Cementitious foam compositions

Lightweight cementitious foams of the invention have excellent dynamic and dimensional stability due to use of foaming system comprising polycarboxylate surfactant foam generating agent, foam stabilizer (e.g., PVOH), and shrinkage reducing admixture to inhibit plastic shrinkage and micro-cracking of cement. The foaming system can be used in conventional cement mortars or concretes as well as with exemplary cementitious slurry systems of the invention, which include an expansive agent, a cross-linking agent for the foam stabilizer. Microfibers can be used in the foam, slurry, or both, to prevent micro-cracking. Cementitious foams can be made without use of autoclave or lightweight aggregates to achieve enhanced compressive strength and thermal insulation properties that compare favorably with conventional foams and insulation materials at comparable densities.

Electronic throttle on control handle

A steering and engine speed control mechanism for operating a vehicle. The control mechanism has a control handle mounted on the vehicle. The control handle is configured to deflect about an axis by movement of an operator's hand. A steering direction of the vehicle is related to a deflection angle of the control handle about the axis. An actuating element for changing the speed of the engine of the vehicle is attached to the control handle and is conveniently movable by an operator's digit to a plurality of positions to effect the desired speed of the engine.

Work machines and methods and systems to control and determine a position of an associated implement

Work machines and methods and systems to control and determine a position of an associated implement are disclosed. An example work machine including a first vehicle component movable relative to a second vehicle component; and a processor to: cause the first vehicle component to move toward a commanded position; predict a first position of the first vehicle component of the work machine using first processes; determine a second position of the first vehicle component using second processes; and in response to a difference between the first position and the second position, to cause the first vehicle component to move further toward the commanded position to correct for the difference.

Selectively moveable valve elements for aspiration and irrigation circuits

Various arrangements of fluidics systems are disclosed. In one arrangement, an aspiration circuit for a fluidics system is disclosed that selectively controls aspiration. The aspiration circuit comprises an aspiration line operatively connected to a surgical instrument, an aspiration exhaust line operatively connected to a waste receptacle; an aspiration vent line connected at a first end to the aspiration line; and a selectively variable vent valve operatively connected to the aspiration vent line. The variable vent valve may be selectively moved to vary aspiration pressure within the aspiration line. Other fluidics systems are disclosed that include a selectively positionable irrigation valve that may also be incorporated into a fluidics system that includes a variable vent valve.

Urinary catheter assembly

A condom-catheter system includes a condom-catheter with a tube extending to a collection bag. A rotary junction is disposed between the tube that is connected to the condom-catheter and the tube that is connected to the collection bag.

Olefin polymerization processes

A process for producing an olefin polymer employs a gas phase polymerization reactor having a product discharge system comprising first and second pairs of lock hoppers, wherein each pair comprises an upstream lock hopper connected by valve means to the reactor and a downstream lock hopper connected by valve means to the upstream lock hopper and by further valve means to a product recovery system, and wherein a first cross-tie is provided between the upstream lock hoppers of the first and second pairs of lock hoppers and a second cross-tie is provided between the downstream lock hoppers of the first and second pairs of lock hoppers. Operation of the second cross-tie during product removal cycles is controlled in accordance with reactor pressure.

Pressure control in phacoemulsification system

A surgical system comprises a pressurized irrigation fluid source; an irrigation line fluidly coupled to the pressurized irrigation fluid source; a hand piece fluidly coupled to the irrigation line; an irrigation pressure sensor located at or along the pressurized irrigation fluid source or irrigation line; and a controller for controlling the pressurized irrigation fluid source. The controller controls the pressurized irrigation fluid source based on a reading from the irrigation pressure sensor and an estimated flow value modified by a compensation factor.

Piperidinone Derivatives as MDM2 Inhibitors for the Treatment of Cancer

The present invention provides MDM2 inhibitor compounds of Formula I, wherein the variables are defined above, which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor.

Adjustable golf training and teaching device for head and chin adjustment with stereo view of golf ball

A portable, adjustable golf training and teaching device when attached to the golfers hat, assists in head, chin, spine and eye adjustment. The present invention can be adjusted in the address or set-up position to allow the players shoulders to rotate freely under the chin unrestricted, also maximizes the shoulder rotation during the backswing. With the device attached to the brim of a golfer's hat and the viewing holes properly set the device produces a stereo or three dimensional view of the containment area around the golf ball to allow the golfer to monitor any movement in the golf swing. The present invention allows the golfer to view the target and the ball in flight after being struck. The device can be used to train, practice and play on the golf course.

Heterocyclic compounds as mdm2 inhibitors for the treatment of cancer

The present invention provides MDM2 inhibitor compounds of Formula I or II, or the pharmaceutically acceptable salts thereof, wherein the variables are defined above, which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor.

Methods and table supports for additive manufacturing

The present disclosure generally relates to methods for additive manufacturing (AM) that utilize table support structures in the process of building objects, as well as novel table support structures to be used within these AM processes. The table support structures include a first leg portion extending vertically from a build platform; a platform portion including a horizontal top surface supported on the first leg portion; and a plurality of supports extending from the platform portion to a downfacing surface of the object.

Tufting method and brushroll for vacuum cleaner

A method of tufting, with a tufting tool, a brushroll dowel for a vacuum cleaner having a bristle stiffener protruding from the dowel and a bristle hole adjacent the bristle stiffener. The tufting tool includes a notch. The method provides a brushroll with bristles tufted into the bristle hole adjacent the bristle stiffener. A brushroll for a vacuum cleaner can be made using an injection molding process, with bristle stiffeners integrally molded with the dowel and a plurality of stiffened bristles protruding from the brush dowel adjacent to the bristle stiffeners.

Three-Dimensional Printing of Metallic Materials

Methods of printing metallic objects include providing parameters of an object for printing, and controlling a deposition of a fluid metallic material to form the object. At least an outer surface region of the fluid metallic material is converted to a solid region after deposition.

