COMPOSITIONS OF SILICONE FOR PAPERS PELABLES PRESENTING OF THE CHARACTERISTICS OF SEPARATION AMELIOREES

Derivatives mono and di-alkenyl substituted maleic acid used to prevent early hardening of polysiloxane materials molding, molding compositions of polysiloxanes containing such inhibitors.

FILM DOUBLE-LAYERED Of a PHOTOVOLTAIC MODULE

La présente invention concerne un film thermoplastique bi-couches d'un module photovoltaïque, comprenant deux couches dont une couche forme l'encapsulant (22) et l'autre couche forme le backsheet (26), l'ensemble encapsulant-backsheet (22, 26) présentant une épaisseur supérieure à 100 µm (micromètre), caractérisé en ce que : a) l'encapsulant (22) consiste en une couche comprenant : - de 0% à 100% d'une ou plusieurs polyoléfines contenant un polyéthylène choisi parmi un homopolymère de l'éthylène ou un copolymère comprenant au moins 50% en moles d'éthylène et d'un ou plusieurs comonomères ; - de 0% à 100% d'un polymère greffé polyamide comprenant un tronc en polyoléfine, représentant de 50% à 95% en masse du polymère greffé polyamide, contenant un reste d'au moins un monomère insaturé (X) et au moins un greffon en polyamide, représentant de 5% à 50% en masse dudit polymère greffé polyamide. b) le backsheet (26) comprend une couche formée d'un polymère greffé polyamide identique à celui de ...

FILM BI-LAYERS OF A PHOTOVOLTAIC MODULE

FILM DOUBLE-LAYERED Of a PHOTOVOLTAIC MODULE

La présente invention concerne un film thermoplastique bi-couches d'un module photovoltaïque, comprenant un encapsulant (22) consistant en un polymère greffé polyamide comprenant un tronc en polyoléfine, et un backsheet (26) comprenant une couche formée d'un polymère dont le module d'Young est supérieur à 1,1 GPa, de préférence supérieur ou égal à 1,3 GPa. L'invention se rapporte également à un module photovoltaïque incorporant un tel film et à l'utilisation de ce film aux mêmes fins.

PROCESS AND SYSTEM MAKING IT POSSIBLE TO LIMIT PROVIDED ENERGY HAVE a SENSOR

Ce système limiteur d'énergie comprend : - un générateur d'impulsions opérationnel (32) pour générer des impulsions à une fréquence prescrite ; - un pilote de capteur opérationnel (36) pour fournir une tension d'excitation pulsée à un capteur associé (38), où le pilote de capteur (36) fournit en sortie un signal de pilote de capteur qui correspond à la forme d'onde reçue du générateur d'impulsions (32) ; - un circuit résistance-capacité (RC) couplé entre une source de tension pilote associée (34) et le pilote de capteur (36), où le circuit RC contraint une sortie du signal de pilote de capteur (36) à limiter le courant moyen appliqué au capteur associé (38).

FLUOROPOLYMER THERMOPLASTIC ELASTOMER

L'invention concerne un objet ou une partie d'objet fabriqué à partir d'une composition comprenant au moins un fluoropolymère F, dans lequel : l'au moins un fluoropolymère F comprend des motifs de fluorure de vinylidène et au moins 30 % en poids de motifs dérivés d'au moins un monomère de formule (I) : (I) CX1X2=CX3Y, dans laquelle chacun des X1, X2 et X3 est indépendamment choisi parmi H, Cl, F, Br, I et les groupes alkyle comprenant de 1 à 3 atomes de carbone qui sont optionnellement partiellement ou complètement halogénés et Y est un groupe alkyle comprenant de 1 à 3 atomes de carbone qui est optionnellement partiellement ou complètement halogéné ; - la proportion de l'au moins un fluoropolymère F dans la composition est d'au moins 80 % en poids ; et - la viscosité de la composition est d'au moins 1000 Pa.s à une température de 230 °C et à un taux de cisaillement de 100 s-1.

FILM DOUBLE-LAYERED Of a PHOTOVOLTAIC MODULE

PROCESS AND DEVICE TO CARRY OUT IN-SITU AN OPENING CROSSING IN UNPANNEAU HAS SANDWICH COMPOSITE STRUCTURE HAS ALVEOLAR HEART

ANORGANISCHE PIGMENTE

NICHTGEWEBTE THERMOPLASTISCHE KERNHÜLLE AUS FASERVLIESMATERIAL FÜR SAUGFÄHIGE ARTIKEL

AUFBAU EINER ZURÜCKVERBINDUNG MIT BEGRENZTER LEISTUNGSPEKTRUMSDICHTE FÜR MOBILES SATELLITEN KOMMUNIKATIONSSYSTEM

System and method for improving security using intelligent base storage

The present invention presents a system and method for providing improved security within a computer system by using an intelligent based storage system operating with the host unit whereby, the intelligent based storage system independently provides monitoring of files that should not be accessed, monitoring of files that should be accesses with strict regularity, and analysis of access patterns.

Active twist hollow beam system

A system for actively controlling the span-wise rotational twist of a hollow beam along its longitudinal axis, including a hollow beam structure having a leading edge and a trailing edge region, the beam being split along its length, an actuator arranged between split surfaces of the beam, the actuator adapted to move the split surfaces in a longitudinal direction relative to each other, inducing a twist in the beam. The hollow beam is affixed to an external structure at one or both ends, with only the zero warping displacement points of the beam being attached to the external structure, material or device. In one embodiment, the actuator is a plurality of solid blocks with high thermal expansion coefficients arranged between frames of the split surfaces of the beam, with alternating blocks being heated by resistance heaters to cause expansion in the spanwise longitudinal direction.

Hemostasis band with inflatable compartments and methods of using same

The present application discloses various embodiments of a hemostasis band comprising inflatable compartments and methods of using same. These inflatable compartments provide enhanced fit and/or comfort features.

Structural module tie

A structural module (1) has a structural frame having structural members forming floor plates (2), wall plates (3), vertical columns (4), braces (7) extending at angles from the columns to the floor plates, and wall studs. The columns and the braces are configured to transfer vertical loads without assistance from the studs. There may be a module-to-module tie (200) affixed to at least one column, and each tie may be affixed to a top surface of a column, to link columns of adjoining modules together in a horizontal plane, and to accommodate misalignment of the modules in the horizontal plane.

