, and a motor generator, wherein the expansion-compressor device, the pump, and the motor generator are operatively connected and arranged in series, and a power transmitting device for disconnecting the pump from the motor generator, when the expansion-compressor device is driven by the motor generator so as to be operated as a compressor device.

Black pearl shiny powder and method for making such powder

Colored mica titanium-based pigment and coated product using the same

(57)【要約】 【課題】 本発明の目的は有機性物質を用いずに雲母 チタン系顔料の色調を改善することにある。 【解決手段】 薄片状雲母基板と、前記雲母基板に被覆 された複合酸化物と、を含み、前記複合酸化物を構成す る金属として、チタンと、鉄と、ニッケルを含むことを 特徴とする有色雲母チタン系顔料及びそれを塗布した塗 装体。

Semi-transmissive reflecting plate and liquid crystal display device using it

(57)【要約】 【課題】 本発明の目的は、外光使用時と内部光源使用 時で異なる色調を呈する半透過型反射板及びそれを用い た液晶表示装置を提供することにある。 【解決手段】 雲母表面が、低次酸化チタンを含む酸化 チタン層で被覆されてなる光拡散性酸化チタン被覆雲母 粉体を基板中に含むことを特徴とする半透過型反射板な いしこれを用いた液晶表示装置。

Fluid pump and fluid machine

A fluid pump includes a driving part, a movable part that is movable by power transmitted from the driving part via a transmission part, a fixed part disposed on a side of the movable part, opposite to the transmission part, to form an operating chamber having an outlet from which a fluid flowing into the operating chamber is pressure-fed to an outside in a liquid state by the movable part, and an introduction passage for introducing a part of the fluid in the operating chamber to the transmission part. Accordingly, the liquid fluid can be introduced to the transmission part such as a bearing through the introduction passage.

Patent JPH058168B2

Promoter for expression and use thereof

PROMOTER FOR EXPRESSION AND USE THEREOF Abstract of the Disclosure A novel DNA isolate encoding for a promoter region of human nerve growth factor-2, a recombinant vector containing said DNA, and a transformant carrying said recombinant vector are disclosed. The promoter of the present invention is useful as a means for analyzing an expression control mechanism of a nerve specific protein and can be used as a promoter which is incorporated into vectors used in the preparation of disease model animals, the treatment of diseases of organisms and the establishment of drug screening systems.

Heat-sealable paperboard

The invention relates to a heat-sealable paperboard comprising a paperboard substrate (1) comprising a first side and a second side, a first dispersion coating layer (2) on the first side of the paperboard substrate (1), and a second dispersion coating layer (3) on the first dispersion coating layer (2), wherein the first dispersion coating layer (2) comprises a latex and pigment and the second dispersion coating layer (3) comprises a polyolefin.

Color titanated mica pigment and coated-body using the same

A color titanium dioxide coated mica pigment and a coated body applied the pigment which comprise a flaky mica substrate and a composite oxide that is coated onto said mica substrate, and titanium, iron, and nickel are comprised as a metal that is composed of said composite oxide, can improve the color tone of the titanium dioxide coated mica pigment without using an organic substance and a color titanium dioxide coated mica pigment and a coated body applied the pigment which coats a titanium dioxide layer onto said composite oxide can provide a pigment which has color tone flip-flop property that the color tone changes according to the observed direction.

LOST HEAT USE SYSTEM

Un système de recueil de chaleur perdue destiné à un moteur à combustion interne a pour objet de recueillir la chaleur perdue provenant du moteur et de faire une utilisation maximum de la chaleur perdue recueillie pour obtenir un effet maximum d'amélioration du taux de consommation de carburant. Le système d'utilisation de chaleur perdue comporte un cycle de recueil de chaleur perdue (300) destiné à recueillir la chaleur perdue provenant d'un moteur à combustion interne et comportant un dispositif de détente (150) destiné à engendrer une force d'entraînement en rotation à partir de la chaleur perdue recueillie, un cycle de réfrigération (200) comportant un dispositif de compresseur (240) destiné à comprimer un réfrigérant et un moyen de transmission de puissance (110, 130) entraîné en rotation par un moyen de génération de force d'entraînement (10, 130) et relié de façon fonctionnelle au dispositif de compresseur (140) pour entraîner en rotation celui-ci. Dans ce système, le dispositif de détente (150) est relié de façon fonctionnelle au dispositif de compresseur (140) afin d'entraîner en rotation celui-ci. The purpose of a waste heat collection system for an internal combustion engine is to collect the waste heat from the engine and to make maximum use of the waste heat collected to obtain a maximum effect of improving the rate of fuel consumption. . The waste heat utilization system includes a waste heat collection cycle (300) for collecting waste heat from an internal combustion engine and having an expansion device (150) for generating a driving force in rotation from the waste heat collected, a refrigeration cycle (200) comprising a compressor device (240) intended to compress a refrigerant and a power transmission means (110, 130) driven in rotation by a generation means of driving force (10, 130) and operatively connected to the compressor device (140) to rotate the latter. In this system, the expansion device (150) is operatively ...

