Driver circuitry and operation

This application relates to methods and apparatus for driving a transducer with switching drivers. A driver circuit has first and second switching drivers for driving the transducer in a bridge-tied-load configuration, each of the switching drivers having a respective output stage for controllably switching the respective driver output node between high and low switching voltages with a controlled duty cycle. Each of switching drivers is operable in a plurality of different driver modes, wherein the switching voltages are different in said different driver modes. A controller controls the driver mode of operation and the duty cycle of the switching drivers based on the input signal. The controller is configured to control the duty cycles of the first and second switching drivers within defined minimum and maximum limits of duty cycles; and to transition between driver modes of operation when the duty cycle of one of the switching drivers reaches a duty cycle limit.

Driver circuitry and operation

This application relates to methods and apparatus for driving a transducer with switching drivers. A switching driver has first and second supply node for receiving supply voltages and includes an output bridge stage, a capacitor and a network of switches. The network of switches is operable in different switch states to provide different switching voltages to the output bridge stage. A controller is configured to control the switch state of the network of switches and a duty cycle of output switches of the output bridge stage based on an input signal to generate an output signal for driving the transducer.

Pouched products with enhanced flavor stability

The disclosure provides products configured for oral use, the products including a mixture of a particulate filler, water, one or more organic acids, and one or more flavoring agents, the product having a pH value of less than about 7.0. The products exhibit greater stability over time with respect to whiteness and/or flavor component concentration than products which do not contain one or more organic acids.

Driver circuitry and operation

This application relates to methods and apparatus for driving a transducer with switching drivers where the switching driver has an output bridge stage for switching an output node between switching voltages and a modulator for controlling the duty cycle of the output bridge stage based on an input signal. The switching driver also includes a voltage controller for providing the switching voltages which is operable to provide different switching voltages in different driver modes. A controller is provided to control the driver mode of operation and the duty cycle of the switching driver based on the input signal, and the controller is configured to transition from a present driver mode to a new driver mode by controlling the voltage controller to provide the switching voltages for the new mode and controlling the modulator to vary the duty cycle of the output bridge stage. The change in duty cycle is controlled such that there is no substantial discontinuity in switching ripple due to the mode transition.

Oral products with controlled release

The disclosure provides products configured for oral use, the products including compositions containing an active ingredient and a filler component. The oral products are configured to release at least a portion of the active ingredient when positioned within an oral cavity of a consumer. The release of the active ingredient may be a relatively fast release or a relatively slow release.

Methods of manufacturing an oral composition

The disclosure provides for oral compositions comprising a clarified tobacco extract and one or more filler components. In another aspect, the disclosure provides methods of preparing a clarified tobacco extract. Such methods can comprise processing a tobacco extract through at least one ultrafiltration step to provide a filtered tobacco extract and passing the filtered tobacco extract through a solution comprising one or more non-molecularly imprinted polymer (NIP) to provide the clarified tobacco extract.

Oral compositions with reduced water activity

The disclosure provides for oral compositions and products that can have a relatively low water content and/or a relatively low water activity. Such compositions and products can comprise at least one active ingredient, a filler/carrier component, and water in an amount of less than 10% by weight, based on the total weight of the composition. Further, the compositions and products can have a water activity of about 0.85 or less.

Oral composition with beet material

The disclosure provides products configured for oral use, the products including one or more active ingredients and a beet material, at least a portion of the one or more active ingredients being bound to the beet material. In some embodiments, oral products as described herein may include a beet material, a filler material, and one or more active ingredients, at least a portion of the one or more active ingredients being bound to the beet material and the filler material. Active ingredients included in the product may be configured for release according to different release rates, which rates may depend at least in part on the material to which the active ingredient is bound.

Oral compositions with reduced water content

The disclosure provides for oral compositions that exhibit desired properties associated with moist products while incorporating a relatively low water content. Such compositions may include at least one releasable material, at least one filler/carrier component, and at least one water substitute, such as a polyol. The water substituted may be present in an amount of about 25% by weight or greater based on the total weight of the oral composition, and the compositions and products formed therewith can exhibit a relatively low water activity, such as in the range of about 0.85 or less. The present disclosure further provides methods of forming an oral composition with a mouthfeel corresponding to a moist product while having a relatively low water activity.

Oral composition with nanocrystalline cellulose

The disclosure provides a composition including nanocellulose and at least one active ingredient. Further provided is a fleece material including a nonwoven fabric and nanocellulose. The nanocellulose may be cellulose nanofibrils, nanocrystalline cellulose, or bacterial cellulose.

Oral product

The disclosure provides products configured for oral use and a process for preparing such oral products. The products include a cellulose material selected from the group consisting of maize fiber, oat fiber, barley fiber, rye fiber, buckwheat fiber, sugar beet fiber, bran fiber, bamboo fiber, wood pulp fiber, cotton fiber, citrus pulp fiber, grass fiber, willow fiber, poplar fiber, cocoa fiber, derivatives thereof, and combinations thereof; and a cannabinoid.

Oral composition with salt inclusion

The disclosure provides compositions and products configured for oral use, the compositions and products including a filler material, an active ingredient, and a salt component. The salt component may be present in an amount of between about 3.0% and about 4.5% by weight based on the total weight of the composition. The compositions and products as described herein may particularly exhibit a desired flavor profile.

Oral compositions with reduced water content

The disclosure provides for oral compositions that exhibit desired properties associated with moist products while incorporating a relatively low water content. Such compositions may include at least one releasable material, at least one filler/carrier component, and at least one water substitute, such as a polyol. The water substituted may be present in an amount of about 25% by weight or greater based on the total weight of the oral composition, and the compositions and products formed therewith can exhibit a relatively low water activity, such as in the range of about 0.85 or less. The present disclosure further provides methods of forming an oral composition with a mouthfeel corresponding to a moist product while having a relatively low water activity.

Multiple component feed methods and systems

Multiple components are selected, conveyed, and measured in a polymerization system. A control system adjusts the system variables to the desired values. Portions of the components can be fed to a pre-contactor before introduction into the polymerization reactor. The catalyst component concentrations and residence times are tightly controlled in the pre-contactor to affect product properties. The pre-contactor can be a single or multiple combinations of a CSTR or plug flow pre-contactors.