High strength polyvinylidene fluoride composite

The invention relates to fluoropolymer composites having a fluoropolymer matrix containing a functionalized fluoropolymer composition, and reinforced with fibers. The fibers can be chopped fibers, long fibers, or a mixture thereof, and the fluoropolymer matrix preferably is based on polyvinylidene fluoride. Any type of fibers, sized or unsized may be used with the functionalized fluoropolymer matrix composition to form the fluoropolymer composite.

Folding container

Foldable containers and methods of making and using same. A foldable container adjustable between an unfolded condition and a folded condition has a roof panel and an opposing base panel, and a front panel and an opposing door panel. Each of the front panel and the door panel is hingedly connected to only the roof panel. The container includes a first side panel and a disparately sized opposing second side panel. A first extender is associated with the first side panel and a disparately sized second extender is associated with the second side panel. A set of tracks is situated on the first side panel. When folded, the second panel is upwardly adjacent the base panel, the first panel is upwardly adjacent the second panel, a group comprising the front panel and the door panel is upwardly adjacent the first panel, and the roof panel is upwardly adjacent the group.

Scrubbing or scouring pad

The scrubbing or scouring pad of the invention is an artificial sponge made from a foam material that changes firmness or rigidity based on the temperature thereof. The foam sponge is then covered with a plastic mesh to increase the scouring power thereof. If desired, the foam may also include thermochromic additives therein that change the color of the foam based on the temperature. This provides a visual indication of the temperature of the foam.

Transmission of pulse power and data in a communications network

In one embodiment, a method includes transmitting data on two wire pairs carrying pulse power, wherein the pulse power comprises a plurality of voltage pulses with the voltage pulses on the wire pairs offset between the wire pairs to provide continuous power and identifying transitions between at least one of a pulse-on time and a pulse-off time, and a pulse-off time and a pulse-on time on at least one of the wire pairs. Data transmission on the wire pair is controlled during the identified transitions on the wire pair to prevent interference between the pulse power and the data.

Folding Container

A foldable container adjustable between an unfolded condition and a folded condition comprises a roof panel and an opposing base panel, a front panel and an opposing door panel which are each hingedly connected to solely the roof panel, a right side panel and an opposing left side panel, a right side roof skirt and an opposing left side roof skirt having disparate heights, a left side compound beam and a right side compound beam extending from the base panel, and a left side hinge-beam structure and a right side hinge-beam structure each having a hinge point and a skirt retaining portion. The right side panel and the left side panel are hingedly coupled to their respective hinge-beam structures at the hinge points. The hinge points lie in different horizontal planes. The hinge points lie within a midline of their respective side panel.

Claudin6 antibodies and methods of treating cancer

The present disclosure provides antigen-binding proteins which bind to Claudin-6 (CLDN6). In various aspects, the antigen-binding proteins bind to Extracellular Loop 2 (EL2) of the extracellular domain of CLDN6. Related polypeptides, nucleic acids, vectors, host cells, and conjugates are further provided herein. Kits and pharmaceutical compositions comprising such entities are moreover provided. Also provided are methods of making an antigen-binding protein and methods of treating a subject having cancer.

Silicone polymer network compositions

A silicone composition containing a polyethersiloxane block copolymer network and a fluid within the network is useful as a component of various personal care compositions.

Polyether siloxane copolymer network compositions

A composition comprising the reaction products of M a M H b M E c D d D H e D E f T g T H h T E i Q j where M=R 1 R 2 R 3 SiO 1/2 ; M H =R 4 R 5 HSiO 1/2 ; M E =R 6 R 7 R E SiO 1/2 ; D=R 8 R 9 SiO 2/2 ; D H =R 10 HSiO 2/2 ; D E =R 11 R E SiO 2/2 ; T=R 12 SiO 3/2 ; T H =HSiO 3/2 ; T E =R E SiO 3/2 ; and Q=SiO 4/2 ; where R 1 , R 2 , R 3 , R 8 , R 9 and R 12 are independently monovalent hydrocarbon radicals having from one to sixty carbon atoms; R 4 , R 5 and R 10 are independently monovalent hydrocarbon radicals having from one to sixty carbon atoms or hydrogen; R 6 , R 7 , R 11 are independently monovalent hydrocarbon radicals having from one to sixty carbon atoms or R E ; each R E is independently a monovalent hydrocarbon radical containing one or more oxirane moieties having from one to sixty carbon atoms; the stoichiometric subscripts a, b, c, d, e, f, g, h, i, and j are either zero or positive subject to the following limitations: a+b+c>1; b+e+h>1; c+f+i>1; b+e+h>c+f+i; and when d+e+f+g+h+i+j=0, a+b+c=2. In a preferred embodiment the reaction product of the present invention is a polyether siloxane copolymer network. In another preferred embodiment embodiment the reaction product of the present invention is a polyether siloxane copolymer network swollen with a volatile low molecular weight silicon containing compound. These compositions are useful for a variety of personal care compositions.

Cosmetic compositions using polyether siloxane copolymer network compositions

A composition comprising the reaction products of M a M H b M E c D d D H e D E f T g T H h T E i Q j where M=R 1 R 2 R 3 SiO 1/2 ; M H =R 4 R 5 HSiO 1/2 ; M E=R 6 R 7 R E SiO 1/2 ; D=R 8 R 9 SiO 2/2 ; D H =R 10 HSiO 2/2 ; D E =R 11 R E SiO 2/2 ; T=R 12 SiO 3/2 ; T H =HSiO 3/2 ; T E =R E SiO 3/2 ; and Q=SiO 4/2 ; where R 1 , R 2 , R 3 , R 8 , R 9 and R 12 are independently monovalent hydrocarbon radicals having from one to sixty carbon atoms; R 4 , R 5 and R 10 are independently monovalent hydrocarbon radicals having from one to sixty carbon atoms or hydrogen; R 6 , R 7 , R 11 are independently monovalent hydrocarbon radicals having from one to sixty carbon atoms or R E ; each R E is independently a monovalent hydrocarbon radical containing one or more oxirane moieties having from one to sixty carbon atoms; the stoichiometric subscripts a, b, c, d, e, f, g, h, i, and j are either zero or positive subject to the following limitations: a+b+c>1; b+e+h>1; c+f+i>1; b+e+h>c+f+i; and when d+e+f+g+h+i+j=0, a+b+c=2. In a preferred embodiment the reaction product of the present invention is a polyether siloxane copolymer network. In another preferred embodiment embodiment the reaction product of the present invention is a polyether siloxane copolymer network swollen with a volatile low molecular weight silicon containing compound. These compositions are useful for a variety of personal care compositions.