TGF-ß SUPERFAMILY PRODUCTION/SECRETION PROMOTER

A TGF-ß superfamily production/secretion promoter containing a compound which is represented by the formula (I) (wherein R1 represents halogeno, an optionally substituted heterocyclic group, optionally substituted hydroxy, optionally substituted thiol, or optionally substituted amino; A represents optionally substituted acyl, an optionally substituted heterocyclic group, optionally substituted hydroxy, or optionally esterified or amidated carboxyl; B represents an optionally substituted aromatic group; X represents oxygen, sulfur, or optionally substituted nitrogen; and Y represents a divalent hydrocarbon group or heterocyclic group) or containing a salt or prodrug of the compound. The promoter is useful as a preventive/remedy for autonomic neuropathy, bladder function disorders, auditory disorders, bone diseases, etc.

Rab7l1 interacts with lrrk2 to modify intraneuronal protein sorting and parkinson' s disease risk

The present invention relates to methods and compositions for treating Parkinson's disease in a subject.

Air-conditioning control device for electric vehicle

A detector detects a remaining power of a battery. A calculator calculates a demand load of air-conditioning based on at least one of a preset temperature set for air in a passenger compartment of an electric vehicle and an outside temperature of air outside of the electric vehicle. A switching portion switches a mode of air-conditioning between a battery mode and an engine mode based on the calculated demand load and the detected remaining power of the battery. The battery mode causes the battery to supply electric power for air-conditioning, and the engine mode causes an engine of the electric vehicle to supply combustion energy for air-conditioning.

Gene therapies for lysosomal disorders.

La divulgación se refiere, en algunos aspectos, a composiciones y métodos para el tratamiento de las enfermedades asociadas con una función lisosomal aberrante, por ejemplo, la enfermedad de Parkinson (PD) y la enfermedad de Gaucher. En algunas modalidades, la divulgación proporciona las construcciones de expresión que comprenden un transgén que codifica la beta-glucocerebrosidasa (GBA) o una porción de la misma, solo o en combinación con uno o más genes asociados con la PD. En algunas modalidades, la divulgación proporciona métodos para el tratamiento de la enfermedad de Parkinson por medio de la administración de las construcciones de expresión a un sujeto que lo necesite.

Fluid-driven lighting device

A fluid-driven lighting device comprises a main body, shaped like a cylinder, having a first end connected with a water supply pipe and a second end connected with a sprinkler head, an electric generator, mounted on the main body and further comprising a turbine wheel, placed inside the main body and driven by a flow of liquid the main body, and a generator unit, driven by the turbine wheel and generating an electric current; and at least one lighting unit, set on the main body and emitting light, wherein liquid flows through the main body, causing the electric generator to generate an electric current which in turn supplies the lighting unit for emitting light.

A medical implantable lead

Communication machine room wideband noise suppression system

In a communication machine room wideband noise suppression system, a sensing unit detects a noise source produced by a fan during the operation thereof and generates a noise input signal and a feedback signal, which are sent to a signal amplifying unit for signal amplification. The amplified signals are then sent to a signal converting unit and converted into digital signals. A multi-channel hybrid controller receives the digital signals and makes corrections and conduct rapid convergence algorithm to derive a reverse digital signal, which is sent to the signal converting unit and converted into a reverse analog signal. The reverse analog signal is sent to the signal amplifying unit for power amplification to generate a control signal for driving a loudspeaker unit to produce interfering acoustic wave, so as to cancel out the noise source and achieve the purpose of eliminating wideband noise.

Titanium-mica composite material

TITANIUM-MICA COMPOSITE MATERIAL ABSTRACT OF THE DISCLOSURE A titanium-mica composite material including (i) mica, (ii) a first coating composed of a titanium compound or a mixture thereof containing titanium dioxide coated on the surface of the mica, and (iii) a second coating composed of titanium dioxide coated on the first coating. The titanium compound in the first coating is at least one compound selected from the group consisting of low oxides of titanium and titanium oxynitrides. This mica composite material exhibits excellent color tone (e.g., chroma and brightness), good con-sistency of an appearance color and an intereference color, excellent stability, safety, light resistance, acid resistance, alkali resistance, solvent resistance, and heat resistance.

Mesoporous powder and its production

(57)【要約】 【課題】本発明の目的は均質性に優れ、しかも開口径、 開口深さなどの調整を行いやすいメソポーラス粉体ない しその製造方法を提供することにある。 【解決手段】０＜ＳｉＯ 2 ／Ｙ 2 Ｏ＜２の珪酸塩（Ｙ：ア ルカリ金属原子）をカチオン性界面活性剤の存在下、ｐ Ｈ１１以上で溶解する溶解工程と、ｐＨを１０．５以下 とし、前記カチオン性界面活性剤で棒状ミセルを形成 し、かつ珪酸を該棒状ミセル上に析出させる縮合工程 と、前記析出により形成された珪酸塩を外殻としたミセ ル状析出物よりカチオン性界面活性剤を除去する除去工 程と、を含むことを特徴とするメソポーラス粉体の製造 方法及び該方法により得られた塊状メソポーラス粉体。

Fluid machine operable in both pump mode and motor mode and waste heat recovering system having the same

A check valve is provided to each discharge port, which communicates between a corresponding working chamber and a high pressure chamber in an integrated compressor/expander apparatus. A valve mechanism, which is opened in a motor mode, is provided to communicate between the working chamber and the high pressure chamber.