Multiple component feed methods and systems

Multiple components are selected, conveyed, and measured in a polymerization system. A control system adjusts the system variables to the desired values. Portions of the components can be fed to a pre-contactor before introduction into the polymerization reactor. The catalyst component concentrations and residence times are tightly controlled in the pre-contactor to affect product properties. The pre-contactor can be a single or multiple combinations of a CSTR or plug flow pre-contactors.

Coating device with gear pump delivery

Die vorliegende Erfindung betrifft eine Beschichtungsvorrichtung sowie ein Verfahren für die Beschichtung von Kleinteilen mit einem bewegbaren Aufnahmeelement (1) zur Aufnahme und Bewegung der Kleinteile (4) und mindestens einer in oder an dem Aufnahmeelement angeordneten Abgabevorrichtung (2) zur Abgabe eines Beschichtungsstoffes in das Aufnahmeelement sowie mindestens einer Versorgungseinrichtung zur Versorgung der Abgabevorrichtung mit dem Beschichtungsstoff, wobei die Versorgungseinrichtung mindestens eine Zuführleitung (8) und mindestens eine Zahnradpumpe (6) zur Förderung des Beschichtungsstoff in der Zuführleitung zur Abgabevorrichtung (2) aufweist. The present invention relates to a coating device and a method for the coating of small parts with a movable receiving element (1) for receiving and moving the small parts (4) and at least one arranged in or on the receiving element dispensing device (2) for dispensing a coating material in the receiving element and at least one supply device for supplying the dispensing device with the coating material, wherein the supply device has at least one feed line (8) and at least one gear pump (6) for conveying the coating material in the feed line to the dispensing device (2).

Automatic infusion pump tester

Multiple component feed methods and systems

Multiple components are selected, conveyed, and measured in a polymerization system. A control system adjusts the system variables to the desired values. Portions of the components can be fed to a pre-contactor before introduction into the polymerization reactor. The catalyst component concentrations and residence times are tightly controlled in the pre-contactor to affect product properties. The pre-contactor can be a single or multiple combinations of a CSTR or plug flow pre-contactors.

Multiple component feed methods and systems

Multiple component feed methods and systems

Multiple components are selected, conveyed, and measured in a polymerization system. A control system adjusts the system variables to the desired values. Portions of the components can be fed to a pre-contactor before introduction into the polymerization reactor. The catalyst component concentrations and residence times are tightly controlled in the pre-contactor to affect product properties. The pre-contactor can be a single or multiple combinations of a CSTR or plug flow pre-contactors.

Multiple component feed methods and systems

Multiple components are selected, conveyed, and measured in a polymerization system. A control system adjusts the system variables to the desired values. Portions of the components can be fed to a pre-contactor before introduction into the polymerization reactor. The catalyst component concentrations and residence times are tightly controlled in the pre-contactor to affect product properties. The pre-contactor can be a single or multiple combinations of a CSTR or plug flow pre-contactors.

Multiple component feed methods and systems

Multiple components are selected, conveyed, and measured in a polymerization system. A control system adjusts the system variables to the desired values. Portions of the components can be fed to a pre-contactor before introduction into the polymerization reactor. The catalyst component concentrations and residence times are tightly controlled in the pre-contactor to affect product properties. The pre-contactor can be a single or multiple combinations of a CSTR or plug flow pre-contactors.

Shoe cover with slip-resistant sole

A shoe or foot covering with slip-resistant properties is disclosed. In particulars the foot covering includes slip-resistant portions made from a polymeric material that are preferably applied to the bottom surface of the foot covering. The polymeric material contains a metallocene catalyzed branch copolymer which has rubber-like properties.

Absorbent article having a hydrophobic transport layer

An absorbent article comprises an absorbent body of a hydrophilic material having a liquid permeable top cover which has an effective average pore size. A liquid permeable transport layer is located between the top cover and absorbent body. This is made of a material which is less hydrophilic than the absorbent body and has an effective pore size smaller than the topcover pore size. Pref. the absorbent body includes an absorbent hydrogel polymer material.

Absorbent article having a fastening system

A folded absorbent article is provided. The folded absorbent article includes an absorbent assembly having a liquid permeable inner layer, an outer layer, and an absorbent body between the inner and outer layers. The folded absorbent article further includes a pair of ears extending outward from absorbent assembly in the back waist region, with each ear including a loop fastening component, and a pair of spaced-apart hook fastening components on the outer layer in the front waist region. A pair of longitudinally extending foldlines are also provided in the front waist region. An outboard-most longitudinal edge of each of the hook fastening components is spaced apart from a respective side of the absorbent assembly, and an inboard-most longitudinal edge is spaced apart from a respective longitudinally extending foldline at least a distance equal to a predetermined process range.

Disposable bib with an improved pocket formed with an accordion fold

A protective bib garment includes a base sheet member which has lengthwise extending side edges and longitudinal end portions. A catcher member connects to the base sheet member and extends transversely thereacross to form a catcher pocket. The catcher pocket has lateral side edges connected to the side edges of the base sheet member and has a fold portion connected to one longitudinal end portion of the base sheet member to provide an expandable, transversely extending multiple-V fold section therewith. A fastening mechanism holds the garment on a wearer.

Semiabsorbable bone plate spacer.

Une prothèse médicale utilisée pour réduire une fracture osseuse comprend une plaque de fixation d'os, un élément d'espacement pour cette plaque, lequel élément d'espacement consiste en un mélange d'un polymère non absorbable et d'un polymère bioabsorbable, et des moyens de fixation de la plaque d'os et de l'élément d'espacement de la plaque d'os sur l'os. A medical prosthesis used to reduce a bone fracture comprises a bone fixation plate, a spacer for this plate, which spacer consists of a mixture of a non-absorbable polymer and a bioabsorbable polymer, and means for securing the bone plate and the bone plate spacer to the bone.

Programmable port sense and control signal preprocessor for a central office switching system

A community office switching system includes a three-level hierarchy of distributed processors operating in parallel with one another to control the operation of a central office matrix switch network interconnecting 1,920 ports. At the highest level, a stored-program call control processor controls call progression, establishing paths through the matrix switch network. At the second level, a series of special-purpose, stored-program, port control processors each service 960 ports, sensing and transmitting supervisory signals and communicating the occurrence of significant port events to the call control processor. Each port event control processor dedicates approximately 32 microseconds out of every 32 milliseconds to each of the 960 ports in time-multiplexed fashion, and hence no port can ever be locked out at the port-control-processor level. One from a series of stored programs is executed to service each port precisely one every 32 milliseconds. At the lowest level, a digital filtering processor, associated with each port control processor, samples some signals from each port once every millisecond, filters the sampled signals to give one filtered sample every four milliseconds, and stores the filtered samples for presentation to the associated port control processor once every 32 milliseconds.

