Forceps and collection assembly with accompanying mechanisms and related methods of use

The invention includes a forceps and collection assembly for acquiring and storing a plurality of tissue samples in a single pass, and accompanying mechanisms for use with the forceps and collection assembly. The accompanying mechanisms include an endoscope working channel cap assembly configured to minimize compression of a pouch of the forceps and collection assembly as it traverses a seal of the cap assembly, and a flush adapter configured to be coupled to the pouch so as to assist in removing tissue samples in the pouch by flowing fluid through the pouch.

GLUCAGON-LIKE PEPTIDE-1 ANALOGUES AND USES THEREOF

Provided is a glucagon-like peptide-1 (GLP-1) analogue shown as the following formula, wherein X is selected from glycine and glycinamide. The GLP-1 analogue has a non-proteogenic amino acid residue in position 8 relative to the sequence GLP-1, and is acylated with a moiety comprising two acidic groups to the lysine residue in position 26. The GLP-1 analogue is resistant to dipeptidyl peptidase IV so as to have an extended half-life in vivo. Also provided is a use of the GLP-1 analogue in conquering blood sugar. 2. A pharmaceutical composition comprising a therapeutically effective amount of at least one compound of and at least one pharmaceutically acceptable excipient.3. Use of the pharmaceutical composition of for preparation of a medicament.4. The use of the pharmaceutical composition of for preparation of a medicament for the treatment or prevention of type II diabetes claim 3 , impaired glucose tolerance claim 3 , type I diabetes claim 3 , obesity claim 3 , hypertension claim 3 , syndrome X claim 3 , dyslipidemia claim 3 , cognitive disorders claim 3 , atherosclerosis claim 3 , myocardial infarction claim 3 , coronary heart disease claim 3 , cardiovascular disease claim 3 , stroke claim 3 , inflammatory bowel syndrome and/or dyspepsia or stomach ulcers.5. The use of the pharmaceutical composition of for preparation of a medicament for delaying or preventing deterioration of type II diabetes.6. The use of the pharmaceutical composition of for preparation of a medicament for decreasing food intake claim 3 , decreasing β-cell apoptosis claim 3 , increasing β-cell function claim 3 , increasing β-cell mass and/or for restoring β-cell sensitivity to glucose.7. Use of a compound of for preparation of a medicament for the treatment or prevention of type II diabetes claim 1 , impaired glucose tolerance claim 1 , type I diabetes claim 1 , obesity claim 1 , hypertension claim 1 , syndrome X claim 1 , dyslipidemia claim 1 , cognitive disorders claim 1 , atherosclerosis ...

Vaccine composition based on sticholysin encapsulated into liposomes

The current invention relates to the field of Biotechnology applied to human health. Here it is described a vaccine vehicle wherein toxins from eukaryotic organisms are encapsulated into multilamellar vesicles obtained by the dehydration-rehydration procedure whose lipidic composition is dipalmitoylphosphatidylcholine:cholesterol in a 1:1 molar ratio for subcutaneous or intramuscular administration. These compositions do not require the use of other adjuvants. The disclosed compositions allow modulation of CTL-specific immune response against one or several antigens co-encapsulated into toxin-containing liposomes. The vaccinal vehicle of the present invention shows advantages over others disclosed by the previous art due to the robustness and functionality of the induced immune response as well as its immunomodulating properties.

Novel Glucagon Like Peptide Analogs, Composition, and Method of Use

The present invention relates to novel analogs of glucagon like peptide and compositions that are useful for up-regulating insulin expression in mammals and for treating diabetes. In particular, these peptide derivatives have a peptide mimic linker and provides long duration of action for the treatment of diabetes and other insulinotropic peptide related diseases, gastrointestinal function and activities associated with glucagon levels. 7. A GLP-1 analog , which is[Q-linker-d8, Glu22]GLP-1-(7-37)-peptide;[Q-linker-a8-9, Glu22]GLP-1-(7-37)-peptide;[Q-linker-b8-9, Glu22]GLP-1-(7-37)-peptide;[Q-linker-c8, Glu22]GLP-1-(7-37)-peptide;[Q-linker-e8-9, Glu22]GLP-1-(7-37)-peptide;[Q-linker-f8-9, Arg34]GLP-1-(7-37)-peptide;{'sup': '26', 'N-ε-[γ-L-glutamyl(N-α-hexadecanoyl)]-[Q-linker-c8,Arg34]GLP-1-(7-37)-peptide;'}{'sup': '26', 'N-ε-[γ-L-glutamyl(N-α-hexadecanoyl)]-[Q-linker-d8,Arg34]GLP-1-(7-37)-peptide;'}{'sup': '26', 'N-ε-[γ-L-glutamyl(N-α-hexadecanoyl)]-[Q-linker-e8-9,Arg34]GLP-1-(7-37)-peptide;'}{'sup': '26', 'N-ε-[γ-L-glutamyl(N-α-hexadecanoyl)]-[Q-linker-f8-9,Arg34]GLP-1-(7-37)-peptide;'}{'sup': '26', 'N-ε-[γ-L-glutamyl(N-α-hexadecanoyl)]-[Q-linker-a8-9,Arg34]GLP-1-(7-37)-peptide;'}{'sup': '26', 'N-ε-[γ-L-glutamyl(N-α-hexadecanoyl)]-[Q-linker-b8-9,Arg34]GLP-1-(7-37)-peptide;'}{'sup': 26', 'ε, 'N-ε-[(N-ω-carboxyheptadecanoyl)]-[Q-linker-c8,Arg34]GLP-1-(7-37)-peptide;'}{'sup': 26', 'ε, 'N-ε-[(N-ω)-carboxynonadecanoyl)]-[Q-linker-c8,Arg34]GLP-1-(7-37)-peptide;'}{'sup': '(PEG)', 'sub': '2', '[Q-linker-d8]GLP-1-(7-37)-Cys-Ala-NH;'}{'sup': '(PEG)-Ala-NH', 'sub': '2', '[Q-linker-c8]GLP-1-(7-37)-Cys;'}{'sup': '(PEG)', 'sub': '2', '[Q-linker-a8-9]GLP-1-(7-37)-Cys-Ala-NH;'}{'sup': '(PEG)', 'sub': '2', '[Q-linker-b8-9]GLP-1-(7-37)-Cys-Ala-NH;'}{'sup': '(PEG)', 'sub': '2', '[Q-linker-e8-9]GLP-1-(7-37)-Cys-Ala-NH; or'}{'sup': 'PEG)', 'sub': '2', '[Q-linker-f8-9]GLP-1-(7-37)-Cys-Ala-NH.'}8. A pharmaceutical composition comprising a GLP-1 analog of and a pharmaceutically acceptable ...

Apparatus for Creating Graft Devices

An apparatus is provided for applying a restrictive fiber matrix to a conduit to create a graft device. A rotating assembly rotates the conduit, and a polymer delivery assembly delivers the restrictive fiber matrix. A controller controls the polymer deliver assembly and the rotating assembly. 1284-. (canceled)285. An apparatus for applying a restrictive fiber matrix to a tubular member to create a graft device , the apparatus comprising:a rotating assembly constructed and arranged to rotate the tubular member;a polymer delivery assembly constructed and arranged to deliver the restrictive fiber matrix to the tubular member; anda controller constructed and arranged to control the polymer delivery assembly and the rotating assembly.286. The apparatus of wherein the apparatus is constructed and arranged to apply a material layer.287. The apparatus of wherein the material layer comprises at least one intermediate layer positioned between the tubular member and the restrictive fiber matrix.288. The apparatus of wherein the intermediate layer comprises a layer selected from the group consisting of: an adhesive layer; a protective layer; a mechanically protective layer; a chemically protective layer; a compressible layer; an elastic layer; a viscoelastic layer; a viscous layer; a kink-resisting layer; and combinations thereof.289. The apparatus of wherein the tubular member comprises a harvested vessel comprising at least one side branch location and wherein the apparatus is constructed and arranged to modify the application of the restrictive fiber matrix at the location of the at least one side branch location.290. The apparatus of wherein the modification comprises applying at least one of more fiber or less fiber proximate the side branch location.291. The apparatus of further comprising a camera assembly.292. The apparatus of wherein the camera assembly is constructed and arranged to identify a side branch location.293. The apparatus of wherein the tubular member ...

System And Method For Securely Binding And Node-Locking Program Execution To A Trusted Signature Authority

A system and method is disclosed for securely binding an arbitrary program to an authorized instance of a generic execution platform. Once the binding process occurs, the protected software application will not exhibit correct behavior unless run on the execution platform to which it is bound. The system and method withstands repeated attacks which tamper with the software application and the execution platform. The system and method present a mechanism to bind a program, P, to any un-trusted execution platform, E, which contains a Trusted Signing Authority (TSA). The TSA may take many alternate forms including a trusted platform module, secure processor, kernel driver, and hardened software agents.

System And Method Providing Dependency Networks Throughout Applications For Attack Resistance

A method and system is provided to automatically propagate dependencies from one part of a software application to another previously unrelated part. Propagation of essential code functionality and data to other parts of the program serves to augment common arithmetic functions with Mixed Boolean Arithmetic (MBA) formulae that are bound to pre-existing parts of the program. A software application is first analyzed on a compiler level to determine the program properties which hold in the program. Thereafter, conditions are constructed based on these properties and encoded in formulae that encode the condition in data and operations. Real dependencies throughout the application are therefore created such that if a dependency is broken the program will no longer function correctly.