Refrigerating apparatus and fluid machine therefor

A complex fluid machine has an expansion-compressor device, a pump, and a motor generator, wherein the expansion-compressor device, the pump, and the motor generator are operatively connected and arranged in series, and a power transmitting device for disconnecting the pump from the motor generator, when the expansion-compressor device is driven by the motor generator so as to be operated as a compressor device.

Semiconductor epitaxial structures and semiconductor optoelectronic devices comprising the same

A semiconductor epitaxial structure includes a substrate; a semiconductor epitaxial stack layers formed on the substrate; and a plurality of semiconductor buffer layers deposited between the substrate and the semiconductor epitaxial layer with a gradually varied composition along one direction; wherein more than one of the semiconductor buffer layers have a patterned surface.

Coloured titanium dioxide coated mica pigment and article coated using the same

Diffusion plate and liquid crystal display element employing the same

A diffusion plate, a lighting device and a liquid crystal display element by which light from a light source can be utilized efficiently and a beautiful image can be obtained. A diffusion plate by which incident light is diffused and which contains powder having interference light whose wavelength range is approximately the same as the absorption wavelength range, a diffusion plate which contains at least two types of powder whose interference colors are complementary to each other and a liquid crystal display element employing such diffusion plates.

Medical lead assembly and method for implantation thereof

An assembly includes a medical implantable lead adapted to be attached with a distal end of the lead to an organ inside a human or animal body, the medical implantable lead being formed with an inner lumen extending along essentially the entire length of the lead. The assembly also includes a support core that has a desirable stiffness and a suitably cross sectional dimension such that it is insertable into the lumen ( 7 ) in order to increase the stiffness of the lead along its length during its working life when being implanted into a body. A method for implanting a medical implantable lead into a human or animal body makes use of such an assembly.

Retroreflective body

(57)【要約】 【課題】曲面に対しても十分な密着性を持ち、また開封 確認等に役立つ再帰反射体を提供する。 【解決手段】反射基板層と、層と平行な方向に延伸可能 な延伸層と、前記反射基板層の表層側に配置された透明 微小球層とを含むことを特徴とする再帰反射体。前記再 帰反射体において、さらにその表層側に模様層、特にホ ログラム再生層を積層することが好適である。前記再帰 反射体において、さらにその表層側に非延伸層を積層す ることが好適である。前記再帰反射体において、さらに 模様層と他層との間に非延伸層を積層することが好適で ある。前記再帰反射体において、延伸層が弾性を持つこ とを特徴とする再帰反射体。前記再帰反射体において、 延伸層が塑性を持つことを特徴とする再帰反射体。前記 再帰反射体を含むことを特徴とする開封確認用シール、 偽造防止用シール、意匠性シール

Waste heat recovery device

Abwärmenutzungsvorrichtung für einen Verbrennungsmotor, mit einem Clausius-Rankine-Kreis (40) mit einer Pumpe (130a) zum Zirkulieren eines Arbeitsfluids und einer Expansionsvorrichtung (110) zum Erzeugen einer Antriebskraft durch Expandieren des Arbeitsfluids, welches mittels Abwärme von dem Verbrennungsmotor (10) geheizt wird; einem Stromgenerator (120), der durch die an der Expansionsvorrichtung (110) erzeugte Antriebskraft angetrieben werden soll, zum Erzeugen elektrischer Energie; und einer Steuereinheit (400) zum Steuern von Funktionen des Clausius-Rankine-Kreises (40) und des Stromgenerators (120), wobei die Steuereinheit (400) den Betrieb der Pumpe (130a) stoppt, wenn ein Steuersignal für den Stromgenerator (120) aus einem Sollbereich herausfällt, der Stromgenerator (120) einen bürstenlosen Generator mit mehreren Statorwicklungen (U, V, W) aufweist, die Steuereinheit (400) einen Schaltabschnitt (420) mit mehreren Paaren von elektrischen Schaltvorrichtungen (420a–420f) aufweist, wobei jedes Paar eine batterieseitige Schaltvorrichtung (420a–420c) und eine masseseitige Schaltvorrichtung (420d–420f) aufweist, der Betrieb des Stromgenerators (120) durch Einschalten und Ausschalten dieser elektrischen Schaltvorrichtungen (420a–420f) gesteuert wird, wobei die Steuereinheit (400) die masseseitige Schaltvorrichtung (420d–420f) einschaltet, um geschlossene Schaltungen für die jeweiligen Statorwicklungen (U, V, W) zu bilden, nachdem der Betrieb der Pumpe (130a) gestoppt ist, um den Betrieb der Expansionsvorrichtung (110) zu stoppen. A waste heat utilization apparatus for an internal combustion engine, comprising a Rankine cycle (40) having a pump (130a) for circulating a working fluid and an expansion device (110) for generating a driving force by expanding the working fluid heated by waste heat from the internal combustion engine (10) becomes; a power generator (120) to be driven by the driving force generated at the expansion device (110) for generating electric power ...