Material for electric contacts based on silver-tin oxide or silver-zinc oxide and process for its production

A material for electric contacts based on silver-tin oxide is obtained by mixing a powder of silver or an alloy mainly containing silver with a powder consisting mainly of tin oxide and 0.01 to 10 wt. % (in relation to the quantity of tin oxide) of an additive consisting of one or more compounds containing silver, oxygen and a metal from sub-groups II to VI of the periodic system and/or antimony, bismuth, germanium, indium and gallium, compacting the mixture and sintering it. The tin oxide may be replaced by zinc oxide.

Thermal resistant environmental barrier coating

A process for preparing a silicon based substrate with a protective coating having improved thermal resistance at temperature up to at least 1500° C., and the resulting article.

Optical light pipes with laser light appearance

A simulated laser light system includes a light source which emits substantially parallel light rays and a prismatic element having a plurality of prismatic surfaces. The prismatic surfaces define a curved surface either on the inside or the outside of the prismatic element. The prismatic surfaces redirect the light rays emitted from the prismatic element in a plurality of planes which are perpendicular to a tangent to said curved surface. The simulated laser light system appears to emit light from a centerline of the prismatic element when the light is actually emitted from an exterior surface of the prismatic element.

Optical light pipes with laser light appearance

A simulated laser light system includes a light source which emits substantially parallel light rays and a prismatic element having a plurality of prismatic surfaces. The prismatic surfaces define a curved surface either on the inside or the outside of the prismatic element. The prismatic surfaces redirect the light rays emitted from the prismatic element in a plurality of planes which are perpendicular to a tangent to said curved surface. The simulated laser light system appears to emit light from a centerline of the prismatic element when the light is actually emitted from an exterior surface of the prismatic element.

Optical light pipes with laser light appearance

A simulated laser light system includes a light source which emits substantially parallel light rays and a prismatic element having a plurality of prismatic surfaces. The prismatic surfaces define a curved surface either on the inside or the outside of the prismatic element. The prismatic surfaces redirect the light rays emitted from the prismatic element in a plurality of planes which are perpendicular to a tangent to said curved surface. The simulated laser light system appears to emit light from a centerline of the prismatic element when the light is actually emitted from an exterior surface of the prismatic element.

Method and device for preparing a sample for microstructural diagnostics

Die vorliegende Erfindung bezieht sich auf ein Verfahren zur Präparation einer Probe für die Mikrostrukturdiagnostik, insbesondere für die Transmissionselektronenmikroskopie TEM, die Rasterelektronenmikroskopie oder die Rontgenabsorptionsspektroskopie, wobei eine flache, bevorzugt planparallele Scheibe entlang ihrer beiden gegenüberliegenden Oberflächen jeweils so mit einem energiereichen Strahl bestrahlt wird, dass durch strahlbedingten Materialabtrag in diese beiden Oberflächen jeweils eine bevorzugt parallel zu einer zentralen Scheibenebene verlaufende Vertiefung eingebracht wird, wobei diese beiden Vertiefungen beidseits dieser/einer zentralen Scheibenebene verlaufend so eingebracht werden, dass sich ihre Längsachsen, bei Projektion dieser Längsachsen auf diese zentrale Scheibenebene gesehen, unter einem vordefinierten Winkel α > 0°, bevorzugt α ≥ 10°, bevorzugt α ≥ 20°, bevorzugt α ≥ 30°, schneiden und dass im Schnittbereich der beiden Vertiefungen zwischen diesen ein bevorzugt bereits elektronenstrahltransparenter Materialabschnitt vordefinierter minimaler Dicke, gesehen senkrecht zu dieser zentralen Scheibenebene, als Probe verbleibt. Die Erfindung bezieht sich auch auf eine entsprechend ausgebildete Vorrichtung. The present invention relates to a method for the preparation of a sample for microstructure diagnostics, in particular for transmission electron microscopy TEM, scanning electron microscopy or X-ray absorption spectroscopy, wherein a flat, preferably plane-parallel disc is irradiated along its two opposite surfaces each with a high-energy beam that a recess extending preferably parallel to a central disk plane is introduced by beam-induced removal of material into these two surfaces, wherein these two depressions are introduced running on both sides of this / a central disk plane such that their longitudinal axes, viewed in projection of these longitudinal axes on this central disk plane, at a predefined angle α> 0 °, preferably α ≥ 10 °, ...

Method for preparing a sample for microstructural diagnostics and sample for microstructure diagnostics

Verfahren zur Präparation einer Probe (P) für die Mikrostrukturdiagnostik, worin durch materialabtragende Laserstrahlbearbeitung aus einem Substrat ein Probenkörper (PK) mit vorgebbarer Gestalt präpariert und anschließend ein Zielabschnitt (ZA) des Probenkörpers mittels Laserstrahlbearbeitung und/oder Ionenstrahlbearbeitung zur Freilegung eines für eine Mikrostrukturuntersuchung geeigneten Zielvolumens (ZV) weiterbearbeitet wird, mit folgenden Schritten:(a) Freistellen des Probenkörpers (PK) aus dem Substrat mittels mindestens einer Laserbearbeitungsoperation durch Einstrahlen mindestens eines Laserstrahls senkrecht und/oder schräg zu einer Substratoberfläche (SO) derart, dass ein Probenkörper entsteht, welcher an einer Probenkörper-Oberseite (PO) durch einen Bereich der Substratoberfläche sowie seitlich durch schräg oder senkrecht zu der Substratoberfläche orientierte Seitenflächen (S1, S2, S3) begrenzt ist, wobei eine Gestalt des Probenkörpers erzeugt wird, die mindestens einen massiven Handhabungsabschnitt (HA, HA1, HA2) und angrenzend an den Handhabungsabschnitt einen relativ zum Handhabungsabschnitt dünneren Zielabschnitt (ZA) aufweist, welcher an einer Schmalseite durch die Probenkörper-Oberseite (PO) und seitlich durch die senkrecht oder schräg zur Probenkörper-Oberseite verlaufende Seitenflächen (S1, S3) begrenzt ist;(b) Herstellen eines von dem Probenkörper gesonderten Probenkörper-Halters (PH), der an die Gestalt des Probenkörper angepasste Aufnahmestrukturen zum Aufnehmen des Probenkörpers in einer definierten Aufnahmeposition aufweist;(c) Entnehmen des freigestellten Probenkörpers aus dem Substrat;(d) Fixieren des aus dem Substrat entnommenen Probenkörpers an den Aufnahmestrukturen des Probenkörper-Halters;(e) Durchführen mindestens einer weiteren materialabtragenden Bearbeitung mindestens einer Seitenfläche des Probenkörpers im Bereich des Zielabschnitts mittels lonenstrahlbearbeitung zur Freilegung des Zielvolumens, wobei beim Fixieren des Probenkö ...