Process for making cosmetic compositions using polyether siloxane copolymer network compositions

A method of making a cosmetic composition comprising the reaction products of M a M H b M E c D d D H e D E f T g T H h T E i Q j where M=R 1 R 2 R 3 SiO 1/2 ; M H =R 4 R 5 HSiO 1/2 ; M E =R 6 R 7 R E SiO 1/2 ; D=R 8 R 9 SiO 2/2 ; D H =R 10 HSiO 2/2 ; D E =R 11 R E SiO 2/2 ; T=R 12 SiO 3/2 ; T H =HSiO 3/2 ; T E =R E SiO 3/2 ; and Q=SiO 4/2 ; where R 1 , R 2 , R 3 , R 8 , R 9 and R 12 are independently monovalent hydrocarbon radicals having from one to sixty carbon atoms; R 4 , R 5 and R 10 are independently monovalent hydrocarbon radicals having from one to sixty carbon atoms or hydrogen; R 6 , R 7 , R 11 are independently monovalent hydrocarbon radicals having from one to sixty carbon atoms or R E ; each R E is independently a monovalent hydrocarbon radical containing one or more oxirane moieties having from one to sixty carbon atoms; the stoichiometric subscripts a, b, c, d, e, f, g, h, i, and j are either zero or positive subject to the following limitations: a+b+c>1; b+e+h>1; c+f+i>1; b+e+h>c+f+i; and when d+e+f+g+h+i+j=0, a+b+c=2. In a preferred embodiment the reaction product of the present invention is a polyether siloxane copolymer network. In another preferred embodiment embodiment the reaction product of the present invention is a polyether siloxane copolymer network swollen with a volatile low molecular weight silicon containing compound. These compositions are useful for a variety of personal care compositions.

Compact, passively athermalized optical assembly

An optical assembly comprises a light beam source, a collimating lens, and a passive thermally-compensated structure. Concentric rings of dissimilar material are supported by a baseplate and arranged to support a flexure plate at a predetermined distance above the baseplate. The collimating lens is mounted on the flexure plate. A difference in the thermal coefficient of expansion of the rings is chosen so that the flexure plate moves to compensate for thermal shifts in system focal length, while maintaining radial and angular alignment of the lens relative to the laser diode source, so as to provide controlled axial movement of the collimating lens.

UV curable non-toxic epoxysilicone release coating compositions

There is provided a curable substantially uniform mixture of an epoxysilicone, a polyarylonium salt and a compatibilizer in the form a mixture of a long chain alkyl substituted phenol and an alkane diol. The curable mixture is convertable to a non-toxic, tack free adherent release coating for pressure sensitive adhesives.

Coffee product

Microcellular synthetic paintbrush bristles

Synthetic microcellular paintbrush bristles are produced having a generally consistent cross-sectional shape along their length and a rough and irregular surface. The bristles comprise 15 to 40% cells on a volume basis, the cells being predominantly closed in the interior of the bristle and being open along the wall to provide the rough and irregular surface.

Process for binding sheets

Binding apparatus and a related process are particularly suited for binding digitally-printed sheets into booklets. The apparatus is adapted to fold individual sheets (2) and then to apply adhesive to the fold line before gathering the sheets in a collator (15) ready for binding. The collator (15) includes either a rotatable or retractable finger (17, 160) that is moveable to temporarily inhibit registration of a first sheet of a new stack on a stacking area, as a previous stack is transported away.

Liquid injection molding inhibitors for curable compositions

Acetylenic maleates, fumarates and related derivative compounds are new compositions of matter having the formula: R.sub.1 O.sub.2 C--CH═CH--CO.sub.2 R.sub.2 wherein R 1 may be an organic moiety containing at least two carbon atoms triply bonded one to the other as: --C.tbd.C-- and R 2 may be hydrogen, an organic moiety, or R 1 ; suitable for use as liquid injection molding inhibitors either singly or in combination with themselves or other liquid injection molding inhibitors when used for the process of liquid injection molding curable compositions enabling an increase in the size of articles manufactured therefrom, which new compositions of matter cure into the polymerizable or curable resins thereby creating new compositions of matter as cured resins from which said articles of manufacture are produced.

Rubber composition, method for its formation, and automotive tire containing the composition

A rubber composition with disperse phase particles containing poly(phenylene ether) can be formed by a method that includes melt blending an uncured rubber with a poly(phenylene ether) composition containing a poly(phenylene ether) and an oil to form an uncured rubber composition, then curing the uncured rubber composition. Before being blended with the rubber, the poly(phenylene ether) composition exhibits a glass transition temperature of about 40 to about 140° C., and during blending with the rubber, the oil component of poly(phenylene ether) composition migrates from the poly(phenylene ether) composition to the rubber, leaving a poly(phenylene ether)-containing disperse phase that gives rise to a second hysteresis peak temperature of about 160 to about 220° C. as measured by dynamic mechanical analysis of the cured rubber composition. Also described are the poly(phenylene ether) composition used in the method, a cured rubber composition formed by the method, and a tire containing the cured rubber composition.

Use of valbenazine for treating schizophrenia or schizoaffective disorder

Provided herein are methods for treating schizophrenia or schizoaffective disorder by administering to a subject in need thereof (,S)-2-amino-3 -methyl-butyric acid (2 R ,3 R ,11b R )-3- isobutyl-9,10-dimethoxy-l, 3,4,6,7, 1 lb-hexahydro-2H-pyrido[2,l-a]isoquinolin-2-yl ester, or an isotopic variant thereof, or a pharmaceutically acceptable salt or polymorph thereof.

Methods for the administration of certain vmat2 inhibitors

Provided are methods of administering a vesicular monoamine transport 2 (VMAT2) inhibitor chosen from valbenazine and (+)-a-3-isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-ol, or a pharmaceutically acceptable salt and/or isotopic variant thereof, to a patient in need thereof wherein the patient is also being administered a strong cytochrome P450 2D6 (CYP2D6) inhibitor.

Dosing regimen for valbenazine

Provided herein are methods for treating neurological disorders by administering to a subject in need thereof (S)-2-amino-3-methyl-butyric acid (2R,3R,11bR)-3-isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-yl ester, or an isotopic variant thereof, or a pharmaceutically acceptable salt or polymorph thereof according to a dosage schedule disclosed herein.