Methods and apparatus to estimate population reach from marginal ratings

Methods, apparatus, systems, and articles of manufacture are disclosed to to estimate population reach from marginal ratings. An example apparatus includes an interface to access marginal ratings of the media for a recorded audience, marginal ratings of the media for a population audience, and reach of the media for the recorded audience; a reach determiner to iteratively estimate a reach of the media for the population audience based on the marginal ratings for the recorded audience, the marginal ratings for the population audience, and the reach for the recorded audience; and the interface to output the estimated reach for the population audience.

Methods and apparatus to estimate population reach from different marginal ratings and/or unions of marginal ratings based on impression data

Example methods, apparatus, and articles of manufacture are disclosed to estimate population reach. An example apparatus includes an association controller to generate a tree association corresponding to a union of a first margin of media and a second margin of the media; and one or more commercial solvers to determine first multipliers by solving first equations corresponding to panelist impressions and panelist audience totals, the second margin, or the union; perform first parallel computations with a processor to determine second multipliers to solve second equations corresponding to the tree association using the first multipliers; discard the first multipliers; perform second parallel computations to determine third multipliers by solving third equations corresponding to the tree association using database proprietor impression totals; and determine an estimate for a population reach of the media for at least one of the first margin, the second margin, or the union based on the third multipliers.

Methods and apparatus for the analysis of fatty acids

Exemplary embodiments of the present disclosure relate to CO 2 -based chromatography for the efficient and precise separation of fatty acids. The present disclosure is based, in part, on the discovery that a CO 2 -based chromatography system with features, such as, e.g., improved pressure stability, improved sample injection, and superior column packing materials, reproducibly resolve fatty acids.

System and method for minimally invasive thermal ablation treatment planning

Various embodiments are described herein for a system and a method for treatment planning for providing ablative therapy to a patient. The treatment planning may involve segmenting images of the patient to define areas to receive treatment, defining trial parameters, simulating treatment of ablative therapy to the patient according to the trial parameters; analyzing a thermal dose distribution resulting from the simulated treatment to determine treatment effectiveness; determining when the treatment effectiveness meets a treatment effectiveness criteria; and providing an indication of the trial parameters when the treatment effectiveness meets the treatment effectiveness criteria.

Kras g12c inhibitors and methods of using the same

Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.

Systems and Methods of Reducing Virus Migration Through A Virus Removal Filter After Feed Flow Reduction

A valve arrangement for reducing the migration of one or more viruses through a filter when feed flow to the filter is resumed after a reduction in the feed flow. The valve arrangement includes an inlet line having an inlet port to be connected to a supply of product and an outlet port to be connected to an inlet of the filter, a pump, an outlet line, and a recirculation system. The recirculation system includes a recirculation line connecting the outlet line and the inlet line, and a check valve disposed along the recirculation line. When the check valve detects the feed flow reduction, a recirculation loop is created such that product is continuously recirculated through the filter during the reduction, thereby ensuring continuous fluid flow through the filter even during the reduction.

Cis-morpholinone and other compounds as mdm2 inhibitors for the treatment of cancer

wherein the variables are defined above, which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor.

Modified spray-dried ziegler-natta (pro)catalyst systems

A modified spray-dried Ziegler-Natta (pro)catalyst system comprising a Ziegler-Natta (pro)catalyst, a carrier material, and a tetrahydrofuran/ethanol modifier; polyolefins; methods of making and using same; and articles containing same.

Surgical cassette having an aspiration pressure sensor

A cassette having a molded flow channel contained on an elastomeric sheet that is bonded or mechanically attached to a rigid substrate. The flow channel projects outwardly from the exterior of the cassette so that a peristaltic pump having pump head rollers mounted radially from the axis of rotation of the pump motor compress the elastomeric flow channels against the rigid substrate during operation.

Fluid pressure sensing chamber

A pressure sensing chamber having a tubing extension with a reduced diameter portion extending through the chamber. The tubing contains a plurality of ports so as to allow the purging of air from the chamber, but the ports are sized so that bubbles entering the tubing cannot easily flow into the chamber. The reduced diameter portion creates a pressure differential between the holes. This differential pressure creates flow through the chamber under high liquid flow and turbulent liquid flow events.

Fluid pressure sensing chamber

A pressure sensing chamber having a tubing extension extending through the chamber. The tubing contains a plurality of ports so as to allow the purging of air from the chamber, but the ports are sized so that bubbles entering the tubing cannot easily flow into the chamber.

Supported polymerization catalyst

A supported catalyst composition comprising the reaction product of i) a magnesium halide, ii) a solvent, iii) an electron donor compound, iv) and a transition metal compound; an inert support; and ,a cocatalyst composition wherein the supported catalyst is substantially free of other alcohols and wherein the molar ratio of the first alcohol to magnesium is less than or equal to 1.9. Methods of making supported catalyst compositions and methods of making polymers with supported catalysts.

Supported polymerization catalyst

Spray Dried Catalyst Compositions, Methods for Their Preparation and Use in Olefin Polymerization Processes

Un método para producir una composición de catalizador soportada para la polimerización de olefinas, que comprende las etapas de: a) formar una suspensión que comprende uno o más soportes porosos en partículas, uno o más compuestos activadores y uno o más compuestos catalizadores en uno o más diluyentes líquidos, en donde la etapa a) se realiza en un tiempo de 5 horas o menos; y b) secar por pulverización la suspensión para formar una composición de catalizador soportada; en donde la etapa b) se realiza a una velocidad suficiente para producir al menos 200 kg de composición de catalizador soportada en un tiempo de 5 horas o menos. A method of producing a supported catalyst composition for the polymerization of olefins, comprising the steps of: a) forming a suspension comprising one or more particulate porous supports, one or more activator compounds, and one or more catalyst compounds in one or more more liquid diluents, wherein step a) is carried out in a time of 5 hours or less; and b) spray-drying the suspension to form a supported catalyst composition; wherein step b) is carried out at a rate sufficient to produce at least 200 kg of supported catalyst composition in a time of 5 hours or less.