Light-emitting element with multiple light-emitting stacked layers

A light-emitting device includes a carrier; a first light-emitting element formed on a first portion of the carrier, including: a first MQW structure configured to emit a first light with a first dominant wavelength; a second MQW structure configured to emit a second light with a second dominant wavelength on the first MQW structure; wherein the first MQW structure and the second MQW structure both comprise InxGa1-xP or InxGa1-xAs, wherein 0<x<1; and a second light-emitting element, formed on a second portion on of the carrier, including a light-emitting stacked layer configured to emit a third light with a third dominant wavelength, wherein the third light is blue, wherein a difference between the first dominant wavelength and the second dominant wavelength is 5 nm to 30 nm.

Composite auxiliary machine for a vehicle and a control unit thereof

A composite auxiliary machine for a vehicle has proper startup performance in starting an engine. The composite auxiliary machine has a compressor for compressing a refrigerant inside a refrigeration cycle device, a rotary machine connected to the compressor and rotated together therewith, a drive pulley for operating the rotary machine in response to a driving force from the vehicle engine, and a clutch device for transmitting and terminating the driving force of the drive pulley. The rotary machine functions as a generator and an electric motor. A variable displacement mechanism is provided in the compressor to vary an amount of discharge per revolution. A control unit controls to engage the clutch device in starting the vehicle engine, and actuates the rotary machine as an electric motor to actuate the vehicle engine. Then, an amount of discharge of a refrigerant is controlled to become smaller than that necessary in the refrigeration cycle device.

Method for inactivating zika virus and related methods

The present disclosure relates to methods for inactivating a Zika virus which can be used in vaccines and immunogenic compositions. The present disclosure also relates to a method for determining the completeness of inactivation of an arbovirus preparation and to a method for determining the residual formaldehyde content in a pharmaceutical composition comprising an inactivated virus.

Fluid machine

A fluid machine according to the present invention has an expansion-and-compressor device selectively operating as an expansion device for collecting waste heat from an internal combustion engine and converting the collected heat energy into mechanical rotational force, and as a compressor device for compressing refrigerant for a refrigerating cycle for air conditioner. The fluid machine further comprises an electric rotating device selectively operating as an electric power generator and as an electric motor. A power transmission device is further provided between the expansion-and-compressor device and the electric rotating device for selectively transmitting the rotational force from the expansion-and-compressor device to the electric rotating device and vice versa. The power transmission device is composed of a planetary gear train so that it can change rotational speed to be transmitted to the expansion-and-compressor device or to the electric rotating device. Accordingly, the expansion-and-compressor device as well as the electric rotating device can be operated at their most efficient rotational speed.

Gene therapies for lysosomal disorders

terapias gênicas para distúrbios lisossomais. a presente invenção refere-se a composições e métodos para o tratamento de distúrbios associados à função lisossomal aberrante, como a demência frontotemporal (ftd - frontotemporal dementia). a divulgação também fornece construtos de expressão que compreendem um transgene que codifica a progranulina ou uma porção desta. a divulgação fornece métodos de tratamento da ftd pela administração desses construtos de expressão a um indivíduo em necessidade. gene therapies for lysosomal disorders. The present invention relates to compositions and methods for treating disorders associated with aberrant lysosomal function, such as frontotemporal dementia (ftd - frontotemporal dementia). the disclosure also provides expression constructs that comprise a transgene encoding progranulin or a portion thereof. the disclosure provides methods of treating ftd by administering these expression constructs to an individual in need.

Gene therapies for lysosomal disorders

The disclosure relates to compositions and methods for treatment of diseases associated with aberrant lysosomal function, such as fronto-temporal dementia (FTD). The disclosure also provides expression constructs comprising a transgene encoding progranulin or a portion thereof. The disclosure provides methods of treating FTD by administering such expression constructs to a subject in need thereof.

Refrigerating device comprising waste heat utilization equipment

In a refrigerating device comprising waste heat utilization equipment having: a refrigerating cycle 200 formed by sequentially connecting a compressor 210 , a condenser 210 , an expansion valve 240 , and an evaporator 250 ; and a Rankine cycle 300 formed by sequentially connecting a heater 310 using the waste heat of a heat generating device (for example, an internal combustion engine) 10 as a heating source, an expansion device 320 , the above-mentioned condenser 220 , and a pump 330 , in which the drive shafts of the compressor 210 and the expansion device 320 are separated from each other. Then, the output of the expansion device 320 is used mainly for generating electricity.