Methods for the administration of certain VMAT2 inhibitors

Provided are methods of administering a vesicular monoamine transport 2 (VMAT2) inhibitor chosen from valbenazine and (+)-α-3-isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-ol, or a pharmaceutically acceptable salt and/or isotopic variant thereof, to a patient in need thereof wherein the patient has mild, moderate, or severe hepatic impairment.

Methods for the administration of certain VMAT2 inhibitors

Provided are methods of administering a vesicular monoamine transport 2 (VMAT2) inhibitor chosen from valbenazine and (+)-α-3-isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-ol, or a pharmaceutically acceptable salt and/or isotopic variant thereof, to a patient in need thereof wherein the patient is also being administered digoxin.

System and method for tactical couponing

A method of selecting coupon offers in real time comprises: providing at least one tactical couponing database having at least one couponing criterion and providing a local unit. The local unit is adapted to: select coupon offers based on the at least one criterion in the at least one tactical couponing database and to generate coupons having the selected coupon offers.

One-part UV-curable epoxy silicone compositions containing a fluorinated alcohol

Epoxysilicone polyether block copolymers, when combined with certain sulfonium photocatalysts, provide one-component shelf-stable UV curable compositions. Non-polyether containing epoxy silicones form one part UV curable compositions with sulfonium salt solubilized in the presence of fluoroalcohols.

Automatic machine vision microscope slide inspection system and method

A system for automatically detecting the presence of contaminants in samples. The system includes a microscope, controllable stage positioner for holding slides under the microscope, a computer for controlling the stage positioner and a digital camera to capture images through the microscope. The system scans microscope views of regions of a slide sample and provides the digital images to the computer. Image processing routines stored in the computer analyze the digital images and determine whether these images may contain certain contaminants by comparing the characteristics of the objects in the image with the known characteristics of the contaminants. The system also contemplates a method for automatically determining the presence of contaminants in samples including the steps of providing a microscope slide containing a sample, obtaining a plurality of digital microscope images of the sample, storing the digital images in a computer, automatically comparing characteristics of each digital image to characteristics of known contaminants and storing the results of the comparison.

Vmat2 inhibitor compounds, compositions, and methods relating thereto

Methods are provided herein for treating psychiatric disorders relating to 22q11.2 deletion syndrome and for selecting subjects for treatment with a VMAT2 inhibitor. The methods provided herein comprise administering a VMAT2 inhibitor to a subject in need thereof.

Single disc intraluminal fixation patent foramen ovale closure device

Systems and methods for identifying pests in crop-containing areas via unmanned vehicles based on crop damage detection

In some embodiments, methods and systems of identifying at least one pest based on crop damage detection in a crop-containing area include an unmanned vehicle including at least one sensor configured to detect at least one type of pest damage on at least one crop in the crop-containing area and to capture pest damage data. An electronic database includes pest damage identity data associated with one or more crop-damaging pests, and a computing device communicates with the unmanned vehicle and the electronic database via a network. The unmanned vehicle transmits the captured pest damage data via the network to the computing device and, in response to receipt of the captured pest damage data from the unmanned vehicle, the computing device accesses the pest damage identity data on the electronic database to determine an identity of one or more pests responsible for the detected type of pest crop damage.

Low profile, broadband, dual mode, modified notch antenna

A low profile, broadband includes an active conductive edge having a shape which approximates a quadratic curve. Two identical elements may be used in an opposed manner to form signals across their respective active edges, and two pairs of opposed identical elements may be used in quadrature for handling circularly polarized signals with a high degree of polarization purity. The quadratic curvature of the elements can provide sufficient space to co-locate a second, smaller antenna within the same volume and aperture as the larger antenna. Applications include combinations of a wide variety of current communications systems.

Reproduction device for planer

EARLY START MODE METHOD AND DEVICE

Vmat2 inhibitor compounds, compositions, and methods relating thereto

Methods are provided herein for treating psychiatric disorders relating to 22q11.2 deletion syndrome and for selecting subjects for treatment with a VMAT2 inhibitor. The methods provided herein comprise administering a VMAT2 inhibitor to a subject in need thereof.

Tablet Dispensing Product

A dispensing product for storing a plurality of cleaning product tablets and individually dispensing them on demand that has a carousel assembly, a base, a lid, and an advancement mechanism. The carousel assembly has a plurality of depressions sized and configured to receive tablets. The base is underneath the carousel assembly. The lid is on top of the carousel and contains an aperture sized and configured such that a tablet can be withdrawn through the aperture. The advancement mechanism is connected to the carousel assembly and advances the carousel assembly rotationally.

Limited combustible cables

A PVDF-containing LC Cable wherein the Cable contains no more than about 50 weight % PVDF, based on the weight of the Cable, is provided.

Aerial system

Press in bottle adapter

An adapter to be pressed into the neck of a bottle to receive a syringe for accessing the bottle contents by a syringe. The adapter has a distal end that extends into the bottle and a normally closed valve located at that distal end to prevent the contents from leaking out of the bottle if the bottle is inverted. An upper flange of the adapter seats against the top of the bottle and is recessed into the top of the bottle to prevent easy access to pry the adapter out of the bottle. A cap is also disclosed that is adapted to be pressed into the neck of a bottle. The cap has an upper lid that is hinged to a lower body to allow the upper hinge to move between a closed position sealing the bottle and an open position where the bottle is accessible by a syringe.

Method and apparatus for controlling a press

A process controller (14) disposed to monitor and control a press (12). The controller (14) monitors an appropriate variable at the press (12) representative of the force produced at the workpiece (40) upon which the press (12) is operating, and compares this force to historical force data associated with the position at which the force was sampled. The historical data is stored in the form of control arrays, where the control arrays are calculated based upon one or more signature arrays stored during satisfactory press (12) operations upon a similar workpiece (40). The calculation of the control arrays takes into account the deviations in the variables monitored at the press (12), which may include force and position. While monitoring the press (12) based upon the HIGH or LOW control arrays, each force value is compared to the values in the HIGH and LOW control arrays at the time of sampling. The press controller (14) is configured to monitor and control a high speed press (12) and provides control functions during the particular press (12) cycle in which unacceptable sample is taken.

Methods for the administration of certain VMAT2 inhibitors

Provided are methods of administering a vesicular monoamine transport 2 (VMAT2) inhibitor chosen from valbenazine and (+)-a-3-isobutyl-9,10-dimethoxy-1,3,4,6,7,11b hexahydro-2H-pyrido[2,1-a]isoquinolin-2-ol, or a pharmaceutically acceptable salt and/or isotopic variant thereof, to a patient in need thereof wherein the patient is a CYP2D6 poor metabolizer.