System and Mandrel for Creating Graft Devices

A system for applying a fiber matrix on a tubular member is provided. A mandrel, configured for atraumatic placement within the tubular member, is included. Methods for atraumatic placement of a mandrel into a tubular member are also provided. 1290-. (canceled)291. A system for applying a fiber matrix on a tubular member , the system comprising:a fiber matrix delivery assembly;a tubular member; anda mandrel comprising a mandrel first end and a mandrel second end, wherein the mandrel is constructed and arranged to be atraumatically inserted into the tubular member, radially expanded within the tubular member, and attached to the fiber matrix assembly.292. The system of claim 291 , wherein the mandrel further comprises a lumen.293. The system of claim 291 , wherein the mandrel further comprises:a porous portion, andwherein the system is constructed and arranged to deliver fluid from the porous portion to the tubular member.294. The system of claim 291 , wherein the mandrel comprises:a middle portion, and at least one of the mandrel first end or the mandrel second end comprises a smaller diameter than a diameter of the middle portion.295. The system of claim 291 , wherein the mandrel comprises:a shaft, anda balloon surrounding the shaft.296. The system of claim 291 , wherein the mandrel comprises a braided construction.297. The system of claim 291 , wherein the mandrel comprises a helical construction.298. The system of claim 291 , wherein the mandrel comprises a compressible tube constructed and arranged to radially expand when compressed.299. The system of claim 291 , wherein the mandrel is constructed and arranged to radially expand when exposed to a fluid.300. The system of claim 291 , wherein the mandrel comprises:a compressible tube constructed and arranged to radially expand when compressed.301. The system of claim 291 , wherein the mandrel further comprises:a guidewire attached to the mandrel first end.302. The system of claim 301 , wherein the guidewire is ...

Multi-function unit for the offshore transfer of hydrocarbons

A hydrocarbon transfer arrangement for transfer of fluids between an offshore unit and a carrier which are placed in an offloading configuration, includes at least one transfer hose and a gas return hose, wherein the end of the at least one transfer hose is connected to a floating multi-function unit allowing for the transport of the transfer hose between the offshore unit and the carrier, wherein the floating multi-function unit can be lifted out of the water and can be held in a fixed position above water-level and is provided with connection elements for making a fluid connection between the transfer hose end and a manifold of the carrier and with emergency disconnect elements for the at least one transfer hose, placed at a distance from the connection elements.

FGFR4 INHIBITOR AND USE THEREOF

Disclosed is a compound as a fibroblast growth factor receptor 4 (FGFR4) inhibitor (as shown in formula (I)), and a pharmaceutical composition thereof and a preparation method therefor, as well as the use of same in the treatment of FGFR4-mediated diseases. The above-mentioned compounds act by participating in a number of processes, such as regulating cell proliferation, apoptosis, migration, neovascularization. 2. The compound or a pharmaceutically acceptable salt claim 1 , solvate claim 1 , chelate claim 1 , non-covalent complex claim 1 , or prodrug thereof of claim 1 , wherein L claim 1 , Q and T is selected from the following groups:{'sub': '2', '(i) L is C, Q is N, T is CH;'}(ii) L is C, Q is N, T is C;(iii) L is C, Q is C, T is N;(iv) L is C, Q is N, T is CH;{'sub': '2', '(v) L is N, Q is N, T is CH; or'}(vi) L is C, Q is CH, T is O.4. The compound or a pharmaceutically acceptable salt claim 1 , solvate claim 1 , chelate claim 1 , non-covalent complex claim 1 , or prodrug thereof of claim 1 , wherein ring A is phenyl claim 1 , Cheteroaryl or Cheterocyclyl claim 1 , wherein the Cheteroaryl optionally containing 1 claim 1 , 2 or 3 heteroatoms selected from N and S claim 1 , the Cheterocyclyl is a fused bicyclic which has two N atoms and one O atom in the ring.5. The compound or a pharmaceutically acceptable salt claim 1 , solvate claim 1 , chelate claim 1 , non-covalent complex claim 1 , or prodrug thereof of claim 1 , wherein ring A is Cheteroaryl.6. The compound or a pharmaceutically acceptable salt claim 1 , solvate claim 1 , chelate claim 1 , non-covalent complex claim 1 , or prodrug thereof of claim 1 , wherein Ris selected from the group consisting of H claim 1 , halogen claim 1 , cyano claim 1 , Calkyl claim 1 , halogen substituted Calkyl claim 1 , —(CH)NRRsubstituted amino claim 1 , Calkoxy which substituted with substituted Cheterocyclyl claim 1 , wherein Rand Rare each optionally selected from Calkyl.8. The compound or a pharmaceutically acceptable ...

Composite to metal end fitting joint

A composite torque pipe to metal fitting joint including concentric inner and outer shells formed with respective smooth conical surfaces projecting distally and respectively tapered radially inwardly and radially outwardly to form an annulus expanding in thickness for receipt of a tapered connector ring complementally shaped at one end of a composite pipe and bonded along the interface. The present invention includes selecting the sleeves with the corresponding shells and, forming the torque pipe with the tapered ring and bonding the tapered ring in the annulus.

Method and system for media path security

The present disclosure provides a system for media path security includes an authoring system having a content stream transform and corrupter for corrupting content data and providing decorrupting data, a media container for conveying the corrupted content data and decorrupting data, and a client system having a fix-up component for fixing the corrupted content data in dependence upon the decorrupting data. A client system is also provided as having an input for receiving a media container and a fix-up component for fixing the corrupted content data in dependence upon the decorrupting data.

EGFR Inhibitors, Compositions and Methods Thereof

The present invention relates to compounds of Formula I, methods of using the compounds as EGFR inhibitors, and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders such as cancer or infections.

Optical aperture device

An optical module includes an aperture device and a support structure supporting the aperture device. The aperture device defines an aperture edge and an aperture plane. The aperture edge is adapted to define a geometry of a light beam passing the aperture device along an optical axis. The support structure is adapted to hold the aperture device in a defined manner when the aperture plane is inclined with respect to a horizontal plane. A temperature distribution prevails within the aperture device and at least one of the aperture device and the support structure is adapted to maintain at least one of a relative position of the aperture edge with respect to the optical axis and a geometry of the aperture edge substantially unaltered upon an introduction of a thermal energy into the aperture device, where the thermal energy being adapted to cause an alteration in the temperature distribution.

IMMUNOMODULATORS, COMPOSITIONS AND METHODS THEREOF

Provided herein are compounds of Formula (I), methods of using the compounds as immunomodulators, and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders such as cancer or infections. 2. The compound of claim 1 , or a stereoisomer claim 1 , tautomer claim 1 , pharmaceutically acceptable salt claim 1 , prodrug claim 1 , chelate claim 1 , non-covalent complex claim 1 , or solvate thereof claim 1 , wherein claim 1 ,{'sub': 3', '2', 's', '4', '5', '1-4', '1-4', '2', 'q', '4', '5', '4', '5', '4', '4', '4', '5', '2', '4', '2-6', '2-6', '1-6', '3-6', '3-6', '1-4', '1-4', '2-6', '2-6', '1-6', '3-6', '6, 'Ris H, halogen, —(CH)—NRR, Calkyl, Calkoxyl, hydroxyl, oxo, CN, (CH)—CONRR, —NRR, —NRC(═NR)NRR, —S(O)R, Calkenyl, Calknyl, Chaloalkyl or Cheterocycloalkyl, wherein the Cheterocycloalkyl optionally comprising 1, 2 or 3 hetero atoms independently selected from N, S, or O; the Calkyl, Calkoxyl, Calkenyl, Calknyl, Chaloalkyl, and Cheterocycloalkyl optionally substituted with one or more substitutents independently selected Rsubstituents.'}3. The compound of claim 1 , or a stereoisomer claim 1 , tautomer claim 1 , pharmaceutically acceptable salt claim 1 , prodrug claim 1 , chelate claim 1 , non-covalent complex claim 1 , or solvate thereof claim 1 , wherein claim 1 ,{'sub': 3', '2', 's', '4', '5', '2', '4', '1-4', '1-4', '2', 's', '4', '5', '1-4', '1-4', '6, 'Ris H, halogen, —(CH)—NRR, —CN, —S(O)R, Calkyl, Calkoxyl, the —(CH)—NRR, Calkyl, Calkoxyl optionally substituted with one or more substitutents independently selected Rsubstituents.'}4. The compound of claim 1 , or a stereoisomer claim 1 , tautomer claim 1 , pharmaceutically acceptable salt claim 1 , prodrug claim 1 , chelate claim 1 , non-covalent complex claim 1 , or solvate thereof claim 1 , wherein claim 1 ,{'sub': 6', '2', 'k', '7', '8', '7', '7', '8', '7', '7', '8', '2', '7', '6', '1-4', '1-4', '2-6', '2-6', '1-6', '5-6', '5-6', ...

Antenna with Uniform Radiation for Ultra-Wide Bandwidth

An antenna element includes an outer conductor and an inner conductor. The outer conductor forms a perimeter of the antenna element. The inner conductor is physically and electrically connected to the outer conductor only at an intermediate connection at an inner portion of the outer conductor. The outer conductor and the inner conductor are arranged to form a slot therebetween. The slot extends around the inner conductor such that each end of the slot is adjacent to the intermediate connection.

Polymorphic forms of icotinib and uses thereof

The present invention relates to the polymorphic forms of the compound of Formula I, preparation thereof and pharmaceutical compositions, and use of a polymorph above in the treatment of a disease, a disorder or a condition, or in the manufacturing of a medicament for the treatment of a disease, a disorder or a condition.