Solar cell having a graded buffer layer

An IMM solar cell includes a substrate, a bottom cell on the substrate; a graded buffer layer on the bottom cell; a middle cell on the graded buffer layer; a top cell on the middle cell.

Coloured titanium dioxide coated mica pigment and article coated using the same

A color titanium dioxide coated mica pigment and a coated body applied the pigment which comprise a flaky mica substrate and a composite oxide that is coated onto said mica substrate, and titanium, iron, and nickel are comprised as a metal that is composed of said composite oxide, can improve the color tone of the titanium dioxide coated mica pigment without using an organic substance and a color titanium dioxide coated mica pigment and a coated body applied the pigment which coats a titanium dioxide layer onto said composite oxide can provide a pigment which has color tone flip-flop property that the color tone changes according to the observed direction.

Diffuser, illuminating device and liquid crystal display

A diffuser, a backlight and a liquid crystal display by which clearer and brighter display is realized. The diffuser is characterized in that diffusion particles which contain colored pearl-gloss pigment such that mica is covered with titanium composite oxide alone or with titanium dioxide and titanium composite oxide are homogeneously dispersed, and the color tone of the diffused light is corrected by the color tone of the titanium composite oxide. The illuminating device and the liquid crystal display both employ such a diffusion plate.

Diffusion plate and liquid crystal display element employing the same

Method for inactivating zika virus and for determining the completeness of inactivation

The present disclosure relates to methods for inactivating a Zika virus which can be used in vaccines and immunogenic compositions. The present disclosure also relates to a method for determining the completeness of inactivation of an arbovirus preparation. Fig. 1

THERMAL SEALABLE PAPERBOARD

papel-cartão termo-selável. a invenção refere-se a um papel-cartão termo-selável que compreende um substrato de papel-cartão (1) que compreende um primeiro lado e um segundo lado, uma primeira camada de revestimento por dispersão (2) no primeiro lado do substrato de papel-cartão (1) e uma segunda camada de revestimento por dispersão (3) na primeira camada de revestimento por dispersão (2), em que a primeira camada de revestimento por dispersão (2) compreende látex e pigmento e a segunda camada de revestimento por dispersão (3) compreende poliolefina. heat-sealable paperboard. The invention relates to a heat-sealable paperboard comprising a paperboard substrate (1) comprising a first side and a second side, a first dispersion coating layer (2) on the first side of the paperboard (1) and a second dispersion coating layer (3) on the first dispersion coating layer (2), wherein the first dispersion coating layer (2) comprises latex and pigment and the second coating layer by dispersion (3) comprises polyolefin.

Waste heat utilizing system

A waste heat collecting system for an internal combustion engine has an object to collect waste heat from the engine and make most use of the collected waste heat to achieve the maximum effect of improving fuel consumption ratio. The waste heat utilizing system has a waste heat collecting cycle for collecting waste heat from an internal combustion engine and having an expansion device for generating rotational driving force from the collected waste heat, a refrigerating cycle having a compressor device for compressing a refrigerant and a power transmitting means rotationally driven by a driving force generating means and operatively connected to the compressor device to rotationally drive the same. In this system, the expansion device is operatively connected to the compressor device to rotationally drive the same.

Biomarkers for breast cancer

The present invention uses 2-dimensional differential gel electrophoresisgel (2D-DIGE) and mass spetrum techniques to identify breast cancer biomarkers in transformed breast cells. In summary, the present invention identifies numerous putative breast cancer markers from various stages of breast cancer. The results of the invention aids in developing proteins identified as useful diagnostic and therapeutic candidates on breast cancer research.

Hybrid compressor device for a vehicle

In a hybrid compressor for a vehicle where a vehicle engine is stopped when the vehicle is temporally stopped, a pulley, a motor and a compressor can be driven in independent from each other, and are connected to a sun gear, planetary carriers and a ring gear of a planetary gear. A rotational speed of the motor is adjusted by a controller, so that a rotational speed of the compressor is changed with respect to a rotational speed of the pulley. Accordingly, production cost of the hybrid compressor and the size thereof can be reduced, while a cooling function can be ensured even when the vehicle engine is stopped.

Gene therapies for lysosomal disorders.

La divulgación se refiere, en algunos aspectos, a composiciones y métodos para el tratamiento de las enfermedades asociadas con una función lisosomal aberrante, por ejemplo, la enfermedad de Parkinson (PD) y la enfermedad de Gaucher. En algunas modalidades, la divulgación proporciona las construcciones de expresión que comprenden un transgén que codifica la beta-glucocerebrosidasa (GBA) o una porción de la misma, solo o en combinación con uno o más genes asociados con la PD. En algunas modalidades, la divulgación proporciona métodos para el tratamiento de la enfermedad de Parkinson por medio de la administración de las construcciones de expresión a un sujeto que lo necesite.