De-foaming spray dried catalyst slurries

Polymerization process using a supported constrained geometry catalyst

A POLYMERIZATION PROCESS INCLUDES CONTACTING THE FOLLOWING IN A GAS-PHASE REACTOR SYSTEM UNDER POLYMERIZATION CONDITIONS FOR MAKING A POLYMER PRODUCT: A METALLOCENE-BASED CATALYST SYSTEM INCLUDING A SUPPORTED CONSTRAINED GEOMETRY CATALYST, AT LEAST ONE MONOMER, AND AN ADDITIVE SELECTED FROM A GROUP CONSISTING OF AN ALUMINUM DISTEARATE, AN ETHOXYLATED AMINE, AND A MIXTURE THEREOF. THE ADDITIVE MAY BE SELECTED FROM A GROUP CONSISTING OF AN ALUMINUM DISTEARATE, AN ETHOXYLATED AMINE, POLYETHYLENIMINES, AND OTHER ADDITIVES SUITABLE FOR USE IN THE PRODUCTION OF POLYMERS FOR FOOD CONTACT APPLICATIONS AND END PRODUCTS, INCLUDING A MIXTURE OF A POLYSULFONE COPOLYMER, A POLYMERIC POLYAMINE, AND OIL-SOLUBLE SULFONIC ACID, IN A CARRIER FLUID, AND MIXTURES THEREOF.

polymerization process using a supported constrained geometry catalyst

methods for the static charge production of a catalyst and methods for using the catalyst to produce polyolefins

métodos para a produção de carga estática de um catalisador e métodos para o uso do catalisador para produzir polilefinas. são providos catalisadores e métodos para a produção e uso dos mesmos. o método para a fabricação de um catalisador pode incluir contato de um catalisador suportado com um monômero sob condições que reduzem uma carga total do catalisador a menos do que cerca de 75% de uma carga inicial do catalisador. um método para a polimerização pode incluir introdução de um catalisador pré-polimerizado e uma ou mais olefinas em um reator de leito fluidizado de fase gasosa, operação do reator em condições suficientes para produzir a polilefina, em que a polimerização é realizada na ausência substancial de quaisquer aditivos de continuidade. methods for the static charge production of a catalyst and methods for using the catalyst to produce polyylephins. catalysts and methods for their production and use are provided. The method for manufacturing a catalyst may include contacting a supported catalyst with a monomer under conditions that reduce a total catalyst charge to less than about 75% of an initial catalyst charge. A method for polymerization may include introducing a prepolymerized catalyst and one or more olefins into a gas phase fluidized bed reactor, reactor operation under conditions sufficient to produce the polyylephine, wherein the polymerization is performed in the substantial absence of any continuity additives.

Processes for venting olefin polymerization systems

A process for producing an olefin polymer employs a gas phase polymerization reactor in fluid communication with a vent column and a product discharge system. The discharge system can include first and second pairs of lock hoppers, where each pair includes an upstream lock hopper connected by a valve to the reactor and a downstream lock hopper connected by a valve to the upstream lock hopper and by a further valve to a product recovery system, and where a first cross-tie can be provided between the upstream lock hoppers of the first and second pairs of lock hoppers and a second cross-tie can be provided between the downstream lock hoppers of the first and second pairs of lock hoppers. Upon reaching the vent column's maximum removal capacity, additional gas can be removed from the reactor by reducing the frequency of opening the second cross-tie between the downstream lock hoppers.

Perfusion hyperthermia treatment system and method

A perfusion hyper/hypothermia treatment system (100) comprising: a computer system (110); means for obtaining body fluid having a temperature; a plurality of temperature signals (201, 202, 203) coupled to the computer system (110), the temperature signals representative of temperatures at each of a plurality of patient (99) locations on or within a patient (99); means for generating at least one temperature value representative of at least one of the temperatures; a comparator coupled to the temperature value and to a set of stored parameters in the computer system (110) to generate a comparison value; a signal generator which generates a control signal to control a change in the temperature of the body fluid based on the comparison value; and means for perfusing the body fluid into the patient (99).

Extended catalyst life Fischer-Tropsch process

A process for extending the life of a Fisher-Tropsch catalyst in a process for converting synthesis gas produced in an autothermal reactor by the substoichiometric oxidation of a light hydrocarbon gas by removing ammonia from the synthesis gas prior to passing the synthesis gas to a Fischer-Tropsch reactor.

Motor grader

A motor grader including a main frame, an operational frame movable relative to the main frame in three directions, and a linkage system coupling the operational frame to the main frame. The linkage system includes a plurality of hydraulic cylinders each movable between an extended position and a retracted position to adjust the length thereof. The plurality of cylinders is operationally connected such that movement of one cylinder of the plurality of cylinders causes movement of at least another cylinder of the plurality of cylinders. A processor is configured to receive a signal related to the length of at least one cylinder of the plurality of cylinders, and estimate, based in part on the signal, a position of the operational frame relative to the main frame in the three directions.

Agricultural machine having a processor configured to track a position of a draft frame

A motor grader including a main frame, an operational frame movable relative to the main frame about a primary joint, and a plurality of hydraulic cylinders configured to adjust a position of the operational frame relative to the main frame, where each cylinder of the plurality of cylinders is movable between an extended position and a retracted position to adjust the length thereof. The motor grader further includes a processor configured to receive a signal indicating a desired cross slope of the operational frame, receive a signal identifying one of the plurality of cylinders as a lead cylinder, determine a desired position of the operational frame that achieves the desired cross slope of the operational frame, estimate a current position of the operational frame by monitoring a length of the lead cylinder, and adjust the position of the operational frame by controlling a follower cylinder of the plurality of cylinders to create the desired cross slope.

Surgical cassette having an aspiration pressure sensor

A cassette having a molded flow channel contained on an elastomeric sheet that is bonded or mechanically attached to a rigid substrate. The flow channel projects outwardly from the exterior of the cassette so that a peristaltic pump having pump head rollers mounted radially from the axis of rotation of the pump motor compress the elastomeric flow channels against the rigid substrate during operation.

Surgical Cassette having a plurality of latching surfaces

A cassette having a molded flow channel contained on an elastomeric sheet that is bonded or mechanically attached to a rigid substrate. The flow channel projects outwardly from the exterior of the cassette so that a peristaltic pump having pump head rollers mounted radially from the axis of rotation of the pump motor compress the elastomeric flow channels against the rigid substrate during operation.