Virtual machine migration detection by a hosted operating system

In an embodiment, a guest operating system (OS) running on a virtual machine (VM) detects a VM migration, where the embodiment comprises storing, by the guest OS, a VM identifier (VMID) provided by the VM and a first host identifier (HID) provided by a host computer system in a computer memory. The embodiment also comprises determining, by the guest OS, that the VM performs migrations that are transparent to the guest OS. The embodiment further comprises detecting, by the guest OS, that the VM has been migrated based on a comparison of the first HID to a second HID provided to the guest OS in response to an HID request from the guest OS.

OPERATING SYSTEM CODE PATCHING DURING LIVE MIGRATION

For a process of an operating system, it is detected that a live migration has occurred, the live migration comprising a change in a hardware characteristic of a computer system on which the process executes. A first message is broadcast to a set of processors, the first message causing each processor in the set of processors to enter a waiting state. While each of the set of processors is in the waiting state, a portion of a set of program instructions of the operating system is modified. 1. A computer-implemented method comprising:detecting, for a process of an operating system, that a live migration has occurred, the live migration comprising a change in a hardware characteristic of a computer system on which the process executes;broadcasting, to a set of processors, a first message, the first message causing each processor in the set of processors to enter a waiting state; andmodifying, while each of the set of processors is in the waiting state, a portion of a set of program instructions of the operating system.2. The computer-implemented method of claim 1 , wherein the waiting state comprises a state in which a processor in the set of processors does not execute user processes.3. The computer-implemented method of claim 1 , wherein the waiting state comprises a state in which a processor in the set of processors executes a message handler process until receiving the second message claim 1 , the message handler process comprising a kernel process of the operating system.4. The computer-implemented method of claim 1 , further comprising:receiving, from the set of processors, an acknowledgement of the first message, the acknowledgement confirming that a processor in the set of processors is in the waiting state.5. The computer-implemented method of claim 1 , wherein the modifying adjusts the portion to account for the change in the hardware characteristic.6. The computer-implemented method of claim 1 , wherein the change in the hardware characteristic is a change ...

POLYMORPHIC FORMS OF ICOTINIB MALEATE AND USES THEREOF

Provided are Icotinib maleate (the compound of Formula I) and polymorph forms thereof, and methods of preparing and using them. 2. The polymorph form of claim 1 , wherein the polymorph form is of Form I with an X-ray powder diffraction pattern having characteristic peaks at diffraction angles 2θ of approximately 6.1° claim 1 , 8.1° 15.4° claim 1 , 18.5° claim 1 , 20.3° and 24.2°±0.2°.3. The polymorph form of claim 2 , wherein the X-ray powder diffraction pattern has characteristic peaks at diffraction angles 2θ of approximately 6.1° claim 2 , 8.1° claim 2 , 13.4° claim 2 , 15.4° claim 2 , 16.3° claim 2 , 18.5° claim 2 , 20.3° and 24.2°±0.2°.4. The polymorph form of claim 2 , wherein the X-ray powder diffraction pattern is shown as in .5. The polymorph form of claim 2 , wherein the polymorph form has a melting point between 173° C.-176° C.6. The polymorph form of claim 1 , wherein the polymorph form is of Form II with an X-ray powder diffraction pattern having characteristic peaks at diffraction angles 2θ of approximately 7.5° claim 1 , 19.0° and 31.2°±0.2°.7. The polymorph form of claim 6 , wherein the X-ray powder diffraction pattern has characteristic peaks at diffraction angles 2θ of approximately 7.5° claim 6 , 15.0° claim 6 , 19.0° claim 6 , 23.8° and 31.2°±0.2°.8. The polymorph form of claim 6 , wherein the X-ray powder diffraction pattern has characteristic peaks at diffraction angles 2θ of approximately 7.5° claim 6 , 13.8° claim 6 , 15.0° claim 6 , 15.5° claim 6 , 19.0° claim 6 , 22.5° claim 6 , 23.8° and 31.2°±0.2°.9. The polymorph form of claim 6 , wherein the X-ray powder diffraction pattern is shown as in .10. The polymorph form of claim 6 , wherein the polymorph form has a melting point between 182-184° C.13. A pharmaceutical composition comprising a therapeutically effective amount of the polymorph form of and a pharmaceutically acceptable excipient claim 1 , adjuvant or carrier.14. The pharmaceutical composition of claim 13 , wherein the polymorph ...

NEW POLYMORPHIC FORMS OF ICOTINIB PHOSPHATE AND USES THEREOF

Disclosed is Icotinib phosphate (i.e., the compound of Formula (I)) and polymorph forms thereof, and methods of preparing and using them.

Composite to metal joint and method for forming same

A composite pipe to metal fitting joint including a shell formed with a conical cavity receiving a tapered end of a composite tube for bonded therein. The method includes selecting the metal fitting of a composite tube and bonding together.

CRYSTAL FORM OF COMPOUND FOR INHIBITING THE ACTIVITY OF CDK4/6 AND USE THEREOF

The present invention relates to a salt form of (R)—N-(5-((4-ethylpiperazin-1-yl)methyl)pyridin-2-yl)-5-fluoro-4-(6-fluoro-1-methyl-1,2,3,4-tetrahydrobenzo[4,5]imidazo[1,2-a]pyridin-8-yl)pyrimidin-2-amine (compound I) as shown in structural formula (I) or a crystal form thereof, and also relates to a method for preparing the salt form of compound I and/or the crystal form thereof, a pharmaceutical composition containing the salt form and/or the crystal form, and the use of same in the preparation of drugs for treating diseases, illnesses or conditions, or a method for treating diseases, illnesses or conditions. 2. The salt or the crystal form of the salt according to claim 1 , wherein claim 1 , the salt is tartaric acid salt claim 1 , wherein claim 1 , the tartaric acid salt is L-tartaric acid salt.4. A crystal form of a compound as shown in Formula II.5. The crystal form according to claim 4 , wherein claim 4 , the X-ray powder diffraction pattern of the crystal form has characteristic peaks at the diffraction angle 2θ of 4.4±0.2° claim 4 , 23.6±0.2° and 26.9±0.2°.6. The crystal form according to claim 5 , wherein claim 5 , the X-ray powder diffraction pattern of the crystal form has characteristic peaks at the diffraction angle 2θ of 4.4±0.2° claim 5 , 8.7±0.2° claim 5 , 10.8±0.2° claim 5 , 18.4±0.2° claim 5 , 23.6±0.2° and 26.9±0.2°.7. The crystal form according to claim 6 , wherein claim 6 , the X-ray powder diffraction pattern of the crystal form has characteristic peaks at the diffraction angle 26 of 4.4±0.2° claim 6 , 8.7±0.2° claim 6 , 10.8±0.2° claim 6 , 15.9±0.2° claim 6 , 18.4±0.2° claim 6 , 23.6±0.2° and 26.9±0.2°.8. The crystal form according to claim 4 , wherein claim 4 , the crystal form approximately has an X-ray powder diffraction pattern as shown in .9. The crystal form according to claim 4 , wherein claim 4 , the crystal form approximately has an X-ray powder diffraction pattern as shown in .10. The crystal form according to claim 4 , wherein ...

Erk inhibitor and use thereof

Disclosed are a compound (as shown in formula I) as an extracellular signal-regulated kinase (ERK) inhibitor, a pharmaceutical composition thereof, a preparation method therefor, and use thereof in treating ERK-mediated diseases. Said compound plays a role by regulating a plurality of processes such as cell proliferation, apoptosis, migration and angiogenesis.

ICOTINIB HYDROCHLORIDE, SYNTHESIS, CRYSTALLINE FORMS, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF

The invention relates to 4-[(3-ethynylphenyl)amino]-6,7-benzo-12-crown-quinazoline hydrochloride, its new crystalline forms, its therapeutic usage for treatment of diseases mediated by EGFR kinase and its combinatory therapeutic usage together with other therapeutic agents. The invention also provides synthetic methods for preparation of 4-[(3-ethynylphenyl)amino]-6,7-benzo-12-crown-quinazoline hydrochloride, its new crystalline forms, and the relevant synthetic intermediates for synthesis of 4-[(3-ethynylphenyl)amino]-6,7-benzo-12-crown-quinazoline hydrochloride. 3. The method of claim 2 , wherein:R is methyl or ethyl;said base is carbonate or biocarbonate; andsaid nitrating agent is nitric acid.4. The method of claim 1 , wherein R is ethyl.5. The method of claim 4 , wherein X is Cl.6. The method of claim 1 , wherein X is Cl.8. The method of claim 7 , wherein R is Et claim 7 , and X is Cl.10. The method of claim 9 , further comprising crystallizing the hydrochloride salt from a solvent selected from water claim 9 , a lower alcohol claim 9 , ketone claim 9 , ether claim 9 , ester claim 9 , halogenated hydrocarbon claim 9 , alkane claim 9 , halogenated benzene claim 9 , aliphatic nitrile claim 9 , an aromatic solvent claim 9 , and combinations thereof.11. The method of claim 9 , wherein the solvent is isopropanol claim 9 , ethyl acetate claim 9 , 50% aqueous ethanol claim 9 , water claim 9 , N claim 9 ,N-dimethylformamide claim 9 , methanol claim 9 , ethanol claim 9 , acetone or propanol.12. The method of claim 9 , wherein said crystalline form of hydrochloride salt is selected from the group consisting of:(a) Crystalline Form I characterized by a powder X-ray diffraction (PXRD) pattern comprising peaks having 2θ angle values at 5.74±0.2, 10.72±0.2, 11.50±0.2, 21.40±0.2, and 22.98±0.2 degrees;(b) Crystalline Form II characterized by a powder X-ray diffraction (PXRD) pattern comprising peaks having 2θ angle values at 7.46±0.2, 15.04±0.2, 16.24±0.2, 22.46±0.2, and 22. ...