A general formal concept analysis (fca) framework for classification

Described is a system for data classification using formal concept analysis (FCA). In a training phase, the system generates a FCA classification lattice, having a structure, using a set of training data. The set of training data comprises training presentations and classifications corresponding to the training presentations, in a classification phase, a set of test data having classes that are hierarchical in nature is classified using the structure of the FCA classification lattice.

Use of erasable non-volatile memory for storage of changing information

Non-volatile write-once memory (106, 108, 110) is used for storage of variable data. In an example embodiment, segmented flash memory is used, in which individual segments can be erased. At least two segments are used. When a segment is nearly full (222), or when the segment is corrupted (224), the latest values are written to a new segment (226). During initialization, all variables of interest are written into RAM with default values (204). The flash segment being used is read sequentially from oldest entry to newest entry, and values from flash memory are used to overwrite values (or pointers to values) in RAM (216). RAM then contains (or points to) the most recent value for every variable. When a new segment is written, the new segment is written using the values from RAM (236). The method provides for identification of the latest (current) value for each stored item of information, provides for adding new types of data and deleting old types of data, provides for action when a memory segment is full, and provides for recovery from power-failure.

Caffeine recovery from supercritical carbon dioxide

A process and apparatus for caffeine recovery from supercritical carbon dioxide is disclosed. The process involves countercurrent extraction of caffeine from supercritical carbon dioxide with water at pressures in excess of 1,000 p.s.i. in an unpacked extraction column. The apparatus includes an unpacked extraction vessel having a distributor therein for distributing water throughout substantially the entire cross-sectional area of the vessel.

Integrated electrical generator/starter and air conditioning compressor device and system and method for controlling same

An integrated electrical generator/starter and air conditioning compressor device driven by a common drive shaft, or other direct linkage. The device includes an electrical generator/starter and a compressor. The electrical generator/starter is coupled to the drive shaft. The compressor is coupled to the electrical generator/starter and to the drive shaft and acts to pressurize a flow of refrigerant in response to rotation of the drive shaft. The electrical generator/starter is operable in first and second states. In the first state, the electrical generator/starter generates electricity in response to rotation of the drive shaft. In the second state, the electrical generator/starter utilizes electrical power from a battery to rotate the drive shaft.

METHODS TO GENERATE AND USE ORGANOIDS AND TISSUES IN THEM

métodos para gerar e usar organoides e tecidos nos mesmos. a presente invenção refere-se a métodos para geração de organoide que incluem, por exemplo, geração de um organoide de múltiplos tecidos. o organoide de múltiplos tecidos pode incluir cartilagem, osso, epitélio e/ou tecido conjuntivo fibroso. esta divulgação descreve ainda métodos para isolar células dos organoides e métodos de uso de organoides e células dos organoides. methods for generating and using organoids and tissues therein. the present invention relates to methods for generating organoids which include, for example, generating a multi-tissue organoid. the multi-tissue organoid may include cartilage, bone, epithelium and/or fibrous connective tissue. this disclosure further describes methods for isolating cells from the organoids and methods of using organoids and cells from the organoids.

Rate sensitive thermocouple

Cigarette lighter

Millable blocks for making dental prostheses, associated dental prostheses and methods of making

Floor cleaning apparatus

A floor cleaner is provided for cleaning a floor, where the floor cleaner has a front and a rear and includes: a sweeper for sweeping the floor; a scrubber, connected to the sweeper and located in the rear of the sweeper, for wetting and cleaning the floor; and a burnisher, connected to the scrubber and located in the rear of the scrubber, for burnishing the floor.

Varnish compositions for electrical insulation and method of using the same

A varnish composition for producing an electrically insulative thermoset coating is disclosed. The varnish composition includes a functionalized poly(phenylene ether) having at least one aliphatic unsaturated group and exhibiting an intrinsic viscosity in the range of about 0.06 to about 0.25 deciliter per gram, measured in chloroform at 25°C. The varnish composition further includes an unsaturated polyester resin or vinyl ester resin, a reactive liquid monomer, and a compatibilizing agent. When cured, the polymers and reactive liquid monomer form an electrically insulative thermoset.

VMAT2 inhibitors for treating neurological diseases or disorders

Methods are provided herein for treating mania in mood disorders and other neurological diseases or disorders. The methods provided herein comprise administering a VMAT2 inhibitor to a subject in need thereof. A VMAT2 inhibitor useful in the methods provided herein includes (S)-2-Amino-3-methyl-butyric acid (2R,3R,11bR)-3-isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-yl ester.

Automated guided vehicle

An automated guided vehicle (AGV) comprising: a base frame having an upper portion configured to support a material handling apparatus; a propulsion system adapted to propel the base frame; first and second directional sensors disposed at opposing ends of the base frame and at least one operable to emit a sensor field within at least one slot disposed between the upper portion and a lower portion of the base frame; and wherein the sensor fields of the first and second directional sensors each comprise coverage of at least 180 degrees in a substantially horizontal plane and are arranged to provide a combined sensor field substantially surrounding the AGV.

3-(2-pyrrolidinylmethyl)-indole compounds having 5-ht6 affinity

Described herein are compounds with affinity for the 5-HT6 receptor, which have general formula (I) wherein: R1 is selected from the group consisting of H and C1-4alkyl; R2 is selected from the group consisting of H, C1-4alkyl and benzyl; R3 is selected from the group consisting of COR5, SO2R5, CONHC1-4alkyl and C(S)SR6; R4a is selected from the group consisting of H, OH, halo, C1-4alkyl and C1-4alkoxy; R4b is selected from the group consisting of H, hydroxy, halo, C3-7cycloalkyloxy, C1-4alkoxy; C1-4alkyl, benzyloxy, phenoxy, trifluoromethyl, trifluoromethoxy and vinyl; R4c is selected from the group consisting of H, OH, halo, C1-4alkyl and C1-4alkoxy; R4d is selected from the group consisting of H, OH, halo, C1-4alkyl and C1-4alkoxy; R5 is selected from the group consisting of phenyl, pyridyl, thienyl, quinolinyl and naphthyl which are optionally substituted with 1-4 substituents selected from C1-4alkoxy, C1-4alkyl, halo, nitro, trifluoromethyl, trifluoromethoxy, 1,2-methylenedioxy, C1-4alkylcarbonyl, C1-4alkoxycarbonyl and C1-4alkylS-; and R6 is selected from C1-4alkyl, allyl, propargyl and optionally substituted benzyl wherein the benzyl group is optionally substituted with 1-4 substituents selected from cyano, C1-4alkyl and halo. Also described is the use of these compounds as pharmaceuticals to treat indications where inhibition of the 5-HT6 receptor is implicated, such as schizophrenia.