Method for preparing a sample for the microstructure diagnosis and sample for micro structure diagnosis

Method for the preparation of a sample for microstructure diagnostics

Sample holder with a well having a wicking promoter

Sample holding system, including methods and apparatus, including a holder defining a well having a wicking promoter that encourages flow of a sample to the bottom of the well. Methods of making and using the holder are also disclosed.

Oral product and method of manufacture

The disclosure provides products configured for oral use, the products including a mixture of a filler, a sugar alcohol, a salt, an alginate, a sweetener, at least one flavoring agent or at least one active ingredient or at least one of both a flavoring agent and an active ingredient, an optional natural gum; and water. The disclosure also provides methods for manufacturing products configured for oral use.

Oral product comprising a cannabinoid

The disclosure provides solid products configured for oral use and a process for preparing such solid oral products. The products contain an emulsion including a continuous phase and a dispersed phase. The emulsion includes at least one cannabinoid.

Oral product with dissolvable component

A pouched product adapted for release of a water-soluble component therefrom is provided herein. The pouched product can include an outer water-permeable pouch defining a cavity containing a composition that includes a water-soluble component capable of being released through the water-permeable pouch, wherein at least one of the outer water-permeable pouch and the composition is orally dissolvable.

Stimulus-responsive pouch

The disclosure provides a pouched product including a chromogenic material or an electronic component, wherein the chromogenic material and the electronic component are responsive to a stimulus. Such products can be employed to detect various changes associated with the pouched product.

Process

The disclosure provides a pouched oral product, including a saliva permeable pouch and an oral product incorporated within the pouch, wherein the pouch material contains a cannabinoid or has a cannabinoid on its outer surface. Further provided is a process for preparing such a pouched oral product. The process includes providing the oral product, incorporating the oral product within the pouch to provide a pouched oral product; and applying a cannabinoid to the surface of the pouch or applying a cannabinoid to the oral product through the pouch.

Nanoemulsion for oral use

The disclosure provides a nanoemulsion including an oil, water, an emulsifying agent, and an active ingredient, flavorant, or a combination thereof. The nanoemulsion is intended for human oral use.

Agents for oral composition

The disclosure provides compositions and products configured for oral use. For example, a composition is provided that includes a foam containing a lipid and an active agent and/or a flavorant, and a carrier, wherein the foam is adsorbed onto the carrier. Such a foam can be incorporated, e.g., within lozenges and/or pouched oral products. The disclosure further provides an oral product (e.g., a lozenge and/or pouched oral product) including an encapsulated agent, wherein the encapsulated agent is a porous bead with an exterior portion and an interior portion containing a lipid and an active agent and/or a flavorant.

Oral products

A composition configured for oral use is provided, the composition including a filler in an amount of at least 20% by weight, based on the total weight of the composition, and at least one active ingredient including one or more botanical materials, stimulants, amino acids, vitamins, antioxidants, cannabinoids, cannabimimetics, terpenes, pharmaceutical agents, or a combination thereof. The composition further includes a salt and at least one sweetener. The composition has a moisture content of at least about 40% by weight, based on the total weight of the composition.

Oral products with controlled release

The disclosure provides products configured for oral use, the products including compositions containing an active ingredient and a filler component. The oral products are configured to release at least a portion of the active ingredient when positioned within an oral cavity of a consumer. The release of the active ingredient may be a relatively fast release or a relatively slow release.

Oral product

The disclosure provides products configured for oral use and a process for preparing such oral products. The products include a cannabinoid, a filler, and water. The water content of the oral product is at least about 10% by weight of the oral product, and the water activity of the oral product is no greater than about 0.85.

Oral product comprising a cannabinoid

The disclosure provides a nanoemulsion including an oil phase containing at least one cannabinoid and a water phase; wherein at least one of the oil phase and the water phase includes one or more emulsifying agents; and wherein the zeta potential of the nanoemulsion is less than about -10 mV. Further provided are processes for preparing such nanoemulsions.

Oral product

The disclosure provides products configured for oral use and a process for preparing such oral products. The products include a cellulose material selected from the group consisting of maize fiber, oat fiber, barley fiber, rye fiber, buckwheat fiber, sugar beet fiber, bran fiber, bamboo fiber, wood pulp fiber, cotton fiber, citrus pulp fiber, grass fiber, willow fiber, poplar fiber, cocoa fiber, derivatives thereof, and combinations thereof; and a cannabinoid.

Oral cannabinoid product with lipid component

Meltable compositions configured for oral use, the compositions including at least one cannabinoid or cannabimimetic, are provided. The compositions include one or more fillers, typically a sugar alcohol, and a lipid. A method of forming such compositions is also provided.

Oral products with self-emulsifying system

The disclosure provides solid products configured for oral use. The products contain a lipophilic active ingredient, a self-emulsifying delivery system (SEDS), a binder, and at least one sugar, at least one sugar alcohol, or a combination thereof. The SEDS is configured to provide droplets including the lipophilic active ingredient, the droplets have a D 90 value in a range from about 10 to about 1000 nm.

Pouched products with enhanced flavor stability

The disclosure provides products configured for oral use, the products including a mixture of a particulate filler, water, one or more organic acids, and one or more flavoring agents, the product having a pH value of less than about 7.0. The products exhibit greater stability over time with respect to whiteness and/or flavor component concentration than products which do not contain one or more organic acids.

Oral product with cellulosic flavor stabilizer

The disclosure provides products configured for oral use, the products including a mixture of a particulate filler component, a cellulose derivative, water, and one or more flavoring agents. The products exhibit greater stability over time with respect to flavor component concentration than comparative products which do not contain a cellulose derivative.