Software updating method and portable terminal device

A software updating method for updating software stored as compressed code in a nonvolatile memory provided in a portable terminal on the basis of differential data via wireless communication includes the steps of providing a file system area having a fault-tolerant property; decompressing, at the execution of software updating, the compressed code of the software and loading the decompressed code into a random-access memory; updating the software in the random-access memory on the basis of the differential data; compressing the updated software; and storing a backup of a compressed updated code sequence corresponding to a compressed updated portion of the compressed updated software in the file system area and then writing the compressed updated code sequence corresponding to the compressed updated portion of the compressed updated software back to the nonvolatile memory.

HYBRID COMPRESSOR DEVICE

Method for inactivating ZIKA Virus and for determining the completeness of inactivation

The present disclosure relates to methods for inactivating a Zika virus which can be used in vaccines and immunogenic compositions. The present disclosure also relates to a method for determining the completeness of inactivation of an arbovirus preparation.

Patent JPS5822204B2

Methods of determining differential aging and genetic modifiers of genes correlated with a genotype of interest

The invention provides for a computer-implemented method of determining a biological age of a sample from, a subject. The invention also provides for a computer-implemented method of determining differential aging of a sample from a subject. The invention also provides for computer-implemented method of identifying one or more genetic modifiers of a phenotype associated with a genotype of interest comprising, and methods to treat phenotypes associated with genetic risk alleles.

Paperboard for packaging of liquid and/or frozen food

The present invention discloses a paperboard for packaging of liquid and frozen food, comprising a dispersion coating as the only barrier layer on its outside/print side. It has surprisingly been found that a dispersion coating comprising latex and pigment applied on the outside/print side of a paperboard for liquid and/or frozen food may serve as the only barrier against moisture arising from condensation.

Method for inactivating ZIKA Virus and for determining the completeness of inactivation

The present disclosure relates to methods for inactivating a Zika virus which can be used in vaccines and immunogenic compositions. The present disclosure also relates to a method for determining the completeness of inactivation of an arbovirus preparation.

electronic component cooler

【課題】効率のよい電子部品の冷却を容易に実現することができる電子部品冷却装置を提供すること。【解決手段】電子部品Ｅを冷却する電子部品冷却装置１０。冷却管２０は冷媒流路２２と冷媒入口２３１と冷媒出口２３２とを有する。冷媒流路２２にはインナフィン２４が設けてある。冷媒流路２２の幅方向Ｚにおける両外側部と、その間の中央部とには、外側流路２２２と中央流路２２１とが、それぞれ形成されている。外側流路２２２におけるインナフィン２４は、積層方向から見たとき、並び方向Ｙに対して傾斜した複数の傾斜部２４１を有すると共に、傾斜部２４１の傾斜方向が、並び方向Ｙにおいて交互に変わるように配置され、かつ、並び方向Ｙにおいて隣り合う傾斜部２４１の間には、幅方向Ｚに開口する連通路２２３が形成されている。中央流路２２１における流路抵抗は、外側流路２２２における流路抵抗よりも小さい。【選択図】図１３

Ultraviolet-screening zinc oxide excellent in transparency and composition containing the same

The present inventors conducted investigations in order to develop a metal oxide which enables effective UV-screening; i.e. which has excellent screening ability against ultraviolet rays, particularly against long-wavelength ultraviolet rays, as well as excellent visible-light transmission; and to provide a UV-screening composition that contains the metal oxide and can be applied to external use. As a result, the present inventors have found that zinc oxide produced by a particular method has a characteristic form; i.e., primary particles having an average particle diameter of 50-100 nm aggregate in a planer shape, and a ratio represented by lnT 360nm /lnT 400nm (T xnm : transmittance of transmitted light of X nm) of 10 or more, and exerts excellent screening effect against long-wavelength ultraviolet rays as well as excellent visible-light transmission. The present invention has been accomplished based on this finding. The zinc oxide of the present invention effectively exerts the above-described excellent characteristics; i.e. UV-screening effect and transparency, and can be applied to a composition for external use such as make-up cosmetics or sunscreen cosmetics.

Composite burner

Gene therapies for neurodegenerative disease

The disclosure relates, in some aspects, to compositions and methods for treatment of neurodegenerative diseases (e.g., amyotrophic lateral sclerosis (ALS) and/or frontotemporal dementia (FTD), Alzheimer's disease, Gaucher disease, Parkinson's disease, Lewy body dementia, or a lysosomal storage disease). In some embodiments, the disclosure provides expression constructs comprising a transgene encoding one or more inhibitory nucleic acids (e.g., targeting C9orf72, TMEM106B, ATNX2, RPS25, etc.), wild-type C9oif72 protein or a portion thereof, or any combination of the foregoing. In some embodiments, the disclosure provides methods of ALS/FTD by administering such expression constructs to a subject in need thereof.

Gene therapies for neurodegenerative disease

The disclosure relates, in some aspects, to compositions and methods for treatment of neurodegenerative disease, for example Alzheimer's disease. In some embodiments, the disclosure provides expression constructs comprising a transgene encoding an APOE Christchurch (e.g., APOE3ch and/or APOE2ch) protein isoform or a portion thereof, an inhibitory nucleic acid targeting an APOE gene or a portion thereof, or any combination of the foregoing. In some embodiments, the disclosure provides methods of treating Alzheimer's disease by administering an expression construct to a subject in need thereof.