SYSTEM AND MANDREL FOR CREATING GRAFT DEVICES

A system for applying a fiber matrix on a tubular member is provided. A mandrel, configured for atraumatic placement within the tubular member, is included. Methods for atraumatic placement of a mandrel into a tubular member are also provided. 1290.-. (canceled)291. A system for applying a fiber matrix on a tubular member , the system comprising:a fiber matrix delivery assembly;a tubular member; anda mandrel comprising a mandrel first end and a mandrel second end and constructed and arranged for atraumatic placement within the tubular member,wherein at least one of the mandrel first end or the mandrel second end comprises a tapered end.292. The system of claim 291 , wherein the mandrel further comprises a tapered segment.293. The system of claim 291 , wherein the mandrel further comprises a curved portion.294. The system of claim 291 , wherein the mandrel comprises a malleable structure.295. The system of claim 291 , wherein the mandrel further comprises a guidewire tip attached to the tapered end.296. The system of claim 295 , wherein the guidewire tip is removable.297. The system of claim 291 , wherein the mandrel comprises an inner tube and an outer tube.298. The system of claim 297 , wherein the outer tube comprises the tapered end.299. The system of claim 298 , wherein the tapered end comprises a resiliently biased tapered end.300. The system of claim 291 , wherein the mandrel further comprises a porous portion.301. The system of claim 300 , wherein the porous portion is configured to deliver fluids to the tubular member.302. The system of claim 291 , wherein the mandrel first end comprises a tapered end and the mandrel second end comprises a tapered end.303. The system of claim 291 , wherein the mandrel further comprises a coating.304. The system of claim 303 , wherein the coating is selected from the group consisting of: friction reducing coating; hydrophilic coating; lubricant coating; antithrombogenic coating; phospholipid coating; heparin-conjugated group ...

Method for protecting data

In the present disclosure, a hash function is computed over a known image, for example, an address range in a program. The result of the hash function is known to be the same at two distinct points in time, before the program is run, i.e. signing at build-time, and during the running of the program, i.e. run time. The value that the programmer wishes to hide, i.e. the secret value, is also known at build-time. At build-time, the secret value is combined with the hash in such a way that the combining operation can be reversed at run time. This combined value, i.e. the salt, is stored along with the program. Later, at runtime, the program computes the same hash value as was computed at signing time, and does the reverse combining operation in order to reveal the secret value.

COMPOUND FUNCTIONING AS BROMODOMAIN PROTEIN INHIBITOR, AND COMPOSITION

The invention relates to a bromodomain inhibitor. The invention also provides compositions and formulations comprising such compounds, and methods of using and preparing such compounds. 2. The compound according to claim 1 , wherein Ris selected from H claim 1 , Calkyl claim 1 , phenyl or Cheteroaryl claim 1 , wherein the Calkyl claim 1 , phenyl or Cheteroaryl is optionally substituted by Calkyl claim 1 , —NH claim 1 , phenyl claim 1 , or Cheteroaryl.3. The compound according to claim 1 , wherein the heteroaryl has 1 claim 1 , 2 or 3 heteroatoms each independently selected from nitrogen or sulfur.6. The compound according to claim 1 , wherein Ris H or Calkyl.7. The compound according to claim 1 , wherein Ris H or —CH.9. The compound according to claim 1 , wherein X is selected from H claim 1 , Calkyl or phenyl claim 1 , wherein the phenyl is unsubstituted or optionally substituted by halogen claim 1 , halo Calkyl claim 1 , Calkyl claim 1 , Calkoxy claim 1 , Calkylthio claim 1 , Calkoxycarbonyl claim 1 , or Calkyl-SO—.10. The compound according to claim 1 , wherein X is selected from H claim 1 , Calkyl or phenyl claim 1 , wherein the phenyl is unsubstituted or optionally substituted by F claim 1 , Cl claim 1 , methyl claim 1 , trifluoromethyl claim 1 , methoxy claim 1 , methylthio claim 1 , methoxycarbonyl or methyl-SO—.14. The compound according to claim 1 , wherein Ris H claim 1 , Calkyl claim 1 , Calkoxy claim 1 , cyano or oxo.15. The compound of claim 1 , wherein Ris H claim 1 , methyl or oxo.16. The compound of claim 1 , wherein Ris —N(R)—SO—R.17. The compound of claim 1 , wherein Rand Rare independently selected from H or Calkyl.18. The compound of claim 1 , wherein Rand Rare independently selected from H claim 1 , methyl or ethyl.21. A compound or a pharmaceutically acceptable salt thereof claim 1 , wherein the compound is:1) 4-(1-(4-chlorobenzyl)-2-methyl-1H-imidazo[4,5-b]pyridin-6-yl)-6-methyl-1H-pyrrolo[2,3-c]pyridin-7(6H)-one;2) 4-(1-(4-methoxybenzyl)-2- ...

Nya kelatbildande kinolinforeningar

EGFR INHIBITOR, COMPOSITION AND PREPARATION METHOD THEREFOR

The present invention relates to the compounds of Formula I, methods of using these compounds as EGFR inhibitors, and pharmaceutical compositions comprising compounds thereof. The compounds are used for treating, preventing or ameliorating diseases or disorders such as cancer or infections. 2. (canceled)3. The compound of claim 1 , or a stereoisomer claim 1 , tautomer claim 1 , deuterated compound claim 1 , pharmaceutically acceptable salt claim 1 , prodrug claim 1 , chelate claim 1 , non-covalent complex or solvate thereof claim 1 , wherein ring A is a 5- to 10-membered aryl or a 5- to 10-membered heteroaryl; wherein the 5- to 10-membered heteroaryl contains 1 claim 1 , 2 or 3 heteroatoms selected from N or S.7. The compound of claim 1 , or a stereoisomer claim 1 , tautomer claim 1 , deuterated compound claim 1 , pharmaceutically acceptable salt claim 1 , prodrug claim 1 , chelate claim 1 , non-covalent complex or solvate thereof claim 1 , Ris selected from H claim 1 , halogen claim 1 , —Calkyl or —Calkoxy.8. The compound of claim 7 , or a stereoisomer claim 7 , tautomer claim 7 , deuterated compound claim 7 , pharmaceutically acceptable salt claim 7 , prodrug claim 7 , chelate claim 7 , non-covalent complex or solvate thereof claim 7 , wherein Ris selected from H claim 7 , —F claim 7 , methyl or methoxy.9. The compound of claim 1 , or a stereoisomer claim 1 , tautomer claim 1 , deuterated compound claim 1 , pharmaceutically acceptable salt claim 1 , prodrug claim 1 , chelate claim 1 , non-covalent complex or solvate thereof claim 1 , wherein R claim 1 , Rand Rare independently selected from H claim 1 , halogen claim 1 , CN claim 1 , OH claim 1 , —Calkyl claim 1 , —Calkoxy and —Ccycloalkyl; the —Calkyl claim 1 , —Calkoxy and —Ccycloalkyl are optionally substituted or unsubstituted by halogen claim 1 , OH claim 1 , NH claim 1 , —Calkyl; R claim 1 , Rand Rare not H at the same time.10. The compound of claim 9 , or a stereoisomer claim 9 , tautomer claim 9 , ...

Pigmented, UV-cured, acrylic-based, pressure sensitive adhesives, and method for making same

Pressure sensitive adhesives that cure to a high cohesive strength at room and elevated temperatures, and a method for making such adhesives, are provided. The adhesives comprise an acrylic copolymer compounded with a pigment and a hydrogen-abstracting photoinitiator. A tackifier and/or multifunctional acrylate or methacrylate can also be added. The acrylic copolymer is prepared from a substantially acid-free monomer mixture of at least one alkyl acrylate and a tertiary amine-containing monomer, such as DMAPMA. Other monomers, including polar vinylic monomers and diesters of ethylenically unsaturated dicarboxylic acids are, preferably, also included. Despite the presence of titanium dioxide or other pigments, the compounded copolymers are UV-cured to a high cohesive strength through the combination of tertiary amine functional groups and hydrogen-abstracting photoinitiators, which form synergistic pairs when irradiated, leading to free radical formation and polymer cross-linking. Unpigmented adhesives are also provided.

Reduced overhead tunneling techniques in a communications network having mobile foreign agents

In a mobile communication system having mobile foreign agents, the present invention eliminates the use of multiple source/destination headers attached to an information packet during the tunneling operation by using either a decapsulation/encapsulation or a forwarding operation with the encapsulated information packet. Either of these operations reduces the overhead incurred in the multiple encapsulation headers by reducing encapsulation of the information packet to a single level. Upon receipt of the information packet at the foreign agent on the communications system, the information packet is directed to the mobile node using a routing chain table maintained by the foreign agent or a next hop routing table maintained by the foreign agent and each mobile foreign agent in the transmission path. Once implemented, these data structures can also assist with routing of information packets within the foreign subnetwork.

Porous spun polymeric structures and method of making same

A non-woven polymeric matrix for separating leukocytes from a blood sample includes a non-woven three dimensional matrix formed from polymeric fibers having a predetermined pore volume fraction including a defined channel configuration, a predetermined pore size in the range of from about 10 μm to about 250 μm, and a plurality of connections between the plurality of fibers. The matrix is configured so as to remove at least about 98% of leukocytes from at least one unit of packed red blood cells. Methods of making and using the matrix are also provided.