Buffered oral compositions

The disclosure provides oral compositions and products including an active agent, a carrier/filler, and a buffer. Preferably, the composition can be configured such that, when in contact with a user's saliva, the composition is at a pH of about 6.5 to about 8. Buffers particularly may include amino acids, such as glycine, or salts thereof, as well as various phosphates.

Oral composition with nanocrystalline cellulose

The disclosure provides a composition including nanocellulose and at least one active ingredient. Further provided is a fleece material including a nonwoven fabric and nanocellulose. The nanocellulose may be cellulose nanofibrils, nanocrystalline cellulose, or bacterial cellulose.

Oral product and method of manufacture

A composition is provided, the composition including a binder system in an amount of at least about 5% by weight, based on the total weight of the composition, and at least one active ingredient and/or flavoring agent. The binder system includes at least one thermoplastic binding material and at least one plasticizer. The composition is typically substantially free of unbleached tobacco material, excluding any nicotine component present.

Oral composition with polymeric component

The disclosure provides oral compositions including at least one active ingredient, a flavorant, or a combination thereof and a polymeric component, the oral compositions having a moisture content of at least about 10% by weight, based on total weight of the oral composition. The polymeric component includes a natural gum, a food grade polymer, or a combination thereof. The natural gum may be a non-galactomannan polysaccharide; a galactomannan polysaccharide selected from the group consisting of fenugreek gum, tara gum, locust bean gum, cassia gum, and combinations thereof; or a combination of guar gum and a second natural gum. The food grade polymer may be selected from proteins, synthetic polymers, non-cellulosic polysaccharides which are not natural gums, and combinations thereof.

Oral product with dissolvable component

A pouched product adapted for release of a water-soluble component therefrom is provided herein. The pouched product can include an outer water-permeable pouch defining a cavity containing a composition that includes a water-soluble component capable of being released through the water-permeable pouch, wherein at least one of the outer water-permeable pouch and the composition is orally dissolvable.

Oral composition with beet material

The disclosure provides products configured for oral use, the products including one or more active ingredients and a beet material, at least a portion of the one or more active ingredients being bound to the beet material. In some embodiments, oral products as described herein may include a beet material, a filler material, and one or more active ingredients, at least a portion of the one or more active ingredients being bound to the beet material and the filler material. Active ingredients included in the product may be configured for release according to different release rates, which rates may depend at least in part on the material to which the active ingredient is bound.

Pouched products with enhanced flavor stability

The disclosure provides products configured for oral use, the products including compositions containing a porous alumina component and a releasable material that is retained in pores of the porous alumina. The releasable material retained in the pores of the porous alumina may be configured for controlled release therefrom.

Oral compositions including gels

The disclosure provides for an oral composition containing a gel. The gel may be formed of a long chain carbohydrate, such as an alginate, that is crosslinked with a suitable crosslinking agent. Other material, such as fillers, active ingredients, flavor components, and the like may be included in the gel or otherwise combined with the gel to form an oral product. The disclosure further provides methods of preparing oral compositions.

Oral composition with salt inclusion

The disclosure provides compositions and products configured for oral use, the compositions and products including a filler material, an active ingredient, and a salt component. The salt component may be present in an amount of between about 3.0% and about 4.5% by weight based on the total weight of the composition. The compositions and products as described herein may particularly exhibit a desired flavor profile.

Oral compositions with reduced water activity

The disclosure provides for oral compositions and products that can have a relatively low water content and/or a relatively low water activity. Such compositions and products can comprise at least one active ingredient, a filler/carrier component, and water in an amount of less than 10% by weight, based on the total weight of the composition. Further, the compositions and products can have a water activity of about 0.85 or less.

Oral products with reduced irritation

The disclosure provides products configured for oral use, the products including one or more agents adapted to or configured to reduce irritation that may be associated with release of a component from the products. Xylitol, in particular, may be useful as an irritation reducing agent. The disclosure further provides methods of reducing irritation associated with the release of one or more components from an oral composition or product.

Lipid-containing oral composition

The disclosure provides a composition including a filler, a lipid having a melting point of about 29°C or above, water, and a flavoring agent or an active ingredient or both a flavoring agent and an active ingredient, which is optionally substantially free of isomalt and substantially free of tobacco material, excluding any nicotine component present, based on the total weight of the composition. The disclosure also provides compositions including a filler, a lipid having a melting point of about 29°C or above, water in an amount of at least about 15% by weight, based on total weight of the composition, and a flavoring agent or an active ingredient or both a flavoring agent and an active ingredient.

Oral products with controlled release

The disclosure provides compositions for oral use and products formed therewith. The compositions can include a carrier component and an active ingredient that are combined so that the active ingredient may be released from the composition in the oral cavity of a consumer in a controlled manner. The carrier component may particularly include a pectin, a gum, and/or an alginate, and preferably may include a low methoxyl pectin.

Moist oral compositions

The disclosure provides for an oral composition, the oral composition including at least one active agent, at least one filler component, and water in an amount sufficient such that the oral composition has a total moisture content of about 15% to about 30% by weight or greater based on the total weight of the oral composition.

Oral products with improved binding of active ingredients

The disclosure provides products configured for oral use, the products including compositions including a filler component including negatively charged groups and an active ingredient including positively charged groups. The active ingredient can be retained by the filler component at least in part through bonding between the negatively charged groups and the positively charged groups such that active ingredient may be release from the product when positioned within an oral cavity of a consumer.

Oral compositions with reduced water content

The disclosure provides for oral compositions that exhibit desired properties associated with moist products while incorporating a relatively low water content. Such compositions may include at least one releasable material, at least one filler/carrier component, and at least one water substitute, such as a polyol. The water substituted may be present in an amount of about 25% by weight or greater based on the total weight of the oral composition, and the compositions and products formed therewith can exhibit a relatively low water activity, such as in the range of about 0.85 or less. The present disclosure further provides methods of forming an oral composition with a mouthfeel corresponding to a moist product while having a relatively low water activity.

Oral cannabinoid product with lipid component

Meltable compositions configured for oral use, the compositions including at least one cannabinoid or cannabimimetic, are provided. The compositions include a lipid and one or more fillers, typically a sugar alcohol. A method of forming such compositions is also provided.