Improvements relating to the Manufacture of Metal Studded Bands and Treads for Elastic Tyres.

22,720. O'Brien, J. Oct. 5. [Cognate Application, 2/10.] Tread bands, projections, and surfaces.-Non- skid studs h and two-part eyelets a, bare secured to a tread band, preferably of rubber compound and canvas, and perforated to receive them by an operation which simultaneously splays out the tubular shank g of the stud and the tubular part c of one part of the eyelet over the other part of the eyelet, which preferably has spikes e to enter the treadband. The operation is carried out by the press-tools j, shown in Fig. 7, the head of the stud being placed in the recess i, and the tubular part a of the eyelet placed over the shank of the stud with its base in the recess k; the tread band is then placed in position with the second part b of the eyelet. Preferably, a canvas strip n is placed inside the tread band, so that it is held between the splayed ends of the shanks and the parts b of the eyelets.

Methods for the administration of certain VMAT2 inhibitors

Provided are methods of administering a vesicular monoamine transport 2 (VMAT2) inhibitor chosen from valbenazine and (+)-a-3-isobutyl-9,10-dimethoxy- 1,3,4,6,7,1 lb-hexahydro-2H-pyrido[2,l-a]isoquinolin-2-ol, or a pharmaceutically acceptable salt and/or isotopic variant thereof, to a patient in need thereof wherein the patient is also being administered a strong cytochrome P450 3A4 (CYP3A4) inhibitor.

Low precipitate polyamide based tubing

Low precipitate polyamide tubing useful to transport fluids such as automotive fuel.

UV curable epoxysilicone blend compositions

Blends of epoxysilicone polymers and vinyl ether monomers or oligomers and an effective amount of a suitable iodonium photocatalyst provide an ultraviolet curable low viscosity silicone coating composition.

Vmat2 inhibitors for the treatment of hyperkinetic movement disorders

Methods for treating hyperkinetic diseases and disorders, such as tardive dyskinesia, are provided. In a certain embodiment, the potent VMAT2 inhibitor (+)a-3-isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-ol ((+)a-HTBZ) is used in the methods described herein for treating a subject in need thereof.

Methods for the administration of certain vmat2 inhibitors

Provided are methods of administering a vesicular monoamine transport 2 (VMAT2) inhibitor chosen from valbenazine and (+)-a-3-isobutyl-9,10-dimethoxy-1,3,4,6,7,1 lb-hexahydro-2H-pyrido[2,l-a]isoquinolin-2-ol, or a pharmaceutically acceptable salt and/or isotopic variant thereof to a patient in need thereof wherein the patient is being treated with a strong cytochrome P450 3A4 (CYP3A4) inducer.

Methods for the administration of certain vmat2 inhibitors

Provided are methods of administering a vesicular monoamine transport 2 (VMAT2) inhibitor chosen from valbenazine and (+)-a-3-isobutyl-9,10-dimethoxy-1,3,4,6,7,1 lb-hexahydro-2H-pyrido[2,l-a]isoquinolin-2-ol, or a pharmaceutically acceptable salt and/or isotopic variant thereof to a patient in need thereof wherein the patient is being treated with a strong cytochrome P450 3A4 (CYP3A4) inducer.

Piperidine-indole compounds having 5-HT6 affinity

Described herein are compounds with affinity for the 5-HT 6 receptor, which have the general formula: wherein: R 1 is selected from the group consisting of H and C 1-4 alkyl; R 2 is selected from the group consisting of H, C 1-4 alkyl and benzyl; -- -- -- represents a single or double bond; R 3 is selected from the group consisting of COR 5 and SO 2 R 5 ; R 4a is selected from the group consisting of H, OH, halo, C 1-4 alkyl and C 1-4 alkoxy; R 4b is selected from the group consisting of H, hydroxy, halo, C 3-7 cycloalkyloxy, C 1-4 alkoxy, C 1-4 alkyl, benzyloxy, phenoxy, trifluoromethyl, trifluoromethoxy and vinyl; R 4c is selected from the group consisting of H, OH, halo, C 1-4 alkyl and C 1-4 alkoxy; R 4d is selected from the group consisting of H, OH, halo, C 1-4 alkyl and C 1-4 alkoxy; and R 5 is selected from the group consisting of phenyl, pyridyl, thienyl, quinolinyl and naphthyl which are optionally substituted with 1-4 substituents selected from C 1-4 alkoxy, C 1-4 alkyl, halo, nitro, trifluoromethyl, trifluoromethoxy, 1,2-methylenedioxy, C 1-4 alkylcarbonyl, C 1-4 alkoxycarbonyl and C 1-4 alkylS--. Also described is the use of these compounds as pharmaceuticals to treat indications where inhibition of the 5-HT 6 receptor is implicated, such as schizophrenia.

Managing position independent code using a software framework

A method for managing position independent code using a software framework is presented. A software framework provides the ability to cache multiple plug-in's which are loaded in a processor's local storage. A processor receives a command or data stream from another processor, which includes information corresponding to a particular plug-in. The processor uses the plug-in identifier to load the plug-in from shared memory into local memory before it is required in order to minimize latency. When the data stream requests the processor to use the plug-in, the processor retrieves a location offset corresponding to the plug-in and applies the plug-in to the data stream. A plug-in manager manages an entry point table that identifies memory locations corresponding to each plug-in and, therefore, plug-ins may be placed anywhere in a processor's local memory.

Printable paper release compositions

The combination of an aqueous silicone release emulsion selected from the group of aqueous silicone emulsions consisting of condensation curable and addition curable silicone emulsions with an aqueous polyurethane emulsion creates a mixed release emulsion that cures to a linerless release coating which is printable when applied to a substrate such as paper.

Vmat2 inhibitors for the treatment of hyperkinetic movement disorders

Methods for treating hyperkinetic diseases and disorders, such as tardive dyskinesia, are provided. In a certain embodiment, the potent VMAT2 inhibitor (+)a-3-isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-ol ((+)a-HTBZ) is used in the methods described herein for treating a subject in need thereof.