Aromatic candle

(57)【要約】 【課題】本発明は、従来の蝋燭が備える燃焼力や、光の 明るさを保持しながら、様々な種類の芳香成分を配合す ることを可能とし、長期にわたって芳香性を保持し得る 蝋燭を提供することを目的とする。 【解決手段】 前記目的を達成するために、本発明にか かる芳香性蝋燭は、常温では固体であるが高温で溶解す る燃料体と、前記溶解した燃料体を吸い上げ、炎を安定 燃焼させる芯と、によって形成された蝋燭において、酸 化ケイ素を主成分とする多孔性物質に香料物質を担持さ せた香料担持体を配合したことを特徴とする。

genetic therapies for lysosomal disorders

A presente invenção refere-se em alguns aspectos, às composições e métodos para o tratamento de doenças associadas com a função lisossômica aberrante, por exemplo, doença de Parkinson e doença de Gaucher. Em algumas modalidades, a divulgação fornece construções de expressão compreendendo um transgene que codifica um ou mais ácidos nucleicos inibidores que direcionam o SCNA ou uma parte deste, TMEM106B ou uma parte deste, ou qualquer combinação dos anteriores. Em algumas modalidades, a presente invenção fornece métodos para a doença de Parkinson através da administração de tais construções de expressão a um indivíduo com sua necessidade. The present invention relates in some respects to compositions and methods for the treatment of diseases associated with aberrant lysosomal function, for example, Parkinson's disease and Gaucher disease. In some embodiments, the disclosure provides expression constructs comprising a transgene that encodes one or more inhibitory nucleic acids that target the SCNA or a part of it, TMEM106B or a part of it, or any combination of the above. In some embodiments, the present invention provides methods for Parkinson's disease by administering such expression constructs to an individual in need.

A paperboard for packaging of liquid and/or frozen food

The present invention discloses a paperboard for packaging of liquid and frozen food, comprising a dispersion coating as the only barrier layer on its outside/print side. It has surprisingly been found that a dispersion coating comprising latex and pigment applied on the outside/print side of a paperboard for liquid and/or frozen food may serve as the only barrier against moisture arising from condensation.

Gene therapies for lysosomal disorders

The disclosure relates, in some aspects, to compositions and methods for treatment of diseases associated with aberrant lysosomal function, for example Parkinson's disease (PD) and Gaucher disease. In some embodiments, the disclosure provides expression constructs comprising a transgene encoding beta-Glucocerebrosidase (GBA) or a portion thereof alone or in combination with one or more PD-associated genes. In some embodiments, the disclosure provides methods of Parkinson's disease by administering such expression constructs to a subject in need thereof.

Tgf-beta superfamily production/secretion promoter

Heterogeneously integrated semiconductor device and manufacturing method thereof

A heterogeneously integrated semiconductor device includes a substrate comprising a first material; a recess formed within the substrate and having a bottom portion with a first width, a top portion with a second width and a middle portion with a third width larger than the first width and the second width; and a first semiconductor layer filled in the bottom portion and including a second material different from the first material.

Patent TWI304757B

Semiconductor device and the manufacturing method thereof

The present disclosure discloses a method forming a semiconductor light-emitting unit, comprising the steps of providing a semiconductor substrate; epitaxially growing a reaction layer on the semiconductor substrate; and epitaxially growing a buffer layer on the reaction layer; wherein the buffer layer and the semiconductor substrate are lattice-mismatched, and a dislocation density of the buffer layer is smaller than smaller than 1*109 cm−2.

Rod-shaped mesoporous powder, humectant adsorbing powder, and cosmetic preparation using the same

A rod-shaped mesoporous powder which is mainly composed of silicon oxide and has homogenous pore, and obtained by a process comprises, a dissolution step wherein a concentration of 0.3-1.2M of a silicate which is in the range of 0<SiO 2 /Y 2 O<2 (Y: alkali metal atom) is dissolved in the presence of a cationic surfactant and the pH is 11 or more, a condensation step wherein the pH is adjusted to 10.5 or less within 30 minutes, a rod micelle is formed with said cationic surfactant and a silicate is condensed on said rod micelle, and a removal step wherein said cationic surfactant is removed from a micelle state condensation which has an outer shell made of the silicate by said condensation.

Aav vectors encoding parkin and uses thereof

The disclosure relates, in some aspects, to compositions and methods for delivery of transgenes to a subject. In some embodiments, the disclosure provides expression constructs (e.g., vectors containing an expression construct) comprising a transgene encoding human Parkin or a portion thereof. In some embodiments, the disclosure provides methods of treating a neurodegenerative disease (e.g., Parkinson's disease) by administering such expression constructs to a subject in need thereof.