Oral product with a basic amine and an ion pairing agent

The disclosure provides compositions configured for oral use, the compositions including at least one filler, water, a basic amine, and an organic acid, an alkali metal salt of an organic acid, or a combination thereof, wherein the organic acid has a logP value of from about 1.4 to about 8.0. At least a portion of the basic amine is associated with at least a portion of the organic acid or the alkali metal salt thereof. The association is in the form of a basic amine-organic acid salt, an ion pair between the basic amine and a conjugate base of the organic acid, or a combination of both. Further provided are methods for stabilizing a composition configured for oral use and for enhancing a predicted buccal absorption of a composition configured for oral use.

Diaper article with elasticized waist panel

The present invention provides a distinctive absorbent article which includes a backsheet layer which delimits at least one waistband portion of the article. A substantially liquid-permeable topsheet layer is located in facing relation with an inner surface of the backsheet layer, and an absorbent body is located between the topsheet layer and the backsheet layer. An elastic member, which is connected to the waistband portion, is composed of an elastomeric, nonwoven fibrous web material, and is constructed and arranged to shirr the waistband portion.

Housing, in particular lock housing with electrical interconnections

Es handelt sich um ein Schloßgehäuse aus Kunststoff, insbesondere Spritzguß-Kunststoff, für einen Kraftfahrzeugtürverschluß, mit einem oder mehreren elektrischen Bauteilen (6), denen elektrische Leitungen (7) mit Anschlußeinrichtungen zugeordnet sind. Die an die elektrischen Leitungen (7) anzuschließenden Bauteile (6) weisen einen oder mehrere federnde Anschlußleiter (9) zur Kontaktierung mit den Anschlußeinrichtungen (8) der elektrischen Leitungen (7) auf. Außerdem ist vorgesehen, daß die federnden Anschlußleiter (9) der elektrischen Bauteile (6) derart ausgebildet sind, daß die Federwirkung der Anschlußleiter (9) in etwa orthogonal zur Fügerichtung der elektrischen Bauteile (6) ausgerichtet ist. <IMAGE> It is a lock housing made of plastic, in particular injection molded plastic, for a motor vehicle door lock, with one or more electrical components (6), to which electrical lines (7) with connection devices are assigned. The components (6) to be connected to the electrical lines (7) have one or more resilient connecting conductors (9) for making contact with the connecting devices (8) of the electrical lines (7). It is also provided that the resilient connection conductors (9) of the electrical components (6) are designed such that the spring action of the connection conductors (9) is oriented approximately orthogonally to the joining direction of the electrical components (6). <IMAGE>

Housing, in particular lock housing for a motor vehicle door lock, gear housing or similar cable carrier

Gehäuse, insbesondere Schloßgehäuse für einen Kraftfahrzeugtürverschluß, Getriebegehäuse oder dergleichen Leitungsträger, aus Kunststoff, insbesondere Spritzguß-Kunststoff, mit einem oder mehreren elektrischen Bauteilen (6), denen elektrische Leitungen (7) mit Anschlußeinrichtungen (8) zugeordnet sind, wobei die elektrischen Leitungen (7) mit dem Gehäuse fest verbunden sind, dadurch gekennzeichnet, daß – die an die elektrischen Leitungen (7) anzuschließenden Bauteile (6) einen oder mehrere federnde Anschlußleiter (9) zur Kontaktierung mit den Anschlußeinrichtungen (8) der elektrischen Leitungen (7) aufweisen, wobei – für den oder die federnden Anschlußleiter (9) eine Abstützung (17) an dem anzuschließenden Bauteil (6) vorgesehen ist. Housing, in particular lock housing for a motor vehicle door lock, gear housing or similar cable carrier, made of plastic, in particular injection molded plastic, with one or more electrical components (6), to which electrical cables (7) with connection devices (8) are assigned, the electrical cables ( 7) are firmly connected to the housing, characterized in that - The components (6) to be connected to the electrical lines (7) have one or more resilient connecting conductors (9) for contacting the connecting devices (8) of the electrical lines (7), wherein - For the one or more resilient connecting conductors (9) a support (17) is provided on the component (6) to be connected.

Oral compositions including gels

The disclosure provides for an oral composition containing a gel. The gel may be formed of a long chain carbohydrate, such as an alginate, that is crosslinked with a suitable crosslinking agent. Other material, such as fillers, active ingredients, flavor components, and the like may be included in the gel or otherwise combined with the gel to form an oral product. The disclosure further provides methods of preparing oral compositions.

Self-regulating heater utilizing ferrite-type body

A self-regulating heater is provided by placing ferrite-type body member, which is highly lossy when exposed to a high frequency magnetic field and has a predetermined Curie temperature, on or around a central conductor which is connected or is adapted to be connected to a power source which provides high frequency alternating current to the conductor. The current passing through the central conductor produces a magnetic field around the conductor, which causes the ferrite-type body to be heated by internal losses to its Curie temperature. The heater self-regulates at the Curie temperature of the ferrite-type body. The power source is preferably a constant current, impedance matched power source. The ferrite-type body member can be ferromagnetic or ferrimagnetic. The ferrite-type body is preferably ferrimagnetic, such as ferrite beads, rings, and the like, which heat by hysteresis losses.

Compounds and compositions as protein kinase inhibitors

The invention provides novel pyrimidine and pyridine derivatives and pharmaceutical compositions thereof, and methods for using such compounds. For example, the pyrimidine and pyridine derivatives of the invention may be used to treat, ameliorate or prevent a condition which responds to inhibition of anaplastic lymphoma kinase (ALK) activity, focal adhesion kinase (FAK), zeta-chain-associated protein kinase 70 (ZAP-70), insulin-like growth factor (IGF-1R), or a combination thereof.

Compounds and compositions as protein kinase inhibitors

The invention provides novel pyrimidine and pyridine derivatives and pharmaceutical compositions thereof, and methods for using such compounds. For example, the pyrimidine and pyridine derivatives of the invention may be used to treat, ameliorate or prevent a condition which responds to inhibition of anaplastic lymphoma kinase (ALK) activity, focal adhesion kinase (FAK), zeta-chain-associated protein kinase 70 (ZAP-70), insulin-like growth factor (IGF-1R), or a combination thereof.