Sound suppression material and method

A sound suppression method includes using a passive noise suppression technology to destructively interfere with a sound wave (200) propagating through a structure (100) at portions (106) of the structure that are positioned apart less than half of a wavelength of the sound wave.

Method and system for efficient emulation of multiprocessor address translation on a multiprocessor host

A method (and system) for emulating a target system's memory addressing using a virtual-to-real memory mapping mechanism of a host multiprocessor system's operating system, includes inputting a target virtual memory address into a simulated page table to obtain a host virtual memory address. The target system is oblivious to the software it is running on.

Heavy peptide approach to accurately measure unprocessed c-terminal lysine

The present disclosure provides a method for accurately measuring post-translational modifications in proteins such as antibodies. In particular, the method pertains to the use of heavy isotopic standards to generate a calibration curve to allow for accurate quantitation of a modified peptide. The method may be used to accurately quantify C-terminal truncation in antibodies using mass spectrometry.

METHOD FOR THE MANUFACTURING OF AN INSTANT COFFEE, INSTANT COFFEE, METHOD OF PREPARING A COFFEE DRINK AND CAPSULE FOR THE PREPARATION OF A COFFEE DRINK

produto de café a presente invenção refere-se a um método para a fabricação de um café instantâneo, o método compreendendo: fornecer um material de café torrado finamente moído; fornecer um extrato aquoso de café; misturar o material de café torrado finamente moído com o extrato de café aquoso para formar uma primeira mistura; e secar a primeira mistura, sendo que, antes da secagem, o material de café torrado finamente moído: (i) é aquecido a uma temperatura de 70 a 100°c em um meio aquoso; ou (ii) é mantido a uma temperatura de 5 a 70°c em um meio aquoso por período de, ao menos, 1 hora. Coffee Product The present invention relates to a method for making an instant coffee, the method comprising: providing a finely ground roasted coffee material; provide an aqueous coffee extract; mixing the finely ground roasted coffee material with the aqueous coffee extract to form a first blend; and drying the first mixture, whereby, prior to drying, the finely ground roasted coffee material: (i) is heated to a temperature of 70 to 100°C in an aqueous medium; or (ii) is maintained at a temperature of 5 to 70°C in an aqueous medium for a period of at least 1 hour.

Polystyrene binding peptides and methods of use

Combinatorially generated peptides are provided that have binding affinity for polystyrene (PS). The peptides may be used to deliver benefit agents to various PS surfaces.

Universal rolling mill

PEDIATRIC DOSAGE FORMS OF VITAMIN D, METHODS OF PREPARATION AND USE

Se describen formas de dosificación pediátricas y de liberación modificada de compuestos de vitamina D, y métodos de elaboración y uso de las mismas.

Cross iteration common sub-expression elimination

Device for converting a displacement in a direction into a force in the same direction

An active optical system is described which includes a mirror deformable by a force applied through a device for converting a displacement in a direction into a force in the same direction. A stepper motor is selectively driven to cause rotation of a nut which drives a shaft longitudinally. Linear displacement of the shaft is applied to force generating flexures which are guided in their flexing by guidance flexures. Force is applied to the mirror by the force generating flexures. The force is maintained even when the stepper motor is not energized. A load cell is interposed between the mirror and the force generating flexures. Signals from the load cell are fed back to a control system.

Vmat2 inhibitors for treating neurological diseases or disorders

Methods are provided herein for treating mania in mood disorders and other neurological diseases or disorders. The methods provided herein comprise administering a VMAT2 inhibitor to a subject in need thereof. A VMAT2 inhibitor useful in the methods provided herein includes (S)-2-Amino-3-methyl-butyric acid (2R,3R,11bR)-3-isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-yl ester.

Purification of cadmium

Claudin6 antibodies and methods of treating cancer

The present disclosure provides antigen-binding proteins which bind to Claudin-6 (CLDN6). In various aspects, the antigen-binding proteins bind to Extracellular Loop 2 (EL2) of the extracellular domain of CLDN6. Related polypeptides, nucleic acids, vectors, host cells, and conjugates are further provided herein. Kits and pharmaceutical compositions comprising such entities are moreover provided. Also provided are methods of making an antigen-binding protein and methods of treating a subject having cancer.

Polypeptide fibers and processes for making them

Described herein are polypeptide fibers, such as silk fibers, produced by regeneration and methods for making the fibers.

Use of erasable non-volatile memory for storage of changing information

Non-volatile write-once memory (106, 108, 110) is used for storage of variable data. In an example embodiment, segmented flash memory is used, in which individual segments can be erased. At least two segments are used. When a segment is nearly full (222), or when the segment is corrupted (224), the latest values are written to a new segment (226). During initialization, all variables of interest are written into RAM with default values (204). The flash segment being used is read sequentially from oldest entry to newest entry, and values from flash memory are used to overwrite values (or pointers to values) in RAM (216). RAM then contains (or points to) the most recent value for every variable. When a new segment is written, the new segment is written using the values from RAM (236). The method provides for identification of the latest (current) value for each stored item of information, provides for adding new types of data and deleting old types of data, provides for action when a memory segment is full, and provides for recovery from power-failure.

BATTERY CHARGING AND DISCHARGING OF MULTIPLE PACKS AT DIFFERENT STATES OF CHARGE (SOCs)

The present disclosure provides a method of selectively charging or discharging a system with multiple battery packs connected in parallel when at least one of the battery packs has a significantly different voltage or states of charge (SOCs) than the other battery packs. The method includes charging or discharging the battery pack(s) with a voltage or state of charge (SOC) farthest from a target value until the voltage(s) or SOC(s) is within a range of another battery pack at which point the battery packs may be connected and charging or discharging can resume for the set of connected packs. This process is repeated until all the battery packs are at a predetermined minimum or maximum voltage or SOC threshold. The present disclosure also provides a method for selectively operating and charging at least one of a plurality of battery packs depending on the respective states of the battery packs.

Book bindery and trimming apparatus

Book bindery and trimming apparatus which is directly connectable to the output of a digital printer enable substantially automatic book production. Individual sheets are cut from a printed web, folded and driven into a sheet stacker. The stacker collects the sheets onto a pair of vanes mounted on respective drums until the end of a book is reached. At this point the stacker is moved to its next position(s) and the sheets forming the collected book are deposited on a stack collector. Meanwhile, a new pair of vanes present themselves for book collection. The collected book progresses through a stitcher, for wire stitching, and then to the trimming apparatus. The trimming apparatus has a book path inclined downwardly towards a backstop which, in cooperation with front stop fingers, ensures reliable alignment of the book for trimming.

