27-05-2021 дата публикации
Номер: US20210155594A1
Принадлежит:
The present invention relates to novel heterocyclic compounds useful in preparing drugs for the prevention or treatment of diseases associated with STAT3 protein. Specifically, these drugs are useful in the prevention or treatment of solid tumors, blood cancers, radiation or drug-resistant cancers, metastatic cancers, inflammatory diseases, immune system diseases, diabetes, macular degeneration, papillomavirus infections and tuberculosis. 2. The compound claim 1 , or a pharmaceutically acceptable salt or isomer thereof according to claim 1 , wherein{'sub': 1', '2', '3', '1', '2', '3, 'each of X, Xand Xis independently C or N, provided that at least one of X, Xand Xis N;'}{'sub': 1', '1', '6', '1', '6', '1', '6', '1', '6, 'Ris hydrogen, halo, C-C-alkyl, halo-C-C-alkyl, C-Calkoxy or C-C-alkylamino;'}{'sub': 2', '2', '1', '6', '1', '6', '1', '6', '1', '6', '1', '6', '1', '6', '1', '6', '1', '6', '6', '10', '6', '10', '6', '10', '1', '6', '6', '10, 'Ris hydrogen, hydroxy, halo, carboxy, —C(═O)—NH—NH, C-C-alkyl, C-C-alkoxy, halo-C-C-alkoxy, C-C-alkoxy-carbonyl, carboxy-C-C-alkoxy, aminocarbonyl-C-C-alkoxy, C-C-alkoxy-carbonyl-C-C-alkoxy, C-C-aryl, C-C-aryl-oxy, C-C-aryl-C-C-alkyl-aminosulfonyl, C-C-aryl-carbonyl, aminocarbonyl, 5- to 8-membered heterocycloalkyl or 5- to 8-membered heterocycloalkylcarbonyl, wherein'}the heterocycloalkyl has 1 to 3 heteroatoms selected from N, O and S, and the aryl is optionally substituted with nitro or halo;{'sub': 3', '6', '10', '1', '6, 'Ris hydrogen or C-C-aryl-C-C-alkyl;'}{'sub': 4', '1', '6', '1', '6', '1', '6', '1', '1', '6', '4', '1', '6, 'Ris nitro, nitroso, amino, amino-sulfonyl, C-C-alkylsulfonyl-amino, C-C-alkylsulfonylhydroxyamino or halo-C-C-alkylsulfonyl-amino; provided that when Ris C-C-alkyl, Ris not C-C-alkylsulfonyl-amino;'}{'sub': 6', '10, 'A ring is C-C-aryl or 5- or 6-membered saturated or unsaturated heterocycle having 1 to 3 heteroatoms selected from N, O and S;'}{'sub': '2', 'D is —CH— optionally substituted with ...
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