Closing device for a motor vehicle hood and method

Es ist Aufgabe der Erfindung, eine Schließvorrichtung für ein Kraftfahrzeug bereitzustellen, mit der ein Spalt einer Tür oder Klappe minimiert werden kann. Insbesondere ist es eine Zielsetzung, Verletzungsrisiken gering zu halten. Eine Schließvorrichtung weist zur Lösung ein Gesperre aus Drehfalle und Sperrklinke für ein Verrasten der Drehfalle auf. Es gibt einen Antrieb, mit dem das Gesperre ganz oder teilweise mittels eines Schwinghebels, auch Schwinge genannt, so bewegt werden kann, dass ein Türspalt oder Klappenspalt verkleinert werden kann. Wird also eine Tür oder Klappe geschlossen, so verbleibt zunächst ein Spalt zwischen Tür und Türrahmen bzw. zwischen einem Rahmen und der zugehörigen Klappe. Durch den Antrieb kann die Schwinge und damit das Gesperre oder Teile des Gesperres so bewegt werden, dass sich dieser Spalt verringert. Um das Gewicht und die Zahl der Teile zu minimieren, sind Drehfalle und Sperrklinke vorzugsweise drehbar an der Schwinge durch Achsen befestigt.

Method for making a fastening system for a dynamic fitting diaper

A method for forming a plurality of adhesive fastener assemblies includes the step of providing a substantially continuous web of substrate material along a selected, longitudinal machine-direction (132). The substrate web has a laterally extending cross direction (134) which is substantially perpendicular to the machine direction, and has laterally opposed, longitudinally extending side edge regions (142 and 144) thereof. A selected fastening means, such as a layer of primary adhesive (54), is positioned and applied onto a major facing surface (186) of the substrate web (140). A first longitudinally extending web of stiffening material (154) is attached to the major surface of the substrate web (140) at a location which is proximate a first side edge region (142) of the substrate web. A second longitudinally extending web of stiffening material (156) is attached to the major surface of the substrate web (140) at a location which is proximate the second side edge region (144) of the substrate web (140). The web of substrate material and the webs of stiffening material thereby form a substrate composite (192). The substrate web is separated along a longitudinally extending medial region thereof, with a substantially regularly undulating serpentine separation line (158) to provide an opposed pair of fastener tab subassemblies (194 and 196).

System for detection of spaced droplets

System, including methods and apparatus, for spacing droplets from each other and for detection of spaced droplets.

Disposable absorbent article having a dual fastening system

Thioxanthenone antitumor agents

1-[[(Dialkylamino)alkyl]amino]-4-substituted-thioxanthen-9-ones of the formula: (see above formula) (wherein n is 2 or 3; R1 and R2 are each alkyl; Q is -CH2NHR3, -CH2NR4SO2R7, -CH2NHCHO, -CH=N-Ar, -CO-NR5R6, -CH2NR4COR7, -CH2N(C2H5) CHO or -CH2NR4PO(O-alkyl)2; R3, R4 and R6 are each H or alkyl; R5 is H, alkyl or Ar; R7 is alkyl or Ar; R8 is H, alkyl, alkoxy or halogen; and Ar is phenyl optionally substituted by methyl, methoxy, halogen or nitro) are disclosed as antitumor agents. Compositions containing the thioxanthenones and methods of treating tumors and cancer in mammals with the thioxanthenones are also disclosed.

Tread-disc assist dual truck mounted brake assembly

Brake system for retarding rotating machinery. It has an actuator with a first portion and a second portion. Actuator is supplied with energy and generates force causing relative motion of the first and second portions. The second portion is connected to an actuator lever and the first portion is connected to a brakebeam. The lever has a second pivot connection also connected to the brakebeam and it has a third pivot connection attached to a reaction device. The reaction device is connected to an equalizer lever which is connected to a second brakebeam and a second reaction device. The second reaction device is connected back to the first brakebeam, or to the first portion of the actuator. The brakebeams each have three pivot connections at each end. Two are about parallel to the brakebeam and one is perpendicular. A pair of brake hangers are pivotally attached to the two parallel pivot connections, and a proportionalization lever is pivotally attached to the vertical pivot connection. It receives force from the brakebeam, and conveys the force to force delivery means at its ends. Each brake hanger has means to receive force from the force delivery means at the ends of the proportionalization lever, and each brake hanger has a brake shoe for forcible application to the rotating machinery to retard the rotating machinery.

Method and device for producing (cigarette) packs

The invention relates to a method for attaching banderoles (10) to (cigarette) packs (11), wherein the banderoles (10) are withdrawn from a supply by a banderole conveyor (33), coated with glue during transport and placed and linked by glue in a rolling-off movement of segments (35) on an inward surface of the pack in such a manner that limbs (20) laterally project from the pack surface. During a transversal displacement of the packs (11) during the further transport in receptacles of a connecting conveyor (23), the projecting limbs (20) are folded down. The packs are then distributed to preferably two discharge conveyors (48, 49).

Thermal cautery devices with improved heating profiles and method of testing thermal cautery devices

Thermal cautery and thermal ligating devices (1)improved by the addition of a thermally conductive plate proximate the resistive heating element (11) used in those devices.

Synthesis of cyclodepsipeptide compounds having antineoplastic and/or antimicrobial activity

The present invention is directed to effective methods of synthesizing cyclodepsipeptide compounds having antineoplastic and/or antimicrobial activity. Total syntheses of the eighteen-membered ring cyclodepsipeptides kitastatin (1a) and respirantin (1b) are taught. One important step in the synthesis is an intramolecular transesterification of the ?-ketoester alcohol 6 to afford the protected macrocycle 5. The synthetic products were shown to be identical to the natural products and the absolute stereochemistry of 6 of the 7 asymmetric centers of cyclodepsipeptide 1b was unequivocally established. Kitastatin (1a) and respirantin (1b) were found to be remarkable inhibitors of cancer cell growth and are related to the antimycin family of antibiotics.

System for Producing Heat in Alternating Magnetic Fields

This invention provides a system for providing heating in an alternating magnetic field using lossy heat producing magnetic particles. This invention discloses a system comprising a combination of particles wherein the first particles are lossy heat producing particles, which have a preselected Curie temperature to provide self-regulating heating in the alternating magnetic field, and the second particles are nonlossy particles which have high permeability which are not heat producing particles but which maintain the coupling of the magnetic circuit and maintain the desired magnetic field focus and intensity through the area in which the first lossy heat producing particles are positioned. Thus, in this invention, when the first lossy heating particles approach or are at their Curie temperature and have declining permeability and would otherwise lose the desired coupling with the magnetic circuit, the second nonlossy high permeability particles maintain the coupling of the magnetic circuit as well as the desired intensity of the magnetic field through the first lossy heating particles to provide the desired field strength throughout the heating period. This invention prevents premature loss of heating due to loss of coupling of the magnetic circuit with the lossy heating particles and provide other advantages. This invention also provides magnetic particles coated with an electrically resistive coating, which coated particles exhibit useful properties in the above particle systems.