非常に高利得のヘテロ接合バイポーラトランジスタを製造する方法

(57)【要約】 【課題】 エミッタ／ベース接合に比較的広いバンドギ ャップをもつヘテロ接合バイポーラトランジスタを提供 する。 【解決手段】 垂直方向に一体化されたプロファイルを もつヘテロ接合バイポーラトランジスタは、基体層と、 コレクタ接点層と、コレクタ層と、ベース層と、ＡｌＧ ａＡｓで形成されたエミッタ層とを備え、このエミッタ 層は、エミッタメサを形成するようにエッチングされ、 エミッタメサに隣接して比較的薄い不動態化層を残すよ うにされる。不動態化層の上にベース金属接点が形成さ れ、巾の広いバンドギャップが形成されて、エミッタ／ ベース接合における表面再結合速度を最小にすると共 に、デバイスの全利得（β）を増加する。ベース金属接 点は、ｎ−型の不動態化層にｐ−オーミック金属を蒸着 することにより形成される。ｐ−オーミック接点はアニ ールされて、不動態化層を通してｐ−型金属拡散を生じ させると共に、ベース層との反応を生じさせて、オーミ ック接点を形成する。

Forceps and collection assembly with accompanying mechanisms and related methods of use

The invention includes a forceps and collection assembly for acquiring and storing a plurality of tissue samples in a single pass, and accompanying mechanisms for use with the forceps and collection assembly. The accompanying mechanisms include an endoscope working channel cap assembly configured to minimize compression of a pouch of the forceps and collection assembly as it traverses a seal of the cap assembly, and a flush adapter configured to be coupled to the pouch so as to assist in removing tissue samples in the pouch by flowing fluid through the pouch.

Endoscopic medical instrument and related methods of use

A medical instrument has a tubular member having a distal end and a proximal end, a handle attached to the proximal end of the tubular member, a distal assembly including a pivot and an end effector assembly supported on the pivot. The end effector assembly has a pair of end effectors. The medical instrument also includes an elongate member corresponding to each of the pair of end effectors. Each elongate member extends through the tubular member and has a proximal end attached to the handle and a distal end attached to the end effector assembly.

Device which thermally protects rotor of high pressure compressor

(57)【要約】 【解決手段】 互いに軸方向で間隔をおいてロータ１に 設けた周方向溝５内に回転羽根３の基部４を挿入して係 止する形式の高圧圧縮機用のロータ１を熱的に保護する ための装置において、ロータ１が、回転羽根３のための 隣接の２つの周方向溝５の間に、ロータの全周にわたり 延びているフック８を備えた少なくとも１つの別の周方 向溝７を有している。ロータのフック８に適合した輪郭 を有する少なくとも１つのフート１１を備えた板状の少 なくとも２つの蓄熱セグメント６が半径方向で相前後し て別の周方向溝７内に挿入されて係止され、その際、蓄 熱セグメントとロータとの間、及び回転羽根とロータと の間に、絶縁層のための中空室１３が設けられており、 この絶縁層内で圧縮機空気１０の速度が著しく減少す る。 【効果】 高熱からの保護作用が有利に得られる。

Burner

In a burner of the double cone type, at least one relief slit (30) is arranged in the front plate (18) locally between the regions having different axial expansions. The flexible connection remaining between the two outlet regions may be made integrally within the same casting or via a further welded-on part. Excessive thermal stresses are advantageously avoided thereby.

Pos focused media enhanced shopping systems - pricing and shrinkage control

A media enhanced shopping cart system comprises a shopping cart comprising a frame, a basket, a handle, a base tray, a plurality of wheels, a read component for performing a proximity scan of the shopping cart, a locationing component for determining a location of the shopping cart within a store based on the scan, and a display component for displaying at least one advertisement for a product based on the location of the shopping cart within the store, wherein the locationing component is further operable to determine a location of the product within the store relative to the shopping cart based on the scan, and wherein the display component is further operable to display an indication of the location of the advertised product relative to the location of the shopping cart.

Cutting apparatus for living plant materials

A reciprocating cutting apparatus for cutting living plant material. The cutting apparatus includes a frame. A reciprocating cutting assembly is mounted at one end of the frame for cutting the materials. The frame includes structure for synchronizing the feeding of the materials with the cutting assembly. The living plant material is fed into the cutting assembly in the upward stroke and held still on the downward or cutting stroke. The cutting assembly can be adjusted for cutting the desired strip width of living plant material. The cutting apparatus further includes structure mounted on the frame which applies pressure to the living plant material just prior to the living plant material being cut.

Novel glucagon like peptide analogs, composition, and method of use

The present invention relates to novel analogs of glucagon like peptide and compositions that are useful for up-regulating insulin expression in mammals and for treating diabetes. In particular, these peptide derivatives have a peptide mimic linker and provides long duration of action for the treatment of diabetes and other insulinotropic peptide related diseases, gastrointestinal function and activities associated with glucagon levels.

Novel glucagon like peptide analogs, composition, and method of use

Multi-antenna structure with two radiating antennas with one antenna fed from the other antenna

A multi-antenna structure includes a monopole-like or loop-like antenna structure with an antenna feed configured to connect to electrical circuitry; and a slot-like antenna structure adjacent to the monopole-like or loop-like antenna structure and capacitively fed by the monopole-like or loop-like antenna structure, wherein the monopole-like or loop-like antenna structure and the slot-like antenna structure operate as a combined antenna with extended bandwidth relative to operation individually. The monopole-like or loop-like antenna structure can include a horizontal member and a plurality of vertical members connected to the horizontal member. The slot-like antenna structure can include two parallel horizontal members separated by a slot and a vertical member at one end of the slot connected to each of the two parallel horizontal members separated and another end of the slot is open.

Polymorphic forms of icotinib and uses thereof

INSTANTANEOUS ELLIPSOMETER OR SPECTROSCOPIC SCATTEROMETER AND MEASURING METHOD THEREOF

L'invention concerne un ellipsomètre ou scattéromètre spectroscopique comprenant une source de lumière (1), un polariseur (5), un système optique d'illumination (2, 4) adapté pour diriger un faisceau lumineux incident polarisé (11) vers un échantillon (6), un séparateur optique de faisceau à division de front d'onde (20) disposé pour recevoir un faisceau lumineux secondaire (12) formé par réflexion, transmission ou diffraction, le séparateur optique de faisceau à division de front d'onde (20) étant orienté pour former trois faisceaux divisés collimatés, un dispositif optique de modification de polarisation (25) et un dispositif optique séparateur de polarisation (26) pour former six faisceaux séparés angulairement, un système optique de focalisation (27) formant six images alignées et séparées spatialement sur la fente d'entrée d'un spectromètre imageur (30) et un système de traitement d'image adapté pour traiter l'image des six sous-images spectrales pour en déduire une mesure spectroscopique d'ellipsométrie ou de scattérométrie. The invention relates to a spectroscopic ellipsometer or scaterometer comprising a light source (1), a polarizer (5), an optical illumination system (2, 4) adapted to direct an incident polarized light beam (11) towards a sample ( 6), a wavefront splitting optical beam splitter (20) arranged to receive a secondary light beam (12) formed by reflection, transmission or diffraction, the wavefront splitting optical beam splitter (20 ) being oriented to form three collimated divided beams, a polarization modifying optical device (25) and a polarization splitting optical device (26) to form six angularly separated beams, a focusing optical system (27) forming six aligned images and spatially separated on the input slit of an imaging spectrometer (30) and an image processing system adapted to process the image of the six spectral sub-images to deduce a spectro measurement scopic of ellipsometry or scaterometry. ...

Microvessel closing device with flexible terminal fiber

(57)【要約】 【課題】 繊維を一構成要素とする微小な閉塞デバイス であって、脈管構造の遠位部分における非常に細い血管 内で主に使用され得る閉塞デバイスを提供する。 【解決手段】 a)対向する端部、該端部間に伸びる保持 具軸、軸方向長さ、および該軸に沿って伸びる少なくと も１つの通路を有する少なくとも１つの保持具と、b)上 記少なくとも１つの通路の少なくとも１部分を通じて通 過する複数の繊維と、c)該保持具の対向する端部の少な くとも１つに固着する少なくとも１つの柔軟な先端部と を備えた、脈管閉塞デバイス。

Polymorph forms of icotinib maleate and uses thereof

Provided are Icotinib maleate(the compound of Formula I) and polymorph forms thereof, and methods of preparing and using them.

Distal end for ligating band dispenser

A supporting structure for a ligating band dispensing device adapted to be coupled to a distal end of an endoscope comprises a substantially cylindrical outer support surface adapted to receive a plurality of ligating bands thereon, wherein the support surface includes a channel extending therethrough from a distal end to a proximal end. The support surface further includes a plurality of shallow slots and deeper slots disposed on the distal end for retaining a trigger string. The shallow slots and deeper slots may be arranged in an alternating fashion, and each of the slots may be narrower than the trigger string to prevent the trigger string from prematurely exiting the slots. The support surface may also include a plurality of axially extending ridges to assist in deployment of the ligating bands by preventing the bands from sliding along the trigger line and facilitating rolling of the bands along the support surface.