Liquid venting surgical cassette

A surgical system having a cassette with an aspirant collection chamber and an aspiration vent line that draws fluid from the aspirant collection chamber. The pressure within the collection chamber is maintained near ambient so that when the aspiration vent line is open, fluid flows from the collection chamber and into the aspiration line. Such a system does not require a second source of irrigation fluid, minimizes pressure surges into the irrigation fluid line and does not affect the fluidic performance of the aspiration system. In addition, various vent pressures can be achieved by varying the vertical position of the reservoir relative to the aspiration line.

Liquid venting surgical system and cassette

A surgical system having a cassette with an aspirant collection chamber and an aspiration vent line that draws fluid from the aspirant collection chamber. The pressure within the collection chamber is maintained near ambient so that when the aspiration vent line is open, fluid flows from the collection chamber and into the aspiration line. Such a system does not require a second source of irrigation fluid, minimizes pressure surges into the irrigation fluid line and does not affect the fluidic performance of the aspiration system. In addition, various vent pressures can be achieved by varying the vertical position of the reservoir relative to the aspiration line.

Method of testing a surgical system

A method of testing a surgical system that takes advantage of the fact that in a balanced irrigation/aspiration system (inflow≧outflow) the duration of the aspiration pressure recovery to the irrigation fluid source pressure immediately following pump stop is independent of pump run time. This method provides a more reliable way of detecting restricted irrigation flow configurations not detectable by the current methods, such as marginal irrigation flow cases that could potentially lead to surgical complications (e.g. chamber collapse during post-occlusion break surge).

Surgical system

A surgical system with a variable controller that allows the user to selectively vary the level of venting performance.

Selectively moveable valve elements for aspiration and irrigation circuits

Various arrangements of fluidics systems are disclosed. In one arrangement, an aspiration circuit for a fluidics system is disclosed that selectively controls aspiration. The aspiration circuit comprises an aspiration line operatively connected to a surgical instrument, an aspiration exhaust line operatively connected to a waste receptacle; an aspiration vent line connected at a first end to the aspiration line; and a selectively variable vent valve operatively connected to the aspiration vent line. The variable vent valve may be selectively moved to vary aspiration pressure within the aspiration line. Other fluidics systems are disclosed that include a selectively positionable irrigation valve that may also be incorporated into a fluidics system that includes a variable vent valve.

Liquid venting surgical cassette

A surgical system having a cassette with an aspirant collection chamber and an aspiration vent line that draws fluid from the aspirant collection chamber. The pressure within the collection chamber is maintained near ambient so that when the aspiration vent line is open, fluid flows from the collection chamber and into the aspiration line. Such a system does not require a second source of irrigation fluid, minimizes pressure surges into the irrigation fluid line and does not affect the fluidic performance of the aspiration system. In addition, various vent pressures can be achieved by varying the vertical position of the reservoir relative to the aspiration line.

Surgical System

A surgical system with a variable controller that allows the user to selectively vary the level of venting performance.

Selectively moveable valve elements for aspiration and irrigation circuits

Various arrangements of fluidics systems are disclosed. In one arrangement, an aspiration circuit for a fluidics system is disclosed that selectively controls aspiration. The aspiration circuit comprises an aspiration line operatively connected to a surgical instrument, an aspiration exhaust line operatively connected to a waste receptacle; an aspiration vent line connected at a first end to the aspiration line; and a selectively variable vent valve operatively connected to the aspiration vent line. The variable vent valve may be selectively moved to vary aspiration pressure within the aspiration line. Other fluidics systems are disclosed that include a selectively positionable irrigation valve that may also be incorporated into a fluidics system that includes a variable vent valve.

Selectively moveable valve elements for aspiration and irrigation circuits

Selectively moveable valve elements for aspiration and irrigation circuits

Pressure control in phacoemulsification system

A surgical system comprises a pressurized irrigation fluid source; an aspiration pressure sensor associated with an aspiration line; and a controller for controlling the pressurized irrigation fluid source. The controller controls the pressurized irrigation fluid source based on a reading from the aspiration pressure sensor and an estimated flow value modified by a compensation factor.

Pressure control in phacoemulsification system

A surgical system comprises a pressurized irrigation fluid source; an irrigation line fluidly coupled to the pressurized irrigation fluid source; a hand piece fluidly coupled to the irrigation line; an irrigation pressure sensor located at or along the pressurized irrigation fluid source or irrigation line; and a controller for controlling the pressurized irrigation fluid source. The controller controls the pressurized irrigation fluid source based on a reading from the irrigation pressure sensor and an estimated flow value modified by a compensation factor.

Testing of pressure sensor in surgical cassette

A method of determining the accuracy of a pressure sensor (54) in a surgical cassette (14) is disclosed. The method involves displacing a diaphragm (64) of the sensor (54) a pre-defined amount of displacement, and measuring the force exerted on the diaphragm (64) by the displacing step. The accuracy of the pressure sensor (54) is determined by comparing the force measured in the measuring step to a pre-defined force for the pre-defined amount of displacement.

Testing of pressure sensor in surgical cassette

A method of determining the accuracy of a pressure sensor in a surgical cassette is disclosed. The method involves displacing a diaphragm of the sensor a pre-defined amount of displacement, and measuring the force exerted on the diaphragm by the displacing step. The accuracy of the pressure sensor is determined by comparing the force measured in the measuring step to a pre-defined force for the pre-defined amount of displacement.

Pressure sensing in surgical console

A method of determining the accuracy of a pressure sensor (56) in a surgical console (12) is disclosed. The method involves actuating a linear actuator (18) so that its plunger (26) is linearly displaced a pre-defined amount, and measuring the force exerted by the plunger (26) on a non-compliant member. The accuracy of the linear actuator (18) and the plunger are determined by comparing the force measured in the measuring step to a pre-defined force.