Propulsion system for integral trains

PROPULSION SYSTEM FOR INTEGRAL TRAINS ABSTRACT OF THE INVENTION A rail vehicle propulsion system having an engine whose speed is a function of a selected vehicle speed an alternator connected to the engine for generating an electrical signal to drive on electric motor connected to the axle by a variable automatic mechanical transmission. The electric motor reflects the load on the axle to the engine through the alternator. The alternator drives a plurality of electric motor transmission combinations. For ease of servicing, the engine and alternator are mounted on a removable pallet.

Oral composition with polymeric component

The disclosure provides oral compositions including at least one active ingredient, a flavorant, or a combination thereof and a polymeric component, the oral compositions having a moisture content of at least about 10% by weight, based on total weight of the oral composition. The polymeric component includes a natural gum, a food grade polymer, or a combination thereof. The natural gum may be a non-galactomannan polysaccharide; a galactomannan polysaccharide selected from the group consisting of fenugreek gum, tara gum, locust bean gum, cassia gum, and combinations thereof; or a combination of guar gum and a second natural gum. The food grade polymer may be selected from proteins, synthetic polymers, non-cellulosic polysaccharides which are not natural gums, and combinations thereof.

4-'7-halo-2-quino(xa-)linyloxy!phenoxy-propionic acid derivatives as antineoplastic agents

The invention provides compounds of the formula (I): wherein A, X, Y, and Z are as defined in the specification. The compounds are effective anti-tumor agents. The invention also provides pharmaceutical compositions comprising a compound of the above formula or a salt thereof, intermediates useful for preparing a compound of the above formula, and therapeutic methods comprising administering a compound of the above formula or a salt thereof to a mammal in need thereof.

Oral composition with salt inclusion

The disclosure provides compositions and products configured for oral use, the compositions and products including a filler material, an active ingredient, and a salt component. The salt component may be present in an amount of between about 3.0% and about 4.5% by weight based on the total weight of the composition. The compositions and products as described herein may particularly exhibit a desired flavor profile.

Fastening system for disposable diaper with disposability feature

There is disclosed a disposable diaper in which the waistband is closed by a mechanical fastener. A second fastener means is included and positioned on the article to enable rolling or folding the garment after use and thereby secure it in a neat bundle for disposal. In the disclosed embodiments, the mechanical fastener is comprised of hook tabs at the rear waistband which engage a patch of loop material adhesively bonded on the front waistband. The second fastener means of the disclosed embodiments utilizes the tabs which engage a compatible component on the garment placed in the same half portion with the tabs. The disclosed species of the second (disposability) fastener means include: (1) tabs comprised of a hook component on one surface and loop component on the opposite surface thereof: or (2) tabs comprised of a hook component and a loop component on the outer surface in the same (rear) half of the garment; or (3) tabs comprised of a hook component and a loop component on the outer surface at the rear half of the cover in the region of the ears which is comprised of either the loop material mounted on the garment outer surface or is a non-woven material portion configured to function with the hook component and perform the secondary fastening function: or (4) tabs comprised of a hook component area and a pressure-sensitive adhesive area, the latter adhesively fastening the tabs to the rear half of the outer polymer cover sheet of the garment: or (5) tabs comprised of a hook component and transverse interlocking slots in the tabs, which link the ends of the rear waistband around the rolled garment to secure it for disposal.

Compounds and compositions as protein kinase inhibitors

The invention provides novel pyrimidine and pyridine derivatives of formula (I) and pharmaceutical compositions thereof, and methods for using such compounds. For example, the pyrimidine and pyridine derivatives of the invention may be used to treat, ameliorate or prevent a condition which responds to inhibition of anaplastic lymphoma kinase (ALK) activity, focal adhesion kinase (FAK), zeta-chain-associated protein kinase 70 ZAP-70), insulin-like growth factor (IGF- 1R), or a combination thereof.

Melanocortin-4 receptor binding compounds and methods of use thereof

Provided are MC4-R binding compounds of the formula XVII: (XVII), wherein L2 is a linker group, and P1, P2, P3, P4, Z1, Z2, Z3, Z4, Z5, t, s, and R are as described in the specification. Methods of using the compounds to treat MC4-R associated disorders, such as disorders associated with weight loss, are also provided.

Method, system and composition for soldering by induction heating

This invention provides a method for soldering using induction heating, which is accomplished by the use of lossy heating particles in or on the solder (3) and an alternating magnetic field. The lossy heating particles (3) useful in this invention are magnetic particles, which can be ferromagnetic particles or ferrimagnetic particles, preferably ferrites, which have a Curie temperature at least equal to the flow temperature of the solder (3). These particles thereby provide a self-regulation feature which prevents overheating of the solder in the articles (1, 2) being soldered. The invention also discloses the use of particles with surface properties whereby the particles can either be wetted by the solder (3) and remain in the solder (3) when the solder (3) flows or it can be nonwettable by the solder whereby the particles separate from the solder when the solder flows. This invention also discloses solder compositions (3), systems and assemblies utilizing the above combinations of solder and lossy heating particles (3).

Driver circuitry and operation

This application relates to methods and apparatus for driving a transducer with switching drivers. A switching driver has first and second supply node for receiving supply voltages and includes an output bridge stage, a capacitor and a network of switches. The network of switches is operable in different switch states to provide different switching voltages to the output bridge stage. A controller is configured to control the switch state of the network of switches and a duty cycle of output switches of the output bridge stage based on an input signal to generate an output signal for driving the transducer.

Oral product comprising a cannabinoid

The disclosure provides solid products configured for oral use and a process for preparing such solid oral products. The products contain an emulsion including a continuous phase and a dispersed phase. The emulsion includes at least one cannabinoid.

Heater straps

An elongated flexible heater strip is provided having a transmission line section and a heater section employing a high mu material to control temperature at the Curie temperature of the high mu material; the above elements and a return buss being confined in a conductive sheath having a plurality of transverse slots to render the strap flexible, so that it may be cinched about a member to be heated; a strip of conductive material, such as copper, extending at least along the transmission line section interiorly of said sheath to reduce the resistance thereof and increase the current carrying capacity of the strap.