Coupling

Chromatography medium for use in purification of enveloped virus particles or exosomes

An anion exchange chromatography medium (1) for use in purification of enveloped virus particles or exosomes from a feed, the anion exchange chromatography medium comprising a support material being functionalized with a ligand comprising a diamine functionality generating at least one weak anion exchange group to an ionic capacity of 10-500 µmol/mL.

A method for separating adeno-associated virus capsids, compositions obtained by said method and uses thereof

The present disclosure is directed to a method for separating adeno-associated virus capsids fully packaged with genetic material from adeno-associated virus capsids not fully packaged with genetic material, the method comprising the following steps: a) adding a liquid sample comprising adeno-associated virus capsids to a chromatography material, wherein the liquid sample comprises adeno-associated virus capsids of a purity of at least 90% and of a concentration of at least 1012 adeno-associated virus capsids/ml, of which at least 10% of the adeno-associated virus capsids are adeno-associated virus capsids fully packaged with genetic material, wherein the chromatography material comprises a strong, or partially strong, anion exchange chromatography material comprising a support and a ligand for binding to the adeno-associated virus capsids; wherein the chromatography material comprises a surface extender connecting the ligand to the support, wherein the surface extender is a polymer, wherein the polymer is selected from: (i) a polymer having a naturally occurring skeleton, such as a polysaccharide, such as starch, cellulose, dextran, or agarose; and (ii) a polymer having a synthetic skeleton, such as a polyvinyl alcohol, a polyacrylamide, a polymethacrylamide, or a polyvinyl ether; b) eluting the adeno-associated virus capsids fully packaged with genetic material from the chromatography material; wherein the adeno-associated virus capsids eluted in step (b) are eluted into eluate fractions, which eluate fractions combined comprise at least 50% of the adeno-associated virus capsids of the liquid sample added in step (a), of which at least 60% of the adeno-associated virus capsids are fully packaged with genetic material. Further disclosed are compositions, including pharmaceutical compositions, obtained by said separation method, as well as uses of such compositions, and uses of an anion chromatography material for separation of adeno-associated virus capsids.

Complex fluid machine

A complex fluid machine ( 100 ) comprises a compressor device ( 110 ) for a refrigerating cycle ( 20 ) and an expansion device ( 120 ) for Rankine cycle ( 30 ) to collect waste heat from an engine ( 10 ) and convert into a rotational force, wherein the compressor device ( 110 ) and the expansion device ( 120 ) are arranged in a fluid machine housing ( 111, 101 c , 121 ), but those devices ( 110, 120 ) are operatively independent from each other. The compressor and expansion devices ( 110, 120 ) are formed as scroll type devices, and each of the fixed scroll wraps ( 112 b , 122 b ) are formed at a common base plate ( 101 ) and extend in opposite directions.

Gene therapies for lysosomal disorders.

La divulgación se refiere, en algunos aspectos, a composiciones y métodos para el tratamiento de las enfermedades asociadas con una función lisosomal aberrante, por ejemplo, la enfermedad de Parkinson (PD) y la enfermedad de Gaucher. En algunas modalidades, la divulgación proporciona las construcciones de expresión que comprenden un transgén que codifica la beta-glucocerebrosidasa (GBA) o una porción de la misma, solo o en combinación con uno o más genes asociados con la PD. En algunas modalidades, la divulgación proporciona métodos para el tratamiento de la enfermedad de Parkinson por medio de la administración de las construcciones de expresión a un sujeto que lo necesite.

A fluid-driven lighting apparatus

Composite type compressor

A dynamotor capable of operating as either a motor or a generator is used with both the armature portion and the field portion thereof capable of being rotated. In the case where a pulley operatively interlocked with the output shaft of the prime mover is mounted on the rotary shaft of the armature portion, the drive shaft of the compressor is mounted on the rotating field portion. Once the dynamotor is operated in motor mode, the rotational speed of the compressor is increased to the sum of the input rotational speed and the rotational speed of the dynamotor. The compressor is stopped by disconnecting a power feed circuit. When the input rotational speed is too high, the dynamotor is operated in generator mode. In this way, the rotational speed is reduced in accordance with the generated electric energy.

Method for inactivating Zika virus and for determining the completeness of inactivation

The present disclosure relates to methods for inactivating a Zika virus which can be used in vaccines and immunogenic compositions. The present disclosure also relates to a method for determining the completeness of inactivation of an arbovirus preparation.

Gene therapies for lysosomal disorders.

La descripción se refiere a composiciones y métodos para el tratamiento de enfermedades asociadas con una función lisosomal anómala, tales como la enfermedad de Parkinson y la enfermedad de Gaucher. La descripción proporciona construcciones de expresión que comprenden un transgén que codifica beta-glucocerebrosidasa, un ARN inhibidor que se dirige a alfa-sinucleína, o una combinación de los anteriores. La descripción proporciona, además, métodos para tratar la enfermedad de Gaucher, la enfermedad de Parkinson u otras sinucleinopatías mediante la administración de dichas construcciones de expresión a un sujeto que lo necesita.