Pressure sensing in surgical console

A method of determining the accuracy of a pressure sensor in a surgical console is disclosed. The method involves actuating a linear actuator so that its plunger is linearly displaced a pre-defined amount, and measuring the force exerted by the plunger on a non-compliant member. The accuracy of the linear actuator and the plunger are determined by comparing the force measured in the measuring step to a pre-defined force.

Selectively moveable valve elements for aspiration and irrigation circuits

An aspiration circuit for a fluidics system (11) for selectively controlling aspiration, comprises an aspiration line (52) operatively connected to a surgical instrument (42), an aspiration exhaust line (54) operatively connected to a waste receptacle (58). The aspiration vent line (60) is connected at a first end to the aspiration line; a selectively variable vent valve (62) is operatively connected to the aspiration vent line, wherein the variable vent valve may be selectively moved to selectively change aspiration pressure within the aspiration line. An irrigation line (50) is operatively connected to the surgical instrument (42) and an irrigation pressure sensor is operatively connected to the irrigation line (50). An actuator is connected to the vent valve (62), wherein the irrigation pressure sensor and actuator are connected to a controller (40), which is operative to initiate the actuator to move the vent valve in response to predetermined pressure values detected by the irrigation pressure sensor to vary the aspiration pressure within the aspiration line. The vent valve (62) is a rotary valve that further comprises an input opening (68), an output opening (69) and a channel (66) that connects the input opening to the output opening. The vent valve (62) may be selectively rotated to selectively position the channel (66) in at least partial communication with the aspiration vent line (60).

Selectively moveable valve elements for aspiration and irrigation circuits

An aspiration circuit for a fluidics system (11) for selectively controlling aspiration, including an aspiration line (52) operatively connected to a surgical instrument; an aspiration pump to create an aspiration flow in the aspiration line; an aspiration exhaust line (54) operatively connected to the aspiration pump on one end and to a waste receptacle (58) on an opposing end; an aspiration vent line (60) connected at a first end to the aspiration line between the aspiration pump and the surgical instrument; and a selectively variable vent valve (62) operatively connected to the aspiration vent line (60), wherein the variable vent valve (62) may be selectively moved to selectively change aspiration pressure within the aspiration line; The aspiration circuit further includes an irrigation line (50) operatively connected to the surgical instrument (42); an irrigation pressure sensor (475) and an actuator, the irrigation pressure sensor being positioned to detect irrigation pressure in the irrigation line and the actuator being operatively connected to the vent valve; wherein the irrigation pressure sensor (475) and the actuator are connected to a controller, and wherein the controller (40) is operative to initiate the actuator to move the vent valve in response to pressure detected by the irrigation pressure sensor to vary the aspiration pressure within the aspiration line (52).

Liquid venting surgical system and cassette

A surgical system having a cassette with an aspirant collection chamber and an aspiration vent line that draws fluid from the aspirant collection chamber. The pressure within the collection chamber is maintained near ambient so that when the aspiration vent line is open, fluid flows from the collection chamber and into the aspiration line. Such a system does not require a second source of irrigation fluid, minimizes pressure surges into the irrigation fluid line and does not affect the fluidic performance of the aspiration system. In addition, various vent pressures can be achieved by varying the vertical position of the reservoir relative to the aspiration line.

Suction control for phacoemulsification aspiration system

The invention relates to a suction control for phacoemulsification aspiration system, comprising: a) a handpiece (22) having an aspiration function; b) a control console (12) c) an aspiration pump (16) at least partially located in the control console, the aspiration pump providing vacuum to the surgical handpiece through an aspiration line (20); d) an aspiration vent (30) in the aspiration line between the handpiece and the pump; and e) a user adjustable input device in the control console, the user adjustable input device varying the operation of the operation of the aspiration vent and/or aspiration pump based upon user inputs.

Fluid pressure sensing chamber

A pressure sensing chamber having a tubing extension with a reduced diameter portion extending through the chamber. The tubing contains a plurality of ports so as to allow the purging of air from the chamber, but the ports are sized so that bubbles entering the tubing cannot easily flow into the chamber. The reduced diameter portion creates a pressure differential between the holes. This differential pressure creates flow through the chamber under high liquid flow and turbulent liquid flow events.

Fluid pressure sensing chamber

Fluid pressure sensing chamber

Noninvasive pressure sensing assembly

The present invention improves upon prior art pressure sensors by providing a noninvasive pressure sensing assembly capable of accurately indicating relatively minute pressure changes. The present invention generally includes separating a pressure chamber from a pressure transducer by a thin, compliant membrane. The unique shape of the membrane assures that minute movements in the membrane are transferred to the measuring pressure transducer. Any change in pressure within the chamber will vary the amount of force exerted by the membrane against the transducer which, when any preload is deducted, will indicate the pressure within the chamber.

Fluid pressure sensing chamber

A pressure sensing chamber having a tubing extension with a reduced diameter portion extending through the chamber. The tubing contains a plurality of ports so as to allow the purging of air from the chamber, but the ports are sized so that bubbles entering the tubing cannot easily flow into the chamber. The reduced diameter portion creates a pressure differential between the holes. This differential pressure creates flow through the chamber under high liquid flow and turbulent liquid flow events.

Fluid pressure sensing chamber

Fluid pressure sensing chamber

Fluid pressure sensing chamber

A pressure sensing chamber having a tubing extension extending through the chamber. The tubing contains a plurality of ports so as to allow the purging of air from the chamber, but the ports are sized so that bubbles entering the tubing cannot easily flow into the chamber.

Fluid pressure sensing chamber

Fluid pressure sensing chamber

Fluid pressure sensing chamber

A pressure sensing chamber having a tubing extension extending through the chamber. The tubing contains a plurality of ports so as to allow the purging of air from the chamber, but the ports are sized so that bubbles entering the tubing cannot easily flow into the chamber.

Fluid pressure sensing chamber

Liquid venting surgical system and cassette

Irrigation/aspiration system

A surgical system with irrigation and aspiration lines having different compliance or stiffness, with the irrigation line having a higher compliance than the aspiration line.