Receiving apparatus for radio beacon systems

Varnish compositions for electrical insulation and method of using the same

A varnish composition for producing an electrically insulative thermoset coating is disclosed. The varnish composition comprises a functionalized poly(phenylene ether), an unsaturated polyester, and/or a vinylester resin. The varnish composition further comprises a reactive liquid monomer and a block copolymer comprising a poly(olefin) block, or a poly(diolefin) block, and at least one terminal poly(alkenyl aromatic) block comprising repeat units derived from an alkenyl aromatic monomer. When cured, the polymers and reactive liquid monomer forms an electrically insulative thermoset that provides superior crack resistance.

Claudin-6 antibodies and drug conjugates

The present disclosure provides antigen-binding proteins which bind to Claudin-6 (CLDN6). In various aspects, the antigen-binding proteins bind to Extracellular Loop 2 (EL2) of the extracellular domain of CLDN6. Related polypeptides, nucleic acids, vectors, host cells, and conjugates are further provided herein. Kits and pharmaceutical compositions comprising such entities are moreover provided. Also provided are methods of making an antigen-binding protein and methods of treating a subject having cancer.

Strip guiding apparatus

Dental prosthesis manufacturing process, dental prosthesis pattern & dental prosthesis made thereby

A dental prosthesis is made by first forming a model of a patient's dentition. A three dimensional digital data corresponding to the surfaces of the model is then created. Based on this data, a three dimensional digital data file is then created substantially corresponding to the dental prosthesis to be manufactured. The three dimensional digital data of the dental prosthesis to be manufactured is next transmitted to automated prototyping equipment, and using the automated prototyping equipment, a wax pattern of the dental prosthesis is manufactured based upon this three dimensional digital data of the dental prosthesis. Finally, using this wax pattern in the lost wax investment casting process, the dental prosthesis is made. Prior to investment casting, marginal edges of the wax pattern are adjusted manually.

Clay-binding peptides and methods of use

Combinatorially generated peptides are provided that have binding affinity for clay. The peptides may be used to deliver benefit agents to various clay surfaces.

Integrated fuel reformer and heat exchanger

An integrated exothermic hydrocarbon fuel reformer ( 12 ) and heat exchanger ( 14 ) is a compact, modular structure in which reaction air pre heating for the ambient air and simultaneous cooling for the hydrogen rich reformate is provided by a nested series of alternating reformate passages ( 42 ) and air passages ( 44 ) created by a corrugated fin ( 38 ) brazed between inner and outer concentric walls ( 32 and 34 ). The reformer outer wall ( 22 ) and air pre heating exchanger outer wall ( 34 ) may be a common structure. In addition, a secondary heat exchanger ( 16 ) of similar structure may be abutted to the primary heat exchanger ( 14 ) for further reformate cooling and further waste heat recovery.

Locking dispenser for a canister

A dispenser system for a canister. The system includes an actuator and a cover that can prevent inadvertent actuation. The actuator may include a button, a stem connector and an actuator housing. The stem connector may include wings with a protrusion to create a snap-fit with the actuator housing, thereby holding the stem connector in place during operation of the dispenser system.

Electrical wiring system

drill rod

Mesh driven strands

A computer implemented method comprises receiving a mesh representing a 3D object, the mesh comprising a plurality of 2D shapes, receiving a strand feature comprising a plurality of virtual strands, and associating each strand of the plurality of virtual strands with a 2D shape of the mesh.

Piperidine-indole compounds having 5-ht6 affinity

Described herein are indole compounds with affinity for the 5-HT6 receptor, which have general formula (I) wherein, R1 is selected from the group consisting of H and C1-4alkyl; R2 is selected from the group consisting of H, C1-4alkyl and benzyl; represents a single or double bond; R3 is selected from the group consisting of COR5 and SO2R5; R4a is selected from the group consisting of H, OH, halo, C1-4alkyl and C1-4alkoxy; R4b is selected from the group consisting of H, hydroxy, halo, C3-7cycloalkyloxy, C1-4alkoxy, C1-4alkyl, benzyloxy, phenoxy, trifluoromethyl, trifluoromethoxy and vinyl; R4c is selected from the group consisting of H, OH, halo, C1-4alkyl and C1-4alkoxy; R4d is selected from the group consisting of H, OH, halo, C1-4alkyl and C1-4alkoxy; and R5 is selected from the group consisting of phenyl, pyridyl, thienyl, quinolinyl and naphthyl which are optionally substituted with 1-4 substituents selected from C1-4alkoxy, C1-4alkyl, halo, nitro, trifluoromethyl, trifluoromethoxy, 1,2-methylenedioxy, C1-4alkylcarbonyl, C1-4alkoxycarbonyl and C1-4alkylS-. Also described is the use of the compounds as pharmaceuticals to treat indications where inhibition of the 5-HT6 receptor is implicated, such as schizophrenia.

Preparation of 2-chloro-5-trifluoromethylpyridine

Valbenazine dosage regimen for the treatment of hyperkinetic movement disorders

Erk inhibitors and uses thereof.

La presente descripción proporciona compuestos y composiciones que son inhibidores de ERK1, ERK2 o ambos, y métodos de uso de los mismos.

Pigment and method of producing the same

Claudin18 antibodies and methods of treating cancer

The present disclosure provides antigen-binding proteins which bind to Claudin-18.2 (CLDN18.2); bispecific antigen-binding proteins which bind to CLDN18.2 and a second antigen; and conjugates thereof. In various aspects, the antigen-binding proteins bind to Extracellular Loop 1 (EL1) of the extracellular domain of CLDN18.2. Related polypeptides, nucleic acids, vectors, host cells, and conjugates are further provided herein. Kits and pharmaceutical compositions comprising such entities are moreover provided. Also provided are methods of making an antigen-binding protein and methods of treating a subject having cancer.

Safety tire, method of making and method of improved traffic safety with use thereof

A tire in which a tire manufacturer has determined the tractive capacity at numerous levels of tread wear, the tire having at least one visual warning indicator located at a tread depth corresponding to a percentage loss of tractive capacity. Also, a method of making the tire and a method improving traffic safety through use of such a tire combined with educating the consumer as to proper use of the tire.