Communication control device for a subscriber station of a bus system, programming tool and method for programming subscriber stations in a bus system having subscriber stations communicating according to different protocols

Es sind eine Teilnehmerstation (20) für ein Bussystem (1) und ein Verfahren zum Programmieren einzelner Teilnehmerstationen (20) in einem Bussystem (1), das nach unterschiedlichen Protokollen kommunizierenden Teilnehmerstationen (10, 20) aufweist, bereitgestellt. Die Teilnehmerstation (20) hat eine Kommunikationssteuereinrichtung (21) zum Erstellen oder Lesen zumindest einer Nachricht (7, 8, 9) für/von mindestens eine/r weiteren Teilnehmerstation (10; 20) des Bussystems (1), bei welchem zumindest zeitweise ein exklusiver, kollisionsfreier Zugriff einer Teilnehmerstation (10, 20) auf einen Bus (5) des Bussystems (1) gewährleistet ist, wobei die Kommunikationssteuereinrichtung (21) zur Vorbereitung einer Programmierung von mindestens einer weiteren Teilnehmerstation (10) im Bussystem (1) ausgestaltet ist, solange Nachrichten (7) zu senden, welche die mindestens eine weitere Teilnehmerstation (10) zum Aussenden von Fehlerrahmen (8) veranlassen, bis die mindestens eine weitere Teilnehmerstation (10) in einem Fehlerzustand ist, in welchem die mindestens eine weitere Teilnehmerstation (10) keine Fehlerrahmen (8) mit einer aktiven Fehlerkennung mehr aussenden.

Method, system and device for assisting a patient in complying with a medical regime

The invention relates to a method, system and dispensing device for assisting a patient in complying with a medical regimen. The system includes an electronic dispensing device to be used by the patient which comprises a device to obtain information about the regimen. A device registers operation of the dispensing device by the patient taking the medicines. A warning device reminds a patient of the regimen. A medicine packing station packs the medicine within a package in portions to be taken according to the regimen. A database stores information about the regimen. A service centre is provided to assist when necessary, A communication network is provided for communication between the dispensing device and the service centre and/or between the service centre and the patient.

Vaccine compositions based on sticholysin encapsulated in liposomes

The present invention relates to the field of biotechnology as applied to human health. The invention describes a vaccine vehicle in which toxins from eukaryotic organisms are encapsulated in liposomes with multiple lipid layers, obtained by means of the process of dehydration/rehydration, the lipid composition of which is dipalmitoylphosphatidylcholine:cholesterol in a molar ratio of 1:1, which are designed for subcutaneous or intramuscular administration. These compositions do not require the use of other adjuvants. The compositions described allow modulation of the specific CTL immune response to one or more antigens co-encapsulated in the liposomes that contain the toxin. The vaccine vehicle of the present invention presents advantages as compared with others described in the prior art owing to the robust and functional nature of the immune response induced and also the immunomodulating properties thereof.

Method and device for monitoring data communication

Verfahren zur Überwachung einer Datenkommunikation in einem mehrere Teilnehmer aufweisenden Kommunikationssystem, das ein von den Teilnehmern gemeinsam nutzbares Kommunikationsmedium aufweist, wobei das Verfahren die folgenden Schritte aufweist: Ermitteln der Teilnehmer des Kommunikationssystems, Bilden einer ersten Sammlung von möglichen Nachrichten, die durch wenigstens einen der ermittelten Teilnehmer über das Kommunikationsmedium aussendbar sind, Ermitteln von über das Kommunikationsmedium ausgesendeten Nachrichten, Auswerten der ermittelten Nachrichten. Method for monitoring data communication in a communication system having a plurality of subscribers, which has a communication medium that can be used jointly by the subscribers, the method comprising the following steps: determining the subscribers of the communication system, forming a first collection of possible messages which are ascertained by at least one of the subscribers Participants can be sent out via the communication medium, determining messages sent out via the communication medium, evaluating the determined messages.

FGFR4 inhibitor and use thereof

Disclosed is a compound as a fibroblast growth factor receptor 4 (FGFR4) inhibitor (as shown in formula (I)), and a pharmaceutical composition thereof and a preparation method therefor, as well as the use of same in the treatment of FGFR4-mediated diseases. The above-mentioned compounds act by participating in a number of processes, such as regulating cell proliferation, apoptosis, migration, neovascularization. <img file="dest_path_image002.jpg" he="51.06" img-content="drawing" img-format="jpg" inline="yes" orientation="portrait" wi="60.06"/>

Method, system and device for assisting a patient in complying with a medical regime

The invention relates to a method, system and dispensing device for assisting a patient in complying with a medical regimen. The system includes an electronic dispensing device to be used by the patient which comprises a device to obtain information about the regimen. A device registers operation of the dispensing device by the patient taking the medicines. A warning device reminds a patient of the regimen. A medicine packing station packs the medicine within a package in portions to be taken according to the regimen. A database stores information about the regimen. A service centre is provided to assist when necessary, A communication network is provided for communication between the dispensing device and the service centre and/or between the service centre and the patient.

Polymorphic forms of icotinib and uses thereof

Provided are polymorphic forms of the compound of Formula I, preparation thereof and pharmaceutical compositions, and use of a polymorph above in the treatment of a disease, a disorder or a condition, or in the manufacturing of a medicament for the treatment of a disease, a disorder or a condition.

Optical aperture device

There is provided an optical module comprising an aperture device and a support structure supporting the aperture device, the aperture device defining an aperture edge and an aperture plane. The aperture edge is adapted to define a geometry of a light beam passing the aperture device along an optical axis. The support structure is adapted to hold the aperture device in a defined manner when the aperture plane is inclined with respect to a horizontal plane. A temperature distribution prevails within the aperture device and at least one of the aperture device and the support structure is adapted to maintain at least one of a relative position of the aperture edge with respect to the optical axis and a geometry of the aperture edge substantially unaltered upon an introduction of a thermal energy into the aperture device, the thermal energy being adapted to cause an alteration in the temperature distribution.

System and method for securely binding and node-locking program execution to a trusted signature authority

Particulate detergent compositions

A particulate detergent composition having a bulk density of 700 g/l or less and containing at least 10 wt.% (preferably at least 15 wt.%) of organic detergent surfactant comprises a base powder composed of at least two granular components. Less than 80 % by weight, preferably less than 66 % by weight, of the base powder has a compressibility (measured at 20-25 °C and about 40 % relative humidity) of 17 % or more. Preferably one of the components of the base powder is a granule containing a high level (at least 60 wt.%) of anionic surfactant.

Bicyclic compounds, compositions and use thereof

Provided are compounds having a structure of formula (I), pharmaceutical compositions comprising such compounds and use thereof. The compounds are useful in treating, preventing or ameliorating diseases or disorders such as cancer.

2 Step cam system

This invention relates to a mooring system comprising a vessel and a elongate mooring column having an upper end connected to an arm on the vessel projecting from the vessel bow and a lower end connected to the sea bed via anchor lines, characterised in that the arm is pivotable arond a transverse axis.

Detachable aneurysm neck bridge

Movie distribution system

A system is disclosed for distributing data representing movies and/or mini-series. The system includes a database for storing and cataloging data representing pre-recorded movies. A billing system is connected to the database for selectively providing and controlling access to the data. The system further includes a user interface including means for requesting the data and means for viewing the data. A transmission network is connected between the user interface and the database for selectively transmitting the data therebetween. Upon the billing system providing access to a user, the requesting means generates a data request for retrieving the data from the database for transmission of the data via the transmission network for viewing by the viewing means.

Cleansing compositions containing film

A composition comprising a cleanser base and a plurality of film pieces, wherein the composition has a moisture content of about 22% or less. Also, a method of making a composition, comprising the steps of combining pieces of film with a cleansing material to make a cleansing mixture, and forming the mixture into a product of desired shape and size. Also, A method of delivering an active material during cleansing, comprising cleansing with water and a composition, wherein the composition comprises a plurality of film pieces, said film pieces comprising an active material and a polymer selected from water-soluble polymers, water- dispersible polymers, and combinations thereof.

Optical assembly

An optical assembly supported in an arrangement, especially in an objective or in an illuminating or exposure system, in the interior of a housing comprising at least one optical element, especially a lens, a mirror, or an aperture, wherein the at least one element is influenceable by at least one manipulator is characterized in that the at least one manipulator is arranged either outside of the housing or in a holding means that is separated entirely or to a large extent by the help of a decoupling means, and that there is provided an effective coupling between the manipulator and the element to be influenced by the manipulator in the interior of the arrangement.

Electrolytically deployable braided vaso-occlusion device

This is a braided tubular device used in the occlusion of various lumen or cavities in the body. In particular, it may be used to form an endovascular occlusion. Most desirably, it is braided of a majority of super-elastic alloy ribbons and therefore is both inherently non-stretching and most difficult to permanently deform. It may be deployed using an electrolytically severable joint. A radio-frequency modulated current may optionally be applied to the device after its placement in the body. The elongated device preferably is insulated along its length to optimize its occlusive activity without harm to the body.

Shape-memory alloy molding parts

A part for a mold is disclosed. The part includes a body formed of a shape-memory alloy. The body includes a first shape or first configuration at a first temperature and a second shape or second configuration at a second temperature. In one embodiment, the first shape includes at least one protrusion and the second shape is straight. A part of the present disclosure eliminates damage to a molded piece during removal of a molded piece from an injection mold by changing its shape in such a way that is suitable for part ejection.

Crystal form of compound for inhibiting the activity of cdk4/6 and use thereof

The present invention relates to a salt form of (R)-N-(5-((4-ethylpiperazin-1-yl)methyl)pyridin-2-yl)-5-fluoro-4-(6-fluoro-1-methyl-1,2,3,4-tetrahydrobenzo[4,5]imidazo[1,2-a]pyridin-8-yl)pyrimidin-2-amine (compound I) as shown in structural formula (I) or a crystal form thereof, and also relates to a method for preparing the salt form of compound I and/or the crystal form thereof, a pharmaceutical composition containing the salt form and/or the crystal form, and the use of same in the preparation of drugs for treating diseases, illnesses or conditions, or a method for treating diseases, illnesses or conditions.