A control system for controlling the operating parameters of a surgical system

A control system is provided for a surgical device including a handpiece (12,112,212,312,412,512) adapted to deliver irrigation fluid from a source to, and to draw aspiration fluid from, an operative site, said control system comprising a control console (14,114,214,314,414,514) having a control module including a central processing unit (CPU) (16,116,216,316,416,516), and having an aspiration pump (18,118,218,318,418,518); wherein an irrigation flow sensor (22,122,222,322,423,527), capable of providing irrigation fluid flow information to the central processing unit, is provided in the control console or in the handpiece. Irrigation flow measurements provided by the sensing capability allows the control system to vary irrigation pressure and/or flow, aspiration pressure and/or flow and power supplied to the handpiece more accurately than prior art sensors that monitor aspiration flow in ophthalmic surgery systems.

surgical system, cartridge for use in a surgical system, and method of venting a suction line extending from a handpiece to a suction pump mechanism.

Method of controlling the operating parameters of a surgical system

A control system for a surgical system that includes an irrigation fluid flow sensing capability. The sensing capability may be placed in the control console or in the handpiece. Irrigation flow measurements provided by the sensing capability allows the control system to vary irrigation pressure and/or flow, aspiration pressure and/or flow and power supplied to the handpiece more accurately than prior art sensors that monitor aspiration flow.

Peristaltic pump

A peristaltic pump wherein the pumping mechanism is enclosed in a vacuum chamber. Placement of the pumping mechanism within a vacuum chamber decreases the pressure differential between the inside and the outside of the pump channel, thereby minimizing changes in trapped fluid volume.

Infusion control system

An infusion control system having a flexible, collapsible infusion container. The container can be compressed between rollers or plate so at to pressurize the container. Such a system allows for rapid pressure response rates without the need of venting devices or air filtering. The may also include an irrigation flow sensor. The sensor may be placed in the control console or in the infusion handpiece. Irrigation flow measurements provided by the sensor allows the control system to vary irrigation pressure and/or flow, aspiration pressure and/or flow and power supplied to the handpiece more accurately than sensors that monitor aspiration flow.

Suction control for phacoemulsification aspiration system

The invention relates to a suction control for phacoemulsification aspiration system, comprising: a) a handpiece (22) having an aspiration function; b) a control console (12) c) an aspiration pump (16) at least partially located in the control console, the aspiration pump providing vacuum to the surgical handpiece through an aspiration line (20); d) an aspiration vent (30) in the aspiration line between the handpiece and the pump; and e) a user adjustable input device in the control console, the user adjustable input device varying the operation of the operation of the aspiration vent and/or aspiration pump based upon user inputs.

Method of controlling a surgical system based on a load on the cutting tip of a handpiece

A surgical system that is able to sense the onset of an occlusion or other surgical event as well as the instant an occlusion breaks. To help avoid overheating of the tip, the system determines an approximate temperature of the eye using an irrigation flow rate and reduces the power to the handpiece automatically if an overheating situation is predicted. Alternatively or in addition, the system monitors the power drawn by the handpiece, which is indicative of the cutting load on the tip, and automatically adjusts the power or stroke of the tip to compensate for increased loads on the tip.

Liquid venting surgical system and cassette

A surgical system having a cassette with an aspirant collection chamber and an aspiration vent line that draws fluid from the aspirant collection chamber. The pressure within the collection chamber is maintained near ambient so that when the aspiration vent line is open, fluid flows from the collection chamber and into the aspiration line. Such a system does not require a second source of irrigation fluid, minimizes pressure surges into the irrigation fluid line and does not affect the fluidic performance of the aspiration system. In addition, various vent pressures can be achieved by varying the vertical position of the reservoir relative to the aspiration line.

Chirurgisches System mit Flüssigkeitsrücklauf

Peristaltic pump

A peristaltic pump wherein the pumping mechanism is enclosed in a vacuum chamber (22). Placement of the pumping mechanism within a vacuum chamber (22) decreases the pressure differential between the inside and the outside of the pump channel (10), thereby minimizing changes in trapped fluid volume.

catalyst compositions comprising small silica support materials and methods of use in polymerization reactions

COMPOSIçõES CATALISADORAS COMPREENDENDO PEQUENOS MATERIAIS DE SUPORTE DE SìLICA E MéTODOS DE USO NAS REAçõES DE POLIMERIZAçãO. A presente invenção refere-se a composições catalisadoras a- perfeiçoadas, e processos de polimerização que empregam tais composições catalisadoras aperfeiçoadas. Um exemplo de uma composição catalisadora aperfeiçoada é um sistema catalisador suportado, que inclui pelo menos um composto de titânio, pelo menos um composto de magnésio, pelo menos um composto doador de elétrons, pelo menos um composto ativador, e pelo menos um material de suporte de sílica, pelo menos um material de suporte de sílica contendo um tamanho mediano de partícula na faixa de 20 até 50 mícrons com não mais do que 10% das partículas contendo um tamanho menor do que 10 mícrons e não mais do que 10% das partículas contendo um tamanho maior do que 50 mícrons, e diâmetro médio de poro de pelo menos 220 Angstróms. CATALYST COMPOSITIONS UNDERSTANDING SMALL SILICA SUPPORT MATERIALS AND METHODS OF USE IN POLYMERIZATION REACTIONS. The present invention relates to improved catalyst compositions, and polymerization processes employing such improved catalyst compositions. An example of an improved catalyst composition is a supported catalyst system, which includes at least one titanium compound, at least one magnesium compound, at least one electron donating compound, at least one activating compound, and at least one support material at least one silica support material containing a median particle size in the range of 20 to 50 microns with no more than 10% of the particles containing a size of less than 10 microns and not more than 10% of the particles containing a size greater than 50 microns, and average pore diameter of at least 220 Angstroms.

Catalyst compositions comprising small silica support materials and methods of use in polymerization reactions

Fischer-tropsch synthesis using microchannel technology and novel catalyst and microchannel reactor

The disclosed invention relates to a process for converting a reactant composition comprising H 2 and CO to a product comprising at least one aliphatic hydrocarbon having at least about 5 carbon atoms, the process comprising: flowing the reactant composition through a microchannel reactor in contact with a Fischer-Tropsch catalyst to convert the reactant composition to the product, the microchannel reactor comprising a plurality of process microchannels containing the catalyst; transferring heat from the process microchannels to a heat exchanger; and removing the product from the microchannel reactor; the process producing at least about 0.5 gram of aliphatic hydrocarbon having at least about 5 carbon atoms per gram of catalyst per hour; the selectivity to methane in the product being less than about 25%. The disclosed invention also relates to a supported catalyst comprising Co, and a microchannel reactor comprising at least one process microchannel and at least one adjacent heat exchange zone.

Fischer-Tropsch synthesis using microchannel technology and novel catalyst and microchannel reactor

Disclosed is a process for converting a reactant composition comprising H 2 and CO to a product comprising at least one aliphatic hydrocarbon having at least about 5 carbon atoms, the process comprising: flowing the reactant composition through a microchannel reactor in contact with a Fischer-Tropsch catalyst to convert the reactant composition to the product, the microchannel reactor comprising a plurality of process microchannels containing the catalyst; transferring heat from the process microchannels to a heat exchanger; and removing the product from the microchannel reactor; the process producing at least about 0.5 gram of aliphatic hydrocarbon having at least about 5 carbon atoms per gram of catalyst per hour; the selectivity to methane in the product being less than about 25%. Also disclosed is a supported catalyst comprising Co, and a microchannel reactor comprising at least one process microchannel and at least one adjacent heat exchange zone.

Bimetallic catalyst, method of polymerization and bimodal polyolefins therefrom

Bimetallic catalysts, and methods of producing a bimetallic catalyst comprising a modified Ziegler-Natta catalyst and a metallocene are provided, in one embodiment the method including combining: (a) a Ziegler-Natta cataylst comprising a Group 4, 5 or 6 metal halide and/or oxide, optionally including a magnesium compound, with (b) a modifier compound (“modifier”), wherein the modifier compound is a Group 13 alkyl compound, to form a modified Ziegler-Natta catalyst. Also provided is a method of olefin polymerization using the bimetallic catalyst of the invention. The modified Ziegler-Natta catalyst is preferably non-activated, that is, it is unreactive towards olefin polymerization alone. In one embodiment, the molar ratio of the Group 13 metal (of the modifier) to the Group 4, 5 or 6 metal halide and/or oxide is less than 10:1 in one embodiment. The bimetallic catalyst of the present invention are useful in producing bimodal polymers, particularly bimodal polyethylene, having a Polydispersity (Mw/Mn) of from 12 to 50. These bimodal polyolefins are useful in such articles as pipes and films.

Bimetallic catalyst, method of polymerization and bimodal polyolefins therefrom

Bimetallic catalysts, and methods of producing a bimetallic catalyst comprising a modified Ziegler-Natta catalyst and a metallocene are provided, in one embodiment the method including combining: (a) a Ziegler-Natta cataylst comprising a Group 4, 5 or 6 metal halide and/or oxide, optionally including a magnesium compound, with (b) a modifier compound (“modifier”), wherein the modifier compound is a Group 13 alkyl compound, to form a modified Ziegler-Natta catalyst. Also provided is a method of olefin polymerization using the bimetallic catalyst of the invention. The modified Ziegler-Natta catalyst is preferably non-activated, that is, it is unreactive towards olefin polymerization alone. In one embodiment, the molar ratio of the Group 13 metal (of the modifier) to the Group 4, 5 or 6 metal halide and/or oxide is less than 10:1 in one embodiment. The bimetallic catalyst of the present invention are useful in producing bimodal polymers, particularly bimodal polyethylene, having a Polydispersity (Mw/Mn) of from 12 to 50. These bimodal polyolefins are useful in such articles as pipes and films.

Bimetallic catalyst, method of polymerization and bimodal polyolefins therefrom

Producing polyolefin products

A method of polymerizing olefins is disclosed. The method comprises contacting ethylene and at least one comonomer with a catalyst system to produce a polyolefin polymer that is multimodal. The catalyst system comprises a first catalyst that promotes polymerization of the ethylene into a low molecular weight (LMW) portion of the polyolefin polymer and a second catalyst that promotes polymerization of the ethylene into a high molecular weight (HMW) portion of the polyolefin polymer. The first catalyst and at least a portion of the second catalyst are co-supported to form a commonly-supported catalyst system and at least a portion of the second catalyst is added as a catalyst trim feed to the catalyst system.

Continuity compositions and olefin polymerization method using them

Una composición de continuidad, que comprende: a) 2-20% en peso de al menos una sal carboxilato metálica, en la que dicha sal carboxilato metálica está modificada con b) 2-20% en peso de al menos una amina grasa, y c) al menos un vehículo líquido, en la que el porcentaje en peso se basa en el porcentaje en peso total de a), b) y c). A continuity composition, comprising: a) 2-20% by weight of at least one metal carboxylate salt, wherein said metal carboxylate salt is modified with b) 2-20% by weight of at least one fatty amine, and c ) at least one liquid vehicle, in which the weight percent is based on the total weight percent of a), b) and c).

Instrumento quirúrgico articulable con vías conductoras para la comunicación de la señal.

Una cubierta para una junta de articulación que se soporta en una unidad de vástago alargado de un instrumento quirúrgico que se acopla operativamente a un efector extremo quirúrgico que incluye al menos un conductor de efector de extremo en éste; la cubierta incluye al menos una vía eléctricamente conductora que se extiende desde el extremo distal de la cubierta para formar una vía eléctricamente conductora desde el conductor de efector de extremo a un conductor de vástago en la unidad de vástago alargado al tiempo que facilita el funcionamiento de la junta de articulación; se describen, además, diversas disposiciones de conductores que facilitan el paso de la corriente eléctrica entre un efector de extremo para un sistema de control a través de la junta de articulación.