Boolean logic tree reduction circuit

A method and apparatus are provided for performing a Boolean logic tree function on all bits of a multiple-bit binary input data word having a plurality of bit positions. Each bit has one of first and second complementary logic states. A modified data word is formed by packing all the bits of the input data word having the first logic state into a first contiguous set of bit positions in the modified data word and all the bits of the input data word having the second logic state into a second contiguous set of the bit positions in the modified data word. The number of bit positions in the first and second sets is greater than or equal to zero. A result of the Boolean logic tree function is generated based on a pattern of the first and second logic states in the modified data word.

Convertible wire wheel hub cover

ABSTRACT OF THE DISCLOSURE An automotive vehicle wheel cover has a hub cover and a wire basket with decorative, interconnected wire spokes. The hub cover is constructed with a central opening to receive a removable plate. The plate is equipped with a threaded nipple which will receive a threaded stud on a hubcap so that the hubcap can be used to secure a retention ring against the wire basket to secure the hub-cap, the retention ring and the wire basket relative to the hub cover and to a vehicle wheel having a bolt on flange and a tire rim. The wheel cover system may also be converted to accommodate a locking hubcap arrangement. When the wheel cover is utilized in this manner the plate and hubcap are removed and a hub spacer is secured to the vehicle wheel against the bolt-on flange with lug bolts or nuts. A replacement hubcap with a central axial recess is substituted for the original non-locking hubcap and a specially configured locking bolt is seated in the central recess of the hubcap and threadably engaged with the hub spacer by means of a special key. A decorative masking cap is mounted upon the hubcap over the locking bolt to conceal the recess and locking bolt from view. The length of the hub spacer and the position of a fastener on the hub spacer are adjustable.

Connector assembly for furniture members

Powder detergents and their manufacturing processes.

Multistage turbocompressor

A multistage turbocompressor is equipped with a tapping point between two compressor stages. The guide-blade cascade of the stage arranged directly upstream or downstream of the tapping point is designed with adjustable geometry. The pressure at the tapping point can be set within wide limits, irrespective of the compressor operating point, by an adjustment of this guide-blade cascade.

Media enabled shopping cart system and associated methods

Disclosed herein is a user interface in a media enabled shopping system, the system including a display component attached to a media enabled shopping cart, the display component including a screen comprising a viewable area, and an embedded computing device affixed to the shopping cart and operably coupled to the display component, the embedded computing device comprising a central processing unit, a memory and a network transceiver configured for wireless communication. The embedded computing device stores an executable set of software instructions which, when executed, cause the embedded computing device to generate the user interface on the display to navigate a plurality of options in the media enhanced shopping cart, said user interface including a plurality of menu options in a scrolling menu and dynamically magnified content associated with the menu option upon selection of a menu option. A method of navigating a media enabled shopping cart interface is also disclosed.

System and method for dynamic, variably-timed operation paths as a resistance to side channel and repeated invocation attacks

A system and method for constructing variably-timed operation paths and applying those paths to any algorithm. In particular, the system and method may be applied to cryptography algorithms as a means to resist side- channel, repeated invocation, and any similar attacks based on the physical characteristics of a system for a given software implementation. The method has the benefit of being generally applicable to any algorithm and has the ability to constrain performance to known timing windows.

Improved distal end for ligating band dispenser

A supporting structure for a ligating band dispensing device adapted to be coupled to a distal end of an endoscope comprises a substantially cylindrical outer support surface adapted to receive a plurality of ligating bands thereon, wherein the support surface includes a channel extending therethrough from a distal end to a proximal end. The support surface further includes a plurality of shallow slots and deeper slots disposed on the distal end for retaining a trigger string. The shallow slots and deeper slots may be arranged in an alternating fashion, and each of the slots may be narrower than the trigger string to prevent the trigger string from prematurely exiting the slots. <IMAGE>

Cleaning compositions

A tablet of compacted particulate detergent composition comprising non-soap surfactant and detergency builder, and; a) disintegration-promoting particles comprising water-insoluble disintegrant which can swell to at least twice its volume on contact with water, and a water-absorbent carrier which so swells to a lesser extent, and b) water-soluble polymeric binder solid at 25°C, and either c) comprising 2 to 40%wt of water-soluble disintegration-promoting particles comprising at least 40% of materials selected from; compounds with water solubility at 20°C of at least 50 grams per 100 grams of water; phase I sodium tripolyphosphate; sodium tripolyphosphate that contains water of hydration in an amount which is at least 0.5%wt of the sodium tripolyphosphate in the particles, or d) having a diametral fracture stress of at least 14 kPa. Process for making tablets with said detergent compositions.

Uses of bone morphogenetic proteins

Tissue connector apparatus and methods

A tissue connector assembly having a flexible member and a surgical fastener such as a surgical clip releaseably coupled to the flexible member. A needle may be secured to one end portion of the flexible member with the surgical clip coupled to the other end portion of the flexible member. A locking device may be used to releaseably couple the flexible member to the surgical clip. The tissue connector assembly may have one or more piercing members, each releaseably coupled to the surgical fastener. A flexible member such as a suture may be used to couple one or both piercing members to respective ends of the fastener.

Detergent compositions

Multi-function unit for the offshore transfer of hydrocarbons

A hydrocarbon transfer arrangement for transfer of fluids between an offshore unit and a carrier which are placed in an offloading configuration, includes at least one transfer hose and a gas return hose, wherein the end of the at least one transfer hose is connected to a floating multi-function unit allowing for the transport of the transfer hose between the offshore unit and the carrier, wherein the floating multi-function unit can be lifted out of the water and can be held in a fixed position above water-level and is provided with connection elements for making a fluid connection between the transfer hose end and a manifold of the carrier and with emergency disconnect elements for the at least one transfer hose, placed at a distance from the connection elements.

System and method providing dependency networks throughout applications for attack resistance

A method and system is provided to automatically propagate dependencies from one part of a software application to another previously unrelated part. Propagation of essential code functionality and data to other parts of the program serves to augment common arithmetic functions with Mixed Boolean Arithmetic (MBA) formulae that are bound to pre-existing parts of the program. A software application is first analyzed on a compiler level to determine the program properties which hold in the program. Thereafter, conditions are constructed based on these properties and encoded in formulae that encode the condition in data and operations. Real dependencies throughout the application are therefore created such that if a dependency is broken the program will no longer function correctly.

Glucagon-like peptide-1 analogue and use thereof

Provided is a glucagon-like peptide-1 (GLP-1) analogue shown as the following formula, wherein X is selected from glycine and glycinamide. The GLP-1 analogue has a non-proteogenic amino acid residue in position 8 relative to the sequence GLP-1, and is acylated with a moiety comprising two acidic groups to the lysine residue in position 26. The GLP-1 analogue is resistant to dipeptidyl peptidase IV so as to have an extended half-life in vivo. Also provided is a use of the GLP-1 analogue in conquering blood sugar.

Techniques for distributing information using multicast subsets

Techniques for sending data in a packet-switched communications network include determining multiple subsets of adjacent network nodes of the network. The adjacent network nodes communicate without intervening network nodes with a particular network node through an interface on the particular network node. Each subset includes multiple adjacent network nodes. Subset definition data is sent through the interface. The subset definition data indicates which adjacent network nodes belong to which subset. Data for fewer than all adjacent network nodes in all subsets are sent by including, in a multicast data packet sent over the interface with a multicast destination address, subset identifier data that indicates a particular subset. When such data is received by a node, it is discarded unless the subset identifier matches the receiving node's subset identifier. Among other effects, this allows routing messages to be more efficiently sent to better performing neighboring network nodes.

Media enabled shopping cart system and associated methods

INSTANTANE SPECTROSCOPIC ELLIPSOMETER OR SCATTEROMETER AND MEASUREMENT METHOD THEREOF

L'invention concerne un ellipsomètre ou scattéromètre spectroscopique comprenant une source de lumière (1), un polariseur (5), un système optique d'illumination (2, 4) adapté pour diriger un faisceau lumineux incident polarisé (11) vers un échantillon (6), un séparateur optique de faisceau à division de front d'onde (20) disposé pour recevoir un faisceau lumineux secondaire (12) formé par réflexion, transmission ou diffraction, le séparateur optique de faisceau à division de front d'onde (20) étant orienté pour former trois faisceaux divisés collimatés, un dispositif optique de modification de polarisation (25) et un dispositif optique séparateur de polarisation (26) pour former six faisceaux séparés angulairement, un système optique de focalisation (27) formant six images alignées et séparées spatialement sur la fente d'entrée d'un spectromètre imageur (30) et un système de traitement d'image adapté pour traiter l'image des six sous-images spectrales pour en déduire une mesure spectroscopique d'ellipsométrie ou de scattérométrie. The invention relates to a spectroscopic ellipsometer or scalerometer comprising a light source (1), a polarizer (5), an optical illumination system (2, 4) adapted to direct a polarized incident light beam (11) towards a sample ( 6), a wavefront division optical beam splitter (20) arranged to receive a secondary light beam (12) formed by reflection, transmission or diffraction, the wavefront division beam optical splitter (20). ) being oriented to form three collimated split beams, an optical polarization modifying device (25) and a polarization separating optical device (26) for forming six angularly separated beams, a focusing optical system (27) forming six aligned images and spatially separated on the input slot of an imaging spectrometer (30) and an image processing system adapted to process the image of the six spectral sub-images for deduce a spectroscopic measurement of ellipsometry or ...