Olefin polymerization processes

A process for producing an olefin polymer employs a gas phase polymerization reactor having a product discharge system comprising first and second pairs of lock hoppers, wherein each pair comprises an upstream lock hopper connected by valve means to the reactor and a downstream lock hopper connected by valve means to the upstream lock hopper and by further valve means to a product recovery system, and wherein a first cross-tie is provided between the upstream lock hoppers of the first and second pairs of lock hoppers and a second cross-tie is provided between the downstream lock hoppers of the first and second pairs of lock hoppers. Operation of the second cross-tie during product removal cycles is controlled in accordance with reactor pressure.

Olefin Polymerization Processes

In a process for producing an olefin polymer, at least one olefin monomer is polymerized in a polymerization reactor to produce a particulate polymer product containing hydrocarbon impurities including unreacted monomer and other C1 to C8 hydrocarbons. The polymer product is contacted with a gas-containing stream in a stripping vessel under conditions effective to strip hydrocarbon impurities from the polymer product and produce a stripped particulate polymer product and a gaseous first effluent stream containing inert gas and hydrocarbon impurities. The stripped particulate polymer product is recovered and the atmosphere adjacent the stripped particulate polymer product is sensed with a photoionization detector configured to ionize C4 to C8 hydrocarbons. The amount of the gas-containing stream supplied to the stripping vessel is then adjusted based upon such sensing.

Supported polymerization catalyst

[105] A SUPPORTED CATALYST COMPOSITION COMPRISING THE REACTION PRODUCT OF i) AMAGNESIUM HALIDE, ii) A SOLVENT, iii) AN ELECTRON DONOR COMPOUND, iv) AND A TRANSITION METAL COMPOUND; AN INERT SUPPORT; AND A COCATALYST COMPOSITION WHEREIN THE SUPPORTED CATALYST IS SUBSTANTIALLY FREE OF OTHER ALCOHOLS AND WHEREIN THE MOLAR RATIO OF THE FIRST ALCOHOL TO MAGNESIUM IS LESS THAN OR EQUAL TO 1.9. METHODS OF MAKING SUPPORTED CATALYST COMPOSITIONS AND METHODS OF MAKING POLYMERS WITH SUPPORTED CATALYSTS.

High isolation passive switch

A radio frequency switch disposed over a substrate having ground plane conductors disposed over an opposite surface thereof is described. The switch has at least two terminals, and includes a plurality of pairs of transistors, each one of said transistors coupled between a reference potential and a common transmission line which is coupled to one of the pair of terminals. A pair of topside conductors are disposed over the substrate to couple the transistors through plated vias to a bottom ground plane conductor. The switch further includes a series connected transistor disposed between the r.f. line and a second one of the terminals of the circuit.

Compact ink jet printhead

A compact thermal ink jet printhead including a printhead substrate, a plurality of side by side columnar arrays of drop generators formed in the printhead substrate, and drive circuits formed in the printhead substrate for energizing each ink drop generator. The printhead substrate has an ink drop generator packing density of at least 10.43 ink drop generators per square millimeter.

Method for enhancing the activity of the ziegler-natta catalyst

Un método para formar una composición precursora modificada de un catalizador Ziegler-Natta (ZN), que comprende: proporcionar una composición precursora del catalizador ZN para el tratamiento con un compuesto de alquil aluminio en un disolvente orgánico líquido, donde la composición precursora del catalizador ZN incluye al menos un compuesto de titanio, en donde la provisión de la composición precursora incluye precipitar al menos un compuesto de magnesio con él al menos un compuesto de titanio sobre un material portador; tratar el al menos un compuesto de titanio de la composición precursora con el compuesto de alquil aluminio en el disolvente orgánico líquido, donde el compuesto de alquil aluminio convierte el al menos un compuesto de titanio de la composición precursora en un estado modificado del catalizador ZN; y eliminar al menos una porción del compuesto de alquil aluminio y los compuestos derivados de la reacción en el disolvente orgánico líquido no consumido al convertir el al menos un compuesto de titanio de la composición precursora en el estado modificado de la composición precursora para formar la composición precursora modificada del catalizador ZN; donde la precipitación del al menos un compuesto de magnesio con él al menos un compuesto de titanio sobre el material portador incluye: disolver el al menos un compuesto de magnesio y el al menos un compuesto de titanio a una razón molar de 3:1 a 5:1 (moles del al menos un compuesto de magnesio: moles de al menos un compuesto de titanio) en tetrahidrofurano para formar una solución de compuesto de Magnesio/compuesto de Titanio; mezclar el material portador en la solución de compuesto de Magnesio/compuesto de Titanio; y eliminar el tetrahidrofurano para formar la composición precursora del catalizador ZN. A method of forming a modified Ziegler-Natta (ZN) catalyst precursor composition, comprising: providing a ZN catalyst precursor composition for treatment with an aluminum alkyl compound in a liquid organic ...

Methods to integrate aluminoxane production into catalyst production

Un método para integrar la producción de aluminoxano en la producción de catalizador, que comprende: hacer reaccionar un compuesto de hidrocarbil aluminio y agua en un disolvente reciclado para producir al menos una mezcla de reacción que comprende un aluminoxano, un resto del compuesto de hidrocarbil aluminio y el disolvente reciclado; combinar al menos una porción de la mezcla de reacción con un componente catalizador para producir al menos una composición de catalizador; separar la composición de catalizador del disolvente reciclado en la mezcla de reacción; y reciclar al menos una porción del disolvente separado para producir aluminoxano adicional, comprendiendo el disolvente separado al menos una porción del resto del compuesto de hidrocarbil aluminio. A method of integrating the production of aluminoxane into the production of catalyst, comprising: reacting a hydrocarbyl aluminum compound and water in a recycled solvent to produce at least one reaction mixture comprising an aluminoxane, a residue of the hydrocarbyl aluminum compound and the recycled solvent; combining at least a portion of the reaction mixture with a catalyst component to produce at least one catalyst composition; separating the catalyst composition from the recycled solvent in the reaction mixture; and recycling at least a portion of the separated solvent to produce additional aluminoxane, the separated solvent comprising at least a portion of the remainder of the aluminum hydrocarbyl compound.

Continuity additives and their use in polymerization processes