Tapered screw extrusion process for making soap with a second phase

A process utilizing a tapered screw impeller extending at least partly into the extruder cone within the extrude region in a plodder assembly for manufacturing an improved multiphase soap bar product, which enables the use of a broader range of soap materials/formulas, including a broader range of secondary discontinuous phases materials with similar or slightly higher hardness compared to the primary continuous phase hardness, which allows more feasible, easy and convenient production.

Localization cataloguing tool

A code arrangement for facilitating the localization of an information source comprising a collector module for collecting information units to be localized from the information source and for causing a copy of the information units to be localized, a synchronization module for receiving the localized information units and comparing each to a current version of the information unit from the information source to determine if the information unit has changed and a dispersing module for storing the localized information unit if the information unit is unchanged. A related processor and method may include features similar to the elements of the code arrangement.

Method of fabricating double photoresist layer self-aligned heterojunction bipolar transistor

A heterejunction bipolar transistor and a method for fabricating an HBT with self-aligned base metal contacts using a double photoresist, which requires fewer process steps than known methods, while minimizing damage to the active emitter contact region. In particular, a photoresist is used to form the emitter mesa. The emitter mesa photoresist is left on and a double polymethylmethacrylate (PMMA) and photoresist layer is then applied. The triple photoresist combination is patterned to create a non-critical lateral alignment for the base metal contacts to the emitter mesa, which permits selective base ohmic metal deposition and lift-off. By utilizing the double photoresist as opposed to a metal or dielectric for masking, an additional photolithography step and etching step is eliminated. By eliminating the need for an additional etching step, active regions of the semiconductors are prevented from being exposed to the etching step and possibly damaged.

VACCINAL COMPOSITIONS BASED ON STICHOLISINE ENCAPSULATED IN LIPOSOMES

La presente invención se relaciona con el campo de Biotecnología aplicada a la salud humana. En la misma se describe un vehículo vacunal donde se encapsula toxinas provenientes de organismos eucariontes en liposomas de múltiples capas lipídicas obtenidos por el procedimiento de deshidratación-rehidratación cuya composición lipídica es dipalmitoilfosfatidilcolina: colesterol en una relación molar 1:1, destinadas a la administración subcutánea o intramuscular. Estas composiciones no requieren del empleo de otros adyuvantes. Las composiciones descritas posibilitan la modulación de la respuesta inmune CTL específica contra uno o varios antígenos co-encapsulados en liposomas que contienen la toxina. El vehículo vacunal de la presente invención presenta ventajas frente a otros descritos por el arte previo debido a la robustez y funcionalidad de la respuesta inmune que induce así como a sus propiedades inmumoduladoras. The present invention relates to the field of Biotechnology applied to human health. It describes a vaccine vehicle where toxins from eukaryotic organisms are encapsulated in liposomes of multiple lipid layers obtained by the dehydration-rehydration procedure whose lipid composition is dipalmitoylphosphatidylcholine: cholesterol in a 1: 1 molar ratio, intended for subcutaneous administration or intramuscular. These compositions do not require the use of other adjuvants. The compositions described enable the modulation of the specific CTL immune response against one or several antigens co-encapsulated in liposomes containing the toxin. The vaccine vehicle of the present invention has advantages over others described by the prior art due to the robustness and functionality of the immune response that it induces as well as its immumodulatory properties.

Powder detergent compositions.

700 g/l veya daha az olan bir kütle yogunluguna sahip ve agirlikça en az %10 (tercihen agirlikça en az %15) organik deterjan yüzey aktifi içeren bir toz deterjan bilesimi en az iki granül bilesen içeren bir baz toz içerir. Baz tozun agirlikça %80'den daha azi, tercihen %66'dan daha azi %17'den daha fazla olan bir sikistirilabilirlige (20-25 C'de ve yaklasik %40 nispi nemde ölçülen) sahiptir. Tercihen baz tozun bilesenlerinden birisi bir yüksek seviyede (agirlikça en az %60) anyonik yüzey aktif içeren bir granüldür. A powder detergent composition having a bulk density of 700 g / l or less and containing at least 10% (preferably at least 15% by weight) organic detergent surfactant contains a base powder containing at least two granule components. The base powder has a compressibility (measured at 20-25 ° C and about 40% relative humidity), which is less than 80% by weight, preferably less than 66%, and more than 17%. Preferably one of the components of the base powder is a granule containing a high level (at least 60% by weight) of anionic surfactant.

Endoscopic fundoplication devices and methods for treatment of gastroesophageal reflux disease

Endoscopic devices and methods used for fastening multiple tissue layers, such as, for example, an endoscopic fundoplication procedure, are disclosed. The endoluminal device includes a tissue fastener, a flexible needle having means for grasping and releasing a portion of the tissue fastener, and a deflector for deflecting and guiding the needle toward the multiple tissue layers.

Method for attaching an end-fitting to a drive shaft tube

A method for attaching an end-fitting (30), such as a yoke-type end fitting (30), to a tubular drive shaft (22) of the type used in the drive line of vehicles, comprises the steps of deforming the end of the drive shaft tube (22) such as by swaging it onto a tool or replica (42) of the end-fitting (30) so that the inner diameter of the tube end is less than the outer diameter of the end-fitting (30); and then press-fitting the end-fitting (30) into the deformed tube end. The resulting attachment is free of slippage that otherwise results from directly swaging the tube end onto the end-fitting (30). A preferred embodiment employs smooth undulating splines (38) on the end-fitting (30) and an outer sleeve (40) over the tube end and utilizes electromagnetic-induced swaging.

Endoscopic fundoplication devices and methods for treatment of gastroesophageal reflux disease

Endoscopic devices and methods used for fastening multiple tissue layers, such as, for example, an endoscopic fundoplication procedure, are disclosed. The endoluminal device includes a tissue fastener, a flexible needle having means for grasping and releasing a portion of the tissue fastener, and a deflector for deflecting and guiding the needle toward the multiple tissue layers.

Kras g12c inhibitor and pharmaceutical use thereof

Provided are compounds of formula (I), which have KRAS mutation tumor regulating activity. Also provided are a method for providing these compounds and a pharmaceutical composition comprising the same.

Tissue connector apparatus and methods

A tissue connector assembly comprising a clip movable between an open configuration and a closed configuration and a mechanical restraining device attached to the clip for restraining the clip in its open configuration. A needle may be releasably attached to the clip. A flexible member may also interconnect the clip and the needle. In one embodiment, a plurality of strands are releasably attachable to the clip for restraining the clip in its open configuration. A method for connecting tissues is also disclosed.

Improvements in screw stoppers for containers

658,811. Stoppers. TORRINGA, H. F. March 10, 1949, No. 6571. [Class 125(iii)] In a screw stopper device for containers 1 of the kind in which the inturned ends of a substantially U-shaped loop 7 supporting the stopper project into slots 4 on opposite sides of the container mouthpiece 2 or a threaded member 3 engageable thereon, each inturned end 5 of the loop is shaped and adapted to engage with an abutment 6 or shaped recess 19 provided in the slot into which it projects. The stopper is swung laterally away from the outlet of the container. The closing cap 8, Fig. 1, with an elastic lining disc 9, is carried by the loop which pivots on the threaded ring 3. The loop is first attached to the ring, without spreading the limbs of the loop, by slipping the slots 12 of the pivots 5 over the pins 6 in the slots 4 of the ring, as in Fig. 4, and then rotating the loop until the cap is in the screwing position, as in Fig. 6. The slots 4 may have slight abutments to engage shallow recesses on the loop pivot ends, so that the loop must be forced to assume the position of Fig. 4, and is held upright in the screwing position. In the embodiment shown in Fig. 8 the loop 7 has a threaded ring 17 in which the cover cap 13 engages, and the loop pivots have tapered flattenings 18 which fit in corresponding flattenings 19 in the slots of the mouthpiece to keep the loop in the screwing position. The loop is also held in this position by a resilient annular spring 15 which is fitted in a slit on the mouthpiece when the loop has been positioned. The cover 13 may have a removable plate 14 to indicate the contents &c. The stopper may be fitted on the valves of pneumatic tyres &c.

A system and method for aggressive self-modification in dynamic function call systems

Embodiments of the invention provide a system and method for software obfuscation for transforming a program from a first form to more secure form that is resistant to static and dynamic attacks. In an embodiment, the method utilizes a sophisticated pre-analysis step to comprehend the function-call structure, the function-call layout, and the entire function call graph of the program, in order to determine strategic points in the program for changing the program. The method provides resistance to static attacks by transforming the original function-call layout to a new layout. In an embodiment changing the layout may include changing the function boundaries. The method also provides resistance to static attacks by transforming the original function-call structure to a new structure to be able to self modify as the transformed program executes in memory. In an embodiment, changing the function-call structure may include modifying when and how functions are called, and/or choosing random paths of execution that lead to the same result. The transformed program is semantically equivalent to the original program but is more resistant to static and dynamic attacks.

Surgical connection apparatus and methods

Surgical connection apparatus comprises a support structure, a plurality of clips, which can be self-closing clips, each clip being releasably coupled to the support structure, and a plurality of barbs, each barb being coupled to the support structure, the barbs being separate from the clips, which are ejectable from the support structure independently of the barbs.

Process for identifying a road user and arrangement for carrying out the process

Process for producing a heterobipolar transistor using two-layer photoresists